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The middle-age spread & how to avoid it

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on The middle-age spread & how to avoid it

The middle age spread & how to avoid it healthy diet weight loss help lose weight weight loss diets fat loss prevent weight gain middle-aged

A common issue I hear from clients trying to lose weight pertains to the so-called ‘middle age spread’. “It’s not my fault I can’t lose weight” they say. “I’m getting older and my waist, hips and thighs refuse to get slimmer.”

Is it true?

Based on the following facts you might think so:

 

  • At approximately age 20, the metabolic rate starts to decrease on average 2% every decade

  • Many North Americans gain an average of 20 pounds between the ages of 25 and 55

  • Weight gain typically peaks for men in their 40’s and for women in their 50’s

  • An 11 pound weight gain can significantly increase an individual’s risk of developing diabetes, heart disease and cancer.

Makes you want to throw in the towel right? Not so fast! Studies show you CAN avoid the middle age spread and age without uncontrollable weight gain. Think Demi Moore, Meryl Streep or Helen Mirren.

How so? Simply by choosing to eat better and by moving more (plus a few bonus supplements to boost your results).

Step 1

Eat a clean, colorful diet and avoid processed foods.

  • Carbohydrate clean-up: As renowned food author Michael Pollan states: ‘Eat food, not too much, mostly plants.’ Aim for deeply colored varieties rich in phytonutrients such as kale and purple cabbage, plus antioxidant-rich berries, fibrous whole grains (remember the label must say 100% whole grain), and legumes. Try eliminating ALL whites from your diet, including white flour, sugar, pasta and breads.

  • Go for ‘pro’ at every meal and snack: Before eating, be sure to ask yourself ‘what’s my protein source?’ Protein triggers the release of the hormone glucagon which facilitates the breakdown of fat. Ideal sources of protein include lean chicken, organic beef, turkey, egg whites, soy and fish. For extra benefits, I advise my clients to include a very high quality protein supplement such as proteins+ or Vegan proteins+. Simply add into smoothies, yogurt, liquids or baking –no blender required.

  • Add some fat-fuel: Avoid fatty meats, cheese, margarine and dressings containing refined vegetable oils or trans fats. Instead, make essential fats such as Omega-3s found in cold water fish, nuts, seeds a daily food staple. Besides increasing brain function, cardiovascular health and more, studies show consuming an Omega-3 fish oil formula can help you shed excess fat more efficiently.

Other eating tips to boost weight loss and metabolism at any age:

  • Instead of coffee, try antioxidant-rich green tea

  • Eat smaller meals more frequently and avoid eating after 7pm

  • Skip all artificial sweeteners, try stevia instead

  • Throw out your salt shaker and season foods with flavorful spices

  • Enjoy a glass of red wine daily – studies show those who do so are more likely to keep their waist lines in-check. Please remember this means drinking red wine in moderation–too much may pack on the pounds.

Step 2

Move more, include weight bearing exercises. Torch calories and boost your metabolism with regular cardiovascular exercise, strength training and stretching such as yoga every day. Yes, do something every day!

  • Aim for 4-5 cardio sessions per week for a minimum of 30 minutes

  • Include weight-bearing exercise such as strength training 2-3 times per week

  • Attend a yoga, pilates or a stretch class

  • Look for other ways to sneak more activity in your day such as walking or taking the stairs

For every pound of muscle you gain, your metabolism increases as much as 15%, burning an extra 35-50 calories per day – even while resting. Lean (not bulky) muscle mass also means stronger bones and better posture.

To boost your results, consider hiring a trainer to set-up a program and/or purchase free weights and DVDs to practice at home.

Step 3

Incorporate all-natural supplements with research-proven ingredients

My top picks include:

  • A daily high-potency, complete multi-vitamin such as one enhanced with Green Tea to assist with weight loss. I like multi+ daily trim.

  • A protein formula (as noted above), look for one that’s 100% pure, no sugar, highly absorbable and provides all essential amino acids.

  • A high-quality fish oil formula.

Last, to really (I mean really) succeed, make steps 1, 2 and 3 your lifestyle and not a temporary experiment. Expect occasional set-backs, go easy on yourself and enjoy the renewed energy and vitality you will experience as you age middle-spread-free!

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Effective Weight Loss Methods

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Effective Weight Loss Methods

Effective Weight Loss Methods Fat Loss Lose Weight Weight Training Exercise Fish Oil Green Tea EGCG

Losing weight can be hard.

Here are a few key steps that will help make shedding those extra pounds much easier and healthier.

Exercise

A great way to start your day is with exercise and it is one of the most effective ways of losing weight. There are many forms of exercise ranging from walking, working out at the gym or even doing household chores. The key is to keep moving!

Walking is a simple way of getting your daily dose of exercise. It could be as little as 30 minutes a day. Try using your arms or including a couple of hills for an even better result.

Eliminate white foods from your diet

These white foods are also called “refined carbohydrates,” which includes white pasta, rice, bread, flour, salt and sugar. As a rule of thumb, foods that are white are typically refined. Refined foods lack fiber and nutrients and may even make you gain weight!

Replace these white foods with sprouted grains, millet, quinoa, brown rice, and spelt as they are better sources of nutrients.

A Harvard study found that women who ate more that two servings of whole grains per day were 49% less likely to become overweight.

Be sure to avoid starchy grains at night time, as this can actually promote weight gain. The best dinner combination for weight loss is protein and veggies. For dinner tomorrow night have some quality protein, such as chicken or wild salmon and fill the rest of your plate with vegetables.

Eliminate sugar from your diet

This step is one of the most important to your health. Sugar is full of empty calories. It also increases insulin levels in your body.

Did you know one can of soda can contain between 8-12 teaspoons of sugar?

Some great alternatives to sugar include maple syrup, date syrup, stevia, agave and raw honey. Be sure to use in moderation.

Green tea

There are many benefits to green tea and one of them is weight loss. Green tea contains powerful antioxidants called polyphenols. These antioxidants can neutralize and prevent damage from disease-promoting free radicals.

