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Patent application: Levels of Oct1 as a method of identifying CSCs

§ June 18th, 2010 § Filed under Nano Medicine Comments Off on Patent application: Levels of Oct1 as a method of identifying CSCs

(WO2010065400) Cancer Biomarker and Methods of Using Thereof.

Excerpt from PCT Biblio. Data:

International Application No.: PCT/US2009/065742
Publication Date: 10.06.2010

Excerpt from Description:

Described herein are biomarkers which can be used for identifying a subject at risk for or evaluating the progression of cancer. In certain aspects, these biomarkers can be used to identify cancer stem cells. These biomarkers can include Octl or molecular variants thereof and downstream targets of Octl. In addition, described herein are methods for reducing the expression of these biomarkers associated with cancer.

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Roquette: A new way of exploring microalgae

§ June 17th, 2010 § Filed under Nano Medicine Comments Off on Roquette: A new way of exploring microalgae

Origin?Appeared on Earth some 3 billion years ago

First use dated back 2000 years to the Chinese

What are they?An extremely diverse group of microorganisms at the origin of the life

At least 30,000 species known from fresh or marine water, of which 100 are studied and only around 10 exploited

What about nutrition?Original and alternative source of many essential nutrients: proteins, lipids, vitamins, pigments.
And sustainability?At the origin of the food chain

An alternative raw material to marine resources

Inspired by this promising portrait and faithful to its avowed aim of sustainable innovation, the ROQUETTE group took up the challenge of creating an industry devoted to microalgae. The objective is simple: explore this resource, only recently re-discovered, from biodiversity to extraction of compounds of interest via process optimisation. To ensure the success of this large-scale project, ROQUETTE brings together diverse and complementary skills: production, analytics, nutrition, R&D, regulation but also marketing and sales force.

Faced with the desire of populations to preserve their health through the different stages in life and the nutritional priorities of companies, ROQUETTE hopes to offer ingredients or innovative biomass produced by the microalgae industry for the Nutrition and Health fields. These natural and sustainable compounds would be included in the composition of dietary supplements or functional foods.

As evidence of its commitment to this new way, ROQUETTE proposes the first of many ingredients: Chlorella. It is one of the most important species in the microalgal industry. This success is mainly due to its extraordinary complete composition (proteins, vitamins, pigments such as lutein, lipids etc.). Nowadays, the most common way of consuming Chlorella is as a dietary supplement. Indeed, whether in powder or tablet form, this microalga delivers all its nutritional benefits to consumers.

Download the complete press release (PDF document)

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New Article from North County Times – BIOTECH: International Stem Cell Clears Debt, Gets Patent

§ June 17th, 2010 § Filed under Nano Medicine Comments Off on New Article from North County Times – BIOTECH: International Stem Cell Clears Debt, Gets Patent

By BRADLEY J. FIKES – bfikes@nctimes.com | Posted: June 15, 2010 3:21 pm |

OCEANSIDE —- For the first time in years, International Stem Cell Corp. has cleared its balance sheet of debt and has enough cash to last for “another year or so,” the company’s chairman said in a conference call Tuesday.

The improved finances means International Stem Cell can focus more attention on advancing its technology to create stem cells from unfertilized, or “parthenogenetic,” human egg cells, said chairman Kenneth Aldrich.

“We’ve not had that kind of financial security of knowing we could see forward for 12 months without having to go back to the markets since probably the summer of ’07, so it’s a most welcome change for us,” Aldrich said in the conference call.

The company said in a June 14 filing that it struck debt-reduction deals with investors Socius CG II Ltd. and Optimus Capital Partners LLC. The deals exchanged stock previously issued to the investors for promissory notes, with no cash changing hands.

Aldrich said the company reached another important milestone earlier this month when the U.S. Patent and Trademark Office granted it a patent for its parthenogenetic stem cell technology. The patent is the first of several pending, Aldrich said.

Stem cells are the “ancestral” cells that turn in the various kinds of cells in the body. Companies are studying how to use them for disease treatments, or to screen drugs before they’re tested in humans.

International Stem Cell says its stem cells have the advantage of being immune-matched to large segments of the population. That means any replacement tissues or organs created from them will be less likely to be rejected after transplant, the company says.

Also, because they are not derived from human embryos, the cells don’t raise the ethical issues that concern many about embryonic stem cells, taken from days-old embryos.

The patent, number 7,732,202, applies to the company’s method of creating its parthenogenetic stem cells. Other pending patents concern how to make stem cells that can be immune-matched.

International Stem Cell trades over the counter under the ticker ISCO.

Visit http://www.internationstemcell.com or call 760-940-6383.

Call staff writer Bradley J. Fikes at 760-739-6641. Read his blogs at bizblogs.nctimes.com.

SOURCE: http://www.nctimes.com/business/article_7c49ef56-a04f-5cad-98cc-1b99790dc223.html

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Decitabine may target ovarian CSCs?

§ June 14th, 2010 § Filed under Nano Medicine Comments Off on Decitabine may target ovarian CSCs?

Two-Drug Phase I Trial Shows Promise in Treating Late-Stage Ovarian Cancer, ScienceDaily, June 13, 2010. Excerpt:

“Our hypothesis is that decitabine isn’t just targeting active ovarian cancer cells, but also cancer stem cells that seem to survive the first treatments,” [Kenneth] Nephew said. “By keeping tumor suppression genes from being methylated, carboplatin and other platinum-based treatments for ovarian cancer have a better chance of success in the late stages.”

This news release is about the publication entitled: A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer by Fang Fang, Curt Balch and 9 co-authors, including Kenneth P Nephew and Daniela E Matei, Cancer 2010(Jun 8) [Epub ahead of print].

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The changing face of PR and why it matters to regenmed

§ June 12th, 2010 § Filed under Nano Medicine Comments Off on The changing face of PR and why it matters to regenmed

This may seem a little off-topic for those who don’t know me but for those of you who do, you’ll know this is a little mix of many of my primary loves – cell therapy/regenerative medicine, communications/public relations, social media, and all things internet/technology.

This is a reprint (with permission) of an article I was invited to write for the 2009 World Stem Cell Report.

______________________________________________________________________

If you’re breathing, you’re in PR [1]
Some Do’s and Don’ts and 2.0s for orgs/co’s in cell therapy & ReGEN

You may be one of them. The scientist who can’t get the job or promotion you want. The company not securing customers fast enough. The investigator not finding collaborators. The company not finding quality employees. The company failing to secure much needed investment. The big company not effectively penetrating new, niche markets like cell therapy-regenerative medicine. The executive or investigator not getting the speaking invites to create the buzz needed to help move things forward.

Whatever the challenge, consider a healthy dose of marcom. [2]

Ok, I’m biased and it certainly isn’t a single panacea for all these problems, but seriously. A good profile (personal or corporate) – built from a solid reputation and strong relationship network – can help address almost any challenge you or your company is facing.

INTRODUCTION

I know. You don’t believe me. Humor me and answer this one question. If you could double the number of people that know about your company or technology, the number of people that learn, hear, or read something about your research, product or service in the average 30–day period, and/or the number of people that interact with one of your employees or colleagues every week, would that – on the whole – likely help or hinder you in addressing at least some of the primary challenges you are currently facing?

See where I’m going with this? Even if your challenges are deeply scientific or technical, is it possible to imagine that if only you knew the right person …?

Your existence depends on human interaction. Your success depends on how well you interact and the impressions you make. The impressions are not solely or even primarily driven by the brilliance of your technology or the compelling weight of your data. This is likely more true than you may think. For those of you who have read Malcolm Gladwell’s book, Blink, you will appreciate just how much people’s perceptions are influenced not by logic, data, or comprehensive consideration but by the judgments of the subconscious in a matter of seconds.

The PR (public relations) I discuss in the following pages is not spin and it’s not advertising. It’s about establishing and maintaining relationships that result in profile among your various kinds of constituents be they your collaborators, peers, investors, employers, employees, customers, or potential strategic partners.

Successful people and companies use effective PR to create relationships, turn them into interactive networks, and then leverage them to help solve the challenges they face.

This has always been true. What are so radically changing today are the tools which people and companies can now employ to conduct effective PR, create relationships, and build networks all at a fraction of the cost, with greater returns, and performed by individuals or small companies not previously capable of affecting global impact. These tools are, of course, online.

A successful strategy for PR is now increasingly determined by how well online tools are employed to engage in conversation, create relationships, and build profile.

As it turns out, there are, in my opinion, too few people in this industry who, as yet, understand the power of PR and fewer still who understand the potential of web2.0 to change their fate.

What I will share with you in the next couple pages is:

1. why if you’re breathing, you’re in PR – if you can’t avoid it (and I don’t recommend you try), you should learn to embrace it;

2. the cost of dodging the embrace; and

3. how you can embrace it.

