You are currently browsing the archives for September, 2009

Modular Cre/lox System and Genetic Therapeutics for Colorectal Cancer

§ September 30th, 2009 § Filed under Gene therapy Comments Off

The Cre/lox system is a powerful tool for targeting therapeutic effectors in a wide variety of human disorders. I review a Cre/lox Wnt-targeted system that has shown promise against Wnt-positive colorectal cancer cell lines. In addition to Wnt-specific targeting of cell death inducers, the modular nature of this gene therapy model system can be exploited by designing positive and negative feedback loops to either amplify or inhibit Wnt activity for experimental or therapeutic benefit. I discuss the structural components and performance parameters of the system, the implication of these findings with respect to cancer stem cells, as well as the general applicability of this system to any disorder characterized by differential gene expression. I also consider the issue of gene delivery as we…

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Why Cleanse the Bowel ?

§ September 30th, 2009 § Filed under Integrative Medicine Comments Off

A good cleansing program should always begin by removing the waste in your colon, the last portion of your food processing chain. If you attempt to clean your liver, blood, or lymph system without first addressing a waste filled bowel, the excreted toxins will only get recycled back into your body.

One of the most frequent bowel problems that people experience today is constipation. Constipation is generally attributed to a low fiber diet and lack of sufficient water, which cause our fecal matter to become condensed and compressed.

A constipated system is one in which the transition, or “time”, of toxic wastes is slow and the consistency of the stool can cause strain (which over time may cause hemorrhoids, varicose veins, hiatal hernia, or other mechanically induced problems). The longer the “transit time”, the longer the toxic waste matter sits in our bowel which allows proteins to putrefy, fats to rancify, and carbohydrates to ferment. Read more…

Nutraceuticals and Functional Foods Conference

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

Nutraceuticals and Functional Foods

21st & 22nd October 2009, Crowne Plaza Hotel – St James, London, UK

The awareness of nutrition’s role in a healthy lifestyle in addition to preventing diseases is constantly growing along with the number of new products, approaches, regulatory aspects and related concerns.

SMi’s 10th annual Nutraceuticals and Functional Foods conference is well established in the market place. It is well timed with the announcement of new regulations. Additionally it will focus on new product developments, the challenges and developments in health claims legislation and the key issues facing the industry. Take the opportunity to meet and network with distinguished international speakers and delegates.

With a breadth of topical issues being addressed, this conference is essential for people with a developed interest in nutraceuticals and functional foods. Simon Parker of the MHRA will discuss medicinal claims and the associated statutory procedures, whilst Peter McConville of GlaxoSmithKline will present on the evolution of sports drinks, drawing attention to performance enhancement issues and claim substantiation.

Hear from leading expert Aleksandra Wesolowska from European Advisory Services about the future of health claims legislation and upcoming FSA and FDA regulatory changes. Also covered in this presentation are strategies to mitigate the impacts of these changes, preventing unjustified claims and predicting future changes.

This is a must-attend event for anyone looking to further their understanding of key technologies and developments or network with leading members of this growing industry.

PLUS A HALF – DAY PRE CONFERENCE WORKSHOP

Health Claims Legislation: The Bumpy Road Towards an Approved Health Claim
20th October 2009, Crowne Plaza Hotel – St James, London, UK
In association with analyze & realize

Quote “Nutraceuticals Now” to receive a discount of £100

Click here for more information or to register.

Alternatively contact Charlotte Johnson:
tel.: +44 (0) 20 7827 6060 or
e-mail: cjohnson@smi-online.co.uk

The Total Market For Nutraceuticals In India Is Valued At INR 44 Bn In 2009; It Is Estimated To Reach INR 95 Bn In 2013 (OfficialWire)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

Total market for Nutraceuticals in India is valued at INR 44 bn in 2009; it is estimated to reach INR 95 bn in 2013. Market comprises of two segments – Food Supplements and Vitamins & Minerals.

