Page 11234..1020..»

Nanomedicine | The Scientist Magazine

§ April 26th, 2017 § Filed under Nano Medicine § Tagged Comments Off on Nanomedicine | The Scientist Magazine

From bioimaging to drug delivery and therapeutics, nanotechnology is poised to change the way doctors practice medicine.

By Weihong Tan,Lei Mei,Guizhi Zhu | August 1, 2014

LAGUNA DESIGN/SCIENCE PHOTO LIBRARY/CORBIS

In a 1959 lecture at Caltech famously dubbed Theres Plenty of Room at the Bottom, American physicist and Nobel laureateto-be Richard Feynman discussed the idea of manipulating structures at the atomic level. Although the applications he discussed were theoretical at the time, his insights prophesied the discovery of many new properties at the nanometer scale that are not observed in materials at larger scales, paving the way for the ever-expanding field of nanomedicine. These days, the use of nanosize materials, comparable in dimension to some proteins, DNA, RNA, and oligosaccharides, is making waves in diverse biomedical fields, including biosensing, imaging, drug delivery, and even surgery.

Nanomaterials typically have high surface areato-volume ratios, generating a relatively large substrate for chemical attachment. Scientists have been able to create new surface characteristics for nanomaterials and have manipulated coating molecules to fine-tune the particles behaviors. Most nanomaterials can also penetrate living cells, providing the basis for nanocarrier delivery of biosensors or therapeutics. When systemically administered, nanomaterials are small enough that they dont clog blood vessels, but are larger than many small-molecule drugs, facilitating prolonged retention time in the circulatory system. With the ability to engineer synthetic DNA, scientists can now design and assemble nanostructures that take advantage of ?Watson-Crick base pairing to improve target detection and drug delivery.

Both the academic community and the pharmaceutical industry are making increasing investments of time and money in nanotherapeutics. Nearly 50 biomedical products incorporating nanoparticles are already on the market, and many more are moving through the pipeline, with dozens in Phase 2 or Phase 3 clinical trials. Drugmakers are well on their way to realizing the prediction of Christopher Guiffre, chief business officer at the Cambridge, Massachusettsbased nanotherapeutics company Cerulean Pharma, who last November forecast, Five years from now every pharma will have a nano program.

Technologies that enable improved cancer detection are constantly racing against the diseases they aim to diagnose, and when survival depends on early intervention, losing this race can be fatal. While detecting cancer biomarkers is the key to early diagnosis, the number of bona fide biomarkers that reliably reveal the presence of cancerous cells is low. To overcome this challenge, researchers are developing functional nanomaterials for more sensitive detection of intracellular metabolites, tumor cellmembrane proteins, and even cancer cells that are circulating in the bloodstream. (See Fighting Cancer with Nanomedicine, The Scientist, April 2014.)

The extreme brightness, excellent photostability, and ready modulation of silica nanoparticles, along with other advantages, make them particularly useful for molecular imaging and ultrasensitive detection.

Silica nanoparticles are one promising material for detecting specific molecular targets. Dye-doped silica nanoparticles contain a large quantity of dye molecules housed inside a silica matrix, giving an intense fluorescence signal that is up to 10,000 times greater than that of a single organic fluorophore. Taking advantage of Frster Resonance Energy Transfer (FRET), in which a photon emitted by one fluorophore can excite another nearby fluorophore, researchers can synthesize fluorescent silica nanoparticles with emission wavelengths that span a wide spectrum by simply modulating the ratio of the different dyesthe donor chromophore and the acceptor chromophore. The extreme brightness, excellent photostability, and ready modulation of silica nanoparticles, along with other advantages, make them particularly useful for molecular imaging and ultrasensitive detection.

THE NANOMEDICINE CABINET: Scientists are engineering nanometer-size particles made of diverse materials to aid in patient care. The unique properties of these structures are making waves in biomedical analysis and targeted therapy. See full infographic: JPG | PDF TAMI TOLPAOther materials that are under investigation as nanodetectors include graphene oxide (GO), the monolayer of graphite oxide, which has unique electronic, thermal, and mechanical properties. Semiconductor-material quantum dots (QDs), now being developed by Shuming Nies group at Emory University, exhibit quantum mechanical properties when covalently coupled to biomolecules and could improve cancer imaging and molecular profiling.1 Spherical nucleic acids (SNAs), in which nucleic acids are oriented in a spherical geometry, scaffolded on a nanoparticle core (which may be retained or dissolved), are also gaining traction by the pioneering work of Chad Mirkins group at Northwestern University.2 (See illustration.)

Nanoparticles are also proving their worth as probes for various types of bioimaging, including fluorescence, magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET). For instance, Xiaoyuan Chen, now at the National Institutes of Healths National Institute of Biomedical Imaging and Bioengineering, and Hongjie Dai of Stanford University have developed carbon nanotubes for performing PET scans in mice. When modified with the macromolecule polyethylene glycol to improve biocompatibility, the nanotubes were very stable and remained in circulation for days, far longer than the few hours typical of many molecular imaging agents.3 Further modification with a short-peptide targeting ligand called RGD caused the nanotubes to selectively accumulate in tumors that overexpressed integrin, the molecular target of RGD, enabling precise tumor imaging.

To further increase the specificity of nanodetectors, researchers can add recognition probes such as aptamersshort synthetic nucleic acid strands that bind target molecules. For example, we conjugated gold nanoparticles with aptamers that had been identified through iteratively screening DNA probes using living cancer cells.4 Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors and provide a potential target for early cancer diagnosis. However, CTCs are rare, with blood concentrations of typically fewer than 10 cells per milliliter of blood. Collaborating with physicians to profile samples from leukemia patients, we demonstrated that aptamers are capable of differentiating among different subtypes of leukemia, as well as among patient samples before and after chemotherapy (unpublished data). In addition to leukemia, we have selected aptamers specific to cancers of the lung, liver, ovaries, colon, brain, breast, and pancreas, as well as to bacterial cells. Other researchers have developed nanoparticles with numerous and diverse surface aptamers, enabling them to bind their targets more efficiently and securely.

NANOCAPSULES: A false-color transmission electron micrograph of liposomes, spherical particles composed of a lipid bilayer around a central cavity that can be engineered to deliver both hydrophobic and hydrophilic drugs to specific cells in the body DAVID MCCARTHY/SCIENCE SOURCEThe prototype of targeted drug delivery can be traced back to the concept of a magic bullet, proposed by chemotherapy pioneer and 1908 Nobel laureate Paul Ehrlich. Ehrlich envisioned a drug that could selectively target a disease-causing organism or diseased cells, leaving healthy tissue unharmed. A century later, researchers are developing many types of nanoscale magic bullets that can specifically deliver drugs into target cells or tissues.

Doxil, the first nanotherapeutic approved by the US Food and Drug Administration, is a liposome (~100 nm in diameter) containing the widely used anticancer drug doxorubicin. The therapy takes advantage of the leaky blood vasculature and poor lymphatic drainage in tumor tissues that allow the nanoparticles to squeeze from blood vessels into a tumor and stay there for hours or days. Scientists have also been developing nanotherapeutics capable of targeting specific cell types by binding to surface biomarkers on diseased cells. Targeting ligands range from macromolecules, such as antibodies and aptamers, to small molecules, such as folate, that bind to receptors overexpressed in many types of cancers.

Aptamers in particular are a popular tool for targeting specific cells. Aptamer development is efficient and cost-effective, as automated nucleic acid synthesis allows easy, affordable chemical synthesis and modification of functional moieties. Other advantages include high stability and long shelf life, rapid tissue penetration based on the relatively small molecular weights, low immunogenicity, and ease of antidote development in the case of an adverse reaction to therapy by simply administering an aptamers complementary DNA. We have demonstrated the principle of modifying aptamers on the surfaces of doxorubicin-containing liposomes, which then selectively delivered the drug to cultured cancer cells.5

Recent advances in predicting the secondary structures of a DNA fragment or interactions between multiple DNA strands, as well as in technologies to automatically synthesize predesigned DNA sequences, has opened the door to more advanced applications of aptamers and other DNA structures in nanomedicine. For instance, we have developed aptamer-tethered DNA nanotrains, assembled from multiple copies of short DNA building blocks. On one end, an aptamer moiety allows specific target cell recognition during drug delivery, and a long double-stranded DNA section on the other end forms the boxcars for drug loading. The nanotrains, which can hold a high drug payload and specifically deliver anticancer drugs into target cancer cells in culture and animal models,6 could reduce drug side effects while inhibiting tumor growth. Alternatively, Daniel Anderson of MIT engineered a tetrahedral cage of DNA, often called DNA origami, for folate-mediated targeted delivery of small interfering RNAs (siRNAs) to silence some tumor genes.7 And Mirkins SNAs can similarly transport siRNAs as guided missiles to knock out overexpressed genes in cancer cells. Mirkins group also recently demonstrated that the SNAs were able to penetrate the blood-brain barrier and specifically target genes in the brains of glioblastoma animal models.2 Peng Yin of Harvard Medical School and the Wyss Institute and others are now building even more complex DNA nanostructures with refined functions, such as smart biomedical analysis.8

Conventional assembly of such DNA nanostructures exploits the hybridization of a DNA strand to part of its complementary strand. In addition, we have discovered that DNA nanostructures called nanoflowers because they resemble a ring of nanosize petals, can be self-assembled through liquid crystallization of DNA, which typically occurs at high concentrations of the nucleic acid.9 Importantly, these DNA nanostructures can be readily incorporated with components possessing multiple functionalities, such as aptamers for specific recognition, fluorophores for molecular imaging, and DNA therapeutics for disease therapy.

