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Coronavirus Today: Why Trump’s battle isn’t over – Los Angeles Times

§ October 6th, 2020 § Filed under Nano Medicine Comments Off on Coronavirus Today: Why Trump’s battle isn’t over – Los Angeles Times

Good evening. Im Soumya Karlamangla, and its Monday, Oct. 5. Heres whats happening with the coronavirus in California and beyond.

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After a chaotic weekend of conflicting information about President Trumps battle with COVID-19, the First Patient headed home from Walter Reed National Military Medical Center on Monday evening.

His departure came just three days after he was hospitalized for COVID-19. During that time, he received supplemental oxygen, remdesevir and dexamethasone, medicines typically reserved for the sickest of patients. That Trump was given these treatments so soon after his positive test result was announced raised questions about when the president actually fell sick, when he was first diagnosed, and how serious his symptoms were. Those questions remain unanswered.

Trump and some of his staff maintain that his symptoms are mild. On Sunday, he staged a motorcade drive-by to wave at his supporters lined up outside Walter Reed. On Monday, the president tweeted a message that downplayed the severity of the disease.

Dont be afraid of Covid. Dont let it dominate your life, he wrote on Twitter. I feel better than I did 20 years ago!

Meanwhile, the number of Trump associates testing positive continues to grow. White House press secretary Kayleigh McEnany and aide Nick Luna tested positive for the virus, as did Riverside Pastor Greg Laurie, who attended the Sept. 26 Rose Garden event where Trump announced his nomination of Judge Amy Coney Barrett to the Supreme Court.

Even more could fall sick in the week ahead, as it typically takes between five and seven days to test positive after exposure. Trump traveled to multiple states in the week before the announcement of his diagnosis. Now health officials in New Jersey are trying to contact 200 people who may have been exposed to the virus at a Trump campaign event.

As for Trumps prognosis, experts say he remains contagious and should isolate himself in the White House for 10 days to avoid infecting others. His physician, Dr. Sean Conley, told reporters that the president has met or exceeded all standard hospital discharge criteria, even as he cautioned that Trump could face a relapse and is not entirely out of the woods yet.

If we can get through [next] Monday then we will all take that deep sigh of relief, he said.

California cases and deaths as of 6:36 p.m. PDT Monday:

(Los Angeles Times Graphics)

Track the latest numbers and how they break down in California with our graphics.

See the current status of Californias reopening, county by county, with our tracker.

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Months of lying in a hospital bed stripped away not only 50 pounds from Dr. Jay Buenaflor, but sometimes the will to live. The Imperial County pediatrician, now recovering from a rough battle with COVID-19, is relearning how to swallow, speak, stand and walk. Its a humbling experience, the 48-year-old said, but Im lucky Im still here.

Los Angeles Mayor Eric Garcetti and 10 of the citys public employee unions have struck a deal to delay a furlough program approved last month that would force 15,000 city workers to take one unpaid day off every two weeks. The furloughs would amount to a 10% pay cut aimed at trying to balance the budget during the pandemic. The new arrangement will leave workers with just one unpaid day off before the end of the year.

As San Diego schools allow students back on campus, county education and health officials are crafting guidelines for how to handle kids who show up with a stuffy nose or a cough. Under normal circumstances, such symptoms might simply warrant a trip to the school nurse or perhaps a day or two out of school. But conditions are far from normal. There are a thousand what-ifs and its really hard to get to the essential decisions that need to be made, said a program specialist for the countys Office of Education.

When hipster strip club Jumbos Clown Room closed in March, a group of dancers from the East Hollywood joint realized no one was coming to save them. So they took their show online. Strippers in general are often insanely creative people, said one of the dancers, and with online shows, we are our own creative directors, were our own art directors, were our own cinematographers, lighting designers, set designers.

For general safety, wash your hands for at least 20 seconds (heres a super-fun how-to video). Stop touching your face, and keep your phone clean. Practice social distancing, maintaining a six-foot radius of personal space in public. And wear a mask if you leave home. Heres how to do it right. Watch for symptoms including fever, cough, shortness of breath, chills, repeated shaking with chills, muscle pain, headache, sore throat and loss of taste or smell. If youre worried you might be infected, call your doctor or urgent care clinic before going there. Need a COVID-19 test? Heres how to receive a free test if youre in L.A. County. And heres a map of testing sites across California. Heres how to care for someone with COVID-19, from monitoring their symptoms to preventing the virus spread. If your job has been affected by the pandemic, heres how to file for unemployment. Here are some free resources for restaurant workers and entertainment industry professionals having trouble making ends meet. Advice for helping kids navigate pandemic life includes being honest about uncertainties, acknowledging their feelings and sticking to a routine. Heres guidance from the CDC. In need of mental health services? Here are resources for coping during the crisis from the CDC and the L.A. County Department of Mental Health. L.A. County residents can also call (800) 854-7771 or text LA to 741741. For domestic violence victims, the pandemic can pose a worst-case scenario, advocates say. If you or someone you know is experiencing such abuse, call the National Domestic Violence Hotline at 1-800-799-SAFE (7233) or L.A. Countys hotline at 1-800-978-3600. Here are more ways to get help.

After months of campaigning by scientists who have studied the role of aerosols in super-spreading events, the Centers for Disease Control and Prevention officially acknowledged that the coronavirus can spread through microscopic respiratory particles capable of remaining in the air for minutes or even hours before being inhaled. In new guidelines posted Monday, the CDC said that social distancing isnt enough to protect against this type of transmission, and warned against spending time in crowded, poorly ventilated indoor spaces. An earlier version of the update briefly appeared on the CDCs website last month.

Though not typically a slam-dunk for Democrats, Nevada is a state Joe Biden has been counting on. But the canvassing and other in-person campaigning tactics that typically help Democrats secure votes have been significantly hampered by the pandemic. Will Biden have enough support to win the battleground state?

A U.S. advisory panel released recommendations for how a coronavirus vaccine should be distributed. It suggests that the vaccine be made available at no cost, and that healthcare workers and first responders get priority.

When the Trump administration wanted to seal U.S. borders in March, health officials said there was no evidence that doing so would slow the spread of the coronavirus. Yet Vice President Mike Pence ordered the Centers for Disease Control and Prevention to use its emergency powers and close the borders anyway. The action has so far caused nearly 150,000 asylum seekers and immigrants to be expelled from the country without the usual due process.

Since March, at least 55 journalists in India have been arrested, investigated or questioned by police in connection with their COVID-19 reporting or for alleged lockdown violations. In a country with one of the biggest tolls from the virus, reporting on government mismanagement of the pandemic has become a dangerous job.

A coffin-maker in Johannesburg, Casey Pillay saw firsthand the way the coronavirus upended South Africa. And then his wife, a midwife who delivered babies of coronavirus-positive women, fell sick.

Todays question comes from readers who want to know: Whats the difference between an osteopath and a regular doctor?

Many Americans seem to be wondering about this distinction after learning that Dr. Sean Conley, who is managing President Trumps COVID-19 care, is a D.O. and not an M.D. On Friday, Google searches for osteopath spiked higher than they have in the past 90 days and continue to climb, according to Google Trends.

Times science reporter Deborah Netburn has some answers for us in her story that published today.

Like M.D.s, D.O.s are fully licensed doctors who practice medicine, prescribe drugs and perform surgeries. They also attend four years of postgraduate school, followed by a year of internship, and do at least two additional years of residency before they begin practicing medicine.

Roughly 25% of medical students nationwide are enrolled in colleges of osteopathic medicine, and there are more than 74,000 D.O.s in practice.

The main difference between M.D.s and D.O.s is philosophical, Dr. Kevin Klauer, a former emergency room physician who now serves as chief executive of the American Osteopathic Assn, told Deborah. In osteopathic medical schools, future D.O.s are taught to take a holistic approach to their patients care rather than just treating an ailment.

Infused into the osteopathic curriculum is a focus on treating the whole person, including the mind, body and spirit, he said.

Our reporters covering the coronavirus outbreak want to hear from you. Email us your questions, and well do our best to answer them. You can find more answers in our Frequently Asked Questions roundup and in our reopening tracker.

For the most up-to-date coronavirus coverage from The Times over the weekend, visit our homepage and our Health section, sign up for our breaking news alerts, and follow us on Twitter and on Instagram.

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Coronavirus Today: Why Trump's battle isn't over - Los Angeles Times

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Dynamic Tattoos Promise To Warn Wearers Of Health Threat – IFLScience

§ October 6th, 2020 § Filed under Nano Medicine Comments Off on Dynamic Tattoos Promise To Warn Wearers Of Health Threat – IFLScience

In the sci-fi novel The Diamond Age by Neal Stephenson, body art has evolved into constantly shifting mediatronic tattoos in-skin displays powered by nanotech robopigments. In the 25 years since the novel was published, nanotechnology has had time to catch up, and the sci-fi vision of dynamic tattoos is starting to become a reality.

The first examples of color-changing nanotech tattoos have been developed over the past few years, and theyre not just for body art. They have a biomedical purpose. Imagine a tattoo that alerts you to a health problem signaled by a change in your biochemistry, or to radiation exposure that could be dangerous to your health.

You cant walk into a doctors office and get a dynamic tattoo yet, but they are on the way. Early proof-of-concept studies provide convincing evidence that tattoos can be engineered, not only to change color, but to sense and convey biomedical information, including the onset of cancer.

Signaling biochemical changes

In 2017, researchers tattooed pigskin, which had been removed from the pig, with molecular biosensors that use color to indicate sodium, glucose or pH levels in the skins fluids.

In 2019, a team of researchers expanded on that study to include protein sensing and developed smartphone readouts for the tattoos. This year, they also showed that electrolyte levels could be detected with fluorescent tattoo sensors.

In 2018, a team of biologists developed a tattoo made of engineered skin cells that darken when they sense an imbalance of calcium caused by certain cancers. They demonstrated the cancer-detecting tattoo in living mice.

UV radiation sensors

My lab is looking at tech tattoos from a different angle. We are interested in sensing external harms, such as ultraviolet radiation. UV exposure in sunlight and tanning beds is the main risk factor for all types of skin cancer. Nonmelanoma skin cancers are the most common malignancies in the U.S., Australia and Europe.

To help address this problem, we developed an invisible tattoo ink that turns blue only in UV light, alerting you when your skin needs protection. The tattoo ink contains a UV-activated dye inside of a plastic nanocapsule less than a micron in diameter or thousandth of a millimeter about the same size as an ordinary tattoo pigment.

The nanocapsule is needed to make the color-changing tattoo particles large enough. If tattoo pigments are too small, the immune system rapidly clears them from the skin and the tattoo disappears. They are implanted using tattoo machines in the same way as regular tattoos, but they last for only several months before they start to degrade from UV exposure and other natural processes and fade, requiring a booster tattoo.

I served as the first human test subject for these tattoos. I created solar freckles on my forearm invisible spots that turned blue under UV exposure and reminded me when to wear sunscreen. My lab is also working on invisible UV-protective tattoos that would absorb UV light penetrating through the skin, like a long-lasting sunscreen just below the surface. Were also working on thermometer tattoos using temperature-sensitive inks. Ultimately, we believe tattoo inks could be used to prevent and diagnose disease.

Temporary high-tech tattoos

Temporary transfer tattoos are also undergoing a high-tech revolution. Wearable electronic tattoos that can sense electrophysiological signals like heart rate and brain activity or monitor hydration and glucose levels from sweat are under development. They can even be used for controlling mobile devices, for example shuffling a music playlist at the touch of a tattoo, or for luminescent body art that lights up the skin.