POINT #1: YOU’RE IN PR. REALLY.

There are a zillion reasons why you underestimate the importance of PR in your career or to your company. There are a zillion other reasons why you think online social media is irrelevant to what you do. Let’s look at five.

1. My company is a research-based, early-stage company conserving burn-rate, with few employees, and nothing to sell. Ergo we don’t have a need for PR stuff like marketing, communications, or profile building.

There is nothing new but certainly nothing outdated in the adage: Everyone is selling something.

Don’t pretend you have no one to impress, you have nothing to sell, or that content is the only thing that impresses in the science business. If you thing you have nothing to market, you just haven’t figured out what it is yet.

Are you looking to recruit quality people? Do you anticipate needing to find and impress new investors sometime this year or next? Would you be interested in engaging in discussions from parties potentially interested in licensing or acquiring some of your IP? Are you looking to impress potential academic or corporate collaborators? Do or will you need to recruit patients for a clinical trial? Do you need to start educating doctors about the potential of your therapeutic or engage them in giving advice about your trial or product? Would you benefit from increased government funding for cell therapy and regenerative medicine? Do you believe there are policy changes that could be made that would benefit this industry?

A better profile and a wider network of contacts can’t help but help you address these needs. If you have anyone to impress (and everyone does), then you need to be talking with them. Will a bigger and better profile hurt your efforts to find good employees, seduce investors, recruit patients, identify collaborators, secure partners, etc? It’s hard to imagine how.

At the very minimum, as a member of the life sciences industry you have an obligation to get out of your lab and communicate to the world around you about the science you are so passionate about. As President Obama encouraged in his address to the April 27, 2009 National Academy of Sciences [3], we all have a duty to do a better job of engaging the people around us in a discussion about the importance of science and the science we’re doing.

2. My company is a big, public, multi-national company with departments that handle marketing, communications, PR, and advertising. Ergo I don’t need to pay attention to these things because they do that.

Firstly, unless you have tenure, chances are between now and retirement you may want/need/be recruited for another job. A strong, personal “brand” (profile) is certainly a huge asset in terms of ensuring you are successful in finding that job and negotiating the right remuneration.

Secondly, if you are ever let out of the lab/office or given internet access, you have the capacity to (and likely already) influence your company’s profile and brand. You are either complementing or distracting from your company’s primary messages and brand.

Thirdly, if you care about your company’s success, don’t assume your company’s department or external marcom firm is doing what needs to be done. Investor relations, marketing and communications firms or departments may be good at investor relations, marketing, and communications but that doesn’t necessarily mean they are good at the kind of profile building that is going to attract and support meaningful business development opportunities or potential investigators, customers, licensees, collaborators, employees, or clinical trial patients.

Finally, too many big companies haven’t yet figured out how or how to successfully use Social Media. If you’re using Social Media (e.g., Facebook, Twitter, FriendFeed, Digg, etc), you might be able to play a leadership role in being the face of your company on these platforms – just don’t do it without permission!

3. My company is a science-based company with a technical sale to scientists who are not receptive to glitzy marketing, advertising, PR, and-the-like. Ergo there is little ROI on spending money on these kinds of things. We don’t “do” marketing.

You may be in a company that believes putting out press releases is an unnecessary distraction from the business of science; or the company that believes that communications is something done only big companies, public companies, stock hustlers, or companies with something to sell.

Wrong. First you’re working on the assumption that all marketing looks like a drug ad.

Second your target audience is human. Humans are susceptible to having their perceptions influenced via all the usual means. Even if you don’t want to look at it so crassly, you would have to agree they are susceptible to forming more positive impressions of your company or product if information about it is available, packaged nicely, and easily accessible. You would also have to agree that any impression or sale is easier to make when there is a personal relationship/contact.

Your network is one of your most valuable assets to you and to your company. Building a global network and industry profile is marketing under what ever name you want to call it.

4. All this web 2.0 and social media stuff is for tech geeks and kids. They are not my target market and don’t have a critical mass of the kinds of people I need to building profile among.

Let’s assume for a moment, this is true. If you’re looking to be an attractive employer to potential, young employees you may want to reconsider.

Secondly, young people grow up and become industry leaders and executives. Is it too early to start shaping their perceptions?

Thirdly, there is the occasional executive that is actually occasionally influenced by input from their younger employees. I know – it’s crazy!

Furthermore, it’s not true. For example, I have a very high percentage of c-level executives on my LinkedIn Cell Therapy Industry Group, Jim Till who proved the existence of the stem cell in his ground-breaking nature paper in 1963, is an active poster on Twitter, and the average age of social media users is much older than you believe – check your data.

5. Twitter-schmitter. Today’s social media sites are tomorrow’s relics. They’re all hype when they launch and then they fall out of favor and are no longer useful. I’m a serious business professional with no time or need for these gimmicks that have no real business applications or executives like me on them.

If you think LinkedIn, Twitter, or Facebook (my three favorite and most used social media sites) are not going to be around and successful for long enough to have a real impact on your business, you’re definitely one to bet against the odds.

If you think serious business is not being done and useful business connections being made on these sites (see the last paragraph in the point above), you’re dead wrong. I’ve found customers, employees, and collaborators for my customers using social media in addition to getting them speaking engagements and highlighted in publications.

The point? Everyone has some kind of PR (marketing, communications, profile building, networking, advertising, community participation, publishing, speaking, etc) to do. Your potential audience, network, and impact are all much bigger than likely believe to be true.

My guess? You have more than likely significantly underestimated the value of engaging in PR. And, you have likely significantly overestimated the time and financial cost of engaging in PR.

That brings me to Point #2.

POINT #2: THERE IS A REAL COST TO YOU AND YOUR COMPANY IN PRETENDING YOU DON’T DO OR NEED TO DO PR.

All I should really have to do here is refer you back to point #1. The benefits of engaging in PR are the costs for not. Nevertheless, I will briefly expound.

Your next job, employee, collaboration, investor, customer, patient, etc will be influenced by the profile of you and/or your company. While your CV – comprised of its peer-reviewed publications, presentations, and collegial references – is still an important driver in people’s perceptions in our industry what often makes someone or some company stand out among the others (perhaps even imperceptibly) is the overall profile one has created. One’s profile is increasingly judged online.

That brings me to revise Point #2 to the following:

There is a real cost to you and your company in pretending you can/should ignore the PR power of web2.0’s social media.

I’m going to steal now from my October 2008 blog posting on the subject. [4]

Only a few minutes ago (relatively speaking in the passage of time) most companies didn’t think they needed to have a website or a domain name strategy. This seems as foolish now as ignoring social medial will seem in a few minutes from now.

In 1995 – a mere 14 years ago – I was a young associate in a downtown law firm making a pitch to a skeptical management committee at a weekend retreat that the firm needed a website and an email “system”. It was not an easy sell. They “knew” lawyers would never send their own emails and certainly not use it to communicate with clients. Similarly they were convinced a website would likely not bring in any new clients and existing clients would not likely find a website useful.

How quickly they were proven wrong.

We are at a similar technological threshold. Most companies are ignoring the importance of “social media” to their corporate strategy. Most consider using social media an unnecessary “luxury” in exactly the same way websites, domain names, and email were considered by people in their positions only a few years ago. They do not understand how social media is already changing the way they do business, the importance of staking position/profile early, nor the pain they will feel in the very near future for having failed to be proactive in building and leveraging online communities.

This is very understandable. In times of fiscal constraint one tends to focus on that which hurt you yesterday or causes you the most pain today. Nonetheless, the companies that will succeed tomorrow are looking at tomorrow now and preparing for it. Tomorrow’s mainstream business activities involve social media as much as today’s involves website and email.

For those thinking that this will be true only for businesses that deal direct with the retail consumer, they’re dead wrong. If you have a constituency that you need to keep informed about and actively engaged in your company, then this applies to you. Whether its business (B2B) customers, investors, media, patients, recruits, employees, or collaborators, they are online and engaging in social media. If you’re not there, they’re listening to and engaging with someone else.

LinkedIn now has 42 million members with 1,945,047 members who identify themselves in biotech, pharma, or healthcare. Some 300,000+ of them are in biotechnology. There are 293 biotechnology groups in LinkedIn and 375 biotechnology groups on Facebook. The LinkedIn cell therapy industry group has 400+ members engaging in active discussions and exchanges of information in the public forum and using the platform to make and strengthen connections offline.

Bottom line? There are so many different kinds of social media out there that can be used to reach so many different kinds of audiences at a fraction of the cost of traditional media that it’s just good business to figure out how to use it to your advantage. In fact, you may be feeling the pain of ignoring it already and just don’t know it…

Which brings me to point #3.