Another example of novel nanoparticles is DNA micelles, three-dimensional nanostructures that can be readily modified to include aptamers for specific cell-type recognition, or DNA antisense for gene silencing. The lipid core and sphere of projecting nucleic acids can enter cells without any transfection agents and have high resistance to nuclease digestion, making them ideal candidates for drug delivery and cancer therapy.

Researchers are developing many types of nanoscale magic bullets that can specifically deliver drugs into target cells or tissues.

Such advances in targeting are now making it possible to deliver combinations of drugs and ensure that they reach target cells simultaneously. Paula Hammond and Michael Yaffe of MIT recently reported a liposome-based combination chemotherapy delivery system that can simultaneously deliver two synergistic chemotherapeutic drugs, erlotinib and doxorubicin, for enhanced tumor killing.10 Erlotinib, an inhibitor of epidermal growth factor receptor (EGFR), promotes the dynamic rewiring of apoptotic pathways, which then sensitizes cancer cells to subsequent exposure to the DNA-damaging agent doxorubicin. By incorporating erlotinib, a hydrophobic molecule, into the lipid bilayer shell while packaging the hydrophilic doxorubicin inside of the liposomes, the researchers achieved the desired time sequence of drug releasefirst erlotinib, then doxorubicinin a one-two punch against the cancer. They also demonstrated that the efficiency of drug delivery to cancer cells was enhanced by coating the liposomes with folate.

Scientists are also engineering smart nanoparticles, which activate only in the disease microenvironment. For example, George Church of Harvard Medical School and the Wyss Institute and colleagues invented a logic-gated DNA nanocapsule that they programmed to deliver drugs inside cells only when a specific panel of disease biomarkers is overexpressed on the cell surface.11 And Donald Ingbers group, also at Harvard Medical School and the Wyss Institute, developed microscale aggregates of thrombolytic-drug-coated nanoparticles that break apart under the abnormally high fluid shear stress of narrowed blood vessels and then bind and dissolve the problematic clot.12

With these and other nanoplatforms for targeted drug delivery being tested in animal models, medicine is now approaching the prototypic magic bullet, sparing healthy tissue while exterminating disease.

In addition to serving as mere drug carriers that deliver the toxic payload to target cells, nanomaterials can themselves function as therapeutics. For example, thermal energy is emerging as an important means of therapy, and many gold nanomaterials can convert photons into thermal energy for targeted photothermal therapy. Taking advantage of these properties, we conjugated aptamers onto the surfaces of gold-silver nanorods, which efficiently absorb near-infrared light and convert energy from photons to heat. These aptamer-conjugated nanorods were capable of selectively binding to target cells in culture and inducing dramatic cytotoxicity by converting laser light to heat.13

Magnetic nanoparticles are also attractive for their ability to mediate heat induction. Jinwoo Cheon of Yonsei University in Korea developed coreshell magnetic nanoparticles, which efficiently generated thermal energy by a magnetization-reversal process as these nanoparticles returned to their relaxed states under an external, alternating-current magnetic field.14 Using this technology, Cheon and his colleagues saw dramatic tumor regression in a mouse model. A third type of nanosize therapeutic involves cytotoxic polymers. For example, we synthesized a nucleotide-like molecule called an acrydite with an attached DNA aptamer that specifically binds to and enters target cancer cells.15 The acrydite molecules in the resultant acrydite-aptamer conjugates polymerized with each other to form an aptamer-decorated molecular string that led to cytotoxicity in target cancer cells, including those exhibiting multidrug resistance, a common challenge in cancer chemotherapy.

Many other subfields have been advanced by recent developments in nanomedicine, including tissue engineering and regenerative medicine, medical devices, and vaccines. We must proceed with caution until these different technologies prove safe in patients, but nanomedicine is now poised to make a tremendous impact on health care and the practice of clinical medicine.

Guizhi Zhu is a postdoctoral associate in the Department of Chemistry and at the Health Cancer Center of the University of Florida. Weihong Tan is a professor and associate director of the Center for Research at the Bio/Nano Interface at the University of Florida. He also serves as the director of the Molecular Science and Biomedicine Laboratory at Hunan University in China, where Lei Mei is a graduate student.

Here is the original post:
Nanomedicine | The Scientist Magazine

Read the Rest...

Novartis signs collaboration deal with Parvus for diabetes nanomedicine – Pharmaceutical Business Review

§ April 21st, 2017 § Filed under Nano Medicine Comments Off on Novartis signs collaboration deal with Parvus for diabetes nanomedicine – Pharmaceutical Business Review

PBR Staff Writer Published 20 April 2017

Pharma giant Novartis has acquired the exclusive, worldwide rights for Parvus Therapeutics Navacim technology for type 1 diabetes (T1D) treatment.

Novartishas also made an undisclosed equity investment inCanada-based Parvus.

Under the terms, Novartis will develop and market products made from the Navacim technology besides taking responsibility of its clinical-stage development and commercialization efforts.

Parvus CEO Janice M LeCocq said: This is a transformative collaboration for Parvus. We are excited by this strong endorsement of the science behind our Navacim platform, as well as the opportunity to collaborate closely with a globally recognized leader in the field of immunology and autoimmune disease.

“This will augment our resources across the Navacim platform and accelerate the development of our T1D program.

We are also pursuing the development of multiple Navacims that target autoimmune diseases where there is high unmet need for disease-modifying drugs without causing systemic immunosuppression.

Parvus, which has secured an upfront payment for the rights, will handle the existing preclinical activities for the T1D program. It will file the Investigational New Drug (IND) jointly with Novartis through a jointly formed steering committee.

The Canadian pharma will also get funding for its research that will back the preclinical activities of Navacim.

Further, it will be entitled to receivedevelopment, regulatory and sales milestone payments. Along with them, it will get product royalties from the Swiss pharma giant, Novartis.

According to Parvus, Navacims comprise nanoparticles (NPs) coated with disease-relevant peptide-major histocompatibility complexes (pMHCs) that modify the behavior of T lymphocytes which are known to cause the disease.

They are claimed by Parvus to have the ability to specifically treat the autoimmune disease without increasing the risk of infection.

Read more here:
Novartis signs collaboration deal with Parvus for diabetes nanomedicine – Pharmaceutical Business Review

Read the Rest...

Novartis signs collaboration deal with tiny Parvus for diabetes … – FierceBiotech

§ April 19th, 2017 § Filed under Nano Medicine Comments Off on Novartis signs collaboration deal with tiny Parvus for diabetes … – FierceBiotech

Novartis, which has had a busy week for its CAR-T and NASH programs, today moved onto diabetes after penning a new pact with virtual Canadian biotech Parvus Therapeutics to use its leading tech.

Exact monetary terms werent given in the release, but Novartis gets exclusive, worldwide rights to use Parvus Navacims nanomedicine tech, specifically for diabetes patients with Type 1 (T1D), and will take on the clinical and sales work for this program.

On its side, privately owned Parvus will be primarily in charge of the ongoing preclinical work for the T1D program and filing an IND with Novartis.

Parvus has received an undisclosed upfront payment and will also gain a research funding boost to help out with its preclinical work. Biobucks have also been lined up, with Novartis in addition taking an equity investment in the biotech.

Navacims are made up of nanoparticles coated with disease-relevant peptide-major histocompatibility complexes. They are designed to change the behavior of disease-causing T lymphocytes.

Parvus says Navacims “are the first biopharmaceuticals to demonstrate in preclinical models the ability to restore immune tolerance in a disease-specific manner through in vivo formation and expansion of regulatory T-cells without causing general immune suppression, although they will need to go through many more years of clinical trials to assess efficacy and safety in humans.

But for Parvus, this is a major deal at an early stage from one of the biggest biomedical companies in the world, confirming its previously stated desire to team up with a Big Pharma.

This is a transformative collaboration for Parvus, said Janice LeCocq, CEO of Parvus. We are excited by this strong endorsement of the science behind our Navacim platform, as well as the opportunity to collaborate closely with a globally recognized leader in the field of immunology and autoimmune disease.

This will augment our resources across the Navacim platform and accelerate the development of our T1D program.”

The company will also continue work on using Navacims against autoimmune diseases, notably where there is high unmet need for disease-modifying drugs that do not cause systemic immunosuppression.

Read more:
Novartis signs collaboration deal with tiny Parvus for diabetes … – FierceBiotech

Read the Rest...