The advantage of these wearable tattoos is that they can use battery-powered electronics. The disadvantage is that they are much less permanent and comfortable than traditional tattoos. Likewise, electronic devices that go underneath the skin are being developed by scientists, designers and biohackers alike, but they require invasive surgical procedures for implantation.

Tattoos injected into the skin offer the best of both worlds: minimally invasive, yet permanent and comfortable. New needle-free tattooing methods that fire microscopic ink droplets into the skin are now in development. Once perfected they will make tattooing quicker and less painful.

Ready for everyday use?

The color-changing tattoos in development are also going to open the door to a new kind of dynamic body art. Now that tattoo colors can be changed by an electromagnetic signal, youll soon be able to program your tattoos design, or switch it on and off. You can proudly display your neck tattoo at the motorcycle rally and still have clear skin in the courtroom.

As researchers develop dynamic tattoos, theyll need to study the safety of the high-tech inks. As it is, little is known about the safety of the more than 100 different pigments used in normal tattoo inks. The U.S. Food and Drug Administration has not exercised regulatory authority over tattoo pigments, citing other competing public health priorities and a lack of evidence of safety problems with the pigments. So U.S. manufacturers can put whatever they want in tattoo inks and sell them without FDA approval.

So far, there is no evidence that tattoos cause cancer, and one study even found that black tattoos protect against UV-induced skin cancer. Still, many tattoo inks contain or degrade into substances that are known to be hazardous, and health complications including infection, allergy and granuloma have been found in about 2% of tattoos. More research is needed to understand the long-term effects of nano- and microimplants in the skin in general.

A wave of high-tech tattoos is slowly upwelling, and it will probably keep rising for the foreseeable future. When it arrives, you can decide to surf or watch from the beach. If you do climb on board, youll be able to check your body temperature or UV exposure by simply glancing at one of your tattoos.

Carson J. Bruns, Assistant Professor, University of Colorado Boulder

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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There’s a fatal flaw in Dan Tehan’s uni reforms, even if he can’t see it – The Canberra Times

§ October 6th, 2020 § Filed under Nano Medicine Comments Off on There’s a fatal flaw in Dan Tehan’s uni reforms, even if he can’t see it – The Canberra Times

comment, opinion, dan tehan, university funding, trans-disciplinary study, Brian Schmidt

Poor Dan Tehan. His furrowed brow and those eyes, flickering quickly from side to side, show he's really trying, very hard, to find the answer. He wants to understand the link between university and productivity, how abstract learning can make people better at their jobs yet, despite all his best efforts, he just can't see what it is. He can't see how his arts degree has made him more capable or effective as a person. Perhaps it hasn't and perhaps what Tehan always suspected is right: rote-learning lists of names and dates, or solving complicated mathematical equations, actually could have made him, somehow, more competent as a politician, if not as a person. It's almost as if he's still searching, as if he believes there's a list with all the right answers written down carefully. Then he could memorise them, copy them out and get top marks. He'd be happy with that idea. It offers a well-lit path and that'd certainly be much easier than this other vague, nebulous idea - learning how to "think". It's hard not to be sympathetic with him. After all, unis have existed for so long now you'd think the academics might have managed to work out what the answers to the big questions really are and yet, quite obviously, they haven't. Why, some of them (especially those bearded, tweedy, "thinkers" in the arts faculties, the posers who always got the girls) well, Tehan always suspected they don't even know what questions they're trying to answer. And if that doesn't indicate lazy institutions in urgent need of reform; well, what does? There are so many ways of tearing Tehan's proposals apart it's difficult to know where to begin. There's probably no point in even attempting to start: his changes, the price hikes, aren't designed to persuade intellectually - they appeal to instinct. He's just wandering into a delicate and complex system while swinging an axe. He's treated it like a political problem. He's buying Rebekha Sharkie's vote with a few more South Australian uni spaces, and urging Jacqui Lambie to get onside, because he doesn't think she's very clever or even capable, really, of understanding the issues. In his mind this all a simple matter of supply and demand. Money. If only knowledge was that simple, because that's the real issue here: how we go about understanding our world. Tehan's reforms are based around one simple idea - that uni courses are either job-relevant (like medicine) or unrelated to work (like, obviously, arts). He believes knowledge is divided up into specialities, or disciplines (now that's a good hard word, isn't it, with its hint of a sudden smack for anyone not sitting up and paying proper attention). Unfortunately, though, that's not much of a way forward. The biggest breakthroughs don't necessarily arrive by working harder. That's why knowledge can never be divided up by rigid boundaries, the very concept that underlies Tehan's reforms. The biggest surprise is that if the minister just opened his eyes he could see the future of the sector, taking shape right here in Canberra. Disciplinary knowledge - say biology, or history - provides a necessary foundation for understanding. Multi-disciplinary knowledge - say arts/law, or politics/philosophy/economics - adds breadth. But the next big breakthroughs, or opportunities to really challenge our perspective of the way the world works, are unlikely to come simply from studying one field of knowledge more deeply. This is where trans-disciplinary understanding enters the picture by breaking the frame and suddenly allowing greater insight. Biologists, for example, had been studying DNA, the microscopic substance that forms the basic building block for life, since it was first identified back in 1869. It wasn't until the 1950s, however, that Francis Crick and James Watson using an X-ray image suddenly understood they needed to reverse the frame (or "backbone") of the molecule in order to comprehend it, thus "inventing" molecular biology. MORE STUART: Luckily, the ANU's one of the few universities in the world with a Nobel Laureate (Brian Schmidt) as vice-chancellor. All that time spent gazing at the stars means he's had plenty of time to reflect on what knowledge is all about, and perhaps that's why this university is embracing the idea of trans-disciplinary knowledge so enthusiastically. It starts in first year, with the Bachelor of Philosophy. Despite its moniker this course has nothing, necessarily, to do with Plato or the Socratics. It is, however, about engaging spectacular students and guiding them to follow their interests, deeper and deeper, nurturing them until they uncover new understandings. Simply by its definition how could this work ever fall into Tehan's rubric of "job-ready courses". Yet how could anyone doubt, even for a minute, that this is a worthwhile investment in the nation's future? Even more exciting work is being done by the university's newly-appointed distinguished professors. Genevieve Bell's entire career, for example, looks as if it was specifically designed to simply disprove the idea that university is meant to churn out widgets to fit into holes. After living in several Aboriginal communities as a child she then studied anthropology in the US before beginning an exciting, cutting-edge tech career - as you'd probably expect, because isn't this exactly where a "job ready" anthropologist would end up - spending decades working at the highest levels with (computing-giant) Intel. Now she's heading up the ANU's 3Ai institute (don't ask - that's a whole other column by itself). I've previously referred to the exciting way entrepreneurial professor Owen Atkin challenged different disciplines to find answers to the environmental challenges of turning the arid Australian environment into a productive food-bowl. The answers won't come from plant biology alone: they'll be illuminated by knowledge of science, marketing and history. Even politics. Perhaps there is a reason for arts degrees, after all.

https://nnimgt-a.akamaihd.net/transform/v1/crop/frm/fdcx/doc79yuk542smrr2zc0l5e.jpg/r2_426_5046_3276_w1200_h678_fmax.jpg

OPINION

October 6 2020 - 4:30AM

Poor Dan Tehan. His furrowed brow and those eyes, flickering quickly from side to side, show he's really trying, very hard, to find the answer.

He wants to understand the link between university and productivity, how abstract learning can make people better at their jobs yet, despite all his best efforts, he just can't see what it is. He can't see how his arts degree has made him more capable or effective as a person. Perhaps it hasn't and perhaps what Tehan always suspected is right: rote-learning lists of names and dates, or solving complicated mathematical equations, actually could have made him, somehow, more competent as a politician, if not as a person. It's almost as if he's still searching, as if he believes there's a list with all the right answers written down carefully. Then he could memorise them, copy them out and get top marks.

He'd be happy with that idea. It offers a well-lit path and that'd certainly be much easier than this other vague, nebulous idea - learning how to "think".

It's hard not to be sympathetic with him. After all, unis have existed for so long now you'd think the academics might have managed to work out what the answers to the big questions really are and yet, quite obviously, they haven't. Why, some of them (especially those bearded, tweedy, "thinkers" in the arts faculties, the posers who always got the girls) well, Tehan always suspected they don't even know what questions they're trying to answer.

And if that doesn't indicate lazy institutions in urgent need of reform; well, what does?

There are so many ways of tearing Tehan's proposals apart it's difficult to know where to begin. There's probably no point in even attempting to start: his changes, the price hikes, aren't designed to persuade intellectually - they appeal to instinct. He's just wandering into a delicate and complex system while swinging an axe.

He's treated it like a political problem. He's buying Rebekha Sharkie's vote with a few more South Australian uni spaces, and urging Jacqui Lambie to get onside, because he doesn't think she's very clever or even capable, really, of understanding the issues.

In his mind this all a simple matter of supply and demand. Money. If only knowledge was that simple, because that's the real issue here: how we go about understanding our world.

Tehan's reforms are based around one simple idea - that uni courses are either job-relevant (like medicine) or unrelated to work (like, obviously, arts). He believes knowledge is divided up into specialities, or disciplines (now that's a good hard word, isn't it, with its hint of a sudden smack for anyone not sitting up and paying proper attention). Unfortunately, though, that's not much of a way forward.

The biggest breakthroughs don't necessarily arrive by working harder. That's why knowledge can never be divided up by rigid boundaries, the very concept that underlies Tehan's reforms. The biggest surprise is that if the minister just opened his eyes he could see the future of the sector, taking shape right here in Canberra.

Disciplinary knowledge - say biology, or history - provides a necessary foundation for understanding. Multi-disciplinary knowledge - say arts/law, or politics/philosophy/economics - adds breadth. But the next big breakthroughs, or opportunities to really challenge our perspective of the way the world works, are unlikely to come simply from studying one field of knowledge more deeply.

This is where trans-disciplinary understanding enters the picture by breaking the frame and suddenly allowing greater insight. Biologists, for example, had been studying DNA, the microscopic substance that forms the basic building block for life, since it was first identified back in 1869. It wasn't until the 1950s, however, that Francis Crick and James Watson using an X-ray image suddenly understood they needed to reverse the frame (or "backbone") of the molecule in order to comprehend it, thus "inventing" molecular biology.

Luckily, the ANU's one of the few universities in the world with a Nobel Laureate (Brian Schmidt) as vice-chancellor. All that time spent gazing at the stars means he's had plenty of time to reflect on what knowledge is all about, and perhaps that's why this university is embracing the idea of trans-disciplinary knowledge so enthusiastically. It starts in first year, with the Bachelor of Philosophy. Despite its moniker this course has nothing, necessarily, to do with Plato or the Socratics. It is, however, about engaging spectacular students and guiding them to follow their interests, deeper and deeper, nurturing them until they uncover new understandings.

Simply by its definition how could this work ever fall into Tehan's rubric of "job-ready courses". Yet how could anyone doubt, even for a minute, that this is a worthwhile investment in the nation's future?

Even more exciting work is being done by the university's newly-appointed distinguished professors. Genevieve Bell's entire career, for example, looks as if it was specifically designed to simply disprove the idea that university is meant to churn out widgets to fit into holes. After living in several Aboriginal communities as a child she then studied anthropology in the US before beginning an exciting, cutting-edge tech career - as you'd probably expect, because isn't this exactly where a "job ready" anthropologist would end up - spending decades working at the highest levels with (computing-giant) Intel. Now she's heading up the ANU's 3Ai institute (don't ask - that's a whole other column by itself).

I've previously referred to the exciting way entrepreneurial professor Owen Atkin challenged different disciplines to find answers to the environmental challenges of turning the arid Australian environment into a productive food-bowl. The answers won't come from plant biology alone: they'll be illuminated by knowledge of science, marketing and history.

