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International Stem Cell Corporation’s Parthenogenetic Stem Cell Patent is Approved by the United States Patent and Trademark Office

§ June 9th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation’s Parthenogenetic Stem Cell Patent is Approved by the United States Patent and Trademark Office

International Stem Cell Corporation (OTCBB:ISCO), http://www.intlstemcell.com, announced today that the United States Patent and Trademark Office (USPTO) has granted ISCO patent number 7,732,202, the first of several pending patents relating to its development of human parthenogenetic Stem Cells (hpSC). Human parthenogenetic stem cells are a new type of pluripotent stem cell that allows immune matching to potentially solve critical immune rejection problems, and does not involve the ethical issues that surround the use of fertilized human embryos.

Although ISCO’s creation of human parthenogenetic stem cells was first announced in a peer review publication in 2007, the formal allowance of claims by the USPTO will greatly advance the field of regenerative medicine by allowing ISCO to share its knowledge of these hpSC lines more freely with researchers in the US and around the world through partnerships, joint ventures, funded research and licensing arrangements.

The patent protects ISCO’s technology platform, allowing the creation of hpSC from unfertilized eggs, exhibiting similar qualities and pluripotency as embryonic stem cells, with the added ability to be immune-matched to the donor, as illustrated in published peer-reviewed articles. Additional discoveries, also previously published in a peer reviewed journal and the subject of pending ISCO patents, illustrate the creation of ‘homozygous’ hpSC that can be immune matched to millions of persons of differing sexes and racial backgrounds, rather than only to the donor or her family, raising the potential of eventually creating a universal source of stem cells that could benefit most the of the world’s population.

Researchers across the world work with ISCO to study different therapeutic applications of hpSC. Through previously announced collaborative arrangements, ISCO’s scientists are working with major universities and private research organizations to study hpSC to treat liver disease, diabetes, Age-related Macular Degeneration (AMD), corneal blindness and various neural degenerative diseases. In one such research collaboration, internationally-recognized stem cell researcher Hans Keirstead, PhD, at the Reeve-Irvine Research Center (University of California, Irvine), recently published a paper, referring to his use of embryonic stem cells and ISCO’s hpSC in work focused on the derivation of early retinal progenitor tissue.

Andrey Semechkin, PhD, CEO of ISCO said, ‘Other than parthenogenetic stem cells, the three most commonly used and described types of stem cells are human embryonic stem cells (hESC), induced pluripotent stem cells (iPS), and adult stem cells, such as those derived from cord blood, adipose tissue or bone marrow. Parthenogenetic stem cells have unique advantages over each of these other cell types, and we anticipate that since our core patent has been issued, we can now accelerate the adoption of our hpSC lines by researchers in the US and throughout the world.’

‘International Stem Cell Corporation is particularly proud of these accomplishments because we have been funded thus far entirely by investors, without NIH or other governmental aid,’ said Jeffrey Janus, Senior Vice President of ISCO. ‘However, once it is generally recognized that parthenogenetic cells have similar characteristics of embryonic stem cells and offer the potential to solve critical immune rejection issues – while not requiring the destruction of viable human embryos – we expect these cells to be increasingly used in government funded research to study ways of reducing human suffering and treating intractable human diseases.’

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell(TM), while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” ” anticipates,” “expects,” “estimates,”) should also be considered to be forward- looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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CSCs responsible for metastasis identified

§ June 6th, 2010 § Filed under Nano Medicine Comments Off on CSCs responsible for metastasis identified

Cancer stem cells responsible for metastasis identified: HK study, Xinhua News Agency, June 4, 2010. Excerpt:

Hong Kong researchers have identified a subset of cancer stem cells responsible for metastasis in human colorectal cancer which can help better predict the prognosis and design a more suitable treatment for patients, according to a study made public by the University of Hong Kong on Friday.

The researchers from the university’s medicine school discovered that cancer stem cells with a surface marker CD26, which marks a subset of cancer stem cells with metastatic capacity, are present in all terminal colon cancer cells and all metastatic cancer cells.

This news item is about the publication: A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer by Roberta Pang and 13 co-authors, including Wai Lun Law, Ronnie T Poon and Benjamin CY Wong [photos of authors], Cell Stem Cell 2010(Jun 4); 6(6): 603-15. [Summary][Twitter entry][Commentary][FriendFeed entry][Science Pond entry].

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Phase I clinical trial of ICT-107

§ June 3rd, 2010 § Filed under Nano Medicine Comments Off on Phase I clinical trial of ICT-107

Immune response correlation with progression-free survival in glioblastoma following dendritic cell immunotherapy (ICT-107) by Surasak Phuphanich and 9 co-authors, including Manish Singh, Keith Black and John Wu, J Clin Oncol 28:7s, 2010 (suppl; abstr 2097). To be presented at the 2010 ASCO Annual Meeting, June 06, 2010.

Related news releases:

ImmunoCellular Therapeutics Ltd. (IMUC) to Present Cancer Vaccine Candidate, International Business Times, June 02, 2010. Excerpt:

Data from the company’s recent clinical trial of ICT-107, the company’s dendritic cell-based cancer vaccine candidate, will be presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) June 4-8 in Chicago.

See also: Immunocellular brain cancer vaccine shows promise, Reuters, June 02, 2010. Excerpt:

“We are targeting specific antigens that are on cancer stem cells … the only population of cells that can really propagate a tumor,” said Dr. John Yu, director of surgical neuro-oncology at Cedars-Sinai Medical Center in Los Angeles and ImmunoCellular’s chief scientific officer.

Another related news release: Immunocellular Therapeutics Enters into Research Agreement with University of Pennsylvania to Support Phase II Clinical Trial of ICT-107, Business Wire, April 21, 2010.

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8 Tips to Avoid Summer Party Weight Gain

§ June 2nd, 2010 § Filed under Nano Medicine Comments Off on 8 Tips to Avoid Summer Party Weight Gain

Weight Loss Fat Loss Lose Weight Avoid summer weight gain Healthy Eating Salad Recipes BBQ Recipes Lose weight How to lose weightWhy do we love summer so much? Could it be the hot lazy days, the bright skies, the time spent outdoors running, cycling or playing tennis? Or, could it be the food? Yes, the food. It could, quite possibly, be the food.

Summer is the season of picnics, bbqs and social events that evolve around food and, lest we forget, drinks. Delicious, colorful, aromatic dishes and cold refreshing cocktails with decorative multi-colored miniature paper umbrellas. More often than not, these events will include high fat, calorie laden foods and drinks that are hard to resist. Even the most disciplined of eaters may find him or her selves reaching for another helping. It’s no surprise then that summer eating can lead to summer weight gain.

When we consume more energy than we expend, our bodies store the extra calories as fat. A common misconception in summer is that we think we can afford to eat more because we are more active. True, we do tend to take part in more outdoor physical activities in the summer, but a jog in the park may not burn the thousands, yes thousands, of extra calories we devoured at last night’s pool party. Underestimating the number of calories we consume at our summer functions, is the reason why we start to see the number on the scale creep upwards.

The good news is that we do not have to sacrifice summer socializing to keep our bodies at a healthy weight. With a few simple strategies in place we can still enjoy summer festivities without packing on the pounds:

Keep a Food and Exercise Journal

Recording your physical activity and everything you eat and drink every day is an excellent way to help maintain your weight. It’s easier now than ever, thanks to hand-held computer devices and cell phones that offer software applications to help you keep note. Review your journal before you go out to a summer social. If you’ve already eaten more than you should for the day and missed your morning workout, you might be more conscience of what you will eat at the event. Likewise, if you have been particularly careful about your food choices all week, you might decide it’s okay to indulge just a little. Either way, journaling will make you more mindful of what you eat and this will help you choose what is right for you.