Nanomedicine: A Vast Horizon on a Molecular Landscape – Part IX, Organs-on-a-chip II – Lexology (registration)

§ April 19th, 2017 § Filed under Nano Medicine Comments Off on Nanomedicine: A Vast Horizon on a Molecular Landscape – Part IX, Organs-on-a-chip II – Lexology (registration)

This is the ninth article in a review series on Nanomedicine. We reviewed the major research and entrepreneurial development of nanomedicine and the relevant patent landscape (Part I and Part II). The first topic we discussed was Organs-on-a-chip (Part III). Here, we continue our discussion in this field with focus on entrepreneurial developments. We also have other reviews about nanoparticles for drug delivery (Part IV), cancer therapeutics (Part V), and bio-imaging (Part VI). We also included a discussion about functional nanoparticles: quantum dots (Part VII) and magnetic nanoparticles (Part VIII). As in the past, those patent documents cited in the article are summarized in a table at the end.

Recently, Draper announced a three-year agreement with Pfizer. This collaboration focuses on developing effective disease models for testing potential drug candidates based on microphysiological systems, also known as organs-on-a-chip.

The organs-on-a-chip technology is a three-dimensional microfluidic based multi-cell co-culture system that models the physiological, mechanical, and molecular environment of the human body and mimics the physiological functions of human organs. This technology offers unique in vitro disease models for new drug screening and toxicology testing. This technology has attracted attentions not only from academic institutes but also from the pharmaceutical industry. One of the main reasons for this interest is the potential cost and time savings for drug research and the development process. As required by the FDA drug approval process, new drug chemical entities are tested in animals before going into human Phase I testing for the drug approval process. The preclinical animal testing process is tedious and extremely expensive. Additionally, animal models are not always predictive for characterizing drug safety in humans. About 40% of drug compounds fail in Phase I clinical trials (Clinical Development Success Rates 2006-2015, BIO Industry Analysis, June 2016). To address these challenges, organs-on-a-chip has been proposed as a novel method to develop human disease models and replace preclinical animal testing.

We have briefly reviewed the research development and IP landscape in organs-on-a-chip. Here we would like to focus on the entrepreneurial developments in this field. As in the past, those patent documents cited in the article are summarized in the table at the end.

AxoSim Technologies

AxoSim is a New Orleans based startup launched in 2014. Its main pipeline is a Nerve-On-A-Chip, which is a 3D cell-based model mimicking living nerve tissue. It aims at preclinical prediction of neurological safety and efficacy in the early stages of drug development. This technology was developed from Dr. Michael J. Moores group at Tulane University (US 20150112244).

Draper

The Charles Stark Draper Laboratory is an American not-for-profit research and development organization, having a long history from 1932. In 2009, Draper initiated a new area of medical systems. Draper closely collaborated with scientists at MIT to develop microphysiological systems to emulate human organs and create disease models. At the end of 2016, Draper announced a 3-year agreement with Pfizer, using the organs-on-a-chip technology to facilitate pre-clinical drug development with a focus on personalized medicine. Currently Draper has built three microphysiological systems for modeling liver, vasculature and gastrointestinal organs (US 7,670,797, US 8,951,302, US 9,067,179, US 9,528,082).

Emulate Bio

Emulate Bio is a Wyss Institute spin-off company launched in 2014. It focuses on developing multiple organ-on-a-chip systems to model human physiological systems. The technology is based on discoveries in Dr. Donald Ingbers lab, using models of the lung, liver, intestine, skin and brain (US 8,647,861). This lab is also interested in other organ systems such as the kidney and heart. In 2015, Emulate collaborated with Johnson & Johnson and Merck using organs-on-a-chip for drug discovery and development processes. In 2016, Emulate announced a collaboration with Seres Therapeutics to investigate Novel Microbiome Therapeutics for inflammatory Bowel Disease.

Hepregen

Hepregen is a MIT spin-off company founded in 2007, based on a technique developed in Dr. Sangeeta Bhatias lab (US 6,133,030). Its main product, HepetoPac Assay, utilizes a micropatterned hepatocyte co-culture system to model the metabolic activities of a liver system and was released in 2013. Their other pipeline product is HepetoMune, targeting an inflamed human liver model.

HREL

HREL is a Merck supported company, which was incubated in New Jersey from 2007-2011. Its technology originated from Dr. Michael Shulers group at Cornell University (US 7,288,405 and US 8,748,180). In 2013, HREL launched three liver-on-a-chip products for human, rat and dog. HREL has also established a collaboration with Sanofi for pre-clinic drug development.

InSphero

InSphero is a Swiss company founded in 2009. They use a scaffold-free 3D cell culture technique to generate self-assembled microtissues, emulating human organ systems (US 9,267,103 and WO/2017/001680). Their current pipelines include liver, pancreas, tumor, and skin microtissue systems and in vitro toxicology and drug discovery services.

Nortis

Nortis is a Seattle based company, spun out of the University of Washington in 2012. Nortis developed a microfluidic kidney-on-a-chip for drug testing and launched its commercial product on 2015 (US 7,622,298 and US 20150240194A1).

Tara Biosystems

Tara Biosystems is a New York-based Columbia University spin out company founded in 2014. Their focus is on developing a heart-on-a-chip system. The technology is based on research from Dr. Gordana Vunjak-Novakovics group at Columbia University and Dr. Milica Radisics group at Toronto University (US 20170002330A1 and US 20160282338). Tara Biosystems uses a Biowire platform, to introduce electrical stimulation on a microchip to stimulate stem cells to mature into heart tissue. This microtissue mimics adult heart muscles, offering a platform for drug discovery, cardiac toxicology, and personalized cardiology.

TissUse

TissUse is a Berlin, Germany-based company developing a Multi-Organ-Chip platform based on technology discovered in Dr. Roland Lausters lab at Technische Universitat Berlin (US 20130295598). This company uses a multi-organ-chip as a platform to emulate human metabolic activities and accelerate the development of pharmaceutical, chemical, cosmetic, and personalized medical products. Currently, TissUse has announced their 2-Organ-Chip and 4-Organ-Chip products, involving simultaneously culturing from 2 to 4 different organ equivalents on a single chip connected to each other by perfusion channels or vasculature. Their next goal is to develop a human-on-a-chip system, with a larger number of organs cocultured on a single chip.

The Charles Stark Draper Laboratory

The Charles Stark Draper Laboratory

Massachusetts Institute of Technology

Massachusetts Institute of Technology

Wolfgang MORITZ;

Jens KELM

Read the rest here:
Nanomedicine: A Vast Horizon on a Molecular Landscape – Part IX, Organs-on-a-chip II – Lexology (registration)

Read the Rest...

Nanomedicine Awards 2017: applications are now open! – Cordis News

§ April 18th, 2017 § Filed under Nano Medicine Comments Off on Nanomedicine Awards 2017: applications are now open! – Cordis News

The European Technology Platform for Nanomedicine (ETPN) and the EU-funded project ENATRANS, announce the launching of the 3rd edition of the Nanomedicine Awards, which aim to promote and reward two excellent innovative nanomedicine-based solutions that could bring significant benefits to patients, answering thereby unmet medical needs. The winners in both categories will be announced and rewarded during the BIO-Europe conference in Berlin in November 2017. Apply Now!

Open to companies as well as to academic and private researchers across the globe, candidates should: – present totally new approaches based on Nanomedicine for the diagnosis and/or therapy of human diseases – describe explicit and defined potential market.

Applications will be assessed by a panel of highly-qualified nanomedicine, pharma, medtech and investment specialists.

The Awards ceremony will take place during BIO-Europe 2017 in Berlin (Germany), on 7 November 2017.

Both winners will benefit from a full registration to BIO-Europe 2017 including the participation in the partnering event and a public presentation of the awarded projects. In addition, they will be granted an individual session with the experts of the Translation Advisory Board (TAB, http://www.nanomedtab.eu), a presentation slot during the ETPN Annual Event 2017 in Malaga as well as a 1-year free membership to the ETPN (www.etpnanomedicine.eu).

The Award is supported by the EBD Group, the leading partnering firm for the global life science industry, and Nanobiotix, a late clinical-stage nanomedicine company pioneering novel approaches for the treatment of cancer.

THE DEADLINE TO SUBMIT CANDIDATURES IS 15 AUGUST 2017. APPLY ONLINE AT http://nanomedicine-award.com/apply-now/

Read the rest here:
Nanomedicine Awards 2017: applications are now open! – Cordis News

Read the Rest...

Nanomedicine enables all-in-one cancer treatment – nanotechweb.org

§ April 18th, 2017 § Filed under Nano Medicine Comments Off on Nanomedicine enables all-in-one cancer treatment – nanotechweb.org

Cancer is a complex disease to treat, and yet the operating principle of many current treatments is to simply kill healthy cells a little slower than cancerous ones. In response, scientists at The University of Electronic Science and Technology of China have developed a sophisticated nanoparticle-based treatment. Their theranostic nanoparticles carry an anti-cancer drug cargo, and showcase multiple cutting-edge nanomedicine technologies to enhance the drug’s efficacy, including selective drug delivery, photoactive agents, and even signal-jamming genetic material.