From mints that cure smelly feet to chewing gum that helps weight loss… Welcome to the world of NUTRACEUTICALS (Daily Mail)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

Nutraceutical is the name given to a consumer product that combines nutrition and pharmaceutical elements and claims to have health benefits. But do they deliver?

Probiotic Delivery Technology Awarded Patent in China (PR Newswire via Yahoo! Finance)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

The Chinese Patent Office has issued Nutraceutix, Inc. patent No. 02823678.5 for BIO-tract. It is the fourth international patent, from many patents pending, that the technology has been awarded recently based on BIO-tract’s ability to protect sensitive ingredients such as probiotic organisms from stomach acid on their way to optimal release sites in the intestinal tract.

"The End of Medicine" – Harness the Body’s Healing Powers – The Human Organism "Knows" How to Heal Itself Naturally (PRWeb)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

The End of Medicine is a new book detailing a macrobiotic approach to healing ourselves and maintaining our health. It describes the crucial significance of the digestive processes in the onset of illness and in the process of healing. This approach is entirely natural using daily food choices which in many cases will reduce food costs by 30-50% (PRWeb Sep 28, 2009) Read the full story at …

"The End of Medicine" – Harness the Body’s Healing Powers – The Human Organism "Knows" How to Heal Itself Naturally (PRWeb via Yahoo! News)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

The End of Medicine is a new book detailing a macrobiotic approach to healing ourselves and maintaining our health. It describes the crucial significance of the digestive processes in the onset of illness and in the process of healing. This approach is entirely natural using daily food choices which in many cases will reduce food costs by 30-50%

Legumes, protein powerhouse for millions (The Times of India)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

Legumes could turn out to be a nutritional powerhouse to help overcome malnutrition among an estimated 800 million undernourished people in the developing world, says a report.

Legumes can be ‘protein powerhouse’ for 800mn malnourished people (New Kerala)

§ September 29th, 2009 § Filed under Nutraceuticals Comments Off

Washington, Sep 27 : Legumes could turn out to be a nutritional powerhouse to help overcome malnutrition among an estimated 800 million undernourished people in the developing world, says a report.

Protein hydrolysates in sports nutrition

§ September 29th, 2009 § Filed under Nutrition Comments Off

It has been suggested that protein hydrolysates providing mainly di- and tripeptides are superior to intact (whole) proteins and free amino acids in terms of skeletal muscle protein anabolism. This review provides a critical examination of protein hydrolysate studies conducted in healthy humans with special reference to sports nutrition. The effects of protein hydrolysate ingestion on blood amino acid levels, muscle protein anabolism, body composition, exercise performance and muscle glycogen resynthesis are discussed.

Early responses of insulin sensitivity to high-carbohydrate and high-fat overfeeding

§ September 29th, 2009 § Filed under Nutrition Comments Off

Background:
Early molecular changes of nutritionally-induced insulin resistance are still enigmatic. It is also unclear if acute overnutrition alone can alter insulin signaling in humans or if the macronutrient composition of the diet can modulate such effects.
Methods:
To investigate the molecular correlates of metabolic adaptation to either high-carbohydrate (HC) or high-fat (HF) overfeeding, we conducted overfeeding studies in 21 healthy lean (BMI <25) individuals (10 women, 11 men), age 20-45, with normal glucose metabolism and no family history of diabetes. Subjects were studied first following a 5-day eucaloric (EC) diet (30% fat, 50% CHO, 20% protein) and then in a counter balanced manner after 5 days of 40% overfeeding of both a HC (20% fat, 60% CHO) diet and a HF (50% fat, 30% CHO) diet. At the end of each diet phase, in vivo insulin sensitivity was assessed using the hyperinsulinemic-euglycemic clamp technique. Ex vivo insulin action was measured from skeletal muscle tissue samples obtained 15 minutes after insulin infusion was initiated.
Results:
Overall there was no change in whole-body insulin sensitivity as measured by glucose disposal rate (GDR, EC: 12.1 +/- 4.7; HC: 10.9 +/- 2.7; HF: 10.8 +/- 3.4). Assessment of skeletal muscle insulin signaling demonstrated increased tyrosine phosphorylation of IRS-1 (p<0.001) and increased IRS-1-associated phosphatidylinositol 3 (PI 3)-kinase activity (p<0.001) following HC overfeeding. In contrast, HF overfeeding increased skeletal muscle serine phosophorylation of IRS-1 (p<0.001) and increased total expression of p85alpha (P<0.001).
Conclusions:
We conclude that acute bouts of overnutrition lead to changes at the cellular level before whole-body insulin sensitivity is altered. On a signaling level, HC overfeeding resulted in changes compatible with increased insulin sensitivity. In contrast, molecular changes in HF overfeeding were compatible with a reduced insulin sensitivity.