Make the Company your Focus

Before you head out to your event, mentally prepare yourself to be sociable. Be prepared to mingle and converse with everyone. If you put your energy into the people there rather than what is laid out on the buffet table you might have less time to grab a second helping or pick at the party chips—after all, it’s hard to socialize with a mouth full of food. This by no means suggests that you shouldn’t eat anything! You wouldn’t want to offend your host or go home hungry. Eat until you feel satiated and the meal portion of the event seems to be dwindling down, then step away from the food and start chatting up a storm with another guest. And, if the event calls for dancing, swimming, or a sport activity of some kind, get moving once you have given your food time to digest.

Do your Homework

We all have our weakness. For some it may be ice cream, for others it could be fried chicken. Whatever your secret indulgence is, find out how many calories, fat and sodium is contained in a single serving. Armed with this knowledge, you might be dissuaded from taking a second helping, or you might even skip the food altogether and choose a healthier option instead.

Be a Healthy Host

Planning, cooking and cleaning up before and after an event can be a lot of work. But, the single best benefit about hosting a summer party is that you get complete control over the menu. Create mouth watering dishes using seasonal fruits and vegetables, low fat protein and smart healthy fats. Even traditional bbq favourites like potato or pasta salad can be modified to decrease the fat and calorie content by simply switching to a homemade oil, vinegar and herb dressing rather than prepared mayonnaise. Be sure to lay out platters of fiber-filling raw fruits and vegetables instead of chips or crackers for an easy low calorie grab-and-go snack. Your table will look spectacular with all the season’s brightly colored foods, and your guests will love the variety.

Bring a Dish

If you are invited to a backyard bbq offer to bring either part of the main dish or a side, rather than dessert or alcohol. Whatever you bring, make sure you create something you like and it’s healthy. This way, you can load up on at least one healthy option and take smaller amounts of the not so healthy choices.

Exercise Portion Control

Summer eating should be enjoyable. But, nothing can put a kink in your party spirit more than pulling out your measuring cups at the family get together to ensure you haven’t exceeded your portion sizes. Use your hands as your guides: your fist is equivalent to about one cup; your palm is about 3 ounces; your thumb tip is equal to about 1 teaspoon; and your thumb is about 1 ounce. Remember these estimations when loading up your plate. Another good rule to follow is to fill half your plate with complex carbohydrates such as vegetables, a quarter of your plate with lean protein, and the remaining quarter with whole grains.

Don’t drink your Calories

Outdoor summer events can become uncomfortably hot, so it’s important to stay hydrated. Instead of quenching your thirst with alcoholic drinks, fruit juices, soda pop or creamy frozen drinks, reach for water instead. One or two of these other drinks are all right, but anything more than that will add up in the calorie department. Water should be your main drink of choice. If the taste of water is too bland for your party spirit mode, add a squeeze of fresh citrus, some fresh mint or a few handfuls of berries or cucumbers.

Employ the 80:20 Rule

The aim of summer eating (and eating all year round too) should be to eat well at least 80 per cent of the time and reserve only 20 per cent of the time for not so healthy options. It’s okay to indulge once in a while. Don’t beat yourself up if you eat a little more than you should have at last night’s party—guilt is a useless emotion. Besides, with an active lifestyle and a healthy eating program, you shouldn’t see any change in your weight. Today is a new day, enjoy the summer sunshine and have fun.

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International Stem Cell Corporation Moves International Cornea Development Program Forward

§ May 26th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation Moves International Cornea Development Program Forward

International Stem Cell Corporation (OTCBB:ISCO), http://www.intlstemcell.com, today announced significant progress on its international development strategy for stem cell-derived human corneal tissue. Such tissue can potentially be used to replace cadaver-derived corneas in treatment of severe corneal vision impairment and to eliminate the need to use live animals in safety testing of drugs, chemicals and consumer products.

During a recent trip to Asia and Europe, an ISCO senior management team identified and interacted with a group of integrated eye hospitals and ophthalmology research institutions with world-class laboratory facilities, along with potential sources of research funding. One of these is Sankara Nethralaya (http://www.sankaranethralaya.org), one of India’s leading not-for-profit clinical and research organizations dedicated to treatment of eye diseases.

Research during the past ten to fifteen years has demonstrated stem cell differentiation into a variety of human cell types. Rarely has it been possible to produce such integrated, functional human tissue, in this case, tissue that has characteristics compatible with human cornea in structure and function. This tissue technology may offer a first-in-class opportunity for high-quality, cost-efficient transplantation tissue for the 10 million people world-wide suffering from corneal vision impairment, particularly in Asia and Europe. It may also provide a much needed alternative to the use of live and extracted animal eyes in the $500+M market for safety testing of drugs, chemicals and consumer products.

During the coming months, ISCO expects to formalize relationships with a number of entities such as Sankara Nethralaya to provide ISCO’s cornea development program with the scientific, facility and financial resources needed to advance the technology as rapidly as possible to clinical application. The ultimate goal is not only to address the clear unmet medical and safety testing needs, but also to be among the first pluripotent stem cell applications to achieve widespread commercialization.

Dr. Sengamedu Srinivasa Badrinath, President and Chairman Emeritus of Sankara Nethralaya says: ‘At Sankara Nethralaya, we see 1,600 eye patients and do over 100 eye surgeries a day. We employ sixty scientists and clinicians dedicated to the development and application of new state-of-the-art ophthalmic technologies. My senior team at Sankara Nethralaya and I look forward to helping ISCO advance its cornea technology that has potential to significantly reduce the severe quantitative and qualitative limitations in corneal donor tissue across the world today.’

Brian Lundstrom, ISCO’s President, continues: ‘The addition of Sankara Nethralaya to our international collaborative network will contribute substantial scientific and clinical ophthalmology expertise and resources and complement the instrumentation alliance with The Automation Partnership and the safety testing collaboration with Absorptions Systems. The next step is to organize an experienced therapeutic development team to establish the optimal development path with relevant regulatory authorities and create data needed to advance ISCO’s stem cell-derived corneal tissue into clinical trials.’

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human parthenogenetic stem cells (hpSCs) from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website,
http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS
Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “should,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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Biotech tax credit appears perfectly designed for cell therapy companies to recoup research dollars spent in 2009-10

§ May 22nd, 2010 § Filed under Nano Medicine Comments Off on Biotech tax credit appears perfectly designed for cell therapy companies to recoup research dollars spent in 2009-10

Stewart Lyman of Lyman BioPharma Consulting posted a great article in today’s Xconomy summarizing some key points and links to more information about the rules governing the Therapeutic Discovery Project Credit which have now been released by the US Treasury Department. Today, a detailed fact sheet was released about the tax credit program and it seems almost perfectly designed for most cell therapy companies.

Lyman points out a few important details about the application schedule including:

1. The Formal IRS applications (Form 8942) will not be available until June 21st or thereabouts.

2. The application period opens on June 21 and ends on July 21. The postmark on the application is deemed to be the date of delivery. Preliminary review of the applications is to be completed by Sept. 30; this is to ensure that applicants are eligible taxpayers and that their applications are complete. Applicants will receive determinations as to whether or not they qualify for credits and/or grants, and how much they will receive, by Oct. 29.

By way of a little more background, the following is excerpted from a March Forbes.com article by Dean Zerbe:

What does the credit cover?