The researchers have designed each individual nanoparticle to be a toolbox for cancer therapy, able to passively and actively target tumours (Biomater. Sci. 2017 Advance Article). The nanoparticles can act as contrast agents for both magnetic resonance imaging and X-ray, they deliver a concentrated dose of anti-cancer drugs, and they also thwart the cancer’s attempts at developing immunity to the drug. They even deliver a photosensitizer that can be used to specifically weaken cancerous tissue by photodynamic treatment.

Yiyao Liu and colleagues demonstrated the efficacy of their nanodevices in vitro and in vivo on a range of cell lines and on tumours in living mice. They found that their nanoparticle drug-delivery technique effectively stopped tumour growth, whereas tumours in mice treated with the drug alone grew at a rate half that of a control group that had not been treated.

The nanoparticles are complex, many layered spheres. Protected by a jacket of natural polymer is a nugget of silica, holey like a sponge and soaked in doxorubicin, a common anti-cancer drug, along with the photosensitizer. The polymer jacket is pH sensitive so that it falls off in the acidic microenvironment of the tumour, only then releasing the active cargo.

Doxorubicin has two flaws. Firstly, it works by slotting in-between DNA base pairs to stop the replication process needed for cells to divide. This kills cells that need to duplicate quickly, such as cancerous cells, but harms many healthy cell types too. Secondly, it triggers the body’s natural defences, causing cells to over express p-glycoprotein, a microscale pump that removes toxic molecules like doxorubicin from cells, and making the drug less and less effective against cancer.

The scientists at The University of Electronic Science and Technology of China countered both of these flaws. Healthy cell exposure is reduced by the polymer jacket, which makes sure the drug is only released under the conditions expected in a tumour. The jacket itself is covered in signal-jamming RNA to inhibit the expression of the cellular pumps, keeping the doxorubicin trapped inside the cells to allow the drug to work for longer. This impressive display of multifunctional nanoparticle design and synthesis demonstrates the power of nanomedicine for producing synergistic effects, offering new solutions to previously unsurmountable problems.

Personalizing nanoparticles to better target tumours Optimising the killing of tumor cells by targeted CNTs Silica nanoparticles suppress tumour growth

Originally posted here:
Nanomedicine enables all-in-one cancer treatment – nanotechweb.org

Read the Rest...

Department of Nanomedicine | Houston Methodist

§ April 16th, 2017 § Filed under Nano Medicine Comments Off on Department of Nanomedicine | Houston Methodist

The Department of Nanomedicine focuses on interdisciplinary research by combining nanoengineering, mathematical modeling and biomedical sciences to develop nanotechnology-enabled therapeutic and diagnostic platforms for combating diseases including cancer, cardiovascular diseases and infectious diseases. Our research spans a wide range of areas including personalized nanochannel drug delivery systems, injectable nanovectors that achieve desired therapeutic concentrations in target tissue, discovery of new protein biomarkers through proteomics, developing biodegradable synthetic polymers with the biological functions of natural biomaterial scaffolds, and microfluidics for disease diagnostics.

Mauro Ferrari, PhD, president and CEO of the Houston Methodist Research Institute, and his team have developed the first drug delivery system to successfully eliminate lung metastases in mice models withtriple negativebreast cancer.Learn more.

Alessandro Grattoni, PhD Assistant Professor of Nanomedicine, Institute for Academic Medicine Chair, Department of Nanomedicine Houston Methodist

Houston Methodist received about $1.25 million from the Center for the Advancement of Science in Space (CASIS) to develop an implantable device that delivers therapeutic drugs at a rate guided by remote control.Learn more.

Department of Nanomedicine Houston Methodist Research Institute 6670 Bertner Ave. Houston, TX 77030 713.441.1261

See the original post:
Department of Nanomedicine | Houston Methodist

Read the Rest...

The Nanomedicine Market to Grow at a CAGR of 17.1% During the Forecast Period 2017-2023 to Aggregate $392.80 … – Digital Journal

§ April 10th, 2017 § Filed under Nano Medicine Comments Off on The Nanomedicine Market to Grow at a CAGR of 17.1% During the Forecast Period 2017-2023 to Aggregate $392.80 … – Digital Journal

Nanomedicine has the potential to be the future in biotherapeutics replacing the older versions of drug delivery.

Bangalore, India – April 10, 2017 – (Newswire.com)

Infoholic Research LLP, a global market research and consulting organization, has published a study titled Global Nanomedicine Market Drivers, Opportunities, Trends, and Forecasts: 20172023.

According to Infoholic Research, nanomedicine is the future with new revenue stream in the healthcare industry. Nanomedicine could provide cost-effective novel therapies and diagnostics using the empowering capacity of nanotechnology applied in the healthcare industry. Nanomedicine could increase the efficiency and diminish the side effects unlike the other tender therapies for any particular condition. The elementary principles of this technique are based on the targeted drug delivery using nanoparticles (such as nanorobots), proper analysis using sensors and micro electro mechanical system (MEMS), and to diagnose in vivo biochemical activities. The result is an increasingly better understanding of the molecular biology of diseases leading to new targets for more specific and earlier diagnostic and therapeutic treatments. These new options will cause profound changes in future healthcare systems by enabling more personalized, regenerative, and remote medicinal activities. According to Infoholic Research, the Global Nanomedicine market is expected to grow at a CAGR of 17.1% during the forecast period 20172023 to touch an aggregate of $392.80 billion by 2023.

Receive a sample of the report

@https://www.infoholicresearch.com/request-a-sample-report/?repid=4654

The Global Nanomedicine market is analyzed based on two segments application areas and regions. The regions covered in the report are the Americas, Europe, Asia Pacific, and Rest of the World (ROW). In the Americas region, the US and Canada are set to be the leading countries. The Europe is set to be the second leading region and holds more than 23% of the market share in 2016. Germany is one of the leading countries in Europe in terms of revenue. In Asia Pacific, Japan is the most attractive country for the players and holds huge business opportunities. The ROW is set to be an emerging market in the next 56 years.

The application areas covered in the report are Oncology, Cardiovascular, Neurology, Anti-inflammatory, Anti-infective, and other therapeutics. The Cardiovascular, Anti-inflammatory, and Neurology application segments are expected to gain more market share by 2023. The market is expected to be on a positive year on year growth rate, as the Cardiovascular and the Neurology segments have just started to see wide-scale adoption in the field of nanomedicine. The Oncology segment is expected to generate revenue of $144.00 billion by 2023.

Although, the market is experiencing a lack of well-defined FDA directives, which can restore standardization in the field of nanomedicines and related subjects, nanotechnology funding is expected to increase significantly during the forecast period with the increasing investments from government and private sectors. Victor Mukherjee, Assistant Manager (Research Healthcare) at Infoholic Research

Buy complete report onGlobal Nanomedicine market Drivers, Opportunities, Trends, & Forecasts 2017 2023

@https://www.infoholicresearch.com/report/global-nanomedicine-market-trends-2017-2023/

Further, the report also aims to cover the below points:

Provides an in-depth analysis of the key business opportunities in countries and verticals

Provides the complete details about the various types of nanomedicine drugs overview

Provides the complete details about the analysis of top 16 players

Provides industry outlook including current and future market trends, drivers, restraints and emerging technologies

Market is analyzed by countries the US, Germany, Japan, and Others

Press Release Service by Newswire.com

Original Source: The Nanomedicine Market to Grow at a CAGR of 17.1% During the Forecast Period 2017-2023 to Aggregate $392.80 Billion by 2023

Read more:
The Nanomedicine Market to Grow at a CAGR of 17.1% During the Forecast Period 2017-2023 to Aggregate $392.80 … – Digital Journal

Read the Rest...

Researchers develop a lab-scale prototype for the treatment of skin … – Phys.Org

§ April 8th, 2017 § Filed under Nano Medicine Comments Off on Researchers develop a lab-scale prototype for the treatment of skin … – Phys.Org

April 7, 2017 Frontal and lateral views of the developed system. Credit: Universidad Politcnica de Madrid

Researchers from Universidad Politcnica de Madrid, in collaboration with Universitat Politcnica de Valencia and CIBER’s Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), have designed a laser device specifically designed for optical hyperthermia applications.

A joint research project of Universidad Politcnica de Madrid (UPM), Universitat Politcnica de Valencia (UPV) and CIBER’s Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN) has developed a low-cost, lab-scale device for treatments based on optical hyperthermia applications via laser. This technique is used in therapies against skin cancer, and it kills the tumor cells by overheating them. This research has been published in Sensors and Actuators A Physical.

According to the researchers, overheating is achieved by irradiating synthesized metallic nanoparticles. “When receiving radiation, the particles heat the tumor tissue, reaching a temperature between 42 C and 48 C, causing hypoxia that leads to cellular death,” explains Roberto Montes, a researcher from UPV.

The prototype developed by both UPM and UPV researchers consists of an infrared laser with a power up to 500mW able to provide a power density up to 4W/cm2, a sensor that records the temperature in real time during the irradiation, and a laser power regulator, among other components.

However, if the laser is focused on tissues impregnated with gold nanoparticles (Au-NPs), it causes local overheating. This presents a great advantage compared to other techniques that cannot distinguish between healthy tissues and damaged tissues,” says Roberto Montes.