According to a study from the American Society of Nutrition green tea contains antioxidant compounds that may promote exercise-induced abdominal fat loss. Another study found that by drinking 5 cups of tea a day the average person burns an extra 70 – 80 calories.

Remember, not all green teas are created equal. Look for the bright green color to get the full benefits and make sure it’s organic.

Keep a food journal

I always tell my clients to keep a food journal. It helps them figure out exactly what they are eating and where they are going wrong.

Write down what you eat, the portion sizes, the times of the day you eat, and any emotions you are having. Then, at the end of the day analyze what you have written down and see how you can make the next day a healthier one.

Make these tips part of your lifestyle and you will see benefits!

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Healthy Weight Loss-Part2

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Healthy Weight Loss-Part2

Healthy Weight Loss-Part2 fat loss losing weight nutrition health and wellness diet holidays atkins weight loss tips protein breakfast ideas healthy recipes sugar caffeine sleepHere are some quick and easy ways to help you slim down. These little changes add up to losing weight and a healthier you!

Kick the Sugar Habit

According to Dr. Robert Atkins, sugar is the “quintessential anti-nutrient”. It contains no vitamins or minerals. Rather, it is 100% carbohydrate, so it must be immediately metabolized. When sugar is metabolized it depletes our bodies of vital nutrients.

There are healthier solutions available. Stevia and glycerine extracts of Garcinia cambogia (Lose-It) are both very sweet weight-loss aids. Unlike sugar, these natural alternatives are not empty calories, and both also act as appetite suppressants to help curb your calorie cravings.

Accelerate Exercise

Enjoy a cup or capsule of green tea 30 minutes before you exercise. The natural caffeine it contains frees fatty acids, allowing you to burn fat more easily. Green tea also has antioxidant compounds that appear to work with caffeine to increase your calorie burn.

Take chromium before exercising. An essential trace mineral, your body needs chromium to metabolize carbohydrates, proteins and fat. Nearly 90% of North Americans are chromium deficient

Chromium enhances the calorie burning results of exercise to make weight loss easier. When you work out it increases your chromium excretion, which makes supplementation even more important.

Water

Dehydration can significantly slow down your metabolism. Be sure you drink enough healthy liquids (water, fruit juice, herbal teas) to keep your body happy. Avoid “bad” drinks such as soda, sugary drinks and coffee as they aid the dehydration process. In general, you should drink 1/2 ounce (14.5 ml) per pound of body weight daily, just to keep from being dehydrated. Thus, a person weighing 150 pounds would need at least 2.175L of water daily. This number increases dramatically if you are dieting or exercising.

Give your water an added boost by adding 1 or 2 teaspoons of liquid chlorophyll to each liter (quart) of water.

A common fallacy is to drink when you are thirsty. Unfortunately, when exercising you are already dehydrated by the time you become thirsty. A schedule to prevent dehydration begins 2 hours before exercising by drinking at least 500ml. Then 1 hour before, drink 250ml more, and at least 250ml every 15 minutes during exercise. Finally, drink another 500ml within ½ hour of finishing your exercise routine.

Measure, Measure, Measure

When cooking or baking, measure out all ingredients, especially fats (butter, margarine, oils) and sweeteners (molasses, sugar, honey, stevia). Many people estimate these ingredients and, more often than not, they estimate too high thereby adding unnecessary calories.

Spice Up Your Life

Try adding spices to food instead of fat. Both add flavour, but spices also aid digestion. Give “dull” foods a spicy zip and add variety without adding fat by varying the spices you use.

Sprinkle Your Cereal

Incorporate high fiber flax into your food. Not only is it packed with a healthy and flavorful oil, the high fiber content can help you feel full and eat less. Try adding flax to cereals, breads, muffins, and yoghurt.

Become a Dipper

Pass on the butter. Instead, try dipping your bread in flavored extra virgin olive oil (my favorite is rosemary, garlic & chili). Research has shown extra virgin olive oil to be exceptionally healthy, and “dippers” eat fewer calories than those who buttered their bread.

Skip Rope, Not Meals

Did you know? Restricting foods and skipping meals slows the metabolism and can lead to overeating. When you miss a meal or eat too little, your brain initiates a famine response which alerts the body to conserve calories. Your body assumes food is in short supply and goes into a calorie-saving mode, storing fat to keep you from starving to death. Instead of skipping, eat well-balanced healthy meals.

Take Time for You

Take some time every day to do something you enjoy, other than eating. Routinely doing something you enjoy not only makes you feel good about yourself, but provides the emotional support you may be seeking from food.

Playing is not just for kids. Run, jump, swim, have fun! You can get lots of physical activity “playing.” Get out and have a game of tag with your kids or challenge someone to a full-court basketball game. Ride your bike, dance, or go hiking. If you can enjoy enough additional activity everyday to burn an extra 300 calories, you’ll lose 2.5 pounds of fat per month — and tone your muscles. You will love the new you, and so will your kids!

The combined effect of these simple little steps will help turn your body into an efficient calorie-burning machine. This new year, take the steps to a happy healthy new you.

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Healthy Weight Loss-Part 1

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Healthy Weight Loss-Part 1

Healthy Weight Loss fat loss lose weight gaining weight nutrition health and wellness diabetes fiber supplements calories caloric intake ideal weight waist hip ratio running weight training fruit vegetables health and wellness

As we get closer to another new year, many of us will make the obligatory resolution to be healthier and happier, which usually includes losing weight. This year see your resolution through to its conclusion. Make this your thinner, happier and healthier year!

Approximately one-half of North Americans are overweight, one-quarter are obese and three-quarters feel they are above their ideal weight. Clearly the battle of the bulge is an ever-expanding epidemic.

To effectively lose weight and, more importantly, keep it off, we need to understand the chemical reasons why people gain. Gaining weight occurs when we consume more calories than we use. The body efficiently stores these excess calories as fat.