The credit/grant covers research in tax years beginning in 2009 and 2010. The taxpayer is provided a 50% credit/grant for qualified investments in “qualifying therapeutic discovery projects.” What expenses count as qualified investments? The aggregate amount of costs paid or incurred in the taxable year for expenses necessary for and directly related to the conduct of a qualifying discovery project. What doesn’t count? The pay of employees covered by 162(m)(3) of the tax code–think CEOs–doesn’t count. Other excluded items: interest expenses; facility maintenance expenses (e.g. mortgage or rent payments, insurance, utility and maintenance and costs of employment of maintenance personnel); and certain indirect costs (basically general and administrative costs) as defined in the Treasury Regulations at 1.263A-1(e)(4).

What is a qualifying therapeutic discovery project?

According to the legislation, it’s a project designed to do one of three things:

–Treat or prevent diseases or conditions by conducting pre-clinical activities, clinical trials and clinical studies, or carrying out research protocols for the purpose of securing federal government approval by the FDA.

–Diagnose diseases or conditions or to determine molecular factors related to diseases or conditions by developing molecular diagnostics to guide therapeutic decisions.

–Develop a product, process or technology to further the delivery or administration of therapeutics.

Finally, to qualify, a venture may not have more than 250 employees in all businesses of the taxpayer–meaning a small biotech project at a big company wouldn’t qualify.

Which biotech companies might benefit?

Those that are investing significant resources in pre-clinical or clinical studies, which may take years to come to fruition to ultimately satisfy FDA requirements, could now recoup a significant portion of their expenses. Additionally, biotech start-ups focusing on the development of diagnostic assays or applications to advance therapeutics and treatments can also benefit. Finally, companies currently engaged in basic or applied research which may ultimately contribute to curing caner within the next 30 years may also be excellent candidates. Along these lines, companies studying signal transduction pathways, gene therapy and stem cell research seem like prime candidates.

The Cell Therapy Group will be collecting more information about the tax credit and service providers who might be recommended to assist in the application if needed. Contact CTG for more details or watch here for more information.

http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com
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An evolving concept of CSC in tumor biology

§ May 21st, 2010 § Filed under Nano Medicine Comments Off on An evolving concept of CSC in tumor biology

An evolving concept of cancer stem cells in tumor biology: a lecture (34:38 min) by Jeremy N Rich. Webcast of the initial presentation at an Educational Session on Cancer Stem Cells and Treatment Resistance, AACR 101st Annual Meeting, April 17, 2010. [FriendFeed entry].

Comment: Dr. Rich’s research has a primary emphasis on Glioma Cancer Stem Cell and Brain Tumors. An example of a recent publication: Integrin Alpha 6 Regulates Glioblastoma Stem Cells by Justin D Lathia and 10 co-authors, including Jeremy N Rich, Cell Stem Cell 2010(May 7); 6(5): 421-32. [PubMed citation][FriendFeed entry].

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International Stem Cell Corporation and The Automation Partnership Enter into Strategic Alliance to Automate Cornea Tissue Production

§ May 19th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation and The Automation Partnership Enter into Strategic Alliance to Automate Cornea Tissue Production

OCEANSIDE, CA – May 18, 2010 – International Stem Cell Corporation (ISCO.OB), http://www.intlstemcell.com, announced today that it had entered into a strategic alliance with The Automation Partnership (TAP), http://www.automationpartnership.com, to automate and scale up the production of stem cell-derived human corneal tissue. The alliance has been formed to create instrumentation for ISCO and its partners and affiliates to produce development and commercial volumes of donor tissue for cornea transplantation and to reduce the use of animals and animal eyes in safety testing of drugs, chemicals and consumer products.

Cornea-related loss or reduction of vision can be caused by physical injury, infections and degenerative diseases. In cases where cornea replacement is indicated, current medical practice typically involves a one-two hour outpatient procedure under local anesthesia using full or partial corneas from healthy human cadavers. 10 million people worldwide are candidates for such treatment, primarily in Asia and Europe where there is significant quantitative and qualitative shortage of human cornea donation.

Global efforts are underway to transition from the use of live animals and excised animal eyes to test drugs, chemicals and consumer products. For example, Europe’s Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) estimates a need to spend €270M and use 160,000 animals for eye safety testing alone to catch up with the back-log of insufficiently tested agents. In the US, the National Institutes of Health (NIH) and the Environmental Protection Agency (EPA) have launched a five-year program dedicated to finding new, non-animal technologies for toxicity testing of chemical compounds.

ISCO has discovered and filed for patents on a cell culture process for the synthesis of standardized, human, corneal tissue using stem cells. Histology, permeability and optical testing has demonstrated compatibility with natural corneas. Efforts are ongoing to further characterize this tissue and standardize and scale up its synthesis. Automation is necessary to produce sufficient, reproducible tissue for development and commercialization of the therapeutic and toxicity testing applications.

Brian Lundstrom, ISCO’s President, says: “Given the substantial unmet therapeutic and toxicology testing needs for human corneal tissue, ISCO has embarked on a focused effort to advance this technology with international investors, eye clinics, and development and commercialization partners. After reviewing a range of potential cell culture automation companies, we are very pleased that TAP has agreed to contribute their over twenty years of experience towards this goal.”

David Newble, TAP’s CEO says: “TAP has successfully installed and supported over 160 automated cell culture systems worldwide and continues to design new and customize existing equipment for cell culture and other emerging life science applications. The opportunity to join forces with ISCO in the cornea tissue area will enable us to contribute solutions for clear biomedical needs while also creating new technology and knowhow that will be useful in other applications downstream.”

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells (hpSCs) from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website,
http://www.internationalstemcell.com

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

About The Automation Partnership
The Automation Partnership (TAP) provides advanced automation systems and services to improve productivity in life science research, development and production.


For over 20 years TAP has been the leader in the design and development of automated cell culture and processing systems with applications in regenerative medicine, discovery research, bioprocess development and biologics production. Systems include SelecT, CompacT SelecT and Cellmate.

In addition, TAP has a strong track record in providing a range of custom automation solutions for biobanking, biological sample management, compound management and advanced high throughput screening applications.

TAP is a privately-owned company with headquarters near Cambridge, UK and a sales and support facility near Wilmington, Delaware, USA.

FORWARD-LOOKING STATEMENTS
Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “should,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-940-6383
bl@intlstemcell.com
Or
The Automation Partnership
Matthew Walker
Head of Communications
+44 1763 227 200
Matthew.walker@automationpartnership.com

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US Patent: Isolation and use of solid tumor stem cells

§ May 18th, 2010 § Filed under Nano Medicine Comments Off on US Patent: Isolation and use of solid tumor stem cells

Isolation and use of solid tumor stem cells, United States Patent 7,713,710. [FreePatentsOnline][PatentStorm].
Publication Date: May 11, 2010.
Inventors: Clarke; Michael F. (Ann Arbor, MI), Morrison; Sean J. (Ann Arbor, MI), Wicha; Max S. (Ann Arbor, MI), Al-Hajj; Muhammad (Ann Arbor, MI).
Assignee: The Regents of the University of Michigan (Ann Arbor, MI) .
Appl. No.: 11/753,191
Filed: May 24, 2007
Abstract:

A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

Parent Case Text:

CLAIM OF PRIORITY
This application is a Continuation of U.S. patent application Ser. No. 11/150,073, filed Jun. 10, 2005, which is a Continuation of U.S. patent application Ser. No. 09/920,517, filed Aug. 1, 2001, now U.S. Pat. No. 6,984,522, which claims priority to U.S. provisional applications Ser. No. 60/222,794, filed Aug. 3, 2000, and Ser. No. 60/240,317, filed Oct. 13, 2000, all of which are herein incorporated by reference in their entireties.