According to the researchers, there are diverse laser applicators on the market used in dermatology and even surgery. At certain power and wavelengths, the laser energy is converted into heat and produces ablation (burning). The new system does not aim to “burn” the cells with the adjacent inflammation that this causes, but to introduce nanoheaters into such cells, which, when excited by the laser, increase in temperature between 42 C and 48 C, resulting in hypoxia and the cells’ “natural” death.

This equipment is already being successfully used in vitro cellular crops and in therapies that combine hyperthermia with the controlled release of drugs. “Although the equipment has been designed to exclusively work in a lab environment, once the technique is refined, it could be easily applied to a hospital environment with small changes. Of course, we are in an initial phase, and there is much to do toward clinical usage: animal tissue testing, later testing on living animals, and finally to verify its application in patients”, add Javier Ibez.

Explore further: Magnetic hyperthermia, an auxiliary tool in cancer treatments

Hyperthermia (increase in body temperature) has been used for centuries to combat tumours and reduce their effects. The aim of research by the physicist Eneko Garaio is hyperthermia but using a different system (magnetic …

Cancer treatments based on laser irridation of tiny nanoparticles that are injected directly into the cancer tumor are working and can destroy the cancer from within. Researchers from the Niels Bohr Institute and the Faculty …

Precise targeting biological molecules, such as cancer cells, for treatment is a challenge, due to their sheer size. Now ,Taiwanese scientists have proposed an advanced solution, based on a novel combination of previously …

Laser ablation for varicose veins is an effective and minimally invasive technique for the treatment of varicose. However, this kind of therapy is associated with significant collateral damage because of the high output power …

A new imaging technique developed by scientists at MIT, Harvard University, and Massachusetts General Hospital (MGH) aims to illuminate cellular structures in deep tissue and other dense and opaque materials. Their method …

Researchers from Valencia and the Basque Country have developed a new method to detect cocaine and mycoplasma at very low concentrations. It has been designed as an alternative for use in laboratories and is potentially more …

A team of scientists from Australia, Belgium, Italy and the UK have demonstrated how ocean winds can generate spontaneous rogue waves, the first step to predicting the potentially dangerous phenomena.

When the molecules that carry the genetic code in our cells are exposed to harm, they have defenses against potential breakage and mutations.

The ephemeral electron movements in a transient state of a reaction important in biochemical and optoelectronic processes have been captured and, for the first time, directly characterized using ultrafast X-ray spectroscopy …

Why is there more matter than antimatter in the universe? The reason might be hidden in the neutrino nature: one of the preferred theoretical models assumes, that these elementary particles were identical with their own anti-particles. …

Research led by a Stanford scientist promises to increase the performance of high-power electrical storage devices, such as car batteries.

Everyone knows that the game of billiards involves balls careening off the sides of a pool tablebut few people may know that the same principle applies to fusion reactions. How charged particles like electrons and atomic …

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Read more here:
Researchers develop a lab-scale prototype for the treatment of skin … – Phys.Org

Read the Rest...

Research Offers Promising Outlook for Nanomedicine – Controlled Environments Magazine

§ April 7th, 2017 § Filed under Nano Medicine Comments Off on Research Offers Promising Outlook for Nanomedicine – Controlled Environments Magazine

In the past six years, the National Research Programme “Opportunities and Risks of Nanomaterials” (NRP 64) intensively studied the development, use, behavior, and degradation of engineered nanomaterials, including their impact on humans and on the environment.

Twenty-three research projects on biomedicine, the environment, energy, construction materials and food demonstrated the enormous potential of engineered nanoparticles for numerous applications in industry and medicine. Thanks to these projects we now know a great deal more about the risks associated with nanomaterials and are therefore able to more accurately determine where and how they can be safely used.

“One of the specified criteria in the program was that every project had to examine both the opportunities and the risks, and in some cases this was a major challenge for the researchers,” explains Peter Gehr, President of the NRP 64 Steering Committee.

One development that is nearing industrial application concerns a building material strengthened with nanocellulose that can be used to produce a strong but lightweight insulation material. Successful research was also carried out in the area of energy, where the aim was to find a way to make lithium-ion batteries safer and more efficient.

A great deal of potential is predicted for the field of nanomedicine. Nine of the 23 projects in NRP 64 focused on biomedical applications of nanoparticles. These include their use for drug delivery, for example in the fight against viruses, or as immune modulators in a vaccine against asthma. Another promising application concerns the use of nanomagnets for filtering out harmful metallic substances from the blood. One of the projects demonstrated that certain nanoparticles can penetrate the placenta barrier, which points to potential new therapy options. The potential of cartilage and bone substitute materials based on nanocellulose or nanofibres was also studied.

The examination of potential health risks was the focus of NRP 64. A number of projects examined what happens when nanoparticles are inhaled, while two focused on ingestion. One of these investigated whether the human gut is able to absorb iron more efficiently if it is administered in the form of iron nanoparticles in a food additive, while the other studied silicon nanoparticles as they occur in powdered condiments. It was ascertained that further studies will be required in order to determine the doses that can be used without risking an inflammatory reaction in the gut.

The aim of the seven projects focusing on environmental impact was to gain a better understanding of the toxicity of nanomaterials and their degradability, stability and accumulation in the environment and in biological systems. Here, the research teams monitored how engineered nanoparticles disseminate along their lifecycle, and where they end up or how they can be discarded.

One of the projects established that 95 percent of silver nanoparticles that are washed out of textiles are collected in sewage treatment plants, while the remaining particles end up in sewage sludge, which in Switzerland is incinerated. In another project a measurement device was developed to determine how aquatic microorganisms react when they come into contact with nanoparticles.

“The findings of the NRP 64 projects form the basis for a safe application of nanomaterials,” says Christoph Studer from the Federal Office of Public Health. “It has become apparent that regulatory instruments such as testing guidelines will have to be adapted at both national and international level.” Studer has been closely monitoring the research program in his capacity as the Swiss government’s representative in NRP 64. In this context, the precautionary matrix developed by the government is an important instrument by means of which companies can systematically assess the risks associated with the use of nanomaterials in their production processes.

The importance of standardized characterization and evaluation of engineered nanomaterials was highlighted by the close cooperation among researchers in the program. “The research network that was built up in the framework of NRP 64 is functioning smoothly and needs to be further nurtured,” says Professor Bernd Nowack from Empa, who headed one of the 23 projects.

The results of NRP 64 show that new key technologies such as the use of nanomaterials need to be closely monitored through basic research due to the lack of data on its long-term effects. As Gehr points out, “We now know a lot more about the risks of nanomaterials and how to keep them under control. However, we need to conduct additional research to learn what happens when humans and the environment are exposed to engineered nanoparticles over longer periods, or what happens a long time after a one-off exposure.”

Source: Swiss National Science Foundation

Continue reading here:
Research Offers Promising Outlook for Nanomedicine – Controlled Environments Magazine

Read the Rest...

Nano Medicine: Meaning, Advantages and Disadvantages

§ March 30th, 2017 § Filed under Nano Medicine Comments Off on Nano Medicine: Meaning, Advantages and Disadvantages

In this article we will discuss about Nano Medicine:- 1. Meaning of Nano Medicine 2. Advantages of Nano Medicine 3. Disadvantages.

The application of nanotechnology in medicine is often referred to as Nano medicine. Nano medicine is the preservation and improvement of human health using molecular tools and molecular knowledge of the human body. It covers areas such as nanoparticle drug delivery and possible future applications of molecular nanotechnology (MNT) and Nano-vaccinology.

The human body is comprised of molecules. Hence, the availability of molecular nanotechnology will permit dramatic progress in human medical services. More than just an extension of molecular medicine, Nano medicine will help us understand how the biological machinery inside living cells operates at the Nano scale so that it can be employed in molecular machine systems to address complicated medical conditions such as cancer, AIDS, ageing and thereby bring about significant improvement and extension of natural human biological structure and function at the molecular scale.

Nano medical approaches to drug delivery centre on developing Nano scale particles or molecules to improve drug bioavailability that refers to the presence of drug molecules in the body part where they are actually needed and will probably do the most good. It is all about targeting the molecules and delivering drugs with cell precision.

The use of Nano robots in medicine would totally change the world of medicine once it is realized. For instance, by introducing these Nano robots into the body damages and infections can be detected and repaired. In short it holds that capability to change the traditional approach of treating diseases and naturally occurring conditions in the human beings.

1. Advanced therapies with reduced degree of invasiveness.

2. Reduced negative effects of drugs and surgical procedures.

3. Faster, smaller and highly sensitive diagnostic tools.

4. Cost effectiveness of medicines and disease management procedures as a whole.

5. Unsolved medical problems such as cancer, benefiting from the Nano medical approach.

6. Reduced mortality and morbidity rates and increased longevity in return.

1. Lack of proper knowledge about the effect of nanoparticles on biochemical pathways and processes of human body.

2. Scientists are primarily concerned about the toxicity, characterization and exposure pathways associated with Nano medicine that might pose a serious threat to the human beings and environment.