Novus expands from animal to human nutrition (Nutraingredients.com)

§ September 29th, 2009 § Filed under Nutrition Comments Off

The company, which has over 50 years’ experience in animal nutrition and a portfolio of more than 70 products, has set up a Human Nutrition Division to develop ingredients and technologies that can be directly utilized in supplements, beverages and foods.

Friend turned boss, nutrition facts, major search (AP via Yahoo! News)

§ September 29th, 2009 § Filed under Nutrition Comments Off

FRIEND TURNED BOSS: You have lunch together every day, grab an occasional drink after work, and have gotten each other through work-related crises. So wouldn’t it be strange if your office buddy became your new boss?

Closing the nutrition and physical activity gap in Victoria: Victorian Aboriginal nutrition and physical activity … (Australian Policy Online)

§ September 29th, 2009 § Filed under Nutrition Comments Off

This Strategy is the result of a comprehensive review of the Indigenous health promotion literature and a state-wide consultation process to improve nutrition, physical activity and reducing the chronic disease burden among the Victorian Aboriginal Community. Social Policy

Bacolod receives Nat’l Nutrition Council award (Sun Star)

§ September 29th, 2009 § Filed under Nutrition Comments Off

MAYOR Evelio Leonardia said Monday Bacolod City is a recipient of yet another award from the National Nutrition Council (NNC) – the Consistent Regional Outstanding Winner in Nutrition (Crown). read more

Total Nutrition Technology to participate in Charlotte Junior Tennis Ad In Program (dBusinessNews.com)

§ September 29th, 2009 § Filed under Nutrition Comments Off

CHARLOTTE, N.C. – Total Nutrition Technology ( www.tntgetfit.com ), a company specializing in helping people lose weight, manage their health and enhance their sports performance, will participate in the Charlotte Junior Tennis Ad In Program by leading a session on optimizing performance with the right nutrition.

More Healthy Foods for Moms, Kids Nutrition Program (KARK Little Rock)

§ September 29th, 2009 § Filed under Nutrition Comments Off

The Women, Infants and Children (WIC) supplemental nutrition program will see some positive changes October 1st. For the first time, participants will be able to get fresh, frozen or canned fruits and vegetables.

Friend turned boss, nutrition facts, major search (Newsday)

§ September 29th, 2009 § Filed under Nutrition Comments Off

FRIEND TURNED BOSS: You have lunch together every day, grab an occasional drink after work, and have gotten each other through work-related crises. So wouldn’t it be strange if your office buddy became your new boss? It’s more likely to happen in the current economic environment as hiring freezes force companies to promote from within, says Stephen Viscusi, a New York-based author and career …

Medical Nutrition USA, Inc. Chairman & CEO Frank Newman Will Present at Wall Street Analyst Forum in New York City … (Marketwire)

§ September 29th, 2009 § Filed under Nutrition Comments Off

ENGLEWOOD, NJ–(Marketwire – September 28, 2009) – Medical Nutrition USA, Inc. ( NASDAQ : MDNU ) announced today that Chairman & Chief Executive Officer Frank A. Newman, will discuss the Company’s recent, current & future operations at the Wall Street Analyst Forum, Tuesday, Sept. 29. Mr. Newman’s presentation is scheduled at 11:50 am. The Wall Street Analyst Forum is held at the University Club …

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