Google patents entry for Application Number 11/753,191 (The application that led to patent 7,713,710. The filing date was 24 May 2007).

Google patents entry for Application Number 11/150,073 (See Parent Case Text above: the filing date was 10 June 2005).

Google patents entry for Patent Number 6,984.522 (See Parent Case Text above: the filing date was 1 August, 2001 and the issue date was 10 Jan 2006). [FreePatentsOnline][PatentStorm].

Comment:

Not mentioned in the Parent Case Text above is United States Patent 7,115,360. [FreePatentsOnline][PatentStorm]. This patent was issued October 3, 2006 and filed on August 2, 2001.

The Parent Case Text for patent 7,115,360:

CLAIM OF PRIORITY
This patent is the United States national stage of PCT patent application PCT/US01/24243, published Feb. 14, 2002 as WO 02/12447, which is a continuation of U.S. Ser. No. 09/920,517, filed Aug. 1, 2001, now U.S. Pat. No. 6,984,522. This patent also claims priority to provisional patent applications U.S. Ser. Nos. 60/222,794, filed Aug. 3, 2000, and 60/240,317, Oct. 13, 2000.

Information about this patent was found via a Google search for “Isolation and use of solid tumor stem cells”.

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Lose Weight & Feel Great this Summer

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Lose Weight & Feel Great this Summer

lose weight weight loss healthy living how to lose weight healthy eating tips how to get a six-pack abdominal muscles flat tummy tighten tummy slim down exercise fat loss lose fatLooking for a way to slim down so you can fit into that bikini? Healthy weight loss isn’t easy, mostly because it requires significant lifestyle changes. But it is possible, and it’s worth it in the long run.

The basic principle of weight loss remains calories in versus calories expended, but if counting calories was the only way to manage weight, with a little willpower, we would all have the physique we desired. The reality is there are many roads to achieving a healthy weight.

Americans eat out about four to five times per week, and all that dining out can put the calorie conscious at an immediate disadvantage. “The plates at any restaurant in America are piled high with food twice to three times the recommended serving size for anyone trying to lose weight,” says Shari Solomon, a holistic nutrition consultant from Boston. Solomon suggests a simple solution that will also help you save money: “When dining out, as soon as you order, ask for an extra plate. When the meal comes, put half of it onto the empty plate and immediately ask the server to wrap it up to go.”

Recognizing appropriate portion sizes and locating hidden calories are also part of Tucson nutritionist Lauren Kanzler’s approach to mindful eating and weight loss. Kanzler helps her clients avoid fad diets by teaching them about whole foods—fruits, vegetables, beans, lean protein, and the healthy omega fats (3s, 6s, and 9s). Taming blood sugar levels by avoiding refined sugars, opting instead for unprocessed carbohydrates with low Glycemic Index (GI) scores helps control appetite and cravings. Choosing low GI carbs—the ones that produce only small fluctuations in our blood glucose and insulin levels—is the secret to reducing your risk of heart disease and diabetes, and is the key to sustainable weight loss.

Certified health and nutrition coach Randi Dukoff of Jericho, New York, says a balanced breakfast is essential. According to Dukoff, breakfast should feature all three macronutrients to jumpstart the metabolism—think two eggs with a cup of blueberries and a slice of Ezekiel bread with a little butter. Breakfast should comprise at least 25 percent of the day’s calories. People who eat breakfast are more successful at losing weight and sticking to a diet, while those who skip the most important meal of the day are more likely to eat unhealthy snacks, experience cravings, and are more prone to binges.

Another constructive tip from Dukoff is to “ditch soda and drink water in the amount of half your body weight in fluid ounces a day.” That amounts to about nine eight-ounce glasses for a 150-pound person. Soda, which Dukoff refers to as “liquid candy,” contributes about 10 percent of the calories in the American diet.

Dukoff encourages crowding out the “fake foods” with eight daily servings of colorful fruit and vegetables. “Take advantage of spring as a time to eat locally and seasonally, and avoid processed foods like high fructose corn syrup and anything else that you can’t pronounce, which lead to weight gain and disrupted insulin.”

Gina Van Luven, a Health and Nutrition Counselor from Park City, Utah agrees. “There is no ‘magic bullet’ for weight loss because everyone’s body is unique.” The most fundamental weight loss principle is to “eat a diet of mostly whole, unprocessed foods, focusing more on vegetables, since those seem most lacking in the American diet.”

Another important thing that might be hampering your success: your fixation on weight. “Throw your scale away,” says Jeanne S. Boone, a professor of nutrition and health at Palm Beach State Collage in Boca Raton. Boone suggests focusing on your behaviors, on eating more healthfully and increasing physical activity. “Instead of thinking about losing weight, focus on becoming more fit, and the weight (fat loss, really) will take care of itself,” she says. For maximum fat burning, workouts should include both cardiovascular and resistance training.

Lastly, adequate sleep is essential to maintaining a healthy weight. Research shows that people who sleep fewer than six hours a night are more prone to obesity. Even one night of sleep deprivation can raise ghrelin levels, increasing hunger and appetite and contributing to obesity.

And don’t forget that healthy weight management takes time. Shantih Coro, a functional diagnostic nutritionist based in Miami, explains that permanent weight loss requires patience, correcting metabolic imbalances, and lifestyle adjustments. “My fat and weight loss program is not quick,” she says. “I know that when you lose weight fast you gain it back fast. When you lose weight on my program you will be making a lifestyle change.”

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Herbs for Weight Loss

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Herbs for Weight Loss

Herbs for Weight Loss Fat loss Lose Weight Green Tea burns fat gain muscle lose fat Toning weight loss goals health and wellness healthy living fennel seed boost metabolism boosting metabolism
In today’s fast paced world men have become more sedentary and unfortunately put on a few extra pounds. If you’re like most men you will find that those extra pounds have found a “home on your belly”, and you just can’t seem to remove them! Once and for all it’s time to send your “excess baggage” on a vacation… But first, I must emphasize that effective weight loss always requires regular exercise and dietary changes. With that being said, there are many different herbs that can be used to help shed those excess pounds by boosting your metabolism, reducing your appetite, increasing your energy levels and promoting lean muscle mass. The following are my top 5 herbs to look for in a weight loss supplement.

Green Tea Extract (GTE)

Research conducted at the University of Geneva in Switzerland found green tea extract helps raise metabolic rates while increasing the oxidation of fat cells. This study also examined caffeine (which is found naturally in GTE) but found that consuming caffeine by itself did not provide the same effects. Nonetheless, in conjunction with the catechins found in green tea, the 10 to 80 mg of caffeine per cup work together to increase thermogenesis. Basically, by consuming green tea, you allow your body to generate more energy from burning unwanted fat. Furthermore, the polyphenols in green tea inhibit the production of the enzyme amylase which in turns limits the amount of sugar absorbed into the bloodstream.

Cha de Bugre

Cha de Bugre is a rainforest herb highly regarded as an effective aid for suppressing the appetite and reducing fat deposits. With Cha de Bugre you feel full after eating just a small amount of food so you end up eating less. You can reduce your overall caloric intake while also enjoying a balanced approach to curbing your appetite. Your metabolism also stays even throughout the day instead of spiking at mealtime. When your metabolism levels remain constant, you can more effectively burn calories because your system isn’t overloaded with carbs and sugars.