Perhaps there is a reason for arts degrees, after all.

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There's a fatal flaw in Dan Tehan's uni reforms, even if he can't see it - The Canberra Times

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After The Death Of A 6-Year-Old Boy, Officials Work To Ensure Water Safety In Lake Jackson – Houston Public Media

§ October 4th, 2020 § Filed under Nano Medicine Comments Off on After The Death Of A 6-Year-Old Boy, Officials Work To Ensure Water Safety In Lake Jackson – Houston Public Media

Residents will have to wait a while until things return to normal, health officials said.

After the death of a young boy due to contaminated city water in Lake Jackson, health officials are working to ensure the water supply in Brazoria County is safe a process they say could take months.

Josiah McIntyre was just 6 years old when he died on Sept. 8 after suffering from headaches, fever and nausea. It turned out he caught an infection from the brain-eating amoeba Naegleria fowleri.

Traces of the deadly microbe were found at several different water outlets in Lake Jackson, and Gov. Greg Abbott on Sunday issued a disaster declaration for Brazoria County.

The city is now on a boil water notice.

"This is a tragedy," said John Hellerstedt, commissioner of the Texas Department of State Health Services. "It's a rare tragedy, but now we have the opportunity to look in-depth at the water systems here and elsewhere."

The state, city and the local water authority are all working to make the water safe again, he said.

But it'll take a while.

"We have to get through the boil water notice first, which could take two to three weeks," said Toby Baker, executive director of the Texas Commission on Environmental Quality. "After that, we have to get chlorine levels to a state that can burn the entire system, scour the system and kill the amoebas. That could take up to an additional 60 days."

The Brazosport Water Authority distributes water to other places in Brazoria County as well, but officials said testing showed the water is safe outside of Lake Jackson, home to 27,000 people.

The deadly amoeba enters the brain through the nose, said Dr. Scott Lea, professor of internal medicine and infectious diseases at the University of Texas Medical Branch.

"The organism is able to invade through that anatomical structure to get into the central nervous system where it causes a meningoencephalitis, which is devastating to the individual who's affected," he said.

Naegleria fowleri can be found throughout the United States.

"It's more common in warm soils, particular in the summer months," Lea said.

The amoeba thrives in standing water, such as ponds, tanks and insufficiently chlorinated pools, not so much in rivers or streams, and it does not occur in saltwater, Lea said. Chlorine kills it.

It's still not clear how the amoeba got into Lake Jackson's water system.

Besides pumping the system full of chlorine, the TCEQ will bring in experts to look at possible breaches, "to see if there are any places where unfiltered water is entering the water system that the city doesn't know about," the TCEQs Baker said.

He and other officials said this incident is a first for any public water system in Texas. But there have been known cases of naegleria fowleri-caused deaths in public drinking water systems in Arizona, Louisiana as well as in Australia and Pakistan.

While the naegleria infection is fatal in more than 95% of cases, it's still rare. Only a handful of Americans get sick from it every year, primarily children and young adults.

In Texas, there have been 36 infections between 1972 and 2017.

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After The Death Of A 6-Year-Old Boy, Officials Work To Ensure Water Safety In Lake Jackson - Houston Public Media

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|COVID-19 IMPACT ON HEALTHCARE INDUSTRY|Outpatient Surgical Procedures Market By Size,Share,Analysis, New Technology Opportunity Analysis And…

§ October 4th, 2020 § Filed under Nano Medicine Comments Off on |COVID-19 IMPACT ON HEALTHCARE INDUSTRY|Outpatient Surgical Procedures Market By Size,Share,Analysis, New Technology Opportunity Analysis And…

Outpatient Surgical Procedures Market

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Under the COVID-19 outbreak analysis, this report provides analysis of import, supply chain, and export to future influence on the industry and regional government policies. Enterprise competition pattern, detailed analysis about market status, advantages and disadvantages of enterprise products, macroeconomic policies and regional industrial layout characteristics, industry development trends have also been included. The trends of product sales channel will be offered as well.

Considering COVID-19, this report offers a complete and exhaustive analysis on how the epidemic has pushed transformation and reform in the industry. The market study can help understand the market expansion and strategies for business accordingly. In the strategy analysis, it gives insights from market positioning marketing channel to potential growth strategies, thereby providing an in-depth analysis for new entrants or existing competitors in the Outpatient Surgical Procedures industry.

Key Players:University of Washington Medical Center, New York Presbyterian, Mount Sinai Hospital, Massachusetts General Hospital, St Jude Childrens Research Hospital, Cleveland Clinic, Mayo Clinic, Johns Hopkins Medicine, Taipei Veterans General Hospital, University of Maryland Medical

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The market analysis on the Outpatient Surgical Procedures offers a birds eye view of the current proceeding within the Outpatient Surgical Procedures market. The market analysis report has incorporated an analysis of various factors that augment the markets growth. It constitutes restraints, trends, and drivers that transform the market in either a negative orpositive manner.

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Global Outpatient Surgical Procedures Market: Segment Analysis

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Following are the segmentation covered by the market study: By Surgical Procedure Type (Gastrointestinal, Cardiovascular, Neurological, Orthopedic, Gynecologic, Integumentary, Ophthalmic), By Patient Care Setting (Physicians Office, Hospital OPDs, ASCs),

Global Outpatient Surgical Procedures Market: Regional Analysis

The market analysis report includes a thorough study of various factors that determine regional growth such as environmental, economic, social political status, technology, and region. Market analysis has studied the data of sales, revenue, and manufacturers of each region. The market analysis provides region-wise volume and revenue for the forecast period of 2016 to 2028. This market analysis will support the market participants to understand the potential worth of investment in a particular region.

Region- wise Analysis of the Global Outpatient Surgical Procedures Market covers: North America Europe China Japan India Southeast Asia Other regions (Middle East, Central & South America, & Africa)

Global Outpatient Surgical Procedures Market: Competitive Landscape

This market analysis report classifies numerous key manufacturers of the industry. It supports the reader in understanding the policies and collaborations that the industry participants are focusing on in order to combat competition in the industry. The comprehensive market analysis offers a note worthy microscopic look at the industry. The market analysis can classify the footprints of the manufacturers by giving the global revenue of manufacturers and sales by manufacturers, and the global price of manufacturers over the forecast period of 2018 to 2028.

Major Aspects covered in the Report are

An overview of the Outpatient Surgical Procedures Market comprising production, consumption, status, and estimation and market growth. 2016-2028 historical data and market forecast. Overview of the product type market as well as development. Overview of the end-user market and development. Geographical analysis with major countries.

Further, the report provides niche insights for a decision about every possible segment, helping in the strategic decision-making process and market size estimation of the Outpatient Surgical Procedures market on a regional and global basis. Unique research designed for market size estimation and forecast is used for the identification of major companies operating in the market with related developments. The report has an exhaustive scope to cover all the possible segments, helping every stakeholder in the Outpatient Surgical Procedures market.

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|COVID-19 IMPACT ON HEALTHCARE INDUSTRY|Outpatient Surgical Procedures Market By Size,Share,Analysis, New Technology Opportunity Analysis And...

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Chestnut Honey Market is Thriving Worldwide By Size, Revenue, Emerging Trends and Top Growing Companies by 2028 – The Daily Chronicle

§ October 4th, 2020 § Filed under Nano Medicine Comments Off on Chestnut Honey Market is Thriving Worldwide By Size, Revenue, Emerging Trends and Top Growing Companies by 2028 – The Daily Chronicle

The global Chestnut Honey Market study offers a compilation of the current, historical, and future outlook of the industry as well as the factors responsible for market growth. With a SWOT analysis, the business study highlights the weaknesses, strengths, opportunities, and threats of each Chestnut Honey Market player in a comprehensive way.

Sample Copy of This Report: https://www.quincemarketinsights.com/request-sample-68699?utm_source=SG/DC

Under the COVID-19 outbreak analysis, this report provides analysis of import, supply chain, and export to future influence on the industry and regional government policies. Enterprise competition pattern, detailed analysis about market status, advantages and disadvantages of enterprise products, macroeconomic policies and regional industrial layout characteristics, industry development trends have also been included. The trends of product sales channel will be offered as well.

Considering COVID-19, this report offers a complete and exhaustive analysis on how the epidemic has pushed transformation and reform in the industry. The market study can help understand the market expansion and strategies for business accordingly. In the strategy analysis, it gives insights from market positioning marketing channel to potential growth strategies, thereby providing an in-depth analysis for new entrants or existing competitors in the Chestnut Honey industry.

Key Players: R Stephens Apiary, Rowse Honey, Savannah Bee, Sioux Honey, Steens, The Honey, YanbianBaolixiang, Dalian Sangdi Honeybee, Shanghai Guanshengyuan.

The market analysis on the Chestnut Honey offers a birds eye view of the current proceeding within the Chestnut Honey Market. The market analysis report has incorporated an analysis of various factors that augment the markets growth. It constitutes restraints, trends, and drivers that transform the market in either a negative orpositive manner.

Chestnut Honey Market

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This market analysis also offers the scope of different segments and applications that can actually impact the market in the future. The thorough information is based on present trends and historic milestones. The market analysis mentions the volume of sales by region from 2015 to 2026. A thorough evaluation of the limitations included in the market analysis portrays the drivers and gives room for strategic planning.

Global Chestnut Honey Market: Segment Analysis

Each type offers information about return sover the forecast period of 2018 to 2028. The sales method segment also offers revenue by volume and sales over the forecast period of 2018 to 2028. Understanding the segments helps in classifying the importance of various factors that support market growth.

Following are the segmentation covered by the market study: By Type (Extracted Honey, Pressed Honey, Comb Honey), By Application (Cakes and Pastries Segments, Skin Care Products, Medicine Sugar Coatings)

Global Chestnut Honey Market: Regional Analysis

The market analysis report includes a thorough study of various factors that determine regional growth such as environmental, economic, social political status, technology, and region. Market analysis has studied the data of sales, revenue, and manufacturers of each region. The market analysis provides region-wise volume and revenue for the forecast period of 2016 to 2028. This market analysis will support the market participants to understand the potential worth of investment in a particular region.

Region- wise Analysis of the Global Chestnut Honey Market covers: North America Europe Asia Pacific Middle East and Africa South America

Make an Enquiry for purchasing this Report @ https://www.quincemarketinsights.com/enquiry-before-buying-68699?utm_source=SG/DC

Global Chestnut Honey Market: Competitive Landscape

This market analysis report classifies numerous key manufacturers of the industry. It supports the reader in understanding the policies and collaborations that the industry participants are focusing on in order to combat competition in the industry. The comprehensive market analysis offers a note worthy microscopic look at the industry. The market analysis can classify the footprints of the manufacturers by giving the global revenue of manufacturers and sales by manufacturers, and the global price of manufacturers over the forecast period of 2018 to 2028.

Major Aspects covered in the Report are

Further, the report provides niche insights for a decision about every possible segment, helping in the strategic decision-making process and market size estimation of the Chestnut Honey Market on a regional and global basis. Unique research designed for market size estimation and forecast is used for the identification of major companies operating in the market with related developments. The report has an exhaustive scope to cover all the possible segments, helping every stakeholder in the Chestnut Honey Market.

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ABOUT US:

QMI has the most comprehensive collection of market research products and services available on the web. We deliver reports from virtually all major publications and refresh our list regularly to provide you with immediate online access to the worlds most extensive and up-to-date archive of professional insights into global markets, companies, goods, and patterns.