POINT #3: WEB 2.0 HAS PUT THE ABILITY TO DO EFFECTIVE, LOW-COST PR IN YOUR HANDS. THERE ARE NO MORE GATEKEEPERS.

The internet has blown the sense of community up and redefined it. Gone are the days when it was feared the web would destroy “community”. Instead web 2.0 is all about creating more and larger communities than we ever thought possible eliminating all kinds of barriers and cutting across all kinds of definitions.

It used to be (before web 2.0) that corporate profile, marketing, communications, PR, advertising was all quite carefully controlled by managing the one-way push of information to the open receptacles we called “readers” or “audience”. If you wanted a global profile, you needed a global PR firm.

Just like the internet has taken the magic out of the business of travel agents, web 2.0 has forever changed the grip that marketing, communications and PR firms had on the business of managing global corporate profiles. Similarly, a global profile is no longer only the purview of companies sufficiently large to retain the services of such firms or have big, internal PR departments.

Just as the information on how to build long-range missiles is no longer the exclusive domain of rocket scientists, with the empowering tools of web 2.0, successful marcom can now be effectively done by subject-matter experts who are not big-budget marcom professionals.

It’s why newspaper are dying and bloggers are thriving. It’s why small companies are building niche profiles that beat out their Fortune 500 competitors. It’s why startups can have a global profile in weeks on next-to-no budget.

All of that is a rather lengthy introduction to primary point of this article:

In this new world of interconnectedness and easy-to-access information, it is easier than ever for everyone and anyone to influence the profile of a company and what it is offering to the world. That’s the good news. The bad news is that you are expected to. All of which leads to one not-so-original observation of the impact of web 2.0 on companies.

If you’re breathing with an internet connection, you can and should have significant and immediate impact on the awareness and perceptions of your company among people around the globe.

If you’re not creating global awareness and positive perceptions, it may be assumed you’re terminally short of breath.

Like it or not. You can’t help it and you certainly can’t avoid it. And the people forming these perceptions are not just the potential customers of companies with something to sell – they’re current or potential investors, partners, collaborators, patients, purchasers, journalists, regulators, policy-makers, employees, employers, etc.

LIGHTS, CAMERA, ACTION

So what can you do to begin leveraging the power of the PR tools at your fingertips and turn a bungalow profile into a chateau; a respectable list of contacts into a vibrant, enviable network of relationships?

10 Ways to a Better Profile for RegenMed and Cell Therapy Organizations

I’ll start with some rules that apply regardless of the PR platform you’re employing (e.g., traditional ones like conference presentations or journal publications or web2.0 ones like blogging or social networking).

1. You need to have a communications strategy and then mandate and empower your people to communicate your message/story to your audiences.

This doesn’t have to be complicated. It’s about defining your primary/secondary audiences, messages, keywords, and tactics to accomplish your primary/secondary goals.

2. Talk about what you’ve done not about what you’re going to do.

It is very rare that news about what you are going to do is really newsworthy. Don’t be tempted to put out a press release that’s not news just because you haven’t put one out in awhile. For example, a press release that your executive is going to speak at a conference is not news unless they are presenting new data or they are the keynote at the biggest conference of the year. That doesn’t mean you can’t post it on your website or let your network know in other ways but the press release should be used judiciously.

3. Make sure you tell the market story not just the science story. Similarly, be clear about what problem your technology solves not just how brilliant it is.

4. Be upfront about the limitations of your product/service. Don’t try to pretend you have the perfect product/service. Don’t try to be everything to everyone – defining who you are (your company and its product/service profile) is just as much what about what it is than what it is not.

5. Avoid the temptation to promise when you will do something by (e.g., begin or end your trial, submit your IND, launch your product, etc) unless it’s the subject of a contractual obligation. There are too many unknowns that may prevent you from meeting the expectation you created. The ensuing disappointment will hurt your profile and perceptions of your company and its product/service and management.

6. Don’t over communicate your regulatory interactions with the FDA – this is one area where the less said is often better.

7. Wait on that hiring announcements just a little while. It’s critically damaging to put out a press release that now has a very, long online life outside of your control announcing the hire of a key executive only to have him/her not last beyond the first few weeks.

8. Understand that communications, marketing and profile building are very different from advertising. Act accordingly.

9. Value the untapped potential of your existing customers and prospects to spread your gospel.

One of the real discoveries from social media is the alarming willingness of people to zealously proselytize on behalf of companies and products win which they believe. Find ways to actively engage them in doing so. [5]

10. Engage online.

The 8-step Plan to Enhance your Online Profile and Network

1. SEO.

If you’ve decided your profile matters, then your online profile really matters. The fastest way to an impressive online profile is Search Engine Optimization. There are a lot of tricks up the SEO tricksters sleeve and I’m not about to give them all away but suffice it to say that SEO is a multi-pronged attack and there are many arrows in the quiver each with a different use to the same end: higher rankings on the major search engines = increased traffic to the website = greater profile = whatever your end goal is (sales, investors, collaborations, changing the world, etc).

2. Listen & Monitor.

Whether you employ Google Alerts, Twitter search tools, or simple subscriptions to topical news services or blogs, there is a lot of content and discussions being added to the internet every day. You will likely be amazed how much (or how shockingly little) your company and product/service is being discussed and who is behind the discussions. Listening to and reading what’s going on the internet will get you intel about your competitors, new ideas for potential products or studies, new leads for potential collaborators or customers, etc.

3. Follow/Subscribe.

Find your favorite content providers, writers, resources, publications, etc and follow or subscribe to the content their pushing out and discussions they are leading.

4. Join

There’s no harm in joining. People join for all different reasons. There’s no problem in being an observer. In fact it’s likely best you just observe for a while after you join to assess the flavor of the group and discussion so when you do participate you don’t offend.

5. Participate

Once you’re comfortable, start to participate. Engage in discussion, exchange information, and above all make sure you are providing value to the other participants not just talking about yourself. This will be punished.

6. Connect (yourself and others)

There’s a reason why these are called online networks or communities. Use them to connect with people not just for the sake of building a bigger ‘friends’ list but because you have something in common and want to begin building a relationship.

7. Create

Be original. Create something of value you can share. That might just be facilitating a channel in which 3rd party information is exchanged. It might be you writing original content. It might be facilitating introductions.

8. Enjoy and don’t offend.

Most importantly find the online networks that you enjoy, that give something of value to you, then contribute value in return and ensure you don’t offend the rules. Nothing slaps harder than an online, viral slap from a community you’ve offended online. [6]

CONCLUSION

Don’t pretend you have no one to impress. Everyone needs to engage in PR.

Even in the business of science, man cannot live on data alone. You need more than just solid content to affect the kind of impressions that will be critical to your success. Don’t let your data or career speak for itself – it can’t talk.

Web 2.0 has made it exponentially easier – if not expected – to engage in PR and profile building.

What’s missing from this article is the web 2.0 tools I’d recommend you use to put the 8-step plan in place. For that, watch here for further blog postings on the subject. See what I did there?



[1] In this article, I use “PR” not to mean “public relations” as you may have come to understand it used but rather simply to mean any kind of relating to the public via marketing, communications, writing, profile building, networking, advertising, community participation, publishing, speaking, proselytizing, lobbying, etc. It’s a not-so-dirty little secret that we all do it in one form or another or several all at once.


[2] Marketing & communications


[3] See http://www.youtube.com/watch?v=k5-MgZD5IMc at around the 30 minute mark.

[4] Oh, I haven’t mentioned my blog? It’s at http://www.celltherapyblog.com/. Of course if you are a subscriber, this will be a refresher. For those who haven’t read this on my blog, you would have benefited from reading these same thoughts back in October 2008 if you had been a blog subscriber, or if you followed me on Twitter (I’m @celltherapy) or if you were connected with me on LinkedIn (http://www.linkedin.com/in/celltherapy). I’m just saying…


[5] One the flip side these same people will use these same tools to punish companies mercilessly for offending them or the rules of social media.


[6] Just ask Johnson & Johnson about the power of mommy bloggers. Look it up.



http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com
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International Stem Cell Corporation Announces Company Update Conference Call. ISCO Chairman Kenneth Aldrich to Discuss ‘Status of the Company’

§ June 10th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation Announces Company Update Conference Call. ISCO Chairman Kenneth Aldrich to Discuss ‘Status of the Company’

International Stem Cell Corporation (OTCBB:ISCO), a California-based biotechnology company creating human stem cell lines through its patented parthenogenetic process that requires no use of fertilized embryos, today announced that it is has scheduled a conference call for June 15, 2010 at 10:00 a.m. PST. ISCO Chairman, Mr. Kenneth Aldrich will discuss the Company’s newly issued patent, its recently completed financing, and the present status of the company and its vision for the coming year. The dial-in number for participants is 1 (800) 774-6070 and the pass code ID is 8273 225#. An alternate dial-in number is: 1 (630) 691-2753 and the pass code will be the same for both numbers. A replay of the call will be available on the home page of the company’s web site at: http://www.internationalstemcell.com.