3. The societys ethical use of Nano medicine beyond the concerned safety issues, poses a serious question to the researchers.

See the original post:
Nano Medicine: Meaning, Advantages and Disadvantages

Read the Rest...

NanomedTAB goes North – Meet the experts in Gothenburg on 31st May 2017 – Cordis News

§ March 28th, 2017 § Filed under Nano Medicine Comments Off on NanomedTAB goes North – Meet the experts in Gothenburg on 31st May 2017 – Cordis News

The Nanomedicine Translation Advisory Board (NanomedTAB) offers since 2015 a free-of-charge mentoring program for European companies, public and private research entities, and other organisations active in Nanomedicine. The fifth edition is now open, selected projects will be invited to attend face-to-face meetings with the NanomedTAB experts on 31st May 2017 in Gothenburg (Sweden).

Through individal advise and mentoring, the NanomedTAB aims at assessing and accelerating promising nanomedicine projects to the market, based on the diverse experience of top skills industry experts. The objective? Help great projects and teams to get to commercial application faster and more reliably.

– 63 teams have already applied, – from 16 countries in EU and beyond, – half met the criteria for NanomedTAB advice and are currently benefiting from coaching over time.

The fifth edition is now open, submit your applications online before 15h April 2017: http://www.nanomedtab.eu/?apply

Selected projects will be invited to attend the next TAB-In Sessions, a series of face to face meetings with experts to be held on the 31st of May 2017, in Gothenburg (Sweden), in the framework of the NanoMed North Annual Meeting 2017.

Further information about the NanomedTAB as well as profiles of experts can be found at http://www.nanomedtab.eu.

See the original post here:
NanomedTAB goes North – Meet the experts in Gothenburg on 31st May 2017 – Cordis News

Read the Rest...

Global Nanomedicine Market Estimates and Forecasts from 2017 … – MilTech

§ March 28th, 2017 § Filed under Nano Medicine Comments Off on Global Nanomedicine Market Estimates and Forecasts from 2017 … – MilTech

OrbisResearch.com has published new research report on Global Nanomedicine Market Drivers, Opportunities, Trends, and Forecasts: 20172023 to its database.

Overview: Nanomedicine is an offshoot of nanotechnology, and refers to highly-specific medical intervention at the molecular scale for curing diseases or repairing damaged tissues. Nanomedicine uses nano-sized tools for the diagnosis, prevention and treatment of disease, and to gain increased understanding of the complex underlying pathophysiology of the disease. It involves three nanotechnology areas of diagnosis, imaging agents, and drug delivery with nanoparticles in the 11,000 nm range, biochips, and polymer therapeutics.

The majority of nanomedicines used now allow oral drug delivery and its demand is increasing significantly. Although these nanovectors are designed to translocate across the gastrointestinal tract, lung, and bloodbrain barrier, the amount of drug transferred to the organ is lower than 1%; therefore improvements are challenging. Nanomedicines are designed to maximize the benefit/risk ratio, and their toxicity must be evaluated not only by sufficiently long term in vitro and in vivo studies, but also pass multiple clinical studies.

Request a free sample copy of Report with Table of contents@http://www.orbisresearch.com/contacts/request-sample/240671

The major drivers of the nanomedicine market include its application in various therapeutic areas, increasing R&D studies about nanorobots in this segment, and significant investments in clinical trials by the government as well as private sector. The Oncology segment is the major therapeutic area for nanomedicine application, which comprised more than 35% of the total market share in 2016. A major focus in this segment is expected to drive the growth of the nanomedicine market in the future.

Market Analysis: The Global Nanomedicine Market is estimated to witness a CAGR of 17.1% during the forecast period 20172023. The nanomedicine market is analyzed based on two segments therapeutic applications and regions.

Regional Analysis: The regions covered in the report are the Americas, Europe, Asia Pacific, and Rest of the World (ROW). The Americas is set to be the leading region for the nanomedicine market growth followed by Europe. The Asia Pacific and ROW are set to be the emerging regions. Japan is set to be the most attractive destination and in Africa, the popularity and the usage of various nano-drugs are expected to increase in the coming years. The major countries covered in this report are the US, Germany, Japan, and Others.

Therapeutic Application Analysis: Nanomedicines are used as fluorescent markers for diagnostic and screening purposes. Moreover, nanomedicines are introducing new therapeutic opportunities for a large number of agents that cannot be used effectively as conventional oral formulations due to poor bioavailability. The therapeutic areas for nanomedicine application are Oncology, Cardiovascular, Neurology, Anti-inflammatory, Anti-infectives, and various other areas. Globally, the industry players are focusing significantly on R&D to gain approval for various clinical trials for future nano-drugs to be commercially available in the market. The FDA should be relatively prepared for some of the earliest and most basic applications of nanomedicine in areas such as gene therapy and tissue engineering. The more advanced applications of nanomedicine will pose unique challenges in terms of classification and maintenance of scientific expertise.

Key Players: Merck & Co. Inc., Hoffmann-La Roche Ltd., Gilead Sciences Inc., Novartis AG, Amgen Inc., Pfizer Inc., Eli Lilly and Company, Sanofi, Nanobiotix SA, UCB SA and other predominate & niche players.

Competitive Analysis: At present, the nanomedicine market is at a nascent stage but, a lot of new players are entering the market as it holds huge business opportunities. Especially, big players along with the collaboration with other SMBs for clinical trials of nanoparticles and compounds are coming with new commercial targeted drugs in the market and they are expecting a double-digit growth in the upcoming years. Significant investments in R&D in this market are expected to increase and collaborations, merger & acquisition activities are expected to continue.

Enquiry Before buying Report@ http://www.orbisresearch.com/contacts/enquiry-before-buying/240671

Benefits: The report provides complete details about the usage and adoption rate of nanomedicines in various therapeutic verticals and regions. With that, key stakeholders can know about the major trends, drivers, investments, vertical players initiatives, government initiatives towards the nanomedicine adoption in the upcoming years along with the details of commercial drugs available in the market. Moreover, the report provides details about the major challenges that are going to impact on the market growth. Additionally, the report gives the complete details about the key business opportunities to key stakeholders to expand their business and capture the revenue in the specific verticals to analyze before investing or expanding the business in this market.

Countries Covered:Americas,Europe,APAC and Others. Germany and Japan

Companies Covered:

Merck & Co.Inc,

Hoffmann-La Roche Ltd,

Gilead Sciences,

Novartis AG,

Amgen Inc,

Pfizer Inc,

Eli Lilly and Company,

Sanofi,Nanobiotix SA,UCB SA.

About Us:

Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements. We have vast database of reports from the leading publishers and authors across the globe. We specialize in delivering customised reports as per the requirements of our clients. We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialisation. This helps our clients to map their needs and we produce the perfect required market research study for our clients.

Contact Us:

Hector Costello

Senior Manager Client Engagements

4144N Central Expressway,

Suite 600, Dallas,

Texas 75204, U.S.A.

Phone No.:+1 (214) 884-6817; +912064101019

Email ID:sales@orbisresearch.com

See the article here:
Global Nanomedicine Market Estimates and Forecasts from 2017 … – MilTech

Read the Rest...

Therapeutic nanoparticles in clinics and under clinical …

§ March 26th, 2017 § Filed under Nano Medicine Comments Off on Therapeutic nanoparticles in clinics and under clinical …

This site uses cookies to improve performance. If your browser does not accept cookies, you cannot view this site.

There are many reasons why a cookie could not be set correctly. Below are the most common reasons:

This site uses cookies to improve performance by remembering that you are logged in when you go from page to page. To provide access without cookies would require the site to create a new session for every page you visit, which slows the system down to an unacceptable level.

This site stores nothing other than an automatically generated session ID in the cookie; no other information is captured.

In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a website to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it.

Read more here:
Therapeutic nanoparticles in clinics and under clinical …

Read the Rest...

Global Nanomedicine Market: Increased Research Collaborations …

§ March 26th, 2017 § Filed under Nano Medicine Comments Off on Global Nanomedicine Market: Increased Research Collaborations …

According to a recent market research report released by Transparency Market Research, the global nanomedicine market is estimated to expand at a CAGR of 12.3% during the period between 2013 and 2019. The report, titled Nanomedicine Market – Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 – 2019, projects the global nanomedicine market to be worth US$177.60 bn by 2019. The overall market was valued at US$78.54 bn in 2012.

Browse the fullNanomedicine Market (Neurology, Cardiovascular, Anti-inflammatory, Anti-infective, and Oncology Applications) – Global Industry Analysis, Size, Share,Growth, Trends and Forecast, 2013 – 2019report athttp://www.transparencymarketresearch.com/nanomedicine-market.html

The report points out that improvement in technology for nanomedicine has propelled the global nanomedicine market. Rising government support for research and development of nanomedicine, coupled with an increase in investment and healthcare collaborations, is expected to augment the growth of the market during the forecast horizon. High prevalence of chronic diseases and presence of high unmet medical needs will also push the market growth. However, the report notes that the lack of organized regulatory framework and high costs involved in the development of nanomedicine will hinder the growth of the global nanomedicine market during the forecast period. The market has a huge opportunity to grow in the emerging economies along with the identification of new medical applications.