Consequently, weight can be lost by decreasing the calories we consume and by increasing the amount we burn. While lifestyle changes are easier said than done, the most effective dieters combine these strategies for lifelong success.

As long as the body is using fewer calories than it takes in, a person will get “fatter”. Modern science has not yet developed a magic pill to change this fact. However, there are substances that can help reduce your calorie intake or increase the amount you burn.

No substance is magical. If you eat everything in sight and live a sedentary lifestyle you are more likely to be overweight and unhealthy. While there are no quick answers for successful weight loss and long term weight maintenance, establishing a few common-sense habits will help you reach your ideal weight. First and foremost, follow a sensible diet that is both satisfying and nourishing. This builds a solid foundation for any weight-loss program. Consider supplements to bolster your nutritional intake. The vast majority of North Americans do not get enough nutrients from the foods they eat. Adding vitamins, minerals and herbs to your daily routine may reduce these deficiencies and bolster your health.

No health program is complete without the addition of regular exercise. You don’t have to join a gym or buy a fancy machine, just start moving! Walk, take the stairs, stroll around the block at lunch or to the corner store. Experts recommend at least 30 minutes of constant exercise a day, three times a week.

Set realistic and attainable goals. Rapid weight-loss, while tempting, is not desirable. As a rule, the faster you lose weight the more likely you are to gain it back! A healthy weight-loss plan should be targeted toward slow, steady weight-loss, unless directed otherwise by your doctor. Don’t be discouraged by a downward trend in the amount you lose. Expect to only lose about a pound a week after the first week or two. With many calorie-restricted diets there is a rapid initial weight loss, but this is largely fluid. This initial rapid loss of fluid is quickly regained when you return to a normal calorie diet. Thus, reasonable short-term goals for weight loss must be set.

A successful program should include plans for maintaining your new weight after the loss phase is over. There is little, if any benefit in losing a large amount of weight when it is only regained. Weight maintenance is the most difficult part of controlling weight and is often an afterthought. The program you select should include help to permanently change your dietary habits and level of physical activity, thereby altering a lifestyle that likely contributed to weight gain in the past.

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Weight Loss on a Busy Schedule

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Weight Loss on a Busy Schedule

Weight Loss on a Busy Schedule losing weight weight gain healthy eating weight management stress management health and wellnessWhen discussing weight loss techniques in seminars or in private practice, one of the most frequent excuses I hear from people is that they’re too busy or it’s too difficult to eat healthier.

Time may be short for most of us, yes. But throughout my years of teaching and dealing with weight loss clients, I have gathered some very helpful nutritional “tricks” to help even the busiest of people lose weight permanently.

Learn to shop

It takes just as long to go to the grocery store for a bag of chips as it does for an apple! You have to grocery shop anyway, so why not learn the basics of nutrition to fill up your cart?

Here are some healthy food basics to stock-up on:

  1. Fresh fruits – fresh or frozen berries, apples, oranges, kiwi

  2. Vegetables – broccoli, cauliflower, spinach, tomatoes (go for color!)

  3. Omega 3 foods such as wild salmon (tinned is fine), omega-3 eggs, walnuts

  4. Good fats – olive oil, avocados

  5. Lean meats – chicken, turkey, ham slices (look for low-sodium, nitrate-free)

  6. Low-fat dairy options- light cottage cheese, yogurt, milk and low fat cheese

  7. Nuts, seeds – raw, un-salted varieties are best

  8. Healthy spreads – hummus, light cream cheese, organic nut butters

  9. Whole grain breads and pastas – kamut, spelt, rye, oats, flax and multi-grain

  10. A small amount of dark chocolate (70%) for a treat

  11. Protein powder- pure whey formula (free of aspartame and sucralose)

  12. Healthy snack bars- low-sugar and made from real food ingredients such as proteins+, greens+ Hip to be Healthy Squares

  13. Water (or a good quality water filter)

What should not go in your grocery cart:

  • Hydrogenated or partially hydrogenated foods (a.k.a. Trans fatty acids) – certain salad dressings, crackers, chips, margarine. Check your labels!

  • Refined, white flour products – white bread, pasta, muffins, cookies, crackers

  • Pop or sugar juices

  • Candy

  • Overly processed and packaged goods

Pack a lunch to save time, money and calories

A balanced meal includes the proper amount of protein, carbohydrates and fat. Here’s an example:

  • A whole wheat sandwich wrap, with lean turkey, lettuce, tomato, avocado, mustard and low-fat cheese

  • A small container of yogurt (organic soy is an option), that’s low in sugar and fat

  • Dark chocolate square to enjoy for dessert

Know your fast food healthy options

Too busy to pack a lunch? Luckily, there are healthy fast food options such as Wendy’s salads, McDonalds wraps or low fat Subway sandwiches now available.

What’s more, many of these outlets have posted the fat/calorie/sodium content of their menus online. Bottom line, if you’re going for something ‘fast’ you can make it healthy too!

Keep weight loss protein staples on-hand

The problem with weight loss is typically due to an over consumption of carbohydrates and too little protein in the diet.

Here’s a few protein staples to boost your intake (without increasing your waistline):

  • Low fat cheese strings or light cottage cheese

  • Protein powder (such as proteins+, keep a container at work and home)

  • Lean slices of meat (chicken, turkey)

  • Egg whites – can be added to any shake, recipe or made as an omelet (hard-boiled eggs are great to keep in the fridge too)

Make dinner your smallest meal

This is often the most difficult habit to break – but it can be done! For starters, get into the habit of eating a larger breakfast, a mid-sized lunch with a healthy snack or 2 in-between. This way, you won’t be overly ravenous come dinner time.

Some dinner ‘tricks’ to try:

  • Use a smaller-sized plate to automatically reduce your portion sizes

  • Make 2/3rds of the plate a colorful salad or steamed veggies

  • Include a portion of lean protein that’s about the size of a deck of cards

  • Enjoy low-glycemic, high fiber carbs such as wild rice (no more than a palm-size)

  • Add flavor without calories, such as cracked pepper or hot sauce

Suffering from cravings at nighttime? Try drinking watered down juice, herbal tea or chewable vitamin C. If you need to munch, go for veggies.