Coleus forskohlii

This is the only known plant source of forskolin, a natural compound that increases lean body mass and optimizes body composition. Forskolin, initiates biochemical events in the body that allow fat cells to be utilized as energy and helps the bodysbody’s natural hormones maintain and/or increase lean body mass. Specifically, forskolin activates an enzyme called adenylate cyclase, the main enzyme involved in the production of a significant metabolic molecule called cyclic adenosine monophosphate, or cAMP. cAMP is directly responsible for increasing essential lean mass-building hormones at the expense of non-essential body fat.

Caralluma Fimbriata

Clinical trials done on Slimaluma®, a concentrated form of the plant Caralluma Fimbriata, clearly demonstrated that there was reduction in hunger levels, reduction in weight waist circumference, reduction in fat, and reduction in body weight in the active group of participants. Caralluma Fimbriata is well known in Indian folklore records for its use as a potent appetite suppressant and weight-loss promoter.

Fennel Seed

This plant has a long and celebrated history of cultivation as a weight loss herb. The ancient Greeks called the herb marathon, meaning “to grow thin.” Similarly, ancient Roman women took the herb to help prevent obesity. During the Middle Ages through the Renaissance, people used Fennel Seed to suppress their appetite during periods of fasting or just to manage their weight. Fennel Seed promotes weight loss in several ways by such as actually removing fat cells and mucus from the digestive tract, mildly stimulating the metabolism and suppressing the appetite.

Herbs can be an excellent addition to any weight loss program. Remember, weight loss goals should be realistic and promote a lifestyle change.

Before you start any type of alternative remedy, consult with a physician, especially if you are taking prescription or over-the-counter medications.

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The middle-age spread & how to avoid it

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on The middle-age spread & how to avoid it

The middle age spread & how to avoid it healthy diet weight loss help lose weight weight loss diets fat loss prevent weight gain middle-aged

A common issue I hear from clients trying to lose weight pertains to the so-called ‘middle age spread’. “It’s not my fault I can’t lose weight” they say. “I’m getting older and my waist, hips and thighs refuse to get slimmer.”

Is it true?

Based on the following facts you might think so:

 

  • At approximately age 20, the metabolic rate starts to decrease on average 2% every decade

  • Many North Americans gain an average of 20 pounds between the ages of 25 and 55

  • Weight gain typically peaks for men in their 40’s and for women in their 50’s

  • An 11 pound weight gain can significantly increase an individual’s risk of developing diabetes, heart disease and cancer.

Makes you want to throw in the towel right? Not so fast! Studies show you CAN avoid the middle age spread and age without uncontrollable weight gain. Think Demi Moore, Meryl Streep or Helen Mirren.

How so? Simply by choosing to eat better and by moving more (plus a few bonus supplements to boost your results).

Step 1

Eat a clean, colorful diet and avoid processed foods.

  • Carbohydrate clean-up: As renowned food author Michael Pollan states: ‘Eat food, not too much, mostly plants.’ Aim for deeply colored varieties rich in phytonutrients such as kale and purple cabbage, plus antioxidant-rich berries, fibrous whole grains (remember the label must say 100% whole grain), and legumes. Try eliminating ALL whites from your diet, including white flour, sugar, pasta and breads.

  • Go for ‘pro’ at every meal and snack: Before eating, be sure to ask yourself ‘what’s my protein source?’ Protein triggers the release of the hormone glucagon which facilitates the breakdown of fat. Ideal sources of protein include lean chicken, organic beef, turkey, egg whites, soy and fish. For extra benefits, I advise my clients to include a very high quality protein supplement such as proteins+ or Vegan proteins+. Simply add into smoothies, yogurt, liquids or baking –no blender required.

  • Add some fat-fuel: Avoid fatty meats, cheese, margarine and dressings containing refined vegetable oils or trans fats. Instead, make essential fats such as Omega-3s found in cold water fish, nuts, seeds a daily food staple. Besides increasing brain function, cardiovascular health and more, studies show consuming an Omega-3 fish oil formula can help you shed excess fat more efficiently.

Other eating tips to boost weight loss and metabolism at any age:

  • Instead of coffee, try antioxidant-rich green tea

  • Eat smaller meals more frequently and avoid eating after 7pm

  • Skip all artificial sweeteners, try stevia instead

  • Throw out your salt shaker and season foods with flavorful spices

  • Enjoy a glass of red wine daily – studies show those who do so are more likely to keep their waist lines in-check. Please remember this means drinking red wine in moderation–too much may pack on the pounds.

Step 2

Move more, include weight bearing exercises. Torch calories and boost your metabolism with regular cardiovascular exercise, strength training and stretching such as yoga every day. Yes, do something every day!

  • Aim for 4-5 cardio sessions per week for a minimum of 30 minutes

  • Include weight-bearing exercise such as strength training 2-3 times per week

  • Attend a yoga, pilates or a stretch class

  • Look for other ways to sneak more activity in your day such as walking or taking the stairs

For every pound of muscle you gain, your metabolism increases as much as 15%, burning an extra 35-50 calories per day – even while resting. Lean (not bulky) muscle mass also means stronger bones and better posture.

To boost your results, consider hiring a trainer to set-up a program and/or purchase free weights and DVDs to practice at home.

Step 3

Incorporate all-natural supplements with research-proven ingredients

My top picks include:

  • A daily high-potency, complete multi-vitamin such as one enhanced with Green Tea to assist with weight loss. I like multi+ daily trim.

  • A protein formula (as noted above), look for one that’s 100% pure, no sugar, highly absorbable and provides all essential amino acids.

  • A high-quality fish oil formula.

Last, to really (I mean really) succeed, make steps 1, 2 and 3 your lifestyle and not a temporary experiment. Expect occasional set-backs, go easy on yourself and enjoy the renewed energy and vitality you will experience as you age middle-spread-free!

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Effective Weight Loss Methods

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Effective Weight Loss Methods

Effective Weight Loss Methods Fat Loss Lose Weight Weight Training Exercise Fish Oil Green Tea EGCG

Losing weight can be hard.

Here are a few key steps that will help make shedding those extra pounds much easier and healthier.

Exercise

A great way to start your day is with exercise and it is one of the most effective ways of losing weight. There are many forms of exercise ranging from walking, working out at the gym or even doing household chores. The key is to keep moving!

Walking is a simple way of getting your daily dose of exercise. It could be as little as 30 minutes a day. Try using your arms or including a couple of hills for an even better result.

Eliminate white foods from your diet

These white foods are also called “refined carbohydrates,” which includes white pasta, rice, bread, flour, salt and sugar. As a rule of thumb, foods that are white are typically refined. Refined foods lack fiber and nutrients and may even make you gain weight!

Replace these white foods with sprouted grains, millet, quinoa, brown rice, and spelt as they are better sources of nutrients.

A Harvard study found that women who ate more that two servings of whole grains per day were 49% less likely to become overweight.

Be sure to avoid starchy grains at night time, as this can actually promote weight gain. The best dinner combination for weight loss is protein and veggies. For dinner tomorrow night have some quality protein, such as chicken or wild salmon and fill the rest of your plate with vegetables.

Eliminate sugar from your diet

This step is one of the most important to your health. Sugar is full of empty calories. It also increases insulin levels in your body.

Did you know one can of soda can contain between 8-12 teaspoons of sugar?

Some great alternatives to sugar include maple syrup, date syrup, stevia, agave and raw honey. Be sure to use in moderation.

Green tea

There are many benefits to green tea and one of them is weight loss. Green tea contains powerful antioxidants called polyphenols. These antioxidants can neutralize and prevent damage from disease-promoting free radicals.

According to a study from the American Society of Nutrition green tea contains antioxidant compounds that may promote exercise-induced abdominal fat loss. Another study found that by drinking 5 cups of tea a day the average person burns an extra 70 – 80 calories.