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Quince Market Insights

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Phone: APAC +91 706 672 4848 / US +1 208 405 2835 / UK +44 1444 39 0986

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Web: https://www.quincemarketinsights.com

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Chestnut Honey Market is Thriving Worldwide By Size, Revenue, Emerging Trends and Top Growing Companies by 2028 - The Daily Chronicle

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Nanotechnology in Medical Market Potential Growth, Size, Share, Demand and Analysis of Key Players Research Forecasts to 2027 – The Daily Chronicle

§ October 4th, 2020 § Filed under Nano Medicine Comments Off on Nanotechnology in Medical Market Potential Growth, Size, Share, Demand and Analysis of Key Players Research Forecasts to 2027 – The Daily Chronicle

Global Nanotechnology in Medical Market report explores the Nanotechnology in Medical industry around the globe offers details about industry review, classification, meaning, and possibility along with key regions and countries. This research report delivers detailed insights on each and every aspect of the Nanotechnology in Medical Market.

Additionally, the research study divided the market on the basis of product types, application as well as end-user industries of Shooting Ranges.A 360 degree summarize of the competitive scenario of the Global Nanotechnology in Medical Market is presented by Reportspedia, The recent study on the Nanotechnology in Medical market Analysis report provides information about this industry with a thorough assessment of this business.

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Major Players in the Nanotechnology in Medical market are:

3M Cytimmune Novartis Camurus Merck Amgen Access Roche Celgene Mitsui Chemicals Smith and Nephew Pfizer Dentsply International

Nanotechnology in Medical market growth has been segregated into the Americas, APAC, Europe, Middle East & Africa. The Nanotechnology in Medical market size is appropriately divided into pivotal segments in the report. A synopsis of the industry with regards to market size concerning remuneration and volume aspects along with the current Nanotechnology in Medical market shares scenario is also offered in the report.

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Types covered in the Nanotechnology in Medical industry are:

Nano Medicine Nano Diagnosis Other

Applications covered in the report are:

Hospitals Clinics Others

The study wanted to focus on key manufacturers, competitive landscape, and SWOT analysis for the Nanotechnology in Medical industry. Apart from looking into the geographical regions, the report concentrated on key trends and segments that are either driving the enlargement of the industry. Researchers have also focused on individual growth trends besides their contribution to the overall market.

This is probable to drive the Global Nanotechnology in Medical Market over the forecast period. This research report covers the market landscape and its progress prospects in the near future. After study key companies, the report focuses on the new entrant contributing to the enlargement of the market. Most companies in the Global Nanotechnology in Medical Market are currently adopted new technological trends in the market.

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Key highlights of the global Nanotechnology in Medical Market research report:

Some of the key questions answered in this Nanotechnology in Medical Market report:

Table of Contents: Nanotechnology in Medical Market

Chapter 1: Overview of Nanotechnology in Medical Market

Chapter 2: Global Market Status and Forecast by Regions

Chapter 3: Global Nanotechnology in Medical Market Status and Forecast by Types

Chapter 4: Global Nanotechnology in Medical industry Status and Forecast by Downstream Industry

Chapter 5: Nanotechnology in Medical industry Market Driving Factor Analysis

Chapter 6: Market Competition Status by Major Manufacturers

Chapter 7: Major Manufacturers Introduction and Market Data

Chapter 8: Upstream and Downstream Nanotechnology in Medical industry Analysis

Chapter 9: Cost and Gross Margin Analysis

Chapter 10: Marketing Status Analysis

Chapter 11: Nanotechnology in Medical industry Market Report Conclusion

Chapter 12: Research Methodology and Reference

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Zebrafish Embryo Model Helps Understand the Workings of Nanoparticles in Blood – AZoNano

§ October 2nd, 2020 § Filed under Nano Medicine Comments Off on Zebrafish Embryo Model Helps Understand the Workings of Nanoparticles in Blood – AZoNano

Written by AZoNanoOct 1 2020

When nanoparticles are injected into the bloodstream, for instance, to kill solid tumors, it is not known what exactly happens to them.

Now, with new results reported in the ACS Nano journal, scientists from Aarhus University are set to deal with this challenging query by using zebrafish embryos as a new research model in nanotoxicology and nanomedicine.

A wide range of nanoparticles are engineered for targeted drug delivery, but regrettably, just a few of the injected nanoparticles reach the site of target, such as solid tumors. The reason for this low targeting efficiency is frequently considered a black box and thus had not been investigated thoroughly for a number of years.

An international research group, headed by Yuya Hayashi from the Department of Molecular Biology and Genetics (MBG), Aarhus University, has now shown the beauty of zebrafish embryos in nano-bioimaging that can view dynamic interactions between nanoparticles and target cells in a living entity.

Currently, in association with scientists from Interdisciplinary Nanoscience Center (iNANO), Yuya aims to answer the unexplained mysteries in bionanosciencethe first one is the biological identity concept, which elucidates how cells detect nanoparticles via a corona of proteins surrounding each particle.

For the first time, this concept has now been demonstrated in a living organism through the use of zebrafish embryos, revealing what exactly occurs to nanoparticles when they are injected into the blood.

What the Cell Sees in Bionanoscience is one of the initial publications that have established how a protein corona develops around a nanoparticle and how this protein corona indicates the need for reconsidering the way one observes nanoparticles within a biological setting. From elaborate research made in the last several years, researchers have now understood that two opposing effects mostly play a role in the cellular uptake of nanoparticles.

Generally, the protein corona inhibits the surface of the nanoparticle from direct physical interactions with the cell membrane. But what if the protein corona sends a signal that activates a particular biological interaction with receptors positioned on the cell membrane? That is something the cell detects and therefore confers a biological identity to the nanoparticle.

Currently, the scientists from Aarhus University have thus given the first visual proof for the excellent influence of the protein corona with regard to the clearance of nanoparticles from the blood that involved adverse results in the zebrafish embryo model.

The researchers employed a species-mismatched source of proteins for the formation of corona to produce a non-self biological identity and traced the movement of nanoparticles traveling via the blood and to their final targetthat is, endolysosomes in the cell.

This showed an unexpectedly quick uptake and acidification of the nanoparticles by scavenger endothelial cells (functional counterpart to the liver sinusoidal endothelial cells in mammals) followed by pro-inflammatory stimulation of macrophages.

It sounds like a crazy idea to inject nanoparticles with proteins from another animal, but for example, biomolecule-inspired nanomedicines are tested in a mouse model without particular concerns for the species-mismatched combination.

Yuya Hayashi, Department of Molecular Biology and Genetics, Aarhus University

Hayashi continued, Or else some clever folks humanise the mouse to take care of the species compatibility problem. In fact, even at the cell culture level nanoparticles are still routinely tested following the tradition to use serum supplement derived from cows while knowing that nanoparticle-protein interactions are a key driver of cellular uptake.

What makes this kind of experiments rather challenging is to maximally retain the original protein corona in a living organism. If the pre-formed corona gets quickly exchanged by endogenous blood proteins, the hypothesis tested becomes invalid. We have made quite some efforts to characterise the protein corona to ensure the nanoparticles preserve the non-self-biological identity.

Hossein Mohammad-Beigi, Study First Author, Aarhus University

The maximum benefit of the zebrafish model is its power in multicolor immediate imaging, whereby numerous combinations of reporter proteins and fluorescence tracers can be viewed in a basic arrangement at high spatio-temporal resolution. This offers a new chance that lies between less lifelike cell culture systems and more complex rodent experiments, like intravital microscopy.

Using cell cultures, we have learnt quite a lot about how cells recognise nanoparticles rather as dynamic aggregates of proteins but it was never tested in a more realistic situation. With establishment of the zebrafish model, we have finally acquired a means to further explore this question in a living organism.

Yuya Hayashi, Department of Molecular Biology and Genetics, Aarhus University

It was a simple approach with an extreme scenario tested in a very complex system, but I believe we are now one step closer to understanding what the protein corona can really mean to nanoparticles. In an environment rich in proteins, nanoparticles can wear a mask that gives them a biological identity, and its non-selfness can make them a foe. What defines the degree of the non-selfness? Well, it's the next big question we have to address, Hayashi concluded.

Mohammad-Beigi, H., et al. (2020) Tracing the In Vivo Fate of Nanoparticles with a Non-Self Biological Identity. ACS Nano. doi.org/10.1021/acsnano.0c05178.

Source: https://mbg.au.dk/en

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Impact Of Covid-19 on Nanomedicine Market 2020 Industry Challenges, Business Overview and Forecast Research Study 2026 – Crypto Daily

§ October 2nd, 2020 § Filed under Nano Medicine Comments Off on Impact Of Covid-19 on Nanomedicine Market 2020 Industry Challenges, Business Overview and Forecast Research Study 2026 – Crypto Daily

Manhattan, New York, Analytical Research Cognizance: TheNanomedicineMarketreport is based on the basis of product type, application and end-user during the truncated forecast period. The detailed study further offers a broad interpretation on the Nanomedicine market based on a systematic analysis of the market from a variety of reliable sources and thorough data points. Furthermore, the report sheds a light on the Global scale segmenting the market space across various districts, appropriate distribution channels, generated income and a generalized market space.

This intelligence and 2025 forecasts Nanomedicine industry report further exhibits a pattern of analyzing previous data sources gathered from reliable sources and set a precedented growth trajectory for the Nanomedicine market. The report also focuses on a comprehensive market revenue streams along with growth patterns, analytics focused on market trends, and the overall volume of the market.

Request Sample of Global Nanomedicine Market Report @https://www.arcognizance.com/enquiry-sample/923566

Finally, the report provides detailed profile and data information analysis of leading Augmented Reality Company.

This report covers leading companies associated in Nanomedicine Market @GE Healthcare, Johnson & Johnson, Mallinckrodt plc, Merck & Co. Inc., Nanosphere Inc., Pfizer Inc., Sigma-Tau Pharmaceuticals Inc., Smith & Nephew PLC, Stryker Corp, Teva Pharmaceutical Industries Ltd., UCB (Union chimique belge) S.A

Region Segmentation:North America (U.S., Canada, Mexico) Europe (Germany, U.K., France, Italy, Russia, Spain etc.) Asia-Pacific (China, India, Japan, Southeast Asia etc.) South America (Brazil, Argentina etc.) Middle East & Africa (Saudi Arabia, South Africa etc.)

On the basis of types, the Nanomedicine market is primarily split into:Regenerative Medicine, In-vitro & In-vivo Diagnostics, Vaccines, Drug Delivery

On the basis of applications, the market covers:Clinical Cardiology, Urology, Genetics, Orthopedics, Ophthalmology

Some of the major factors contributing to the growth of the global Nanomedicine market:

Nanomedicine Market Report Structure at a Glance:

Access Global Nanomedicine Market Report @https://www.arcognizance.com/report/global-nanomedicine-market-status-and-future-forecast-2015-2025

Table of Content:

Note:Our report does take into account the impact of corona virus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

About us:Analytical Research Cognizance (ARC) is a trusted hub for research reports that critically renders accurate and statistical data for your business growth. Our extensive database of examined market reports places us amongst the best industry report firms. Our professionally equipped team further strengthens ARCs potential. ARC works with the mission of creating a platform where marketers can have access to informative, latest and well researched reports. To achieve this aim our experts tactically scrutinize every report that comes under their eye.