Find an activity that you enjoy and … do it!

Let’s face it, hitting the gym nightly is not realistic for most busy people. Luckily, there are many home options now available to fit into your lifestyle. Elastic bands, home weights, videos and a yoga mat can fit into any and all budgets. For morning-types, set the alarm a bit earlier, lay your shoes out the night-before, rise and go.

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Generic drug a potential treatment for glioblastoma?

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Generic drug a potential treatment for glioblastoma?

DCA research on brain cancer, EurekAlert, May 12, 2010. [FriendFeed entry]. Excerpt: “… the orphan generic drug Dichloroacetate (DCA) may hold promise as potential therapy for … a form of brain cancer called glioblastoma“. Another excerpt:

By extracting glioblastomas from 49 patients over a period of 2 years and studying them within minutes of removal in the operating room, the team showed that tumors respond to DCA by changing their metabolism. Then, the team treated 5 patients with advanced glioblastoma and secured tumor tissues before and after the DCA therapy. By comparing the two, the team showed that DCA works in these tumors exactly as was predicted by test tube experiments. This is very important because often the results in non-human models tested in the lab do not agree with the results in patients. In addition, the team showed that DCA has anti-cancer effects by altering the metabolism of glioblastoma cancer stem cells, the cells thought responsible for the recurrences of cancer.

And,

No conclusions can be made on whether the drug is safe or effective in patients with this form of brain cancer, due to the limited number of patients tested by the study’s leads Drs Michelakis and Petruk. Researchers emphasize that use of DCA by patients or physicians, supplied from for-profit sources or without close clinical observation by experienced medical teams in the setting of research trials, is not only inappropriate but may also be dangerous. …

See also: Generic drug may be potential treatment for deadly brain cancer: U of A medical study by Noreen Remtulla and Julia Necheff, ExpressNews, University of Alberta, May 12, 2010.

And: Potential brain-cancer drug shows promise, CBC News, May 12, 2010. [CBC video].

And: Cancer drug trial raises hopes by Elise Stolte, Edmonton Journal, May 13, 2010.

These news reports are about the publication: Metabolic Modulation of Glioblastoma with Dichloroacetate by Evangelos D Michelakis and 12 co-authors, including Kenneth C Petruk, Sci Transl Med 2010(May 12); 2(31): 31ra34.

See also an editorial: Targeting Cell Metabolism in Cancer Patients by Matthew G Vander Heiden, Sci Transl Med 2010(May 12); 2(31) :31ed1. From the TOC: “Dichloroacetate can safely modify glucose metabolism in aggressive brain tumors when administered to patients“. Last sentence of the editorial: “Time will tell whether this strategy constitutes an effective cancer therapy“.

Comments: After an initial research publication in January 2007 [PubMed citation], DCA attracted much attention. See, for example, the Wikipedia entry for Dichloroacetic acid. And, Cancer society warns of untested drug, CBC News, March 22, 2007.

The Official University of Alberta DCA Website provides FAQs about DCA. It includes, in the News & Updates section, DCA Research Team publishes results of Clinical Trials (dated May 12, 2010) and an earlier Letter from Dr. Evangelos Michelakis (dated October 2008).

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Lallemand: Innovations in cranberry ingredients

§ May 13th, 2010 § Filed under Nano Medicine Comments Off on Lallemand: Innovations in cranberry ingredients

Urinary Tract Infection (UTI) is the most common infection among women: it has been shown that nearly one in three women will have had at least one episode of UTI requiring antimicrobial therapy before they reach the age of 24. Moreover, UTI is characterised by a high reoccurrence rate: it has been estimated that nearly half of the women who have had UTI will experience another one within 12 months. The main causative agent is Escherichia coli (E. coli), normally present in the colon. Symptoms are both uncomfortable and debilitating and associated healthcare costs are high.

UTIs are traditionally treated with antibiotics, however, scientists believe that antibiotic treatments can disrupt the natural occurrence of beneficial bacteria in the body, leading to higher recurrence of UTI. Furthermore, repeated antibiotic treatments can give rise to antibiotic-resistant strains of harmful bacteria. Cranberries are widely documented for their preventive effect against UTI due to their unique anti-adhesion activity against pathogenic bacteria, which is linked to the presence of key phytochemicals: proanthocyanidins (PACs). Today, there is a growing demand for high quality cranberry extracts with high amount of proanthocyanidins to support urinary tract health. Lallemand Health Ingredients, in partnership with leading cranberry expert Decas Botanical Synergies have joined their marketing and R&D efforts to develop high quality cranberry ingredients solutions aimed at meeting this demand.

This article is available in full in the Spring 2010 issue of Nutraceuticals Now

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Forward to Spring 2010 Issue

§ May 13th, 2010 § Filed under Nano Medicine Comments Off on Forward to Spring 2010 Issue

This year is a very special one for everyone in the dietary supplements functional foods and functional drinks industry. Why? Because after four years of consistent annual growth, Finished Products Expo is going solo in 2010. During this period, the show has proven time and again that it is a serious player in the arena and so for the first time, it is moving into a hall of its own, with a dedicated entrance and marketing campaign to boot.

This couldn’t have come at a better time for the event, which believe it or not, began as a pavilion within Vitafoods. Since it started, Finished Products Expo has been gradually gaining momentum with both exhibitors and visitors alike. It has taken time, like all events of its nature, but we wanted to ensure we were creating an offering that was tailored perfectly to the needs and requirements of the industry.

Although it has its own hall and entrance, there will still be those valuable cross-over points with Vitafoods to provide exhibitors and visitors with those all-important networking opportunities which, lets face it, are what makes shows like these tick.

One of the comments that always comes back to me after a stint in Geneva is about how great the shows are socially, which is truly refreshing to hear. So a couple of years ago we decided to capitalise on that even further by actually setting- up a bespoke service for Finished Products Expo – The Distributors Wanted Scheme – so that visitors can search and even be contacted by potential distributors before the event. It’s been described as an online matchmaking scheme, which saves visitors valuable time and money.