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB)

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells (hpSCs) from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCellTM, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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International Stem Cell Corporation’s Parthenogenetic Stem Cell Patent is Approved by the United States Patent and Trademark Office

§ June 9th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation’s Parthenogenetic Stem Cell Patent is Approved by the United States Patent and Trademark Office

International Stem Cell Corporation (OTCBB:ISCO), http://www.intlstemcell.com, announced today that the United States Patent and Trademark Office (USPTO) has granted ISCO patent number 7,732,202, the first of several pending patents relating to its development of human parthenogenetic Stem Cells (hpSC). Human parthenogenetic stem cells are a new type of pluripotent stem cell that allows immune matching to potentially solve critical immune rejection problems, and does not involve the ethical issues that surround the use of fertilized human embryos.

Although ISCO’s creation of human parthenogenetic stem cells was first announced in a peer review publication in 2007, the formal allowance of claims by the USPTO will greatly advance the field of regenerative medicine by allowing ISCO to share its knowledge of these hpSC lines more freely with researchers in the US and around the world through partnerships, joint ventures, funded research and licensing arrangements.

The patent protects ISCO’s technology platform, allowing the creation of hpSC from unfertilized eggs, exhibiting similar qualities and pluripotency as embryonic stem cells, with the added ability to be immune-matched to the donor, as illustrated in published peer-reviewed articles. Additional discoveries, also previously published in a peer reviewed journal and the subject of pending ISCO patents, illustrate the creation of ‘homozygous’ hpSC that can be immune matched to millions of persons of differing sexes and racial backgrounds, rather than only to the donor or her family, raising the potential of eventually creating a universal source of stem cells that could benefit most the of the world’s population.

Researchers across the world work with ISCO to study different therapeutic applications of hpSC. Through previously announced collaborative arrangements, ISCO’s scientists are working with major universities and private research organizations to study hpSC to treat liver disease, diabetes, Age-related Macular Degeneration (AMD), corneal blindness and various neural degenerative diseases. In one such research collaboration, internationally-recognized stem cell researcher Hans Keirstead, PhD, at the Reeve-Irvine Research Center (University of California, Irvine), recently published a paper, referring to his use of embryonic stem cells and ISCO’s hpSC in work focused on the derivation of early retinal progenitor tissue.

Andrey Semechkin, PhD, CEO of ISCO said, ‘Other than parthenogenetic stem cells, the three most commonly used and described types of stem cells are human embryonic stem cells (hESC), induced pluripotent stem cells (iPS), and adult stem cells, such as those derived from cord blood, adipose tissue or bone marrow. Parthenogenetic stem cells have unique advantages over each of these other cell types, and we anticipate that since our core patent has been issued, we can now accelerate the adoption of our hpSC lines by researchers in the US and throughout the world.’

‘International Stem Cell Corporation is particularly proud of these accomplishments because we have been funded thus far entirely by investors, without NIH or other governmental aid,’ said Jeffrey Janus, Senior Vice President of ISCO. ‘However, once it is generally recognized that parthenogenetic cells have similar characteristics of embryonic stem cells and offer the potential to solve critical immune rejection issues – while not requiring the destruction of viable human embryos – we expect these cells to be increasingly used in government funded research to study ways of reducing human suffering and treating intractable human diseases.’

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell(TM), while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” ” anticipates,” “expects,” “estimates,”) should also be considered to be forward- looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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CSCs responsible for metastasis identified

§ June 6th, 2010 § Filed under Nano Medicine Comments Off on CSCs responsible for metastasis identified

Cancer stem cells responsible for metastasis identified: HK study, Xinhua News Agency, June 4, 2010. Excerpt:

Hong Kong researchers have identified a subset of cancer stem cells responsible for metastasis in human colorectal cancer which can help better predict the prognosis and design a more suitable treatment for patients, according to a study made public by the University of Hong Kong on Friday.

The researchers from the university’s medicine school discovered that cancer stem cells with a surface marker CD26, which marks a subset of cancer stem cells with metastatic capacity, are present in all terminal colon cancer cells and all metastatic cancer cells.

This news item is about the publication: A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer by Roberta Pang and 13 co-authors, including Wai Lun Law, Ronnie T Poon and Benjamin CY Wong [photos of authors], Cell Stem Cell 2010(Jun 4); 6(6): 603-15. [Summary][Twitter entry][Commentary][FriendFeed entry][Science Pond entry].

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Phase I clinical trial of ICT-107

§ June 3rd, 2010 § Filed under Nano Medicine Comments Off on Phase I clinical trial of ICT-107

Immune response correlation with progression-free survival in glioblastoma following dendritic cell immunotherapy (ICT-107) by Surasak Phuphanich and 9 co-authors, including Manish Singh, Keith Black and John Wu, J Clin Oncol 28:7s, 2010 (suppl; abstr 2097). To be presented at the 2010 ASCO Annual Meeting, June 06, 2010.

Related news releases:

ImmunoCellular Therapeutics Ltd. (IMUC) to Present Cancer Vaccine Candidate, International Business Times, June 02, 2010. Excerpt:

Data from the company’s recent clinical trial of ICT-107, the company’s dendritic cell-based cancer vaccine candidate, will be presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) June 4-8 in Chicago.

See also: Immunocellular brain cancer vaccine shows promise, Reuters, June 02, 2010. Excerpt:

“We are targeting specific antigens that are on cancer stem cells … the only population of cells that can really propagate a tumor,” said Dr. John Yu, director of surgical neuro-oncology at Cedars-Sinai Medical Center in Los Angeles and ImmunoCellular’s chief scientific officer.

Another related news release: Immunocellular Therapeutics Enters into Research Agreement with University of Pennsylvania to Support Phase II Clinical Trial of ICT-107, Business Wire, April 21, 2010.

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8 Tips to Avoid Summer Party Weight Gain

§ June 2nd, 2010 § Filed under Nano Medicine Comments Off on 8 Tips to Avoid Summer Party Weight Gain

Weight Loss Fat Loss Lose Weight Avoid summer weight gain Healthy Eating Salad Recipes BBQ Recipes Lose weight How to lose weightWhy do we love summer so much? Could it be the hot lazy days, the bright skies, the time spent outdoors running, cycling or playing tennis? Or, could it be the food? Yes, the food. It could, quite possibly, be the food.

Summer is the season of picnics, bbqs and social events that evolve around food and, lest we forget, drinks. Delicious, colorful, aromatic dishes and cold refreshing cocktails with decorative multi-colored miniature paper umbrellas. More often than not, these events will include high fat, calorie laden foods and drinks that are hard to resist. Even the most disciplined of eaters may find him or her selves reaching for another helping. It’s no surprise then that summer eating can lead to summer weight gain.

When we consume more energy than we expend, our bodies store the extra calories as fat. A common misconception in summer is that we think we can afford to eat more because we are more active. True, we do tend to take part in more outdoor physical activities in the summer, but a jog in the park may not burn the thousands, yes thousands, of extra calories we devoured at last night’s pool party. Underestimating the number of calories we consume at our summer functions, is the reason why we start to see the number on the scale creep upwards.

The good news is that we do not have to sacrifice summer socializing to keep our bodies at a healthy weight. With a few simple strategies in place we can still enjoy summer festivities without packing on the pounds:

Keep a Food and Exercise Journal

Recording your physical activity and everything you eat and drink every day is an excellent way to help maintain your weight. It’s easier now than ever, thanks to hand-held computer devices and cell phones that offer software applications to help you keep note. Review your journal before you go out to a summer social. If you’ve already eaten more than you should for the day and missed your morning workout, you might be more conscience of what you will eat at the event. Likewise, if you have been particularly careful about your food choices all week, you might decide it’s okay to indulge just a little. Either way, journaling will make you more mindful of what you eat and this will help you choose what is right for you.

Make the Company your Focus

Before you head out to your event, mentally prepare yourself to be sociable. Be prepared to mingle and converse with everyone. If you put your energy into the people there rather than what is laid out on the buffet table you might have less time to grab a second helping or pick at the party chips—after all, it’s hard to socialize with a mouth full of food. This by no means suggests that you shouldn’t eat anything! You wouldn’t want to offend your host or go home hungry. Eat until you feel satiated and the meal portion of the event seems to be dwindling down, then step away from the food and start chatting up a storm with another guest. And, if the event calls for dancing, swimming, or a sport activity of some kind, get moving once you have given your food time to digest.

Do your Homework

We all have our weakness. For some it may be ice cream, for others it could be fried chicken. Whatever your secret indulgence is, find out how many calories, fat and sodium is contained in a single serving. Armed with this knowledge, you might be dissuaded from taking a second helping, or you might even skip the food altogether and choose a healthier option instead.