On the basis of application, the report segments the global nanomedicine market into oncology, anti-inflammatory, neurology, cardiovascular, anti-infectives, and other applications. In 2012, the overall market was dominated by the oncology segment, which accounted for around 38.0% of the market. This can be attributed to the extensive usage of commercialized nanomedicine products in the field of oncology. However, during the next couple of years, the cardiovascular segment is expected to display the fastest growth owing to the growing geriatric population and increasing demand for nanomedicine-based devices and drugs for the treatment of cardiovascular diseases.

The report studies the global nanomedicine market according to its performance in four key regional segments: Asia Pacific, North America, Europe, and Rest of the World. In 2012, North America dominated the overall market and is expected to continue its dominance during the forecast horizon. Advanced healthcare infrastructure has attributed to the growth of the market in this region. However, during the period between 2013 and 2019, Asia Pacific is forecast to expand at a 14.6% CAGR and emerge as the fastest growing region in the market. Rising awareness about healthcare, coupled with growing prevalence of chronic diseases, has fuelled the nanomedicine market in the region. In countries such as India and China, increased research funding and numerous research collaborations in the field of nanomedicine will further push the market.

The report profiles some of the key players in the global nanomedicine market, such as CombiMatrix Corp, Abbott Laboratories, Celgene Corporation, Mallinckrodt plc, Johnson & Johnson, Merck & Co. Inc., GE Healthcare, Pfizer Inc., Nanosphere Inc., UCB SA, Sigma-Tau Pharmaceuticals Inc., and Teva Pharmaceutical Industries Ltd. The report provides insightful information about the key players, including their financial overview, business strategy, product portfolio, and recent developments.

The research study has been segmented as below:

Global Nanomedicine Market, by Application

Global Nanomedicine Market, by Geography

Browse : Our new press releaseshttp://www.transparencymarketresearch.com/pressrelease/global-nanomedicine-market.htm

About Us

Transparency Market Research (TMR) is a global market intelligence company providing business information reports and services. The companys exclusive blend of quantitative forecasting and trend analysis provides forward-looking insight for thousands of decision makers. TMRs experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information.

TMRs data repository is continuously updated and revised by a team of research experts so that it always reflects the latest trends and information. With extensive research and analysis capabilities, Transparency Market Research employs rigorous primary and secondary research techniques to develop distinctive data sets and research material for business reports.

Contact Mr. Sudip. S 90 State Street, Suite 700 Albany, NY 12207 Tel: +1-518-618-1030 USA – Canada Toll Free: 866-552-3453 Email: sales@transparencymarketresearch.com Website: http://www.transparencymarketresearch.com

Here is the original post:
Global Nanomedicine Market: Increased Research Collaborations …

Read the Rest...

Disadvantages of Nanomedicine – Nanomedicine

§ March 26th, 2017 § Filed under Nano Medicine Comments Off on Disadvantages of Nanomedicine – Nanomedicine

Of course, there are valid arguments against the use of nanomedicine, particularly around the issue of toxicity. As explained in the Scientific American article Nano-risks: A Big Need for a Little Testing, Elements at these microscopic levels can exhibit different properties than they do normally. Furthermore, every nanoparticle is unique, and sometimes the effects or two of the same nanoparticles are not consistent. Thus, some nanoparticles might become dangerous for humans. It has been shown [Young and Martel, 2009] that even nanoparticles that naturally occur in our body can have a serious effect on both our short term and long term health. If these naturally created nanoparticles can harm us, then it would not be wise to proceed with using ones that are artificially engineered with first considering the possible effects and consequences. If nanomedicine was expanded to nanorobotics, then we would need to consider the possible effects of a glitch in the programming, and how sever the effects must be. This reminds us that before nanomedicine can be used extensively, it will need to go through a rigorous process of testing to make sure itdoesn’tdo more harm than good.

Another disadvantage of nanotechnology is the enormous financial costs associated with it. As said in a report by the ETC group, Nanotech Rx, the global health crisisdoesn’tstem from a lack of science innovation or medical technologies; the root problem is poverty and inequality. New medical technologies are irrelevant for poor people if theyaren’taccessible or affordable. There is the problem that nanomedicine will definitely be too expensive for the average citizen, at least at first. It raises a question on whether we should focus instead on improving key aspects of the health system and providing better access to medicine and infrastructure I less developed countries. As the ETC says, access to clean water could make a greater contribution to global health than any single medical intervention. If we cant even maintain a working system using the current possibilities of medicine, should we start by fixing whats wrong before looking at something new, wasting billions of dollars in the process?

Finally, nanomedicine, like all technology, can also be used for malicious purposes. Much of the proposed technology and treatment that nanomedicine will bring can be used for purposes other than originally intended. This leads to problems of ethics and privacy. Nanorobots that could monitor the level of insulin in people in diabetes could also be misused by government and corporations trying to increase surveillance of citizens. Such technology can also be used for military purposes. And where should we draw the line in the practical use of nanomedicine? To illustrate, if such technology allows us to heal people who have lost their vision or damaged their brain, either by an accident or through natural causes, should this technology be released to the general public, allowing people to have biotech implants that give them superior vision or mental abilities? Should this be extended to military purposes? If so, then to what extent? There are many moral and ethical dilemmas regarding nanomedicine that must be answered before this technology is put to use.

Continued here:
Disadvantages of Nanomedicine – Nanomedicine

Read the Rest...

Healthcare Nanotechnology (Nanomedicine) Market to Perceive Substantial Growth During 2015 to 2021 – MilTech

§ March 24th, 2017 § Filed under Nano Medicine Comments Off on Healthcare Nanotechnology (Nanomedicine) Market to Perceive Substantial Growth During 2015 to 2021 – MilTech

New York, NY (SBWIRE) 03/23/2017 Nanotechnology is one of the most promising technologies in 21st century. Nanotechnology is a term used when technological developments occur at 0.1 to 100 nm scale. Nano medicine is a branch of nanotechnology which involves medicine development at molecular scale for diagnosis, prevention, treatment of diseases and even regeneration of tissues and organs. Thus it helps to preserve and improve human health. Nanomedicine offers an impressive solution for various life threatening diseases such as cancer, Parkinson, Alzheimer, diabetes, orthopedic problems, diseases related to blood, lungs, neurological, and cardiovascular system.

A sample of this report is available upon request @ http://www.persistencemarketresearch.com/samples/6370

Development of a new nenomedicine takes several years which are based on various technologies such as dendrimers, micelles, nanocrystals, fullerenes, virosome nanoparticles, nanopores, liposomes, nanorods, nanoemulsions, quantum dots, and nanorobots.

In the field of diagnosis, nanotechnology based methods are more precise, reliable and require minimum amount of biological sample which avoid considerable reduction in consumption of reagents and disposables. Apart from diagnosis, nanotechnology is more widely used in drug delivery purpose due to nanoscale particles with larger surface to volume ratio than micro and macro size particle responsible for higher drug loading. Nano size products allow to enter into body cavities for diagnosis or treatment with minimum invasiveness and increased bioavailability. This will not only improve the efficacy of treatment and diagnosis, but also reduces the side effects of drugs in case of targeted therapy.

Global nanomedicine market is majorly segmented on the basis of applications in medicines, targeted disease and geography. Applications segment includes drug delivery (carrier), drugs, biomaterials, active implant, in-vitro diagnostic, and in-vivo imaging. Global nanomedicine divided on the basis of targeted diseases or disorders in following segment: neurology, cardiovascular, oncology, anti-inflammatory, anti-infective and others. Geographically, nanomedicine market is classified into North America, Europe, Asia Pacific, Latin America, and MEA. Considering nanomedicine market by application, drug delivery contribute higher followed by in-vitro diagnostics. Global nanomedicine market was dominated by oncology segment in 2012 due to ability of nanomedicine to cross body barriers and targeted to tumors specifically however cardiovascular nanomedicine market is fastest growing segment. Geographically, North America dominated the market in 2013 and is expected to maintain its position in the near future. Asia Pacific market is anticipated to grow at faster rate due to rapid increase in geriatric population and rising awareness regarding health care. Europe is expected to grow at faster rate than North America due to extensive product pipeline portfolio and constantly improving regulatory framework.

Major drivers for nanomedicine market include improved regulatory framework, increasing technological know-how and research funding, rising government support and continuous increase in the prevalence of chronic diseases such as obesity, diabetes, cancer, kidney disorder, and orthopedic diseases. Some other driving factors include rising number of geriatric population, awareness of nanomedicine application and presence of high unmet medical needs. Growing demand of nanomedicines from the end users is expected to drive the market in the forecast period. However, market entry of new companies is expected to bridge the gap between supply and demand of nanomedicines. Above mentioned drivers currently outweigh the risk associated with nanomedicines such as toxicity and high cost. At present, cancer is one of the major targeted areas in which nanomedicines have made contribution. Doxil, Depocyt, Abraxane, Oncospar, and Neulasta are some of the examples of pharmaceuticals formulated using nanotechnology.