Nevertheless, there is far more going on than simply networking with industry peers and catching-up with old contacts at Vitafoods and Finished Products Expo. Both shows are known industry-wide as the venues for large-scale innovation launches. All of the major players from the functional foods, functional drinks, dietary supplements and nutraceutical markets converge annually on GENEVA PALEXPO, each one competing healthily with the next for the most cutting-edge product launch. The features that we have at the shows complement this too, with the New Products Zone for example, giving an insight into the next big thing to take the market by storm.

And with innovation the key focus for both Vitafoods and Finished Products Expo, its no surprise that some great business deals have taken place on both show floors over the years. In a niche industry like ours, it’s not impossible to get the majority of the leading players together under one roof and when that happens, it becomes the perfect place to conduct serious business deals, many of which can – and have – shaped the industry forever.

So hopefully this year we’re on course to achieve more of the same. With the recession behind us and a mood of optimism sweeping the industry, there’s no reason why the 2010 installments of these shows can’t be the biggest and best yet. All the initial signs are there that both are set to break records – so watch this space!

Finished Products Expo and Vitafoods take place on 18-20 May 2010 at the Geneva Palexpo, Geneva, Switzerland. Visit http://www.finishedproductsexpo.com or http://www.vitafoods.eu.com for more information.
Chris Lee
Event Director, Finished Products Expo

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International Stem Cell and Absorption Systems Confirm Results Showing Stem Cell Derived Corneal Tissue as an Alternative to Animals for Drug Testing

§ May 12th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell and Absorption Systems Confirm Results Showing Stem Cell Derived Corneal Tissue as an Alternative to Animals for Drug Testing

Other Tests Show Tissue’s Ability to Focus Light, Pointing to Potential Therapeutic Applications

OCEANSIDE, Calif. – May 10, 2010 – International Stem Cell Corporation (OTCBB: ISCO), http://www.internationalstemcell.com/, the first company to perfect a method of creating human “parthenogenetic” stem cells from unfertilized eggs, announces the results of a second set of experiments confirming that its lab-grown corneal tissue closely mimics the drug absorption and drug metabolism characteristics found in normal corneal tissue. Other tests show that the stem cell derived corneal tissue refracts light, thus providing a further indication of its potential therapeutic value in treating corneal injury and disease.

Two sets of collaborative experiments between ISCO and Absorption Systems have now shown that corneal tissue cultured by ISCO exhibits topical drug absorption barrier properties and tissue-appropriate enzymatic activity, making it a promising model for studying human ocular drug absorption as an alternative to live animal testing. ISCO’s human corneal tissue is created in the laboratories of its wholly owned subsidiary, Lifeline Cell Technology (Walkersville, MD).

In a second set of tests conducted by a third party expert, a beam of diverging light was projected through the corneal tissue from different distances, becoming more or less refracted with the changing distance, showing that the corneal tissue was clear and had optical properties that allow the focusing of light. Additional experiments will be conducted to better define these optical characteristics.

According to Jeffrey Janus, Senior VP of ISCO and CEO of Lifeline, “We are very excited to confirm our initial results showing drug absorption that correlates with animal models and add to these results the observation of enzymatic activity. This not only advances our plans to manufacture a product that can be used to reduce the need for tests that use living animals, but it also is one more step toward the potential therapeutic use of this tissue as a treatment for human corneal injury or disease. This has implications, not only in the US, but also in India and Asia, where millions of people suffer from corneal blindness that now goes untreated. The experiments showing light refraction are a tempting indication that this tissue will have therapeutic application.”

“There is a large commercial need for a predictive and reproducible non-animal method for testing the safety of ophthalmic drugs and consumer products,” said Patrick M. Dentinger, President and CEO of Absorption Systems. “The combined knowledge and expertise of ISCO and Absorption Systems have allowed us to take a step forward toward addressing an unmet need in the field of ophthalmology by creating a unique in vitro model to study human ocular drug absorption without using animals. Our collaboration with ISCO underscores our commitment to helping bring safe drugs to market.”

The collaboration between Absorption Systems and ISCO uses Absorption Systems’ know-how in creating and characterizing assay systems to develop superior preclinical methods of testing drugs. Such methods can also reduce the use of laboratory animals currently necessary for other tests, including safety testing of consumer products.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, http://www.internationalstemcell.com/.

ABOUT ABSORPTION SYSTEMS:

Absorption Systems, founded in 1996, assists pharmaceutical, biotechnology and medical device companies in identifying and overcoming ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) barriers in the development of drugs, biologics and medical devices. The company’s mission is to continually develop innovative research tools that can be used to accurately predict human outcomes or to explain unanticipated human outcomes when they occur. The CellPort Technologies® platform, a suite of human cell-based tests systems for drug transporter characterization, exemplifies Absorption Systems’ commitment to innovation. Absorption Systems has facilities near Philadelphia, PA, and in San Diego, CA, and serves customers throughout the world. For information on the company’s comprehensive contract services and applied research programs, please visit http://www.absorption.com/.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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CSC news links 2010-05-08

§ May 9th, 2010 § Filed under Nano Medicine Comments Off on CSC news links 2010-05-08

For links to recent news items about CSC, visit this [Topsy] page. Examples of two news items that have received attention in the past week:?