Be a Healthy Host

Planning, cooking and cleaning up before and after an event can be a lot of work. But, the single best benefit about hosting a summer party is that you get complete control over the menu. Create mouth watering dishes using seasonal fruits and vegetables, low fat protein and smart healthy fats. Even traditional bbq favourites like potato or pasta salad can be modified to decrease the fat and calorie content by simply switching to a homemade oil, vinegar and herb dressing rather than prepared mayonnaise. Be sure to lay out platters of fiber-filling raw fruits and vegetables instead of chips or crackers for an easy low calorie grab-and-go snack. Your table will look spectacular with all the season’s brightly colored foods, and your guests will love the variety.

Bring a Dish

If you are invited to a backyard bbq offer to bring either part of the main dish or a side, rather than dessert or alcohol. Whatever you bring, make sure you create something you like and it’s healthy. This way, you can load up on at least one healthy option and take smaller amounts of the not so healthy choices.

Exercise Portion Control

Summer eating should be enjoyable. But, nothing can put a kink in your party spirit more than pulling out your measuring cups at the family get together to ensure you haven’t exceeded your portion sizes. Use your hands as your guides: your fist is equivalent to about one cup; your palm is about 3 ounces; your thumb tip is equal to about 1 teaspoon; and your thumb is about 1 ounce. Remember these estimations when loading up your plate. Another good rule to follow is to fill half your plate with complex carbohydrates such as vegetables, a quarter of your plate with lean protein, and the remaining quarter with whole grains.

Don’t drink your Calories

Outdoor summer events can become uncomfortably hot, so it’s important to stay hydrated. Instead of quenching your thirst with alcoholic drinks, fruit juices, soda pop or creamy frozen drinks, reach for water instead. One or two of these other drinks are all right, but anything more than that will add up in the calorie department. Water should be your main drink of choice. If the taste of water is too bland for your party spirit mode, add a squeeze of fresh citrus, some fresh mint or a few handfuls of berries or cucumbers.

Employ the 80:20 Rule

The aim of summer eating (and eating all year round too) should be to eat well at least 80 per cent of the time and reserve only 20 per cent of the time for not so healthy options. It’s okay to indulge once in a while. Don’t beat yourself up if you eat a little more than you should have at last night’s party—guilt is a useless emotion. Besides, with an active lifestyle and a healthy eating program, you shouldn’t see any change in your weight. Today is a new day, enjoy the summer sunshine and have fun.

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International Stem Cell Corporation Moves International Cornea Development Program Forward

§ May 26th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation Moves International Cornea Development Program Forward

International Stem Cell Corporation (OTCBB:ISCO), http://www.intlstemcell.com, today announced significant progress on its international development strategy for stem cell-derived human corneal tissue. Such tissue can potentially be used to replace cadaver-derived corneas in treatment of severe corneal vision impairment and to eliminate the need to use live animals in safety testing of drugs, chemicals and consumer products.

During a recent trip to Asia and Europe, an ISCO senior management team identified and interacted with a group of integrated eye hospitals and ophthalmology research institutions with world-class laboratory facilities, along with potential sources of research funding. One of these is Sankara Nethralaya (http://www.sankaranethralaya.org), one of India’s leading not-for-profit clinical and research organizations dedicated to treatment of eye diseases.

Research during the past ten to fifteen years has demonstrated stem cell differentiation into a variety of human cell types. Rarely has it been possible to produce such integrated, functional human tissue, in this case, tissue that has characteristics compatible with human cornea in structure and function. This tissue technology may offer a first-in-class opportunity for high-quality, cost-efficient transplantation tissue for the 10 million people world-wide suffering from corneal vision impairment, particularly in Asia and Europe. It may also provide a much needed alternative to the use of live and extracted animal eyes in the $500+M market for safety testing of drugs, chemicals and consumer products.

During the coming months, ISCO expects to formalize relationships with a number of entities such as Sankara Nethralaya to provide ISCO’s cornea development program with the scientific, facility and financial resources needed to advance the technology as rapidly as possible to clinical application. The ultimate goal is not only to address the clear unmet medical and safety testing needs, but also to be among the first pluripotent stem cell applications to achieve widespread commercialization.

Dr. Sengamedu Srinivasa Badrinath, President and Chairman Emeritus of Sankara Nethralaya says: ‘At Sankara Nethralaya, we see 1,600 eye patients and do over 100 eye surgeries a day. We employ sixty scientists and clinicians dedicated to the development and application of new state-of-the-art ophthalmic technologies. My senior team at Sankara Nethralaya and I look forward to helping ISCO advance its cornea technology that has potential to significantly reduce the severe quantitative and qualitative limitations in corneal donor tissue across the world today.’

Brian Lundstrom, ISCO’s President, continues: ‘The addition of Sankara Nethralaya to our international collaborative network will contribute substantial scientific and clinical ophthalmology expertise and resources and complement the instrumentation alliance with The Automation Partnership and the safety testing collaboration with Absorptions Systems. The next step is to organize an experienced therapeutic development team to establish the optimal development path with relevant regulatory authorities and create data needed to advance ISCO’s stem cell-derived corneal tissue into clinical trials.’

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human parthenogenetic stem cells (hpSCs) from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website,
http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS
Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “should,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-640-6383
bl@intlstemcell.com

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Biotech tax credit appears perfectly designed for cell therapy companies to recoup research dollars spent in 2009-10

§ May 22nd, 2010 § Filed under Nano Medicine Comments Off on Biotech tax credit appears perfectly designed for cell therapy companies to recoup research dollars spent in 2009-10

Stewart Lyman of Lyman BioPharma Consulting posted a great article in today’s Xconomy summarizing some key points and links to more information about the rules governing the Therapeutic Discovery Project Credit which have now been released by the US Treasury Department. Today, a detailed fact sheet was released about the tax credit program and it seems almost perfectly designed for most cell therapy companies.

Lyman points out a few important details about the application schedule including:

1. The Formal IRS applications (Form 8942) will not be available until June 21st or thereabouts.

2. The application period opens on June 21 and ends on July 21. The postmark on the application is deemed to be the date of delivery. Preliminary review of the applications is to be completed by Sept. 30; this is to ensure that applicants are eligible taxpayers and that their applications are complete. Applicants will receive determinations as to whether or not they qualify for credits and/or grants, and how much they will receive, by Oct. 29.

By way of a little more background, the following is excerpted from a March Forbes.com article by Dean Zerbe:

What does the credit cover?

The credit/grant covers research in tax years beginning in 2009 and 2010. The taxpayer is provided a 50% credit/grant for qualified investments in “qualifying therapeutic discovery projects.” What expenses count as qualified investments? The aggregate amount of costs paid or incurred in the taxable year for expenses necessary for and directly related to the conduct of a qualifying discovery project. What doesn’t count? The pay of employees covered by 162(m)(3) of the tax code–think CEOs–doesn’t count. Other excluded items: interest expenses; facility maintenance expenses (e.g. mortgage or rent payments, insurance, utility and maintenance and costs of employment of maintenance personnel); and certain indirect costs (basically general and administrative costs) as defined in the Treasury Regulations at 1.263A-1(e)(4).

What is a qualifying therapeutic discovery project?

According to the legislation, it’s a project designed to do one of three things:

–Treat or prevent diseases or conditions by conducting pre-clinical activities, clinical trials and clinical studies, or carrying out research protocols for the purpose of securing federal government approval by the FDA.

–Diagnose diseases or conditions or to determine molecular factors related to diseases or conditions by developing molecular diagnostics to guide therapeutic decisions.

–Develop a product, process or technology to further the delivery or administration of therapeutics.

Finally, to qualify, a venture may not have more than 250 employees in all businesses of the taxpayer–meaning a small biotech project at a big company wouldn’t qualify.

Which biotech companies might benefit?

Those that are investing significant resources in pre-clinical or clinical studies, which may take years to come to fruition to ultimately satisfy FDA requirements, could now recoup a significant portion of their expenses. Additionally, biotech start-ups focusing on the development of diagnostic assays or applications to advance therapeutics and treatments can also benefit. Finally, companies currently engaged in basic or applied research which may ultimately contribute to curing caner within the next 30 years may also be excellent candidates. Along these lines, companies studying signal transduction pathways, gene therapy and stem cell research seem like prime candidates.

The Cell Therapy Group will be collecting more information about the tax credit and service providers who might be recommended to assist in the application if needed. Contact CTG for more details or watch here for more information.

http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com
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An evolving concept of CSC in tumor biology

§ May 21st, 2010 § Filed under Nano Medicine Comments Off on An evolving concept of CSC in tumor biology

An evolving concept of cancer stem cells in tumor biology: a lecture (34:38 min) by Jeremy N Rich. Webcast of the initial presentation at an Educational Session on Cancer Stem Cells and Treatment Resistance, AACR 101st Annual Meeting, April 17, 2010. [FriendFeed entry].