Remember, not all green teas are created equal. Look for the bright green color to get the full benefits and make sure it’s organic.

Keep a food journal

I always tell my clients to keep a food journal. It helps them figure out exactly what they are eating and where they are going wrong.

Write down what you eat, the portion sizes, the times of the day you eat, and any emotions you are having. Then, at the end of the day analyze what you have written down and see how you can make the next day a healthier one.

Make these tips part of your lifestyle and you will see benefits!

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Healthy Weight Loss-Part2

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Healthy Weight Loss-Part2

Healthy Weight Loss-Part2 fat loss losing weight nutrition health and wellness diet holidays atkins weight loss tips protein breakfast ideas healthy recipes sugar caffeine sleepHere are some quick and easy ways to help you slim down. These little changes add up to losing weight and a healthier you!

Kick the Sugar Habit

According to Dr. Robert Atkins, sugar is the “quintessential anti-nutrient”. It contains no vitamins or minerals. Rather, it is 100% carbohydrate, so it must be immediately metabolized. When sugar is metabolized it depletes our bodies of vital nutrients.

There are healthier solutions available. Stevia and glycerine extracts of Garcinia cambogia (Lose-It) are both very sweet weight-loss aids. Unlike sugar, these natural alternatives are not empty calories, and both also act as appetite suppressants to help curb your calorie cravings.

Accelerate Exercise

Enjoy a cup or capsule of green tea 30 minutes before you exercise. The natural caffeine it contains frees fatty acids, allowing you to burn fat more easily. Green tea also has antioxidant compounds that appear to work with caffeine to increase your calorie burn.

Take chromium before exercising. An essential trace mineral, your body needs chromium to metabolize carbohydrates, proteins and fat. Nearly 90% of North Americans are chromium deficient

Chromium enhances the calorie burning results of exercise to make weight loss easier. When you work out it increases your chromium excretion, which makes supplementation even more important.

Water

Dehydration can significantly slow down your metabolism. Be sure you drink enough healthy liquids (water, fruit juice, herbal teas) to keep your body happy. Avoid “bad” drinks such as soda, sugary drinks and coffee as they aid the dehydration process. In general, you should drink 1/2 ounce (14.5 ml) per pound of body weight daily, just to keep from being dehydrated. Thus, a person weighing 150 pounds would need at least 2.175L of water daily. This number increases dramatically if you are dieting or exercising.

Give your water an added boost by adding 1 or 2 teaspoons of liquid chlorophyll to each liter (quart) of water.

A common fallacy is to drink when you are thirsty. Unfortunately, when exercising you are already dehydrated by the time you become thirsty. A schedule to prevent dehydration begins 2 hours before exercising by drinking at least 500ml. Then 1 hour before, drink 250ml more, and at least 250ml every 15 minutes during exercise. Finally, drink another 500ml within ½ hour of finishing your exercise routine.

Measure, Measure, Measure

When cooking or baking, measure out all ingredients, especially fats (butter, margarine, oils) and sweeteners (molasses, sugar, honey, stevia). Many people estimate these ingredients and, more often than not, they estimate too high thereby adding unnecessary calories.

Spice Up Your Life

Try adding spices to food instead of fat. Both add flavour, but spices also aid digestion. Give “dull” foods a spicy zip and add variety without adding fat by varying the spices you use.

Sprinkle Your Cereal

Incorporate high fiber flax into your food. Not only is it packed with a healthy and flavorful oil, the high fiber content can help you feel full and eat less. Try adding flax to cereals, breads, muffins, and yoghurt.

Become a Dipper

Pass on the butter. Instead, try dipping your bread in flavored extra virgin olive oil (my favorite is rosemary, garlic & chili). Research has shown extra virgin olive oil to be exceptionally healthy, and “dippers” eat fewer calories than those who buttered their bread.

Skip Rope, Not Meals

Did you know? Restricting foods and skipping meals slows the metabolism and can lead to overeating. When you miss a meal or eat too little, your brain initiates a famine response which alerts the body to conserve calories. Your body assumes food is in short supply and goes into a calorie-saving mode, storing fat to keep you from starving to death. Instead of skipping, eat well-balanced healthy meals.

Take Time for You

Take some time every day to do something you enjoy, other than eating. Routinely doing something you enjoy not only makes you feel good about yourself, but provides the emotional support you may be seeking from food.

Playing is not just for kids. Run, jump, swim, have fun! You can get lots of physical activity “playing.” Get out and have a game of tag with your kids or challenge someone to a full-court basketball game. Ride your bike, dance, or go hiking. If you can enjoy enough additional activity everyday to burn an extra 300 calories, you’ll lose 2.5 pounds of fat per month — and tone your muscles. You will love the new you, and so will your kids!

The combined effect of these simple little steps will help turn your body into an efficient calorie-burning machine. This new year, take the steps to a happy healthy new you.

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Healthy Weight Loss-Part 1

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Healthy Weight Loss-Part 1

Healthy Weight Loss fat loss lose weight gaining weight nutrition health and wellness diabetes fiber supplements calories caloric intake ideal weight waist hip ratio running weight training fruit vegetables health and wellness

As we get closer to another new year, many of us will make the obligatory resolution to be healthier and happier, which usually includes losing weight. This year see your resolution through to its conclusion. Make this your thinner, happier and healthier year!

Approximately one-half of North Americans are overweight, one-quarter are obese and three-quarters feel they are above their ideal weight. Clearly the battle of the bulge is an ever-expanding epidemic.

To effectively lose weight and, more importantly, keep it off, we need to understand the chemical reasons why people gain. Gaining weight occurs when we consume more calories than we use. The body efficiently stores these excess calories as fat.

Consequently, weight can be lost by decreasing the calories we consume and by increasing the amount we burn. While lifestyle changes are easier said than done, the most effective dieters combine these strategies for lifelong success.

As long as the body is using fewer calories than it takes in, a person will get “fatter”. Modern science has not yet developed a magic pill to change this fact. However, there are substances that can help reduce your calorie intake or increase the amount you burn.

No substance is magical. If you eat everything in sight and live a sedentary lifestyle you are more likely to be overweight and unhealthy. While there are no quick answers for successful weight loss and long term weight maintenance, establishing a few common-sense habits will help you reach your ideal weight. First and foremost, follow a sensible diet that is both satisfying and nourishing. This builds a solid foundation for any weight-loss program. Consider supplements to bolster your nutritional intake. The vast majority of North Americans do not get enough nutrients from the foods they eat. Adding vitamins, minerals and herbs to your daily routine may reduce these deficiencies and bolster your health.

No health program is complete without the addition of regular exercise. You don’t have to join a gym or buy a fancy machine, just start moving! Walk, take the stairs, stroll around the block at lunch or to the corner store. Experts recommend at least 30 minutes of constant exercise a day, three times a week.

Set realistic and attainable goals. Rapid weight-loss, while tempting, is not desirable. As a rule, the faster you lose weight the more likely you are to gain it back! A healthy weight-loss plan should be targeted toward slow, steady weight-loss, unless directed otherwise by your doctor. Don’t be discouraged by a downward trend in the amount you lose. Expect to only lose about a pound a week after the first week or two. With many calorie-restricted diets there is a rapid initial weight loss, but this is largely fluid. This initial rapid loss of fluid is quickly regained when you return to a normal calorie diet. Thus, reasonable short-term goals for weight loss must be set.

A successful program should include plans for maintaining your new weight after the loss phase is over. There is little, if any benefit in losing a large amount of weight when it is only regained. Weight maintenance is the most difficult part of controlling weight and is often an afterthought. The program you select should include help to permanently change your dietary habits and level of physical activity, thereby altering a lifestyle that likely contributed to weight gain in the past.