New research links ovarian hormones with breast stem-cell growth – Globe and Mail http://bit.ly/brT71E. Hashtag: #cancerSC. Posted to Twitter on Wed May 06, 2010 via TweetDeck. [PubMed Citation]


Broccoli compound limits breast cancer (about sulforaphane) http://bit.ly/9blnNP & http://bit.ly/aOTSDv. Hashtag: #cancerSC. Posted to Twitter on Wed May 05, 2010 via TweetDeck. [PubMed Citation]

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International Stem Cell Corporation Signs Financing Agreement

§ May 6th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation Signs Financing Agreement

OCEANSIDE, CA –May 5, 2010 – International Stem Cell Corporation (ISCO.OB), http://www.intlstemcell.com, today announced it has entered into a definitive agreement dated May 4, 2010 (‘the Agreement”) with Socius CG II, Ltd. (“Socius”), pursuant to which Socius has committed to purchase a single tranche of up to $10 million in non-convertible Series F Preferred Stock (the “Preferred Stock”) from ISCO. The Company issued a warrant to purchase $13,500,000 worth of the Company’s Common Stock, the exercise price of the warrant being determined by the closing bid price for the Company’s Common Stock on the trading day immediately preceding the date the Company initiates the sale of the Series F Preferred.

The Company anticipates that the Closing of the Preferred Stock sale will take place 20 business days after the issuance of the Warrants. Proceeds from these sales will be used to provide general working capital and to fund additional development of the Company’s proprietary Parthenogenetic Stem Cell Lines, development of commercial research products, and other research and development programs and related business activities.

Additional details on the transaction are contained in the Company’s Form 8-K filed today with the Securities and Exchange Commission.

A prospectus relating to this offering is available from:
Investor Relations
International Stem Cell Corporation
2595 Jason Court
Oceanside, CA 92056

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology.

FORWARD-LOOKING STATEMENTS:
Statements pertaining to anticipated future events, including the anticipated closing of the sale of Preferred Stock, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in satisfying the conditions to closing. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.
Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-940-6383
bl@intlstemcell.com
WEST21949392.1

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Google to Invest in Regenerative Medicine

§ May 5th, 2010 § Filed under Nano Medicine Comments Off on Google to Invest in Regenerative Medicine

While the US government prints money to shore up failing and broken business models which no one likes but are considered simply too big (not too important or significant or even useful) to fail, Google is making money and investing it in start ups who expect nothing less than to create “disruptive, even world-changing technologies”.

No suggestion here that GOOG is being altruistic, just that this is the way the new entrepreneur and investor class thinks. Opportunity and money are to be found in technologies that improve the way we live, work, play, eat, and think… and perhaps even improve the world.

To Google Ventures this has already meant wind farms, carbon emission reduction systems, green vehicles, and medical cures. To former Microsoft chief scientist Nathan Myhrvold and his high-level think tank, Intellectual Ventures, this means creating TerraPower – a company intending to revolutionize the nuclear power by developing reactors run on waste uranium – and also actively looking at regenerative medicine technologies.

Having formed the fund a little over a year ago, Google is only now starting to make a splash with the fund. Officially the fund has no specific industry focus saying on the Google Ventures website FAQ:

We are interested in a wide range of industries, including (but not limited to) consumer Internet, software, hardware, clean-tech, biotech, health care and others. First and foremost, we’re looking for entrepreneurs who are tackling problems in creative and innovative ways, with the potential for significant financial return.

Unofficially and yet not so quietly, Google has named a few broad areas of interest. An article in Monday’s New York Times quoted Google Ventures’ managing partner, Bill Maris as saying that while they were not going to name particular investment themes, a few broad ares of interest include:

regenerative medicine, bioinformatics, cloud storage, companies that use large data sets, online monetization and mobile.

There it is. Regenerative medicine right there front and center.

In typical Google tradition, Maris, who looks all of 30 years old on the website, has a successfull and multidisciplinary track record. He was involved in founding Web hosting pioneer Burlee.com (now part of Web.com), where he built much of the key computing, network and technological infrastructure.Prior to that, Bill was a biotechnology and healthcare portfolio manager for Stockholm, Sweden-based Investor AB. Bill’s background also includes research at the Duke University Medical Center, Department of Neurobiology.

Google Ventures is said to be aiming at investing about $100 million a year. Any portion of that for regenerative medicine is more than welcome.

While traditional VC money remains reticent to back RM in any signifant way, Google’s move confirms a trend we’ve been seeing and talking about at the Cell Therapy Group for the past 12 months or so. The multinational lifescience, biopharmaceutical, and healthcare companies along with strategic investors all now have regenerative medicine on their radar. They are all quietly and not-so quietly developing internal and external regenerative medicine strategies.

Please join us in welcoming regenerative medicine to the radar screen. It’s bound to be an exciting ride ahead.

http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com
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CSC news links 2010-05-01

§ May 2nd, 2010 § Filed under Nano Medicine Comments Off on CSC news links 2010-05-01

For links to recent news items, visit these [Twitter] or [FriendFeed] pages. Examples of two news items that have received attention:?

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More about presentations at AACR10

§ May 2nd, 2010 § Filed under Nano Medicine Comments Off on More about presentations at AACR10

Five presentations at the 101th annual meeting of the American Association of Cancer Research were highlighted a news release from Geron Corporation (dated March 3, 2010). One presentation that had an explicit focus on CSC was this poster:

Imetelstat, a telomerase inhibitor in phase I trials in solid tumor and hematological malignancies, has broad activity against multiple types of cancer stem cells [Presentation Abstract].

Also mentioned in the news release was an oral presentation by Jerry W Shay, given as part of the Major Symposium entitled: Role of Telomeres and Telomerase in Chromosomal Stability and Disease [Session Detail]. The presentation was:

Role of telomerase in normal and neoplastic stem cells [Presentation Abstract].

Another poster about the telomerase inhibitor imetelstat (GRN163L) was:

Sensitivity and resistance of non-small cell lung cancer to the telomerase inhibitor imetelstat [Presentation Abstract].

Comments: A search of the ClinicalTrials.gov database for GRN163L revealed 6 trials. Four were ongoing, but not recruiting participants. Two were still recruiting: 1) Safety and Dose Study of GRN163L Administered to Patients With Refractory or Relapsed Solid Tumor Malignancies; 2) A Study of GRN163L With Paclitaxel and Bevacizumab to Treat Patients With Locally Recurrent Or Metastatic Breast Cancer.

