Tumor-Shrinking Nanoparticle Prevents Cancer Recurrence – Controlled Environments Magazine

§ May 3rd, 2017 § Filed under Nano Medicine Comments Off on Tumor-Shrinking Nanoparticle Prevents Cancer Recurrence – Controlled Environments Magazine

A Mayo Clinic research team has developed a new type of cancer-fighting nanoparticle aimed at shrinking breast cancer tumors, while also preventing recurrence of the disease. In the study, published in Nature Nanotechnology, mice that received an injection with the nanoparticle showed a 70 to 80 percent reduction in tumor size. Most significantly, mice treated with these nanoparticles showed resistance to future tumor recurrence, even when exposed to cancer cells a month later.

The results show that the newly designed nanoparticle produced potent anti-tumor immune responses to HER2-positive breast cancers. Breast cancers with higher levels of HER2 protein are known to grow aggressively and spread more quickly than those without the mutation.

In this proof-of-concept study, we were astounded to find that the animals treated with these nanoparticles showed a lasting anti-cancer effect, says Betty Y.S. Kim, M.D., Ph.D., principal investigator, and a neurosurgeon and neuroscientist who specializes in brain tumors at Mayo Clinics Florida campus. Unlike existing cancer immunotherapies that target only a portion of the immune system, our custom-designed nanomaterials actively engage the entire immune system to kill cancer cells, prompting the body to create its own memory system to minimize tumor recurrence. These nanomedicines can be expanded to target different types of cancer and other human diseases, including neurovascular and neurodegenerative disorders.

Kims team developed the nanoparticle, which she has named Multivalent Bi-specific Nano-Bioconjugate Engager, a patented technology with Mayo Clinic Ventures, a commercialization arm of Mayo Clinic. Its coated with antibodies that target the HER2 receptor, a common molecule found on 40 percent of breast cancers. Its also coated with molecules that engage two distinct facets of the bodys immune system. The nanoparticle hones in on the tumor by recognizing HER2 and then helps the immune cells identify the tumor cells to attack them.

The molecules attached to the nanoparticle rev up the bodys nonspecific, clean-up cells (known as macrophages and phagocytes) in the immune system that engulf and destroy any foreign material. The design of the nanoparticle prompts these cells to appear in abundance and clear up abnormal cancer cells. These clean-up cells then relay information about the cancer cells to highly specialized T-cells in the immune system that help eradicate remaining cancer cells, while maintaining a memory of these cells to prevent cancer recurrence. Its the establishment of disease-fighting memory in the cells that makes the nanoparticle similar to a cancer vaccine. Ultimately, the bodys own cells become capable of recognizing and destroying recurrent tumors.

Read the original post:
Tumor-Shrinking Nanoparticle Prevents Cancer Recurrence – Controlled Environments Magazine

Comments are closed.