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Weight Loss on a Busy Schedule

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Weight Loss on a Busy Schedule

Weight Loss on a Busy Schedule losing weight weight gain healthy eating weight management stress management health and wellnessWhen discussing weight loss techniques in seminars or in private practice, one of the most frequent excuses I hear from people is that they’re too busy or it’s too difficult to eat healthier.

Time may be short for most of us, yes. But throughout my years of teaching and dealing with weight loss clients, I have gathered some very helpful nutritional “tricks” to help even the busiest of people lose weight permanently.

Learn to shop

It takes just as long to go to the grocery store for a bag of chips as it does for an apple! You have to grocery shop anyway, so why not learn the basics of nutrition to fill up your cart?

Here are some healthy food basics to stock-up on:

  1. Fresh fruits – fresh or frozen berries, apples, oranges, kiwi

  2. Vegetables – broccoli, cauliflower, spinach, tomatoes (go for color!)

  3. Omega 3 foods such as wild salmon (tinned is fine), omega-3 eggs, walnuts

  4. Good fats – olive oil, avocados

  5. Lean meats – chicken, turkey, ham slices (look for low-sodium, nitrate-free)

  6. Low-fat dairy options- light cottage cheese, yogurt, milk and low fat cheese

  7. Nuts, seeds – raw, un-salted varieties are best

  8. Healthy spreads – hummus, light cream cheese, organic nut butters

  9. Whole grain breads and pastas – kamut, spelt, rye, oats, flax and multi-grain

  10. A small amount of dark chocolate (70%) for a treat

  11. Protein powder- pure whey formula (free of aspartame and sucralose)

  12. Healthy snack bars- low-sugar and made from real food ingredients such as proteins+, greens+ Hip to be Healthy Squares

  13. Water (or a good quality water filter)

What should not go in your grocery cart:

  • Hydrogenated or partially hydrogenated foods (a.k.a. Trans fatty acids) – certain salad dressings, crackers, chips, margarine. Check your labels!

  • Refined, white flour products – white bread, pasta, muffins, cookies, crackers

  • Pop or sugar juices

  • Candy

  • Overly processed and packaged goods

Pack a lunch to save time, money and calories

A balanced meal includes the proper amount of protein, carbohydrates and fat. Here’s an example:

  • A whole wheat sandwich wrap, with lean turkey, lettuce, tomato, avocado, mustard and low-fat cheese

  • A small container of yogurt (organic soy is an option), that’s low in sugar and fat

  • Dark chocolate square to enjoy for dessert

Know your fast food healthy options

Too busy to pack a lunch? Luckily, there are healthy fast food options such as Wendy’s salads, McDonalds wraps or low fat Subway sandwiches now available.

What’s more, many of these outlets have posted the fat/calorie/sodium content of their menus online. Bottom line, if you’re going for something ‘fast’ you can make it healthy too!

Keep weight loss protein staples on-hand

The problem with weight loss is typically due to an over consumption of carbohydrates and too little protein in the diet.

Here’s a few protein staples to boost your intake (without increasing your waistline):

  • Low fat cheese strings or light cottage cheese

  • Protein powder (such as proteins+, keep a container at work and home)

  • Lean slices of meat (chicken, turkey)

  • Egg whites – can be added to any shake, recipe or made as an omelet (hard-boiled eggs are great to keep in the fridge too)

Make dinner your smallest meal

This is often the most difficult habit to break – but it can be done! For starters, get into the habit of eating a larger breakfast, a mid-sized lunch with a healthy snack or 2 in-between. This way, you won’t be overly ravenous come dinner time.

Some dinner ‘tricks’ to try:

  • Use a smaller-sized plate to automatically reduce your portion sizes

  • Make 2/3rds of the plate a colorful salad or steamed veggies

  • Include a portion of lean protein that’s about the size of a deck of cards

  • Enjoy low-glycemic, high fiber carbs such as wild rice (no more than a palm-size)

  • Add flavor without calories, such as cracked pepper or hot sauce

Suffering from cravings at nighttime? Try drinking watered down juice, herbal tea or chewable vitamin C. If you need to munch, go for veggies.

Find an activity that you enjoy and … do it!

Let’s face it, hitting the gym nightly is not realistic for most busy people. Luckily, there are many home options now available to fit into your lifestyle. Elastic bands, home weights, videos and a yoga mat can fit into any and all budgets. For morning-types, set the alarm a bit earlier, lay your shoes out the night-before, rise and go.

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Generic drug a potential treatment for glioblastoma?

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Generic drug a potential treatment for glioblastoma?

DCA research on brain cancer, EurekAlert, May 12, 2010. [FriendFeed entry]. Excerpt: “… the orphan generic drug Dichloroacetate (DCA) may hold promise as potential therapy for … a form of brain cancer called glioblastoma“. Another excerpt:

By extracting glioblastomas from 49 patients over a period of 2 years and studying them within minutes of removal in the operating room, the team showed that tumors respond to DCA by changing their metabolism. Then, the team treated 5 patients with advanced glioblastoma and secured tumor tissues before and after the DCA therapy. By comparing the two, the team showed that DCA works in these tumors exactly as was predicted by test tube experiments. This is very important because often the results in non-human models tested in the lab do not agree with the results in patients. In addition, the team showed that DCA has anti-cancer effects by altering the metabolism of glioblastoma cancer stem cells, the cells thought responsible for the recurrences of cancer.

And,

No conclusions can be made on whether the drug is safe or effective in patients with this form of brain cancer, due to the limited number of patients tested by the study’s leads Drs Michelakis and Petruk. Researchers emphasize that use of DCA by patients or physicians, supplied from for-profit sources or without close clinical observation by experienced medical teams in the setting of research trials, is not only inappropriate but may also be dangerous. …

See also: Generic drug may be potential treatment for deadly brain cancer: U of A medical study by Noreen Remtulla and Julia Necheff, ExpressNews, University of Alberta, May 12, 2010.

And: Potential brain-cancer drug shows promise, CBC News, May 12, 2010. [CBC video].

And: Cancer drug trial raises hopes by Elise Stolte, Edmonton Journal, May 13, 2010.

These news reports are about the publication: Metabolic Modulation of Glioblastoma with Dichloroacetate by Evangelos D Michelakis and 12 co-authors, including Kenneth C Petruk, Sci Transl Med 2010(May 12); 2(31): 31ra34.

See also an editorial: Targeting Cell Metabolism in Cancer Patients by Matthew G Vander Heiden, Sci Transl Med 2010(May 12); 2(31) :31ed1. From the TOC: “Dichloroacetate can safely modify glucose metabolism in aggressive brain tumors when administered to patients“. Last sentence of the editorial: “Time will tell whether this strategy constitutes an effective cancer therapy“.

Comments: After an initial research publication in January 2007 [PubMed citation], DCA attracted much attention. See, for example, the Wikipedia entry for Dichloroacetic acid. And, Cancer society warns of untested drug, CBC News, March 22, 2007.

The Official University of Alberta DCA Website provides FAQs about DCA. It includes, in the News & Updates section, DCA Research Team publishes results of Clinical Trials (dated May 12, 2010) and an earlier Letter from Dr. Evangelos Michelakis (dated October 2008).