Contact Us:Ranjeet Dengale Director Sales Analytical Research Cognizance +1 (646) 403-4695, +91 90967 44448 [emailprotected]

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The Europe exosome diagnostic and therapeutic market is projected to reach US$ 12,524.24 thousand in 2019 to US$ 104,694.72 thousand by 2027 -…

§ October 2nd, 2020 § Filed under Nano Medicine Comments Off on The Europe exosome diagnostic and therapeutic market is projected to reach US$ 12,524.24 thousand in 2019 to US$ 104,694.72 thousand by 2027 -…

October 01, 2020 12:56 ET | Source: ReportLinker

New York, Oct. 01, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Europe Exosome Diagnostic and Therapeutic Market Forecast to 2027 - COVID-19 Impact and Regional Analysis By Application ; Product ; End User, and Country" - https://www.reportlinker.com/p05974359/?utm_source=GNW

Exosome is an emerging industry with a huge potential.Applications of exosomes are expanding rapidly in the areas of disease diagnosis and treatment as well as pharmaceuticals.

Exosomes are nanovesicles and act as a vehicle to deliver therapies to cells of the body.In the future, exosomes can be used as potential biomarkers and in the field of personalized medicine.

Interest in exosome research has increased dramatically in recent years, driving the growth of the exosome diagnostic and therapeutic market in the UK.New exosome therapeutics companies are rapidly entering the marketplace.

The investment flow has also increased to support such innovative therapeutic companies, further boosting the growth of the market. For example, in 2016, ReNeuron Group plc, a leading UK-based stem cell therapy development company, was awarded about US$ 2.6 million grant from Innovate UK to advance its emerging exosome nanomedicine platform. In terms of application, the diagnostics application segment accounted for a larger share of the Europe exosome diagnostic and therapeutic market. Its growth is attributed to an increasing adoption of exosome-based instruments and kits for diagnosis of chronic conditions. Additionally, exosome-based diagnostic products offer benefits such as accuracy, lower processing time, and better ergonomics; these are likely to drive the growth of diagnostic application segment in the Europe exosome diagnostic and therapeutic market In 2019, the instrument segment held a considerable share of the for exosome diagnostic and therapeutic market, by the product.This segment is also predicted to dominate the market by 2027 owing to higher demand for diagnostics instruments.

However, the software segment is anticipated to witness growth at a significant rate during the forecast period. A few major primary and secondary sources for the exosome diagnostic and therapeutic market included in the report are Instrument, US Food and Drug Administration, and World Health Organization, among others. Read the full report: https://www.reportlinker.com/p05974359/?utm_source=GNW

About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Cristal Therapeutics announces a publication in ‘Chemical Science’ on CliCr technology platform, comprising a new class of superior copper free click…

§ September 30th, 2020 § Filed under Nano Medicine Comments Off on Cristal Therapeutics announces a publication in ‘Chemical Science’ on CliCr technology platform, comprising a new class of superior copper free click…

For the optimal performance of CriPec nanomedicines, it is essential to be able to attach a broad range of small molecule active agents and large molecular entities, biologics, to CriPec nanoparticles.

The published research1reports the development of a convenient and versatile fast-reacting molecular entity for gluing very different compounds in a strain-promoted azide-alkyne cycloaddition click reaction to the nanoparticles, as well as a collection of linkers to attach the widely varying active small molecules and biologics. Next to the already demonstrated examples, many additional applications are foreseen such as the construction of antibody drug conjugates in aqueous environments with faster kinetics that is essential for these delicateconstructs.

CliCr is also used to generate virus mimicking nanoparticles. CriVac is a unique antigen carrier platform based on CriPec nanoparticles that, in contrast to viral vectors, do not convey a bystander immune response. CriPec particles' size resemble a virus and the desired numbers of antigen displayed on its surface are controlled via CliCr. CriVac mimics features of a live virus in a tailored manner to induce immunity safely, efficiently and solely to the displayed antigen, offering a prophylactic vaccination strategy which will be readily adaptable to different pathogenic treats.

The very attractive functionalisation possibilities, combined with its versatility, great reactivity and small size offer multiple opportunities for CliCrreagents to become the new standard for non-copper catalyzed click reactions in a multitude of applications.

Dr Cristianne Rijcken, CSO of Cristal Therapeutics, stated:

"This new versatile click reagent originates from an intense collaboration between industry and academic partners. For our nanomedicine applications, a fast, cleanly reacting and small click reagent is absolutely indispensable. These demands required the development of a new reagent, which will be highly attractive both for our proprietary applications and for the wider world of the biological, medical and material science applications. This is ground-breaking technology!"

In case you are interested to learn about the CliCr platform, please reach out to http://www.clicr.euor talk to us at the following virtual conferences

Reference

1. J. Weterings et al. TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azidealkyne cycloaddition reactions, Chemical Science (2020)

https://pubs.rsc.org/en/content/articlehtml/2020/sc/d0sc03477k

About Cristal Therapeutics

Cristal Therapeutics is a phase 2 clinical-stage pharmaceutical company developing targeted nanomedicines for the treatment of cancer and other diseases with high unmet patient need and considerable commercial potential. The Company's product candidates are based on its proprietary CriPec polymeric nanoparticle technology platform, which enables the design of customized nanomedicines with superior therapeutic profiles. CriPec-based products have the potential to provide enhanced efficacy and reduced side effect profiles, thus offering improved disease treatment.

Find out more: http://www.cristaltherapeutics.com

For more information, please contact:

Cristal Therapeutics Jeroen van Egmond Consultant Business Development T: +31 6 272 048 89 E: jeroen.vanegmond@cristaltherapeutics.com

Photo: https://mma.prnewswire.com/media/1283087/Cristal_Therapeutics_Infographic.jpg

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Radiation-proofing the human body for long-term space travel – Axios

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Radiation-proofing the human body for long-term space travel – Axios

Researchers are working to find new ways to protect the human body from radiation in space in order to allow people to live far from Earth for years at a time.

Why it matters: Big thinkers like Elon Musk and Jeff Bezos believe that one day people will be living and working in space, on the Moon and even on Mars for years at a time, but humans arent made to stand up for long to the extreme radiation environment theyll face off Earth.

What's happening: While living in space for years at a time is still a long way off, even shorter-duration missions to relatively nearby targets could still expose astronauts to doses of radiation that may up their odds to develop cancer later in life.

Between the lines: It's not clear exactly how bad the effects of radiation exposure actually are to people living in space.

And scientists are still trying to parse different models for how radiation could cause cancer in astronauts and how high their risks of developing it could be.

What's next: Weill Cornell Medicine geneticist Chris Mason who was involved with NASA research on the biological effects of astronaut Scott Kelly's 340 days in space has written about a 500-year plan to reengineer human genetics to make long-term space travel and even settlement on other worlds possible.

Details: Modifying the DNA of future astronauts through gene therapies or gene editing to make them more resistant to radiation and other threats from long-term space travel is an ambitious strategy.

Yes, but: Scientists need to have a much better idea of exactly what targeted genes do before they could safely and effectively modify DNA in astronauts.

The bottom line: If future humans do eventually make space home, chances are they'll need protection that doesn't yet exist.

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Microarray Market Outlook, Recent Trends and Growth Forecast 2020-2026 – The Research Process

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Microarray Market Outlook, Recent Trends and Growth Forecast 2020-2026 – The Research Process

The Lateral Flow Assay market analysis report contributes a unique combination of market insights and qualitative analysis which later helps companies to achieve remarkable growth. As an advancement this report is generated by our Lateral Flow Assay market research professionals using latest research tools, technics and methodology.

Lateral Flow Assay Market forecasting derived from in-depth understanding attained from future market spending patterns provides enumerated insight to support your decision-making process. Our market forecasting is based on a market model derived from market connectivity, dynamics, and identified persuasive factors around which conventions about the market are made. These conventions are enlightened by fact-bases, put by primary and secondary research instruments, regressive analysis and an extensive connect with industry people.

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The report thoroughly covers the Lateral Flow Assay market by type, applications and regions. The report provides an balanced and detailed analysis of the on-going Lateral Flow Assay trends, opportunities/high growth areas, Lateral Flow Assay market drivers which would help the investors to device and align their market strategies according to the current and future market dynamics.

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The report also presents the market competition landscape and a corresponding detailed analysis of the major vendor/manufacturers in the market. The key manufacturers covered in this report:

A Pin-point overview of TOC of Lateral Flow Assay Market are:

Overview and Scope of Lateral Flow Assay Market

Lateral Flow Assay Market Insights

Industry analysis - Porter's Five Force

Company Profiles

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Microarray Market Outlook, Recent Trends and Growth Forecast 2020-2026 - The Research Process

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Mottley challenges the Americas region to put its best foot forward – Loop News Barbados

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Mottley challenges the Americas region to put its best foot forward – Loop News Barbados

Cuba has been one of the shining lights of the Americas in the regional fight against the coronavirus diesease 2019 (COVID-19).

Prime Minister Mia Mottley made the observation today (September 28) as she thanked the Cuban Government for showing support toits neighbours by supplying nurses and other healthcare professionals to assist in stopping the spread of COVID-19 across terrirtories.

The solidarity which was exemplified by the waves of doctors and nurses that Cuba willingly sent to almost every corner of the Americas. And when Spain and Italy called for help, Cuba answered the call, Mottley said in her address at the 58 Directing Council of the Pan American Health Organization (PAHO).

Mottleychallenged the Americas region to put its best foot forward when combating the threat posed by the virus as she has noted some countries have been hoarding vital equipment and medicine.

We must show the world that despite our language, size and cultural differences, despite our socioeconomic inequities, or because of them, we can put all of that aside and OVERCOME this microscopic catalyst of the change to the old world order that Mother Earth so badly needed, Mottley stated.

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Heres How the Pandemic Finally Ends – POLITICO

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Heres How the Pandemic Finally Ends – POLITICO

Many experts, including the director of the CDC, predict that vaccines could be widely available as early as late spring or summer. But Emanuel believes that theyre underestimating just how difficult it will be to manufacture and distribute the doses at scale. In a report published by the Center for American Progress this summer, he and co-author Topher Spiro pointed out large gaps in the countrys vaccine setup, including potential shortages of production capacity, syringes and packaging.

And then theres the problem of actual shot-in-arm delivery. Pfizers vaccine, for example, needs to be stored at minus 70 degrees Celsius. No doctors office has negative 70, says Emanuel. You cant do the usualyou know, this sort of hodgepodge we have of CVSes, Walmarts, Walgreens, doctors offices, schools. CDC guidance suggests states prepare to distribute doses at hospitals and mobile clinics.

Making sure that most Americans receive two doses of the same vaccine four weeks apart smoothly and efficiently will be a massive government operationone that Emanuel thinks the country can pull off no earlier than November 2021and thats if you have good management skills, good logistics, he says. If there is some element of optimism and not just realism, its in that. There is no evidence this administration has the capacity to manage that.

Its 2021, and youve just gotten your two doses. What happens next will largely depend on two factors: How effective the vaccine is and how many people get it.

The goal is for the vaccine to be effective and widespread enough for the U.S. population to reach the herd immunity thresholdthe point at which, theoretically, Americans can safely take off their masks and attend large sporting events. A rough, back-of-the-envelope estimate for Covid-19 (derived from calculating the point at which each infected person, on average, infects less than one other person) is that society will reach herd immunity when around 60 percent to 70 percent of the population is immune.

Paul Offit, director of the Vaccine Education Center at Childrens Hospital of Philadelphia, walked through the math: Roughly, the formula would state that about two-thirds of the population would need to be vaccinated if [the vaccine] was 75 percent effective against shedding (i.e., transmitting) the virus. If the vaccine is less effective than that, a greater percentage of the population needs to get vaccinated to close in on herd immunity. And vice versa.

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Coronavirus science | Week in review: Post-recovery fatigue, latest on masks and Covid in kids – Health24

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Coronavirus science | Week in review: Post-recovery fatigue, latest on masks and Covid in kids – Health24

LATEST SCIENCE AND RESEARCH

READ | Fatigue is common in people who recover from Covid-19, regardless of severity

As the Covid-19 outbreak continues, we have learnt that people experience the disease differently. Some require hospitalisation where the outcome may be fatal, while others are able to recover at home.