An analogous search for imetelstat yielded the same 6 trials. All 6 trials have been sponsored by Geron Corporation.

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Latest Cell Therapy Approval by FDA. Dendreon’s Provenge.

§ April 30th, 2010 § Filed under Nano Medicine Comments Off on Latest Cell Therapy Approval by FDA. Dendreon’s Provenge.

It has been a long-time coming. It has been hyped and scoffed, bet against and hoped for, but now none of that matters. It’s here. Dendreon has brought Provenge to market. Here, in the word’s of the FDA…

FDA NEWS RELEASE

For Immediate Release: April 29, 2010

FDA Approves a Cellular Immunotherapy for Men with Advanced Prostate Cancer

The U.S. Food and Drug Administration today approved Provenge (sipuleucel-T), a new therapy for certain men with advanced prostate cancer that uses their own immune system to fight the disease.

Provenge is indicated for the treatment of asymptomatic or minimally symptomatic prostate cancer that has spread to other parts of the body and is resistant to standard hormone treatment.

Prostate cancer is the second most common type of cancer among men in the United States, behind skin cancer, and usually occurs in older men. In 2009, an estimated 192,000 new cases of prostate cancer were diagnosed and about 27,000 men died from the disease, according to the National Cancer Institute.

“The availability of Provenge provides a new treatment option for men with advanced prostate cancer, who currently have limited effective therapies available,” said Karen Midthun, M.D., acting director of the FDA’s Center for Biologics Evaluation and Research.

Provenge is an autologous cellular immunotherapy, designed to stimulate a patient’s own immune system to respond against the cancer. Each dose of Provenge is manufactured by obtaining a patient’s immune cells from the blood, using a machine in a process known as leukapheresis. To enhance their response against the cancer, the immune cells are then exposed to a protein that is found in most prostate cancers, linked to an immune stimulating substance. After this process, the patient’s own cells are returned to the patient to treat the prostate cancer. Provenge is administered intravenously in a three-dose schedule given at about two-week intervals.

The effectiveness of Provenge was studied in 512 patients with metastatic hormone treatment refractory prostate cancer in a randomized, double-blind, placebo-controlled, multicenter trial, which showed an increase in overall survival of 4.1 months. The median survival for patients receiving Provenge treatments was 25.8 months, as compared to 21.7 months for those who did not receive the treatment.

Almost all of the patients who received Provenge had some type of adverse reaction. Common adverse reactions reported included chills, fatigue, fever, back pain, nausea, joint ache and headache. The majority of adverse reactions were mild or moderate in severity. Serious adverse reactions, reported in approximately one quarter of the patients receiving Provenge, included some acute infusion reactions and stroke. Cerebrovascular events, including hemorrhagic and ischemic strokes, were observed in 3.5 percent of patients in the Provenge group compared with 2.6 percent of patients in the control group.

Provenge is manufactured by Seattle-based Dendreon Corp.

http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com
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Stem cells for a Webby!

§ April 28th, 2010 § Filed under Nano Medicine Comments Off on Stem cells for a Webby!

I know I haven’t been a very good blogger for quite some time but I wanted to pass on a letter I just received from my friend James Price as a Charter member of the Canadian Stem Cell Foundation. They’re going for a Webby award. You don’t have to be Canadian to support their cause – you just have to:

  • believe in the power of interactive, online network-based activism,
  • support the potential of stem cells to change people’s lives, and
  • wanna have a little fun raising awareness for our otherwise-sometimes-stodgy-science!

Go vote – it’s good for you and the world! (WARNING: you might find out some things about some pretty cool stuff nominated in the other categories while you’re there).

CSCFHeader

Dear Lee,

I’d like to thank everyone who has voted and helped spread the word about the Webby Awards nomination. We think a big part of the Foundation’s success, and especially this nomination, is due to your enthusiasm, creativity and support.

That support has taken us a long way. Right now, we’re in the lead for Best Activism Website. But our lead is narrow, only 3%, so we need you to pull out all the stops. There are only two days left to vote, so let’s make sure it’s a win for stem cells!

Why Activism?

A large part of what makes our website and social media pages work is the Charter community. All the material we create – the Stem Cell Charter, “Rock Star Scientists” video and all the posts on our social media pages – are designed to give the stem cell movement a voice – your voice. You are the most important part of getting the word out about stem cell science and helping people see the amazing potential of the field.

Voting and encouraging others to vote is a perfect way to do this. Tweet, post, blog, email and shout your support from the rooftops. Let’s show the world how important we think stem cell science is.

How to vote

Step 1: Click HERE and fill in your email address and a password.

Step 2: You will receive an email from the Webby Awards – click the link to activate your account.

Step 3: Go HERE TO VOTE and choose RENEW THE WORLD.

Voting closes at midnight on April 29th. We have two days left!

webby banner

Thanks for your support,


James Price
President & CEO



http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com
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Sessions on CSC Therapeutics at AACR10

§ April 27th, 2010 § Filed under Nano Medicine Comments Off on Sessions on CSC Therapeutics at AACR10

There were two poster sessions on Cancer Stem Cell Therapeutics at the 101st Annual Meeting of the American Association for Cancer Research (AACR). The sessions, Cancer Stem Cell Therapeutics 1 and Cancer Stem Cell Therapeutics 2, took place on the morning and afternoon of April 20, 2010 [FriendFeed entry].

Two posters presented in the 2nd session have been highlighted in a news release. See: Alchemia’s HyACT Technology Enhances the Killing of Cancer Stem Cell Populations in Breast and Colorectal Cancer, Business Wire, April 20, 2010 [FriendFeed entry]. One of these is Poster #4293: Evaluation of activated CD44 as a biological target in the eradication of breast cancer stem cells, by Vera J Evtimov and Tracey J Brown [Presentation Abstract]. The other is Poster #4278: HA-Irinotecan targeting of activated CD44 is an effective therapy for the eradication of putative colon cancer stem cells [Presentation Abstract].