Comment: Dr. Rich’s research has a primary emphasis on Glioma Cancer Stem Cell and Brain Tumors. An example of a recent publication: Integrin Alpha 6 Regulates Glioblastoma Stem Cells by Justin D Lathia and 10 co-authors, including Jeremy N Rich, Cell Stem Cell 2010(May 7); 6(5): 421-32. [PubMed citation][FriendFeed entry].

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International Stem Cell Corporation and The Automation Partnership Enter into Strategic Alliance to Automate Cornea Tissue Production

§ May 19th, 2010 § Filed under Nano Medicine Comments Off on International Stem Cell Corporation and The Automation Partnership Enter into Strategic Alliance to Automate Cornea Tissue Production

OCEANSIDE, CA – May 18, 2010 – International Stem Cell Corporation (ISCO.OB), http://www.intlstemcell.com, announced today that it had entered into a strategic alliance with The Automation Partnership (TAP), http://www.automationpartnership.com, to automate and scale up the production of stem cell-derived human corneal tissue. The alliance has been formed to create instrumentation for ISCO and its partners and affiliates to produce development and commercial volumes of donor tissue for cornea transplantation and to reduce the use of animals and animal eyes in safety testing of drugs, chemicals and consumer products.

Cornea-related loss or reduction of vision can be caused by physical injury, infections and degenerative diseases. In cases where cornea replacement is indicated, current medical practice typically involves a one-two hour outpatient procedure under local anesthesia using full or partial corneas from healthy human cadavers. 10 million people worldwide are candidates for such treatment, primarily in Asia and Europe where there is significant quantitative and qualitative shortage of human cornea donation.

Global efforts are underway to transition from the use of live animals and excised animal eyes to test drugs, chemicals and consumer products. For example, Europe’s Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) estimates a need to spend €270M and use 160,000 animals for eye safety testing alone to catch up with the back-log of insufficiently tested agents. In the US, the National Institutes of Health (NIH) and the Environmental Protection Agency (EPA) have launched a five-year program dedicated to finding new, non-animal technologies for toxicity testing of chemical compounds.

ISCO has discovered and filed for patents on a cell culture process for the synthesis of standardized, human, corneal tissue using stem cells. Histology, permeability and optical testing has demonstrated compatibility with natural corneas. Efforts are ongoing to further characterize this tissue and standardize and scale up its synthesis. Automation is necessary to produce sufficient, reproducible tissue for development and commercialization of the therapeutic and toxicity testing applications.

Brian Lundstrom, ISCO’s President, says: “Given the substantial unmet therapeutic and toxicology testing needs for human corneal tissue, ISCO has embarked on a focused effort to advance this technology with international investors, eye clinics, and development and commercialization partners. After reviewing a range of potential cell culture automation companies, we are very pleased that TAP has agreed to contribute their over twenty years of experience towards this goal.”

David Newble, TAP’s CEO says: “TAP has successfully installed and supported over 160 automated cell culture systems worldwide and continues to design new and customize existing equipment for cell culture and other emerging life science applications. The opportunity to join forces with ISCO in the cornea tissue area will enable us to contribute solutions for clear biomedical needs while also creating new technology and knowhow that will be useful in other applications downstream.”

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB):
International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO’s core technology, parthenogenesis, results in creation of pluripotent human stem cells (hpSCs) from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells with minimal immune rejection after transplantation into hundreds of millions of individuals of differing sexes, ages and racial groups. This offers the potential to create the first true stem cell bank, UniStemCell™, while avoiding the ethical issue of using fertilized eggs. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology. More information is available at ISCO’s website,
http://www.internationalstemcell.com

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

About The Automation Partnership
The Automation Partnership (TAP) provides advanced automation systems and services to improve productivity in life science research, development and production.


For over 20 years TAP has been the leader in the design and development of automated cell culture and processing systems with applications in regenerative medicine, discovery research, bioprocess development and biologics production. Systems include SelecT, CompacT SelecT and Cellmate.

In addition, TAP has a strong track record in providing a range of custom automation solutions for biobanking, biological sample management, compound management and advanced high throughput screening applications.

TAP is a privately-owned company with headquarters near Cambridge, UK and a sales and support facility near Wilmington, Delaware, USA.

FORWARD-LOOKING STATEMENTS
Statements pertaining to anticipated technological developments and therapeutic applications, and other opportunities for the company and its subsidiary, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “should,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company’s business, particularly those mentioned in the cautionary statements found in the company’s Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements.

Key Words: Stem Cells, Biotechnology, Parthenogenesis

CONTACTS:
International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
760-940-6383
kaldrich@intlstemcell.com
Or
Brian Lundstrom, President
760-940-6383
bl@intlstemcell.com
Or
The Automation Partnership
Matthew Walker
Head of Communications
+44 1763 227 200
Matthew.walker@automationpartnership.com

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US Patent: Isolation and use of solid tumor stem cells

§ May 18th, 2010 § Filed under Nano Medicine Comments Off on US Patent: Isolation and use of solid tumor stem cells

Isolation and use of solid tumor stem cells, United States Patent 7,713,710. [FreePatentsOnline][PatentStorm].
Publication Date: May 11, 2010.
Inventors: Clarke; Michael F. (Ann Arbor, MI), Morrison; Sean J. (Ann Arbor, MI), Wicha; Max S. (Ann Arbor, MI), Al-Hajj; Muhammad (Ann Arbor, MI).
Assignee: The Regents of the University of Michigan (Ann Arbor, MI) .
Appl. No.: 11/753,191
Filed: May 24, 2007
Abstract:

A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. The solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

Parent Case Text:

CLAIM OF PRIORITY
This application is a Continuation of U.S. patent application Ser. No. 11/150,073, filed Jun. 10, 2005, which is a Continuation of U.S. patent application Ser. No. 09/920,517, filed Aug. 1, 2001, now U.S. Pat. No. 6,984,522, which claims priority to U.S. provisional applications Ser. No. 60/222,794, filed Aug. 3, 2000, and Ser. No. 60/240,317, filed Oct. 13, 2000, all of which are herein incorporated by reference in their entireties.

Google patents entry for Application Number 11/753,191 (The application that led to patent 7,713,710. The filing date was 24 May 2007).

Google patents entry for Application Number 11/150,073 (See Parent Case Text above: the filing date was 10 June 2005).

Google patents entry for Patent Number 6,984.522 (See Parent Case Text above: the filing date was 1 August, 2001 and the issue date was 10 Jan 2006). [FreePatentsOnline][PatentStorm].

Comment:

Not mentioned in the Parent Case Text above is United States Patent 7,115,360. [FreePatentsOnline][PatentStorm]. This patent was issued October 3, 2006 and filed on August 2, 2001.

The Parent Case Text for patent 7,115,360:

CLAIM OF PRIORITY
This patent is the United States national stage of PCT patent application PCT/US01/24243, published Feb. 14, 2002 as WO 02/12447, which is a continuation of U.S. Ser. No. 09/920,517, filed Aug. 1, 2001, now U.S. Pat. No. 6,984,522. This patent also claims priority to provisional patent applications U.S. Ser. Nos. 60/222,794, filed Aug. 3, 2000, and 60/240,317, Oct. 13, 2000.

Information about this patent was found via a Google search for “Isolation and use of solid tumor stem cells”.

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Lose Weight & Feel Great this Summer

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Lose Weight & Feel Great this Summer

lose weight weight loss healthy living how to lose weight healthy eating tips how to get a six-pack abdominal muscles flat tummy tighten tummy slim down exercise fat loss lose fatLooking for a way to slim down so you can fit into that bikini? Healthy weight loss isn’t easy, mostly because it requires significant lifestyle changes. But it is possible, and it’s worth it in the long run.

The basic principle of weight loss remains calories in versus calories expended, but if counting calories was the only way to manage weight, with a little willpower, we would all have the physique we desired. The reality is there are many roads to achieving a healthy weight.

Americans eat out about four to five times per week, and all that dining out can put the calorie conscious at an immediate disadvantage. “The plates at any restaurant in America are piled high with food twice to three times the recommended serving size for anyone trying to lose weight,” says Shari Solomon, a holistic nutrition consultant from Boston. Solomon suggests a simple solution that will also help you save money: “When dining out, as soon as you order, ask for an extra plate. When the meal comes, put half of it onto the empty plate and immediately ask the server to wrap it up to go.”