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Lallemand: Innovations in cranberry ingredients

§ May 13th, 2010 § Filed under Nano Medicine Comments Off on Lallemand: Innovations in cranberry ingredients

Urinary Tract Infection (UTI) is the most common infection among women: it has been shown that nearly one in three women will have had at least one episode of UTI requiring antimicrobial therapy before they reach the age of 24. Moreover, UTI is characterised by a high reoccurrence rate: it has been estimated that nearly half of the women who have had UTI will experience another one within 12 months. The main causative agent is Escherichia coli (E. coli), normally present in the colon. Symptoms are both uncomfortable and debilitating and associated healthcare costs are high.

UTIs are traditionally treated with antibiotics, however, scientists believe that antibiotic treatments can disrupt the natural occurrence of beneficial bacteria in the body, leading to higher recurrence of UTI. Furthermore, repeated antibiotic treatments can give rise to antibiotic-resistant strains of harmful bacteria. Cranberries are widely documented for their preventive effect against UTI due to their unique anti-adhesion activity against pathogenic bacteria, which is linked to the presence of key phytochemicals: proanthocyanidins (PACs). Today, there is a growing demand for high quality cranberry extracts with high amount of proanthocyanidins to support urinary tract health. Lallemand Health Ingredients, in partnership with leading cranberry expert Decas Botanical Synergies have joined their marketing and R&D efforts to develop high quality cranberry ingredients solutions aimed at meeting this demand.

This article is available in full in the Spring 2010 issue of Nutraceuticals Now

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Forward to Spring 2010 Issue

§ May 13th, 2010 § Filed under Nano Medicine Comments Off on Forward to Spring 2010 Issue

This year is a very special one for everyone in the dietary supplements functional foods and functional drinks industry. Why? Because after four years of consistent annual growth, Finished Products Expo is going solo in 2010. During this period, the show has proven time and again that it is a serious player in the arena and so for the first time, it is moving into a hall of its own, with a dedicated entrance and marketing campaign to boot.

This couldn’t have come at a better time for the event, which believe it or not, began as a pavilion within Vitafoods. Since it started, Finished Products Expo has been gradually gaining momentum with both exhibitors and visitors alike. It has taken time, like all events of its nature, but we wanted to ensure we were creating an offering that was tailored perfectly to the needs and requirements of the industry.

Although it has its own hall and entrance, there will still be those valuable cross-over points with Vitafoods to provide exhibitors and visitors with those all-important networking opportunities which, lets face it, are what makes shows like these tick.

One of the comments that always comes back to me after a stint in Geneva is about how great the shows are socially, which is truly refreshing to hear. So a couple of years ago we decided to capitalise on that even further by actually setting- up a bespoke service for Finished Products Expo – The Distributors Wanted Scheme – so that visitors can search and even be contacted by potential distributors before the event. It’s been described as an online matchmaking scheme, which saves visitors valuable time and money.

Nevertheless, there is far more going on than simply networking with industry peers and catching-up with old contacts at Vitafoods and Finished Products Expo. Both shows are known industry-wide as the venues for large-scale innovation launches. All of the major players from the functional foods, functional drinks, dietary supplements and nutraceutical markets converge annually on GENEVA PALEXPO, each one competing healthily with the next for the most cutting-edge product launch. The features that we have at the shows complement this too, with the New Products Zone for example, giving an insight into the next big thing to take the market by storm.

And with innovation the key focus for both Vitafoods and Finished Products Expo, its no surprise that some great business deals have taken place on both show floors over the years. In a niche industry like ours, it’s not impossible to get the majority of the leading players together under one roof and when that happens, it becomes the perfect place to conduct serious business deals, many of which can – and have – shaped the industry forever.

So hopefully this year we’re on course to achieve more of the same. With the recession behind us and a mood of optimism sweeping the industry, there’s no reason why the 2010 installments of these shows can’t be the biggest and best yet. All the initial signs are there that both are set to break records – so watch this space!

Finished Products Expo and Vitafoods take place on 18-20 May 2010 at the Geneva Palexpo, Geneva, Switzerland. Visit http://www.finishedproductsexpo.com or http://www.vitafoods.eu.com for more information.
Chris Lee
Event Director, Finished Products Expo

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International Stem Cell and Absorption Systems Confirm Results Showing Stem Cell Derived Corneal Tissue as an Alternative to Animals for Drug Testing

§ May 12th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell and Absorption Systems Confirm Results Showing Stem Cell Derived Corneal Tissue as an Alternative to Animals for Drug Testing

Other Tests Show Tissue’s Ability to Focus Light, Pointing to Potential Therapeutic Applications

OCEANSIDE, Calif. – May 10, 2010 – International Stem Cell Corporation (OTCBB: ISCO), http://www.internationalstemcell.com/, the first company to perfect a method of creating human “parthenogenetic” stem cells from unfertilized eggs, announces the results of a second set of experiments confirming that its lab-grown corneal tissue closely mimics the drug absorption and drug metabolism characteristics found in normal corneal tissue. Other tests show that the stem cell derived corneal tissue refracts light, thus providing a further indication of its potential therapeutic value in treating corneal injury and disease.

Two sets of collaborative experiments between ISCO and Absorption Systems have now shown that corneal tissue cultured by ISCO exhibits topical drug absorption barrier properties and tissue-appropriate enzymatic activity, making it a promising model for studying human ocular drug absorption as an alternative to live animal testing. ISCO’s human corneal tissue is created in the laboratories of its wholly owned subsidiary, Lifeline Cell Technology (Walkersville, MD).

In a second set of tests conducted by a third party expert, a beam of diverging light was projected through the corneal tissue from different distances, becoming more or less refracted with the changing distance, showing that the corneal tissue was clear and had optical properties that allow the focusing of light. Additional experiments will be conducted to better define these optical characteristics.

According to Jeffrey Janus, Senior VP of ISCO and CEO of Lifeline, “We are very excited to confirm our initial results showing drug absorption that correlates with animal models and add to these results the observation of enzymatic activity. This not only advances our plans to manufacture a product that can be used to reduce the need for tests that use living animals, but it also is one more step toward the potential therapeutic use of this tissue as a treatment for human corneal injury or disease. This has implications, not only in the US, but also in India and Asia, where millions of people suffer from corneal blindness that now goes untreated. The experiments showing light refraction are a tempting indication that this tissue will have therapeutic application.”

“There is a large commercial need for a predictive and reproducible non-animal method for testing the safety of ophthalmic drugs and consumer products,” said Patrick M. Dentinger, President and CEO of Absorption Systems. “The combined knowledge and expertise of ISCO and Absorption Systems have allowed us to take a step forward toward addressing an unmet need in the field of ophthalmology by creating a unique in vitro model to study human ocular drug absorption without using animals. Our collaboration with ISCO underscores our commitment to helping bring safe drugs to market.”

The collaboration between Absorption Systems and ISCO uses Absorption Systems’ know-how in creating and characterizing assay systems to develop superior preclinical methods of testing drugs. Such methods can also reduce the use of laboratory animals currently necessary for other tests, including safety testing of consumer products.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, http://www.internationalstemcell.com/.

ABOUT ABSORPTION SYSTEMS:

Absorption Systems, founded in 1996, assists pharmaceutical, biotechnology and medical device companies in identifying and overcoming ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) barriers in the development of drugs, biologics and medical devices. The company’s mission is to continually develop innovative research tools that can be used to accurately predict human outcomes or to explain unanticipated human outcomes when they occur. The CellPort Technologies® platform, a suite of human cell-based tests systems for drug transporter characterization, exemplifies Absorption Systems’ commitment to innovation. Absorption Systems has facilities near Philadelphia, PA, and in San Diego, CA, and serves customers throughout the world. For information on the company’s comprehensive contract services and applied research programs, please visit http://www.absorption.com/.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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