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CSC news links 2010-04-18

§ April 19th, 2010 § Filed under Nano Medicine Comments Off on CSC news links 2010-04-18

For links to recent news items, visit these [Twitter] or [FriendFeed] pages. Examples of a few news items that have received attention:

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MicroRNA therapy could be a powerful tool to correct the CSC dysregulation?

§ April 17th, 2010 § Filed under Nano Medicine Comments Off on MicroRNA therapy could be a powerful tool to correct the CSC dysregulation?

Medical Hypothesis: No small matter: microRNAs – key regulators of cancer stem cells by Qing Ji, David Karnak, Ping Hao, Rongquan Wang and Liang Xu, Int J Clin Exp Med 2010(Mar 12); 3(1): 84-7 [FriendFeed entry][Full text via PMC]. PubMed Abstract:

Emerging evidence demonstrates that both tumor suppressor and oncogenic miRNAs play an essential role in stem cell self-renewal and differentiation by negatively regulating the expression of certain key genes in stem cells. It seems logical that they may also be critical players in cancer stem cells. Though small in size, miRNAs play a key role in the epigenetic regulation of cancer stem cells. Specifically, the imbalance of oncogenic vs. tumor suppressor miRNAs may lead to dysregulation of cancer stem cells, thus causing excessive self-renewal and survival of cancer stem cells, and resistance to chemo/radiotherapy. We postulate that restoring the balance of miRNAs will correct this dysregulation via the direct and simultaneous modulation of downstream stem cell pathways involved in cancer stem cell self-renewal and/or differentiation. The resultant restoration of key regulatory pathways could improve therapeutic response. Restoring tumor suppressor miRNAs and/or inhibiting oncogenic miRNAs may provide a novel molecular therapy for human cancers, potentially via modulating cancer stem cells.

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International Stem Cell Corporation Engages Leading Immunogeneticists to Advance its Industry-first, Immune-matched Stem Cells

§ April 14th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation Engages Leading Immunogeneticists to Advance its Industry-first, Immune-matched Stem Cells

International Stem Cell Corporation (OTCBB:ISCO), http://www.intlstemcell.com, today added two world-leading immunogeneticists to its scientific advisory board. They and ISCO scientists will study the immune-matching properties of ISCO’s human parthenogenetic stem cell (hpSC) technology and the potential for each hpSC-derived therapeutic cell to be an immune-match for millions of people.

Dr. Hans-Dieter Volk, Professor of Immunology and Chair of the Institute of Medical Immunology and Berlin-Brandenburg Center for Regenerative Therapies (BCRT) at Charité Universitätsmedizin in Berlin, and Dr. Matthias von Herrath, Professor at the La Jolla Institute of Allergy and Immunology at University of San Diego, have agreed to join ISCO’s scientific advisory board. Both have dedicated their careers to experimental and clinical immunology and are highly regarded immunogenetics experts internationally. They will be most valuable as ISCO attempts to demonstrate the unique immune-matching benefits of the hpSC technology experimentally and in clinical practice.

“We believe that providing human cells that can minimize rejection though immune-matching to the recipient is one of the most important tasks in developing effective regenerative medicine therapies,” says Dr. Simon Craw, Vice President at ISCO. “We look forward to Drs. Volk and von Herrath helping us try to demonstrate how that need can be met with our parthenogenetic stem cells.”

Embryonic stem cells (hESC) almost invariably have different forms of genes (called “alleles”) at each genetic position of the paternal and maternal chromosomes, i.e. they are “heterozygous.” This includes the human leukocyte antigen (“HLA”) genes that are largely responsible for the distinction between “self” and “foreign,” and thus acceptance or rejection of transplants. Since hESC are derived from fertilized embryos, they carry the genes of a unique individual, thus the therapeutic cells derived from hESC will carry HLA alleles that can be recognized as foreign and be rejected by most patients unless they receive immunosuppressive therapy. Such therapy is costly, has significant side effects, and often is disabling in the long term.

Like most individuals in the population, induced pluripotent stem cells (“iPS” cells) and adult stem cells are also predominantly heterozygous because they carry paternal and maternal chromosomes. They are a perfect immune match to the patient they came from and are therefore typically administered back to that same individual (“autologous therapy”). However, they would likely be rejected by most other recipients. Autologous therapy is time-consuming and expensive, which goes against the cost containment pressures globally. In addition, the quality of the therapy is directly related to the ability to secure clinically sufficient numbers of functional cells from the patient, which often poses a significant problem in clinical practice.

In contrast, the hpSCs developed by ISCO are derived from unfertilized eggs (“oocytes”) that have been shown in peer-reviewed journals to exhibit unlimited proliferation potential and are pluripotent (can become cells from all three germ layers that form a human being). Most significantly, hpSC can be created in a “homozygous” state, where the alleles, including the HLA alleles, are the same at each genetic position. When these HLA alleles are also found with a high frequency in a population, these “HLA-homozygous” stem cells and their therapeutic derivatives have the potential to be immune matched to millions of people. For example, ISCO’s first homozygous stem cell line with high-frequency HLA alleles has the potential to be immune matched to an estimated 75 million people worldwide.

Dr. Volk says: “Using my experience from transplantation immunology and medicine during the past three decades, I am very pleased to help ISCO in their efforts to make its hpSC technology a clinical reality where therapeutic cell derivatives will be immune matches for millions of people worldwide.” Dr. von Herrath continues: “While stem cell technologies generally offer great regenerative potential, most clinical applications will be limited by immune rejection. I look much forward to joining ISCO in their quest for making stem cell-derived therapy a practical and attractive clinical option for many degenerative diseases.”

Besides the immunogenetic developments, ISCO is advancing its hpSC technology into the differentiation of hpSC into therapeutic cells and tissues and into the establishment of processes and facilities to produce clinical-grade cells. The company is seeking to demonstrate the therapeutic potential of its hpSC technology as a safe, efficient, and superior alternative to other sources of stem cells for human therapy.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “should,” “believes,” “plans,” “anticipates,” “expects,” “estimates”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

Read the Rest...

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