But according to new research presented at a conference on Covid-19 hosted by the European Society of Clinical Microbiology and Infectious Diseases, there is one key factor that many Covid-19 patients, mild and severe alike, experience persistent fatigue.

As more people recover from Covid-19, some are experiencing post-infection problems, the researchers stated.

"Fatigue is a common symptom in those presenting with symptomatic Covid-19 infection. Whilst the presenting features of SARS-CoV-2 infection have been well-characterised, the medium and long-term consequences of infection remain unexplored, explained Dr Liam Townsend, lead study author from St James's Hospital and Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.

"In particular, concern has been raised that SARS-CoV-2 has the potential to cause persistent fatigue, even after those infected have recovered from Covid-19. In our study, we investigated whether patients recovering from SARS-CoV-2 infection remained fatigued after their physical recovery, and to see whether there was a relationship between severe fatigue and a variety of clinical parameters. We also examined persistence of markers of disease beyond clinical resolution of infection, Dr Townsend stated.

The researchers used a scale called the Chalder Fatigue Score to investigate fatigue in 128 recovered Covid-19 patients and found that more than half of the patients reported persistent fatigue after their recovery.

READ | Childrens immune systems respond differently to Covid-19 than those of adults, research suggests

Early in the Covid-19 outbreak, evidence showed that children are likely to experience milder Covid-19 symptoms than adults.

A study published in Science Translational Medicine is the first to compare the immune responses of children and adults. This new research detected some key differences to explain the phenomenon.

For the research, scientists from the Albert Einstein College of Medicine, Childrens Hospital at Montefiore and Yale University investigated cases of 60 adult Covid-19 patients and 65 child patients (all younger than 24 years) between 13 March and 17 May 2020.

The scientists tested the patients blood for several types of immune cells, antibody responses and cytokines produced by immune cells.

The childrens immune responses looked significantly better than those of the adults. Twenty-two adults needed ventilation, in comparison with only five children, and 17 adults died compared to just two of the paediatric patients.

"Our findings suggest that children with Covid-19 do better than adults because their stronger innate immunity protects them against SARS-CoV-2, the novel coronavirus that causes the disease," said co-senior author Dr Betsy Herold, chief of infectious diseases and vice chair for research in the department of paediatrics at Einstein and CHAM.

READ | To what extent is Covid-19 damaging the brain?

Maybe it's a bad trip, or maybe it's the "rona". For one woman hallucinating about lions and monkeys in her home and convinced her husband was someone else it turned out to be the latter.

And she's not the only one.

Scientists are struggling to understand Covid-19's effect on the brain as more patients present with neurological symptoms. In the beginning of the pandemic, these symptoms were often missed as healthcare workers were more concerned about keeping patients breathing than noticing whether they were "seeing things".

Scientists have, however, slowly started taking note of neurological disorders in Covid-19 patients. In July, a UK study detailed more than 40 cases of patients presenting with brain dysfunctions like encephalopathy, ischaemic stroke and Guillain-Barr Syndrome, all of which can cause haemorrhaging and inflammation.

These symptoms were even present in patients with mild Covid-19.

Another study also showed how mini-brains grown in a lab proved that viral replication could take place in their cells, signalling potential long-term brain damage, although how the virus would get into the brain remains an unanswered question.

A research paper explained that an infection of the brain could happen in three stages: loss of taste and smell as it infects the nose's epithelial cells; blood clots in the system that could lead to strokes; and damage to the blood-brain barrier by the ensuing cytokine storm, making our most important organ vulnerable to further infection.

PICS | Striking images show exactly how Covid-19 virus infects lungs

The lungs are the organs most commonly affected by Covid-19, the disease caused by SARS-CoV-2, and researchers from the UNC School of Medicine have published striking images of cells infected by the virus.

The high-powered microscopic images generated by Dr Camille Ehre from UNC (done in collaboration with two other researchers), show high SARS-CoV-2 viral loads on human respiratory surfaces, ready to spread infection in infected individuals and transmit infection to others.

The images were published in the New England Journal of Medicine.

In a laboratory setting, the researchers inoculated the SARS-CoV-2 virus into human bronchial epithelial cells. Using scanning electron microscopy, they examined the cells 96 hours later.

The images below were re-colourised by UNC medical student Cameron Morrison and indicate the following: the infected ciliated cells with strands of mucus (yellow), attached to cilia tips (blue).

In their published paper, the authors explain that cilia are hair-like structures on the surface of airway epithelial cells that transport mucus (and trapped viruses) from the lungs. The airway epitheliums job is to moisten and protect the airways.

READ | Want a breathable, yet effective homemade mask? Use silk, study suggests

As masks are becoming mandatory all over the world, authorities have asked people to use homemade cloth masks instead of single-use surgical and N95 masks that are needed by medical staff.

Face coverings from all materials and shapes are being used. And while all face coverings offer a measure of protection against large and small respiratory droplets, a team of researchers from the University of Cincinnati wanted to examine the efficacy of different household fabrics.

The study, which was recently published in the journal PLOS ONE, wanted to determine what practices would be most effective in practice. The researchers examined cotton, polyester and silk by their resistance to the penetration of small and aerosolised water drops.

They also investigated the breathability of the fabrics, and how they would fare if they were washed repeatedly. In the laboratory, they used the materials as an overlaying barrier for respirators, as well as face coverings. The team then looked at the penetration and absorption of droplets and observed that silk faired the best, both as a barrier and in terms of breathability.

"Cotton traps moisture like a sponge. But silk is breathable. It's thinner than cotton and dries really fast," said Patrick Guerra, an assistant professor of biology at UCs College of Arts and Sciences.

Its not only the fact that silk is dense and breathable that made the researchers take note.

CORONAVIRUS CASES LATEST

SA cases update:

The latest number of confirmed cases is 669 498.

According to the latest update, 16 376 deaths have been recorded in the country.

There have been 601 818 recoveries.

So far, more than 4.12 million tests have been conducted, with 11 359 new tests reported.

Global cases update:

For the latest global data,follow this interactive map from Johns Hopkins University & Medicine.

Late on Saturday night, positive cases worldwide were almost 32.71 million, while deaths were more than 991 000.

The United States had the most cases in the world - more than 7.07 million, as well as the most deaths - more than 204 000.

HEALTH TIPS(as recommended by the NICD and WHO)

Maintain physical distancing stay at least one metre away from somebody who is coughing or sneezing

Practise frequent hand-washing, especially after direct contact with ill people or their environment

Avoid touching your eyes, nose and mouth, as your hands touch many surfaces and could potentially transfer the virus

Practise respiratory hygiene cover your mouth with your bent elbow or tissue when you cough or sneeze. Remember to dispose the tissue immediately after use.

Image credit: Getty Images

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Coronavirus science | Week in review: Post-recovery fatigue, latest on masks and Covid in kids - Health24

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When can we expect a vaccine for children, an important step in the fight against COVID-19? – Poynter

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on When can we expect a vaccine for children, an important step in the fight against COVID-19? – Poynter

Covering COVID-19 is a daily Poynter briefing of story ideas about the coronavirus and other timely topics for journalists, written by senior faculty Al Tompkins. Sign up here to have it delivered to your inbox every weekday morning.

As I read the CDCs new playbook for how to roll out a COVID-19 vaccine, one thing is missing from the plan: how we will vaccinate children. The plan, understandably prioritizes seniors, health care workers, people with medical vulnerabilities, people in jails, homeless shelters and other at-risk populations. The first priority group also includes daycare workers and school teachers, but does not mention the students, except for college students.

There are reasons for this.

First, young people are not immune to COVID-19 but generally are not as likely to become sick from it, even if they are infected. Of course they can, and do, spread the virus to adults. But there is another reason that children may not be vaccinated until late next year at the earliest. All of the leading vaccine trials right now involve adults, not children. So when we get a successful vaccine, possibly later this year, it will be a vaccine that has only been used on adults and will not have been prove safe and effective for children.

The New York Times includes this quote:

Right now Im pretty worried that we wont have a vaccine available for kids by the start of next school year, said Dr. Evan Anderson, a pediatrician at Childrens Healthcare of Atlanta and a professor at the Emory University School of Medicine.

Anderson had a lot more to say in an essay published in the journal Clinical Infectious Diseases.He said the nations vaccine trials for children are stuck in neutral and that they should be moving forward alongside adult vaccines, not waiting for the adult vaccine to be approved before perfecting a vaccine for young people. He writes:

The risk of serious COVID19 in children (both hospitalizations and MIS-C) occurs with disproportionately higher rates in both Hispanics and Blacks as compared to Whites [8-10]. A pediatric COVID-19 vaccine could dramatically reduce hospitalization and racial disparities from COVID-19. Children in the US are dying of COVID-19-related complications; in the first 5 months of the pandemic, 103 children have died in the US from COVID-19 through September 9, 2020.

Anderson makes the important point that if children keep getting infected, even if they do not show symptoms, then the virus will continue to spread even with an adult vaccine:

Without a COVID-19 vaccine, children will likely serve as a reservoir, which would undermine efforts to end the pandemic. Until all children can more safely return to school and parents can return to fulltime work, it is difficult to imagine that the economy can completely recover.

But what about safety? Can you imagine allowing your child to take a shot that is not known to be safe and effective? Anderson says given the known safety of the adult vaccines that have cleared Phase 2 trials, the drug companies could begin testing on older kids first.

Pediatric clinical trials of leading vaccine candidates can safely be initiated now. To establish safety, trials should start with adolescents and older children before expanding to younger children. The strategy of age de-escalating trials to bridge vaccines from adult studies to children is one that has been commonly used in the past to ensure early identification of safety signals while minimizing risks, establishing dosing, and evaluating immune responses. Similar to adult studies, it will take time

Phase 3 drug trials help pharma companies figure out what doses are most effective for which populations. For some drugs, the dose for children is lower, but for others, like those fighting pertussis, the childhood dose is greater than the adult dose. And in the past, such drug trials have had years to figure out those doses.

Fox News reports that some of the front-running drug trials are starting to expand their tests with children in mind:

Moderna and Astra Zeneca (though the latter is on pause in the U.S. for a safety matter) enrolled people aged 18 and older, while arecent proposed trial expansionby Pfizer and BioNTech looks to include those as young as 16.

Jeff Richardson, speaking on behalf of Inovio Pharmaceuticals, told Fox News that in general, industry practice is to begin clinical trials for most infections/diseases with adults and enroll younger subjects in later trials.

Dr. Anna P. Durbin, professor of international health in the Johns Hopkins Bloomberg School of Public Health with a joint appointment in the School of Medicine, said the safety and efficacy of the vaccine needs to be determined in those at highest risk of COVID-19disease first because they will be receiving the vaccine first. Children will not likely be included in the first, highest priority of vaccine recipients.

Meanwhile, a Moderna spokesperson told Fox News of plans to initiate pediatric vaccination trials for COVID-19 by the end of the year.

Still to be seen is whether schools will eventually require children to have been vaccinated against COVID-19, as they require other vaccinations.

There are lots of reports of this happening.

The Indiana University School of Medicine surveyed 1,500 COVID survivors that they call long-haulers people who have lingering symptoms for months after initially getting sick. Long-haulers report many symptoms that are not listed on the CDCs official list. And 423 of the 1,567 long-haulers reported hair loss. Some experts are suggesting the hair loss may be more closely connected to the stress of being infected than to the virus itself.

Among the other symptoms long-haulers citied in addition to hair-loss were night sweats, memory problems, blurry vision and pain in the hands and feet.