To view TOC of this report is available upon request @ http://www.persistencemarketresearch.com/toc/6370

Key players in the global nanomedicine market include: Abbott Laboratories, CombiMatrix Corporation, GE Healthcare, Sigma-Tau Pharmaceuticals, Inc., Johnson & Johnson, Mallinckrodt plc, Merck & Company, Inc., Nanosphere, Inc., Pfizer, Inc., Celgene Corporation, Teva Pharmaceutical Industries Ltd., and UCB (Union chimique belge) S.A.

View post:
Healthcare Nanotechnology (Nanomedicine) Market to Perceive Substantial Growth During 2015 to 2021 – MilTech

Read the Rest...

Research spotlights early signs of disease using infrared light: New … – Science Daily

§ March 22nd, 2017 § Filed under Nano Medicine Comments Off on Research spotlights early signs of disease using infrared light: New … – Science Daily

Research spotlights early signs of disease using infrared light: New …
Science Daily
Researchers have used infrared spectroscopy to spotlight changes in tiny cell fragments called microvesicles to probe their role in a model of the body's …

and more »

Read more here:
Research spotlights early signs of disease using infrared light: New … – Science Daily

Read the Rest...

Global $392.80 Billion Nanomedicine Market Drivers, Opportunities, Trends, and Forecasts, 2023 – Research and … – Yahoo Finance

§ March 21st, 2017 § Filed under Nano Medicine Comments Off on Global $392.80 Billion Nanomedicine Market Drivers, Opportunities, Trends, and Forecasts, 2023 – Research and … – Yahoo Finance

DUBLIN–(BUSINESS WIRE)–

Research and Markets has announced the addition of the “Global Nanomedicine Market – Drivers, Opportunities, Trends, and Forecasts: 2017-2023” report to their offering.

The Nanomedicine Market to Grow at a CAGR of 17.1% During the Forecast Period 2017-2023 to Aggregate $392.80 Billion By 2023.

The nanomedicine market is analyzed based on two segments – therapeutic applications and regions.

The major drivers of the nanomedicine market include its application in various therapeutic areas, increasing R&D studies about nanorobots in this segment, and significant investments in clinical trials by the government as well as private sector. The Oncology segment is the major therapeutic area for nanomedicine application, which comprised more than 35% of the total market share in 2016. A major focus in this segment is expected to drive the growth of the nanomedicine market in the future.

Moreover, nanomedicines are introducing new therapeutic opportunities for a large number of agents that cannot be used effectively as conventional oral formulations due to poor bioavailability. The therapeutic areas for nanomedicine application are Oncology, Cardiovascular, Neurology, Anti-inflammatory, Anti-infectives, and various other areas.

Globally, the industry players are focusing significantly on R&D to gain approval for various clinical trials for future nano-drugs to be commercially available in the market. The FDA should be relatively prepared for some of the earliest and most basic applications of nanomedicine in areas such as gene therapy and tissue engineering. The more advanced applications of nanomedicine will pose unique challenges in terms of classification and maintenance of scientific expertise.

Market Dynamics

Drivers

Restraints

Opportunities

Key Players:

Key Topics Covered:

1 Industry Outlook

2 Report Outline

3 Market Snapshot

4 Market Outlook

5 Market Characteristics

6 Trends, Roadmap and Projects

7 Types: Market Size and Analysis

8 Trending Nanomedicines

9 Regions: Market Size and Analysis

10 Vendor Scenario

11 Vendor Profiles

12 Global Generalist

13 Companies to Watch for

14 Market Landscape

For more information about this report visit http://www.researchandmarkets.com/research/2bv34j/global

View source version on businesswire.com: http://www.businesswire.com/news/home/20170316005594/en/

See the rest here:
Global $392.80 Billion Nanomedicine Market Drivers, Opportunities, Trends, and Forecasts, 2023 – Research and … – Yahoo Finance

Read the Rest...

Global Nanomedicine Market 2017-2023: Emergence of Nanorobotics to Drive the Growth of the $392 Billion Industry … – Yahoo Finance

§ March 20th, 2017 § Filed under Nano Medicine Comments Off on Global Nanomedicine Market 2017-2023: Emergence of Nanorobotics to Drive the Growth of the $392 Billion Industry … – Yahoo Finance

DUBLIN, Mar 17, 2017 /PRNewswire/ —

Research and Markets has announced the addition of the “Global Nanomedicine Market – Drivers, Opportunities, Trends, and Forecasts: 2017-2023” report to their offering.

Research and Markets Logo

The Nanomedicine Market to Grow at a CAGR of 17.1% During the Forecast Period 2017-2023 to Aggregate $392.80 Billion By 2023

The nanomedicine market is analyzed based on two segments – therapeutic applications and regions.

The major drivers of the nanomedicine market include its application in various therapeutic areas, increasing R&D studies about nanorobots in this segment, and significant investments in clinical trials by the government as well as private sector. The Oncology segment is the major therapeutic area for nanomedicine application, which comprised more than 35% of the total market share in 2016. A major focus in this segment is expected to drive the growth of the nanomedicine market in the future.

Moreover, nanomedicines are introducing new therapeutic opportunities for a large number of agents that cannot be used effectively as conventional oral formulations due to poor bioavailability. The therapeutic areas for nanomedicine application are Oncology, Cardiovascular, Neurology, Anti-inflammatory, Anti-infectives, and various other areas.

Globally, the industry players are focusing significantly on R&D to gain approval for various clinical trials for future nano-drugs to be commercially available in the market. The FDA should be relatively prepared for some of the earliest and most basic applications of nanomedicine in areas such as gene therapy and tissue engineering. The more advanced applications of nanomedicine will pose unique challenges in terms of classification and maintenance of scientific expertise.

Key Topics Covered:

1 Industry Outlook 1.1 Industry Overview 1.2 Industry Trends 1.3 PEST Analysis

2 Report Outline 2.1 Report Scope 2.2 Report Summary 2.3 Research Methodology 2.4 Report Assumptions

3 Market Snapshot 3.1 Total Addressable Market (TAM) 3.2 Segmented Addressable Market (SAM) 3.3 Related Markets 3.3.1 mHealth Market 3.3.2 Healthcare Analytics Market

4 Market Outlook 4.1 Overview 4.2 Regulatory Bodies and Standards 4.3 Government Spending and Initiatives 4.4 Porter 5 (Five) Forces

5 Market Characteristics 5.1 Evolution 5.2 Ecosystem 5.2.1 Regulatory Process 5.2.2 Clinical Trials 5.2.3 Pricing and Reimbursement 5.3 Market Segmentation 5.4 Market Dynamics 5.4.1 Drivers 5.4.1.1 Emergence of nanorobotics 5.4.1.2 Applications and advantages of nanomedicine in various healthcare segments 5.4.1.3 Reasonable investments in R&D 5.4.1.4 Increased support from governments 5.4.2 Restraints 5.4.2.1 Long approval process and stringent regulations 5.4.2.2 Problems regarding nanoscale manufacturing 5.4.2.3 Risks related to nanomedicines 5.4.2.4 Undefined regulatory standards 5.4.3 Opportunities 5.4.3.1 Aging population with chronic care needs 5.4.3.2 Population and income growth in emerging countries 5.4.4 DRO – Impact Analysis

6 Trends, Roadmap and Projects 6.1 Market Trends and Impact 6.2 Technology Roadmap

7 Types: Market Size and Analysis 7.1 Overview 7.2 Global Nanomedicine Market in Oncology Segment 7.3 Global Nanomedicine Market in Cardiovascular Segment 7.4 Global Nanomedicine Market in Neurology Segment 7.5 Global Nanomedicine Market in Anti-inflammatory Segment 7.6 Global Nanomedicine Market in Anti-infective Segment 7.7 Global Nanomedicine Market in Other Therapeutic Areas

8 Trending Nanomedicines 8.1 Overview 8.2 Abraxane 8.3 Alimta 8.4 Eligard 8.5 Copaxone 8.6 Rapamune 8.7 Neulasta 8.8 Cimzia 8.9 AmBisome 8.10 Mircera 8.11 Pegasys 8.12 Emend 8.13 Renagel 8.14 Ritalin

9 Regions: Market Size and Analysis 9.1 Overview 9.1.1 Global Nanomedicine Market by Geographical Segmentation 9.2 Key Leading Countries 9.2.1 US 9.2.2 Germany 9.2.3 Japan

10 Vendor Scenario

11 Vendor Profiles 11.1 Merck & Co. Inc. 11.2 Hoffmann-La Roche Ltd. 11.3 Gilead Sciences 11.4 Novartis AG 11.5 Amgen Inc.

12 Global Generalist 12.1 Pfizer Inc. 12.2 Eli Lilly and Company 12.3 Sanofi

13 Companies to Watch for 13.1 Nanobiotix SA 13.2 UCB SA

14 Market Landscape

For more information about this report visit http://www.researchandmarkets.com/research/krjtrq/global

Read More

View original post here:
Global Nanomedicine Market 2017-2023: Emergence of Nanorobotics to Drive the Growth of the $392 Billion Industry … – Yahoo Finance

Read the Rest...

« Older Entries





Page 11234..1020..»