Recognizing appropriate portion sizes and locating hidden calories are also part of Tucson nutritionist Lauren Kanzler’s approach to mindful eating and weight loss. Kanzler helps her clients avoid fad diets by teaching them about whole foods—fruits, vegetables, beans, lean protein, and the healthy omega fats (3s, 6s, and 9s). Taming blood sugar levels by avoiding refined sugars, opting instead for unprocessed carbohydrates with low Glycemic Index (GI) scores helps control appetite and cravings. Choosing low GI carbs—the ones that produce only small fluctuations in our blood glucose and insulin levels—is the secret to reducing your risk of heart disease and diabetes, and is the key to sustainable weight loss.

Certified health and nutrition coach Randi Dukoff of Jericho, New York, says a balanced breakfast is essential. According to Dukoff, breakfast should feature all three macronutrients to jumpstart the metabolism—think two eggs with a cup of blueberries and a slice of Ezekiel bread with a little butter. Breakfast should comprise at least 25 percent of the day’s calories. People who eat breakfast are more successful at losing weight and sticking to a diet, while those who skip the most important meal of the day are more likely to eat unhealthy snacks, experience cravings, and are more prone to binges.

Another constructive tip from Dukoff is to “ditch soda and drink water in the amount of half your body weight in fluid ounces a day.” That amounts to about nine eight-ounce glasses for a 150-pound person. Soda, which Dukoff refers to as “liquid candy,” contributes about 10 percent of the calories in the American diet.

Dukoff encourages crowding out the “fake foods” with eight daily servings of colorful fruit and vegetables. “Take advantage of spring as a time to eat locally and seasonally, and avoid processed foods like high fructose corn syrup and anything else that you can’t pronounce, which lead to weight gain and disrupted insulin.”

Gina Van Luven, a Health and Nutrition Counselor from Park City, Utah agrees. “There is no ‘magic bullet’ for weight loss because everyone’s body is unique.” The most fundamental weight loss principle is to “eat a diet of mostly whole, unprocessed foods, focusing more on vegetables, since those seem most lacking in the American diet.”

Another important thing that might be hampering your success: your fixation on weight. “Throw your scale away,” says Jeanne S. Boone, a professor of nutrition and health at Palm Beach State Collage in Boca Raton. Boone suggests focusing on your behaviors, on eating more healthfully and increasing physical activity. “Instead of thinking about losing weight, focus on becoming more fit, and the weight (fat loss, really) will take care of itself,” she says. For maximum fat burning, workouts should include both cardiovascular and resistance training.

Lastly, adequate sleep is essential to maintaining a healthy weight. Research shows that people who sleep fewer than six hours a night are more prone to obesity. Even one night of sleep deprivation can raise ghrelin levels, increasing hunger and appetite and contributing to obesity.

And don’t forget that healthy weight management takes time. Shantih Coro, a functional diagnostic nutritionist based in Miami, explains that permanent weight loss requires patience, correcting metabolic imbalances, and lifestyle adjustments. “My fat and weight loss program is not quick,” she says. “I know that when you lose weight fast you gain it back fast. When you lose weight on my program you will be making a lifestyle change.”

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Herbs for Weight Loss

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Herbs for Weight Loss

Herbs for Weight Loss Fat loss Lose Weight Green Tea burns fat gain muscle lose fat Toning weight loss goals health and wellness healthy living fennel seed boost metabolism boosting metabolism
In today’s fast paced world men have become more sedentary and unfortunately put on a few extra pounds. If you’re like most men you will find that those extra pounds have found a “home on your belly”, and you just can’t seem to remove them! Once and for all it’s time to send your “excess baggage” on a vacation… But first, I must emphasize that effective weight loss always requires regular exercise and dietary changes. With that being said, there are many different herbs that can be used to help shed those excess pounds by boosting your metabolism, reducing your appetite, increasing your energy levels and promoting lean muscle mass. The following are my top 5 herbs to look for in a weight loss supplement.

Green Tea Extract (GTE)

Research conducted at the University of Geneva in Switzerland found green tea extract helps raise metabolic rates while increasing the oxidation of fat cells. This study also examined caffeine (which is found naturally in GTE) but found that consuming caffeine by itself did not provide the same effects. Nonetheless, in conjunction with the catechins found in green tea, the 10 to 80 mg of caffeine per cup work together to increase thermogenesis. Basically, by consuming green tea, you allow your body to generate more energy from burning unwanted fat. Furthermore, the polyphenols in green tea inhibit the production of the enzyme amylase which in turns limits the amount of sugar absorbed into the bloodstream.

Cha de Bugre

Cha de Bugre is a rainforest herb highly regarded as an effective aid for suppressing the appetite and reducing fat deposits. With Cha de Bugre you feel full after eating just a small amount of food so you end up eating less. You can reduce your overall caloric intake while also enjoying a balanced approach to curbing your appetite. Your metabolism also stays even throughout the day instead of spiking at mealtime. When your metabolism levels remain constant, you can more effectively burn calories because your system isn’t overloaded with carbs and sugars.

Coleus forskohlii

This is the only known plant source of forskolin, a natural compound that increases lean body mass and optimizes body composition. Forskolin, initiates biochemical events in the body that allow fat cells to be utilized as energy and helps the bodysbody’s natural hormones maintain and/or increase lean body mass. Specifically, forskolin activates an enzyme called adenylate cyclase, the main enzyme involved in the production of a significant metabolic molecule called cyclic adenosine monophosphate, or cAMP. cAMP is directly responsible for increasing essential lean mass-building hormones at the expense of non-essential body fat.

Caralluma Fimbriata

Clinical trials done on Slimaluma®, a concentrated form of the plant Caralluma Fimbriata, clearly demonstrated that there was reduction in hunger levels, reduction in weight waist circumference, reduction in fat, and reduction in body weight in the active group of participants. Caralluma Fimbriata is well known in Indian folklore records for its use as a potent appetite suppressant and weight-loss promoter.

Fennel Seed

This plant has a long and celebrated history of cultivation as a weight loss herb. The ancient Greeks called the herb marathon, meaning “to grow thin.” Similarly, ancient Roman women took the herb to help prevent obesity. During the Middle Ages through the Renaissance, people used Fennel Seed to suppress their appetite during periods of fasting or just to manage their weight. Fennel Seed promotes weight loss in several ways by such as actually removing fat cells and mucus from the digestive tract, mildly stimulating the metabolism and suppressing the appetite.

Herbs can be an excellent addition to any weight loss program. Remember, weight loss goals should be realistic and promote a lifestyle change.

Before you start any type of alternative remedy, consult with a physician, especially if you are taking prescription or over-the-counter medications.

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The middle-age spread & how to avoid it

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on The middle-age spread & how to avoid it

The middle age spread & how to avoid it healthy diet weight loss help lose weight weight loss diets fat loss prevent weight gain middle-aged

A common issue I hear from clients trying to lose weight pertains to the so-called ‘middle age spread’. “It’s not my fault I can’t lose weight” they say. “I’m getting older and my waist, hips and thighs refuse to get slimmer.”

Is it true?

Based on the following facts you might think so:

 

  • At approximately age 20, the metabolic rate starts to decrease on average 2% every decade

  • Many North Americans gain an average of 20 pounds between the ages of 25 and 55

  • Weight gain typically peaks for men in their 40’s and for women in their 50’s

  • An 11 pound weight gain can significantly increase an individual’s risk of developing diabetes, heart disease and cancer.

Makes you want to throw in the towel right? Not so fast! Studies show you CAN avoid the middle age spread and age without uncontrollable weight gain. Think Demi Moore, Meryl Streep or Helen Mirren.

How so? Simply by choosing to eat better and by moving more (plus a few bonus supplements to boost your results).

Step 1

Eat a clean, colorful diet and avoid processed foods.

  • Carbohydrate clean-up: As renowned food author Michael Pollan states: ‘Eat food, not too much, mostly plants.’ Aim for deeply colored varieties rich in phytonutrients such as kale and purple cabbage, plus antioxidant-rich berries, fibrous whole grains (remember the label must say 100% whole grain), and legumes. Try eliminating ALL whites from your diet, including white flour, sugar, pasta and breads.

  • Go for ‘pro’ at every meal and snack: Before eating, be sure to ask yourself ‘what’s my protein source?’ Protein triggers the release of the hormone glucagon which facilitates the breakdown of fat. Ideal sources of protein include lean chicken, organic beef, turkey, egg whites, soy and fish. For extra benefits, I advise my clients to include a very high quality protein supplement such as proteins+ or Vegan proteins+. Simply add into smoothies, yogurt, liquids or baking –no blender required.

  • Add some fat-fuel: Avoid fatty meats, cheese, margarine and dressings containing refined vegetable oils or trans fats. Instead, make essential fats such as Omega-3s found in cold water fish, nuts, seeds a daily food staple. Besides increasing brain function, cardiovascular health and more, studies show consuming an Omega-3 fish oil formula can help you shed excess fat more efficiently.