Schools are finding it really difficult to track student attendance when classes are held remotely. FutureEd reported:

Tracking attendance can be complicated by family circumstances: New Jerseys guidance notes that, depending on parents work schedules, some students will have to do their learning in the evening. Such students should be counted as present if they turn in assignments.

Attendance can also be complicated by hybrid models, in which students are on campus some days and learn remotely other days. Ohios guidance specifies that a student cant make up an in-person absence by logging in remotely. Ohio also calls on schools to record attendance and participation by hours and assign hourly values to projects students do at home. Completing a diorama, for instance, would be worth eight hours regardless of how long it takes the student to complete.

A New York Times piece reported:

Around the country, teachers and school administrators are hoping that a patchwork of plans cobbled together over the summer will help address one of the most pressing challenges they face as millions of students start a new school year online: How to make sure they come to virtual class, and what balance to strike between punitive and forgiving policies if they dont.

Attendance data from last spring, while limited, suggests that the problem loomed large in many districts after school buildings closed in mid-March. In onesurvey of 5,659 educators around the country, 34 percent of respondents said that no more than one in four students were attending their remote classes, and a majority said fewer than half their students were attending.

Columbus, Ohio, schools that already had high absenteeism rates are trying to figure out what happened to 1,500 students who never showed up in enrollment records this fall. And Chalkbeat says this is happening around the country, and is especially concerning because lots of the kids schools expected to be in class but are not include kindergarteners.

In Broward County, Florida, school officials noticed something worrying this month.

Schools were back in session, virtually. But a few weeks in, one group of students was missing in large numbers: kindergartners.

At Deerfield Beach Elementary, where 81% of students come from low-income families, there are 52 fewer kindergarten students than there were last fall. Twenty miles south, Harbordale Elementary, where 40% of students are from low-income families, was down 38.

We were definitely concerned, said John Sullivan, who oversees the districts enrollment planning.

Some declines were projected, due to factors like lower birth rates. But this was something different. All told, the districts traditional public schools are serving 2,000 fewer kindergarten students a decline of around 14%.

School districts are seeing similar double-digit declines across the country, fromOakland, CaliforniatoPhiladelphia. Kindergarten enrollment is down 15% from last fall in Hawaiis schools, according to state data.In Los Angeles, its down 14%. And in Gwinnett County, Georgia, where in-person classes have resumed, its down 10% since last fall, state and district figures show.

In Montgomery County, Maryland, the school system says it may allow students to take mental health days during the pandemic.

President Donald Trump is holding up an executive order that he says will forbid insurance companies from discriminating against people with pre-existing conditions as protection in case the Supreme Court rules that Obamacare is unconstitutional. He made the announcement at a rally in Charlotte, North Carolina, Thursday evening.

But like other of Trumps executive orders, this one might not make any difference.University of Michigan law professor Nicholas Bagley tweeted that unless Trump is exercising a power thats been specifically delegated to him, an executive order directed at private parties hasno more legal weight than a press release.

In July, the president held up an executive order that he said would reduce prescription drug prices for millions of Americans. But he didnt actually sign or file the order for months, and when he did, it became clear the order didnt have the authority to prompt a drug pricing change.

Right after the November election, the Supreme Court will hear a case that could determine the future of the Affordable Health Care Act. One of the most popular parts of the act protects people with conditions that insurance companies would rather not cover.

The president said he wanted to work with Congress to stop surprise billing, which happens when patients are treated, often in emergency situations, by providers who are out of network but work in a hospital that is in network. He did not offer any legislation for Congress to consider, just a hope that everybody could work together.

A story in StatNews included an interesting story that said:

Even before the rise of Covid-19, hospitals have increasingly struggled to get health-care associated infections in check. There are 2 million such infections and 90,000 related deaths in U.S. hospitals every year.

As hospitals across the country hunt for ways to reduce the spread of pathogens to patients, a growing chorus of researchers is arguing that a simple swap might help: replace stainless steel surfaces with copper.

Coppers ability to neutralize microbes is well-known. Researchers studying SARS-CoV-2, the disease that causes Covid-19,noted back in Marchthat the virus lasts for several days on stainless steel which most hospitals use for the majority of surfaces but dies within hours of landing on copper.

What we do not know is whether it would make any difference to the spread of hospital infections.

I post this with a little trepidation since it was not that long ago when health experts were saying that face masks didnt help much, right before they told us we had to have them. But with that in mind, read this from The New York Times:

The shields, which have been marketed as an alternative to face masks to guard against the coronavirus, do almost nothing to stop the spread of microscopic airborne droplets that are increasingly understood to be a major vector for spreading the disease, according to a recent study by researchers at the Riken Center for Computational Science, a research institute based in Kobe, Japan.

Face shields may be useful for protecting the wearer from the droplets generated by others, but are almost completely ineffective at protecting others from the wearers own droplets, according to Makoto Tsubokura, a professor at Kobe University and the lead researcher on a team that is using Japans world-beating supercomputer to better understand how to defend against the coronavirus.

It probably is no surprise that big retailers say they will hire more workers for the holiday season but the people will be fulfilling online orders. Target says it hopes to hire 130,000 seasonal workers this year, which is about the same as last year. But many of the workers will be delivering to curbside pickup buyers and working in warehouses rather than retail stores.

Well be back tomorrow with a new edition of Covering COVID-19. Sign up here to get it delivered right to your inbox.

Al Tompkins is senior faculty at Poynter. He can be reached at atompkins@poynter.org or on Twitter, @atompkins.

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When can we expect a vaccine for children, an important step in the fight against COVID-19? - Poynter

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Orthopedic Soft Tissue Repair and Sports Medicine Market is Booming Worldwide By Top Emerging Key Players: , Stryker Corporation, Arthrex, Smith and…

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Orthopedic Soft Tissue Repair and Sports Medicine Market is Booming Worldwide By Top Emerging Key Players: , Stryker Corporation, Arthrex, Smith and…

LOS ANGELES, United States: QY Research has recently published a research report titled, Global Orthopedic Soft Tissue Repair and Sports Medicine Market Research Report 2020. This report has been prepared by experienced and knowledgeable market analysts and researchers. It is a phenomenal compilation of important studies that explore the competitive landscape, segmentation, geographical expansion, and revenue, production, and consumption growth of the global Orthopedic Soft Tissue Repair and Sports Medicine market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global Orthopedic Soft Tissue Repair and Sports Medicine market.

The report includes CAGR, market shares, sales, gross margin, value, volume, and other vital market figures that give an exact picture of the growth of the global Orthopedic Soft Tissue Repair and Sports Medicine market.

Competitive Landscape

Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global Orthopedic Soft Tissue Repair and Sports Medicine market.

Key questions answered in the report:

