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Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Authors: B Thaci, A U Ahmed, I V Ulasov, A L Tobias, Y Han, K S Aboody & M S Lesniak (Source: Cancer Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Interferon-? lipofection II. Mechanisms involved in cell death and bystander effect induced by cationic lipid-mediated interferon-? gene transfer to human tumor cells

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Interferon-β lipofection II. Mechanisms involved in cell death and bystander effect induced by cationic lipid-mediated interferon-β gene transfer to human tumor cells Cancer Gene Therapy advance online publication, May 4, 2012. doi:10.1038/cgt.2012.19 Authors: M S Villaverde, M L Gil-Cardeza, G C Glikin & L M E Finocchiaro (Source: Cancer Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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MicroRNA silencing improves the tumor specificity of adenoviral transgene expression

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Authors: P B Card, R T Hogg, C R Gil del Alcazar & R D Gerard (Source: Cancer Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Targeted therapy via oral administration of attenuated Salmonella expression plasmid-vectored Stat3-shRNA cures orthotopically transplanted mouse HCC

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Authors: Y Tian, B Guo, H Jia, K Ji, Y Sun, Y Li, T Zhao, L Gao, Y Meng, D V Kalvakolanu, D J Kopecko, X Zhao, L Zhang & D Xu (Source: Cancer Gene Therapy) MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to [...]

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Gene Hunt Is On for Mental Disabilities in Children

§ May 6th, 2012 § Filed under Gene therapy Comments Off

By Ewen Callaway of Nature magazine [More] Source:http://rss.sciam.com/sciam/topic/gene-therapy

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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Adoptive cell therapy with tumor-targeted T cells is a promising approach to cancer therapy. Enhanced clinical outcome using this approach requires conditioning regimens with total body irradiation, lymphodepleting chemotherapy, and/or additional cytokine support. However, the need for prior conditioning precludes optimal application of this approach to a significant number of cancer patients intolerant to these [...]

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MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Authors: I M Barbash, S Cecchini, A Z Faranesh, T Virag, L Li, Y Yang, R F Hoyt, J N Kornegay, J R Bogan, L Garcia, R J Lederman & R M Kotin (Source: Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Critical Variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency

§ May 6th, 2012 § Filed under Gene therapy Comments Off

Authors: J C M van der Loo, W P Swaney, E Grassman, A Terwilliger, T Higashimoto, A Schambach, S Hacein-Bey-Abina, D L Nordling, M Cavazzana-Calvoo, A J Thrasher, D A Williams, L Reeves & P Malik (Source: Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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April 2012 Advances: Additional Resources

§ May 6th, 2012 § Filed under Gene therapy Comments Off

The Advances news section in April's issue of Scientific American included stories on digital textbooks, the promise of using gene therapy to fight blindness and how fragile orchids survive. To learn more about any of the stories, follow these links. [More] Source:http://rss.sciam.com/sciam/topic/gene-therapy

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Research and Markets: Breaking the Gene Therapy Barrier for Life-Threatening Red Blood Cell Disorders

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Research and Markets has announced the addition of GlobalData's new report "Breaking the Gene Therapy BarrierSource:http://news.search.yahoo.com/news/rss?ei=UTF-8&p=gene+therapy&eo=UTF-8

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CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

§ April 29th, 2012 § Filed under Gene therapy Comments Off

In conclusion, adoptive immunotherapy with CD20-specific T cells was well tolerated and was associated with antitumor activity. We will pursue alternative gene transfer technologies and culture conditions in future studies to improve CAR expression and cell production efficiency. This study is registered at www.clinicaltrials.gov as NCT00621452. (Source: Blood) MedWorm Sponsor Message: Please have a look [...]

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Prospects for gene transfer for clinical heart failure

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Authors: T Tang, M H Gao & H Kirk Hammond (Source: Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Gene therapy for ventricular tachyarrhythmias

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Gene Therapy advance online publication, April 26, 2012. doi:10.1038/gt.2012.35 Author: J K Donahue (Source: Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Authors: S P Grekova, Z Raykov, R Zawatzky, J Rommelaere & U Koch (Source: Cancer Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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IL15 combined with Caspy2 provides enhanced therapeutic efficiency against murine malignant neoplasm growth and metastasis

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Authors: Y Yang, X-m Zhang, N Zhang, L Cheng, C Li, S Zhang, J-f Zhang, L Dai, H-w Tian, N Yan, P Fan, L-x Dai, F Xu, G Shi, X-l Chen, T Du, Y-m Li, Y-Q Wei & H-X Deng (Source: Cancer Gene Therapy)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures.

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Authors: Turrell SJ, Macnab SA, Rose A, Melcher AA, Whitehouse A Abstract Herpesvirus saimiri (HVS) is capable of infecting a range of human carcinoma cell types with high efficiency and the viral genome persists as high copy number, circular, non-integrated episomes which segregate to progeny upon cell division. This allows HVS-based vectors to stably transduce [...]

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Calcium carbonate microparticles used as a gene vector for delivering p53 gene into cancer cells.

§ April 29th, 2012 § Filed under Gene therapy Comments Off

In this study, CaCO(3) delivering pEGFP-C1-p53 could transfect about 5% of the tumor cells in culture. However, the efficiency of tumor cell apoptosis was surprisingly up to 80%. Meanwhile, the results of MTT assay and crystal violet staining showed that the CaCO(3) microparticles had low cytotoxicity. These findings showed that CaCO(3) microparticles were perspective to [...]

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A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In [...]

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Adeno-associated virus-mediated doxycycline-regulatable TRAIL expression suppresses growth of human breast carcinoma in nude mice

§ April 29th, 2012 § Filed under Gene therapy Comments Off

Conclusion: These data suggest that rAAV-mediated soluble TRAIL expression under the control of the Tet-On system is a promising strategy for breast cancer therapy. (Source: BMC Cancer)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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Epirubicin potentiates recombinant adeno?associated virus type 2/5–mediated TRAIL expression in fibroblast?like synoviocytes and augments the antiarthritic effects of rAAV2/5?TRAIL

§ April 29th, 2012 § Filed under Gene therapy Comments Off

ConclusionThese results suggest that epirubicin enhances the antiarthritic effect of rAAV2/5?TRAIL and that combination treatment might be an important therapeutic alternative, with practical significance for rheumatoid arthritis. (Source: Arthritis and Rheumatism)Source:http://www.medworm.com/rss/medicalfeeds/therapies/Gene-Therapy.xml

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