Other eating tips to boost weight loss and metabolism at any age:

  • Instead of coffee, try antioxidant-rich green tea

  • Eat smaller meals more frequently and avoid eating after 7pm

  • Skip all artificial sweeteners, try stevia instead

  • Throw out your salt shaker and season foods with flavorful spices

  • Enjoy a glass of red wine daily – studies show those who do so are more likely to keep their waist lines in-check. Please remember this means drinking red wine in moderation–too much may pack on the pounds.

Step 2

Move more, include weight bearing exercises. Torch calories and boost your metabolism with regular cardiovascular exercise, strength training and stretching such as yoga every day. Yes, do something every day!

  • Aim for 4-5 cardio sessions per week for a minimum of 30 minutes

  • Include weight-bearing exercise such as strength training 2-3 times per week

  • Attend a yoga, pilates or a stretch class

  • Look for other ways to sneak more activity in your day such as walking or taking the stairs

For every pound of muscle you gain, your metabolism increases as much as 15%, burning an extra 35-50 calories per day – even while resting. Lean (not bulky) muscle mass also means stronger bones and better posture.

To boost your results, consider hiring a trainer to set-up a program and/or purchase free weights and DVDs to practice at home.

Step 3

Incorporate all-natural supplements with research-proven ingredients

My top picks include:

  • A daily high-potency, complete multi-vitamin such as one enhanced with Green Tea to assist with weight loss. I like multi+ daily trim.

  • A protein formula (as noted above), look for one that’s 100% pure, no sugar, highly absorbable and provides all essential amino acids.

  • A high-quality fish oil formula.

Last, to really (I mean really) succeed, make steps 1, 2 and 3 your lifestyle and not a temporary experiment. Expect occasional set-backs, go easy on yourself and enjoy the renewed energy and vitality you will experience as you age middle-spread-free!

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Effective Weight Loss Methods

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Effective Weight Loss Methods

Effective Weight Loss Methods Fat Loss Lose Weight Weight Training Exercise Fish Oil Green Tea EGCG

Losing weight can be hard.

Here are a few key steps that will help make shedding those extra pounds much easier and healthier.

Exercise

A great way to start your day is with exercise and it is one of the most effective ways of losing weight. There are many forms of exercise ranging from walking, working out at the gym or even doing household chores. The key is to keep moving!

Walking is a simple way of getting your daily dose of exercise. It could be as little as 30 minutes a day. Try using your arms or including a couple of hills for an even better result.

Eliminate white foods from your diet

These white foods are also called “refined carbohydrates,” which includes white pasta, rice, bread, flour, salt and sugar. As a rule of thumb, foods that are white are typically refined. Refined foods lack fiber and nutrients and may even make you gain weight!

Replace these white foods with sprouted grains, millet, quinoa, brown rice, and spelt as they are better sources of nutrients.

A Harvard study found that women who ate more that two servings of whole grains per day were 49% less likely to become overweight.

Be sure to avoid starchy grains at night time, as this can actually promote weight gain. The best dinner combination for weight loss is protein and veggies. For dinner tomorrow night have some quality protein, such as chicken or wild salmon and fill the rest of your plate with vegetables.

Eliminate sugar from your diet

This step is one of the most important to your health. Sugar is full of empty calories. It also increases insulin levels in your body.

Did you know one can of soda can contain between 8-12 teaspoons of sugar?

Some great alternatives to sugar include maple syrup, date syrup, stevia, agave and raw honey. Be sure to use in moderation.

Green tea

There are many benefits to green tea and one of them is weight loss. Green tea contains powerful antioxidants called polyphenols. These antioxidants can neutralize and prevent damage from disease-promoting free radicals.

According to a study from the American Society of Nutrition green tea contains antioxidant compounds that may promote exercise-induced abdominal fat loss. Another study found that by drinking 5 cups of tea a day the average person burns an extra 70 – 80 calories.

Remember, not all green teas are created equal. Look for the bright green color to get the full benefits and make sure it’s organic.

Keep a food journal

I always tell my clients to keep a food journal. It helps them figure out exactly what they are eating and where they are going wrong.

Write down what you eat, the portion sizes, the times of the day you eat, and any emotions you are having. Then, at the end of the day analyze what you have written down and see how you can make the next day a healthier one.

Make these tips part of your lifestyle and you will see benefits!

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Healthy Weight Loss-Part2

§ May 14th, 2010 § Filed under Nano Medicine Comments Off on Healthy Weight Loss-Part2

Healthy Weight Loss-Part2 fat loss losing weight nutrition health and wellness diet holidays atkins weight loss tips protein breakfast ideas healthy recipes sugar caffeine sleepHere are some quick and easy ways to help you slim down. These little changes add up to losing weight and a healthier you!

Kick the Sugar Habit

According to Dr. Robert Atkins, sugar is the “quintessential anti-nutrient”. It contains no vitamins or minerals. Rather, it is 100% carbohydrate, so it must be immediately metabolized. When sugar is metabolized it depletes our bodies of vital nutrients.

There are healthier solutions available. Stevia and glycerine extracts of Garcinia cambogia (Lose-It) are both very sweet weight-loss aids. Unlike sugar, these natural alternatives are not empty calories, and both also act as appetite suppressants to help curb your calorie cravings.

Accelerate Exercise

Enjoy a cup or capsule of green tea 30 minutes before you exercise. The natural caffeine it contains frees fatty acids, allowing you to burn fat more easily. Green tea also has antioxidant compounds that appear to work with caffeine to increase your calorie burn.

Take chromium before exercising. An essential trace mineral, your body needs chromium to metabolize carbohydrates, proteins and fat. Nearly 90% of North Americans are chromium deficient

Chromium enhances the calorie burning results of exercise to make weight loss easier. When you work out it increases your chromium excretion, which makes supplementation even more important.

Water

Dehydration can significantly slow down your metabolism. Be sure you drink enough healthy liquids (water, fruit juice, herbal teas) to keep your body happy. Avoid “bad” drinks such as soda, sugary drinks and coffee as they aid the dehydration process. In general, you should drink 1/2 ounce (14.5 ml) per pound of body weight daily, just to keep from being dehydrated. Thus, a person weighing 150 pounds would need at least 2.175L of water daily. This number increases dramatically if you are dieting or exercising.

Give your water an added boost by adding 1 or 2 teaspoons of liquid chlorophyll to each liter (quart) of water.

A common fallacy is to drink when you are thirsty. Unfortunately, when exercising you are already dehydrated by the time you become thirsty. A schedule to prevent dehydration begins 2 hours before exercising by drinking at least 500ml. Then 1 hour before, drink 250ml more, and at least 250ml every 15 minutes during exercise. Finally, drink another 500ml within ½ hour of finishing your exercise routine.

Measure, Measure, Measure

When cooking or baking, measure out all ingredients, especially fats (butter, margarine, oils) and sweeteners (molasses, sugar, honey, stevia). Many people estimate these ingredients and, more often than not, they estimate too high thereby adding unnecessary calories.

Spice Up Your Life

Try adding spices to food instead of fat. Both add flavour, but spices also aid digestion. Give “dull” foods a spicy zip and add variety without adding fat by varying the spices you use.

Sprinkle Your Cereal

Incorporate high fiber flax into your food. Not only is it packed with a healthy and flavorful oil, the high fiber content can help you feel full and eat less. Try adding flax to cereals, breads, muffins, and yoghurt.

Become a Dipper

Pass on the butter. Instead, try dipping your bread in flavored extra virgin olive oil (my favorite is rosemary, garlic & chili). Research has shown extra virgin olive oil to be exceptionally healthy, and “dippers” eat fewer calories than those who buttered their bread.

Skip Rope, Not Meals

Did you know? Restricting foods and skipping meals slows the metabolism and can lead to overeating. When you miss a meal or eat too little, your brain initiates a famine response which alerts the body to conserve calories. Your body assumes food is in short supply and goes into a calorie-saving mode, storing fat to keep you from starving to death. Instead of skipping, eat well-balanced healthy meals.

Take Time for You

Take some time every day to do something you enjoy, other than eating. Routinely doing something you enjoy not only makes you feel good about yourself, but provides the emotional support you may be seeking from food.

Playing is not just for kids. Run, jump, swim, have fun! You can get lots of physical activity “playing.” Get out and have a game of tag with your kids or challenge someone to a full-court basketball game. Ride your bike, dance, or go hiking. If you can enjoy enough additional activity everyday to burn an extra 300 calories, you’ll lose 2.5 pounds of fat per month — and tone your muscles. You will love the new you, and so will your kids!

The combined effect of these simple little steps will help turn your body into an efficient calorie-burning machine. This new year, take the steps to a happy healthy new you.

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