TOC

Table of Contents 1 Orthopedic Soft Tissue Repair and Sports Medicine Market Overview 1.1 Product Overview and Scope of Orthopedic Soft Tissue Repair and Sports Medicine 1.2 Orthopedic Soft Tissue Repair and Sports Medicine Segment by Type1.2.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Sales Growth Rate Comparison by Type (2021-2026)1.2.2 ACL/PCL1.2.3 Meniscal Repair1.2.4 Rotator Cuff1.2.5 Shoulder Labarum1.2.6 Hip Arthroscopy1.2.7 Biceps Tenodesis1.2.8 Others 1.3 Orthopedic Soft Tissue Repair and Sports Medicine Segment by Application1.3.1 Orthopedic Soft Tissue Repair and Sports Medicine Sales Comparison by Application: 2020 VS 20261.3.2 Knee1.3.3 Hip1.3.4 Shoulder1.3.5 Others 1.4 Global Orthopedic Soft Tissue Repair and Sports Medicine Market Size Estimates and Forecasts1.4.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Revenue 2015-20261.4.2 Global Orthopedic Soft Tissue Repair and Sports Medicine Sales 2015-20261.4.3 Orthopedic Soft Tissue Repair and Sports Medicine Market Size by Region: 2020 Versus 2026 2 Global Orthopedic Soft Tissue Repair and Sports Medicine Market Competition by Manufacturers 2.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Sales Market Share by Manufacturers (2015-2020) 2.2 Global Orthopedic Soft Tissue Repair and Sports Medicine Revenue Share by Manufacturers (2015-2020) 2.3 Global Orthopedic Soft Tissue Repair and Sports Medicine Average Price by Manufacturers (2015-2020) 2.4 Manufacturers Orthopedic Soft Tissue Repair and Sports Medicine Manufacturing Sites, Area Served, Product Type 2.5 Orthopedic Soft Tissue Repair and Sports Medicine Market Competitive Situation and Trends2.5.1 Orthopedic Soft Tissue Repair and Sports Medicine Market Concentration Rate2.5.2 Global Top 5 and Top 10 Players Market Share by Revenue2.5.3 Market Share by Company Type (Tier 1, Tier 2 and Tier 3) 2.6 Manufacturers Mergers & Acquisitions, Expansion Plans 2.7 Primary Interviews with Key Orthopedic Soft Tissue Repair and Sports Medicine Players (Opinion Leaders) 3 Orthopedic Soft Tissue Repair and Sports Medicine Retrospective Market Scenario by Region 3.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Retrospective Market Scenario in Sales by Region: 2015-2020 3.2 Global Orthopedic Soft Tissue Repair and Sports Medicine Retrospective Market Scenario in Revenue by Region: 2015-2020 3.3 North America Orthopedic Soft Tissue Repair and Sports Medicine Market Facts & Figures by Country3.3.1 North America Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.3.2 North America Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.3.3 U.S.3.3.4 Canada 3.4 Europe Orthopedic Soft Tissue Repair and Sports Medicine Market Facts & Figures by Country3.4.1 Europe Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.4.2 Europe Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.4.3 Germany3.4.4 France3.4.5 U.K.3.4.6 Italy3.4.7 Russia 3.5 Asia Pacific Orthopedic Soft Tissue Repair and Sports Medicine Market Facts & Figures by Region3.5.1 Asia Pacific Orthopedic Soft Tissue Repair and Sports Medicine Sales by Region3.5.2 Asia Pacific Orthopedic Soft Tissue Repair and Sports Medicine Sales by Region3.5.3 China3.5.4 Japan3.5.5 South Korea3.5.6 India3.5.7 Australia3.5.8 Taiwan3.5.9 Indonesia3.5.10 Thailand3.5.11 Malaysia3.5.12 Philippines3.5.13 Vietnam 3.6 Latin America Orthopedic Soft Tissue Repair and Sports Medicine Market Facts & Figures by Country3.6.1 Latin America Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.6.2 Latin America Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.6.3 Mexico3.6.3 Brazil3.6.3 Argentina 3.7 Middle East and Africa Orthopedic Soft Tissue Repair and Sports Medicine Market Facts & Figures by Country3.7.1 Middle East and Africa Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.7.2 Middle East and Africa Orthopedic Soft Tissue Repair and Sports Medicine Sales by Country3.7.3 Turkey3.7.4 Saudi Arabia3.7.5 U.A.E 4 Global Orthopedic Soft Tissue Repair and Sports Medicine Historic Market Analysis by Type 4.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Sales Market Share by Type (2015-2020) 4.2 Global Orthopedic Soft Tissue Repair and Sports Medicine Revenue Market Share by Type (2015-2020) 4.3 Global Orthopedic Soft Tissue Repair and Sports Medicine Price Market Share by Type (2015-2020) 4.4 Global Orthopedic Soft Tissue Repair and Sports Medicine Market Share by Price Tier (2015-2020): Low-End, Mid-Range and High-End 5 Global Orthopedic Soft Tissue Repair and Sports Medicine Historic Market Analysis by Application 5.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Sales Market Share by Application (2015-2020) 5.2 Global Orthopedic Soft Tissue Repair and Sports Medicine Revenue Market Share by Application (2015-2020) 5.3 Global Orthopedic Soft Tissue Repair and Sports Medicine Price by Application (2015-2020) 6 Company Profiles and Key Figures in Orthopedic Soft Tissue Repair and Sports Medicine Business 6.1 Stryker Corporation6.1.1 Corporation Information6.1.2 Stryker Corporation Description, Business Overview and Total Revenue6.1.3 Stryker Corporation Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.1.4 Stryker Corporation Products Offered6.1.5 Stryker Corporation Recent Development 6.2 Arthrex6.2.1 Arthrex Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.2.2 Arthrex Description, Business Overview and Total Revenue6.2.3 Arthrex Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.2.4 Arthrex Products Offered6.2.5 Arthrex Recent Development 6.3 Smith and Nephew6.3.1 Smith and Nephew Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.3.2 Smith and Nephew Description, Business Overview and Total Revenue6.3.3 Smith and Nephew Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.3.4 Smith and Nephew Products Offered6.3.5 Smith and Nephew Recent Development 6.4 Zimmer Biomet Holdings6.4.1 Zimmer Biomet Holdings Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.4.2 Zimmer Biomet Holdings Description, Business Overview and Total Revenue6.4.3 Zimmer Biomet Holdings Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.4.4 Zimmer Biomet Holdings Products Offered6.4.5 Zimmer Biomet Holdings Recent Development 6.5 Conmed Corporation6.5.1 Conmed Corporation Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.5.2 Conmed Corporation Description, Business Overview and Total Revenue6.5.3 Conmed Corporation Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.5.4 Conmed Corporation Products Offered6.5.5 Conmed Corporation Recent Development 6.6 DePuy Synthes6.6.1 DePuy Synthes Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.6.2 DePuy Synthes Description, Business Overview and Total Revenue6.6.3 DePuy Synthes Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.6.4 DePuy Synthes Products Offered6.6.5 DePuy Synthes Recent Development 6.7 Smith & Nephew6.6.1 Smith & Nephew Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.6.2 Smith & Nephew Description, Business Overview and Total Revenue6.6.3 Smith & Nephew Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.4.4 Smith & Nephew Products Offered6.7.5 Smith & Nephew Recent Development 6.8 LifeNet Health6.8.1 LifeNet Health Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.8.2 LifeNet Health Description, Business Overview and Total Revenue6.8.3 LifeNet Health Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.8.4 LifeNet Health Products Offered6.8.5 LifeNet Health Recent Development 6.9 AlloSource6.9.1 AlloSource Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.9.2 AlloSource Description, Business Overview and Total Revenue6.9.3 AlloSource Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.9.4 AlloSource Products Offered6.9.5 AlloSource Recent Development 6.10 Acera Surgical6.10.1 Acera Surgical Orthopedic Soft Tissue Repair and Sports Medicine Production Sites and Area Served6.10.2 Acera Surgical Description, Business Overview and Total Revenue6.10.3 Acera Surgical Orthopedic Soft Tissue Repair and Sports Medicine Sales, Revenue and Gross Margin (2015-2020)6.10.4 Acera Surgical Products Offered6.10.5 Acera Surgical Recent Development 7 Orthopedic Soft Tissue Repair and Sports Medicine Manufacturing Cost Analysis 7.1 Orthopedic Soft Tissue Repair and Sports Medicine Key Raw Materials Analysis 7.1.1 Key Raw Materials 7.1.2 Key Raw Materials Price Trend 7.1.3 Key Suppliers of Raw Materials 7.2 Proportion of Manufacturing Cost Structure 7.3 Manufacturing Process Analysis of Orthopedic Soft Tissue Repair and Sports Medicine 7.4 Orthopedic Soft Tissue Repair and Sports Medicine Industrial Chain Analysis 8 Marketing Channel, Distributors and Customers 8.1 Marketing Channel 8.2 Orthopedic Soft Tissue Repair and Sports Medicine Distributors List 8.3 Orthopedic Soft Tissue Repair and Sports Medicine Customers 9 Market Dynamics 9.1 Market Trends 9.2 Opportunities and Drivers 9.3 Challenges 9.4 Porters Five Forces Analysis 10 Global Market Forecast 10.1 Global Orthopedic Soft Tissue Repair and Sports Medicine Market Estimates and Projections by Type10.1.1 Global Forecasted Sales of Orthopedic Soft Tissue Repair and Sports Medicine by Type (2021-2026)10.1.2 Global Forecasted Revenue of Orthopedic Soft Tissue Repair and Sports Medicine by Type (2021-2026) 10.2 Orthopedic Soft Tissue Repair and Sports Medicine Market Estimates and Projections by Application10.2.1 Global Forecasted Sales of Orthopedic Soft Tissue Repair and Sports Medicine by Application (2021-2026)10.2.2 Global Forecasted Revenue of Orthopedic Soft Tissue Repair and Sports Medicine by Application (2021-2026) 10.3 Orthopedic Soft Tissue Repair and Sports Medicine Market Estimates and Projections by Region10.3.1 Global Forecasted Sales of Orthopedic Soft Tissue Repair and Sports Medicine by Region (2021-2026)10.3.2 Global Forecasted Revenue of Orthopedic Soft Tissue Repair and Sports Medicine by Region (2021-2026) 10.4 North America Orthopedic Soft Tissue Repair and Sports Medicine Estimates and Projections (2021-2026) 10.5 Europe Orthopedic Soft Tissue Repair and Sports Medicine Estimates and Projections (2021-2026) 10.6 Asia Pacific Orthopedic Soft Tissue Repair and Sports Medicine Estimates and Projections (2021-2026) 10.7 Latin America Orthopedic Soft Tissue Repair and Sports Medicine Estimates and Projections (2021-2026) 10.8 Middle East and Africa Orthopedic Soft Tissue Repair and Sports Medicine Estimates and Projections (2021-2026) 11 Research Finding and Conclusion 12 Methodology and Data Source 12.1 Methodology/Research Approach12.1.1 Research Programs/Design12.1.2 Market Size Estimation12.1.3 Market Breakdown and Data Triangulation 12.2 Data Source12.2.1 Secondary Sources12.2.2 Primary Sources 12.3 Author List 12.4 Disclaimer

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Orthopedic Soft Tissue Repair and Sports Medicine Market is Booming Worldwide By Top Emerging Key Players: , Stryker Corporation, Arthrex, Smith and...

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Global Nano Therapy Market- Industry Analysis and Forecast (2020-2027) – Unica News

§ September 29th, 2020 § Filed under Nano Medicine Comments Off on Global Nano Therapy Market- Industry Analysis and Forecast (2020-2027) – Unica News

Global Nano Therapy Marketwas valued US$ XX Mn in 2019 and is expected to reach US$ XX Mn by 2027, at a CAGR of 8.6% during a forecast period.

Market Dynamics

Nanotechnology is the manipulation of matter on an atomic, molecular, and supramolecular scale. Nanotherapy is a branch of Nano medicine that includes using nanoparticles to deliver a drug to a given target location in the body so as to treat the disease through a process called as targeting.

This report provides insights into the factors that are driving and restraining the global Nano Therapy market. Nanotherapy is also referred to as targeted therapy, which offers to transport the molecules to the affected cells to treat the disease without affecting other negative effects on the healthy cells. Nanoparticles allow for multiple functional groups to be added to the surface. Each of the functional groups contributes to the effectiveness of this method of therapy and deliver its components in a controlled way once it gets to the target cells/tissue. Nano therapy is considered as recent technology for some diseases, which are implemented with the help of submicron-sized molecular devices or nanoparticles. Nanoparticles can improve the drug accessibility in the body with strength, drag out the medication, and can upsurge the half-life of plasma and boost the drug specificity. These are the factors driving the growth of the Nano therapy market.

As compared to the conventional methods, this method has increased more popularity owing to its high accuracy when it comes to administering therapeutic formulations. The market is thriving, with around 250 Nano-medical products being verified or used for humans. Though, with Nano therapy, the carrier is protected from degradations, which allows it to reach given target cells in the body for a local reaction. Nano therapy is considerably used in the treatment of diseases like cancer, diabetes, and cardiovascular diseases. A recent study by the Journal of Diabetes and Metabolic diseases has stated that the incidence of MS ranged from 30.5 to 31.5% in China and 35.8 to 45.3% in India.

However, an absence of controlling standards in the examination of Nano therapy and high expenditure of treatment are several of the major factors that are restraining the growth of the Nano therapy market during the forecast period.

The report study has analyzed revenue impact of covid-19 pandemic on the sales revenue of market leaders, market followers and disrupters in the report and same is reflected in our analysis.

Global Nano Therapy Market Segment analysis

Based on Type, the Nanomaterial segment is anticipated to grow at a CAGR of 20.8% during the forecast period. The nanomaterial is the materials with at least one exterior dimension in the size range of nearly 1 to 100 nanometers. The nanomaterial is intended for developing novel characteristics and has the potential to improve quality of life. The nanomaterial is generally used in cosmetics, healthcare, electronics, and other areas currently. Unceasing development and innovation in the field are impelling the growth of the global nanomaterials market. The amazing chemical and physical properties of materials at the nanometer scale allow novel applications. For instance, energy conservation and structural strength improvement to antimicrobial properties and self-cleaning surfaces. Nanotechnology is being increasingly efficient by spending mainly on R&D activities which are resulting in the development of current technologies and innovations with reference to the new materials.

Global Nano Therapy Market Regional analysis

North America region dominated the Nano therapy market with US$ XX Mn in 2019. The availability of technology, increasing healthcare spending, and government funding for research and development are some of the factors boosting the growth of the Nano therapy market in the region. Europe is expected to follow the Americas and bring in the second leading market share for Nano therapy throughout the forecast period. Europe is mainly driven by awareness and improvement in the nanotechnology sector.

Recent Developments

In 08 May 2019- Cisplatin cis-(diammine) dichloridoplatinum (II) (CDDP) is the first platinum based complex approved by the food and drug administration (FDA) of the United States (US). Cisplatin is the first line chemotherapeutic agent used alone or combined with radiations or other anti-cancer agents for a broad range of cancers such as lung, head and neck.

In May 2019- A new study conducted by scientists from the Indian Institute of Technology, Bombay, have designed hybrid nanoparticles to treat cancer. These nanoparticles are made from gold and lipids. These nanoparticles respond to light and can be directed inside the body to release drugs to a targeted area, and are biocompatible, meaning theyre not toxic to a human body.

In September 2019, researchers at Finlands University of Helsinki, in partnership with the bo Akademi University and Chinas Huazhong University of Science and Technology developed an anti-cancer nanomedicine useful for targeted cancer chemotherapy.

The objective of the report is to present a comprehensive analysis of the Global Nano Therapy Market including all the stakeholders of the industry. The past and current status of the industry with forecasted market size and trends are presented in the report with the analysis of complicated data in simple language. The report covers all the aspects of the industry with a dedicated study of key players that includes market leaders, followers and new entrants. PORTER, SVOR, PESTEL analysis with the potential impact of micro-economic factors of the market have been presented in the report. External as well as internal factors that are supposed to affect the business positively or negatively have been analyzed, which will give a clear futuristic view of the industry to the decision-makers. The report also helps in understanding Global Nano Therapy Market dynamics, structure by analyzing the market segments and project the Global Nano Therapy Market size. Clear representation of competitive analysis of key players by Application, price, financial position, Product portfolio, growth strategies, and regional presence in the Global Nano Therapy Market make the report investors guide. Scope of the Global Nano Therapy Market

Global Nano Therapy Market, By Type

Nanomaterial and Biological Device Nano Electronic Biosensor Molecular Nanotechnology Implantable Cardioverter-Defibrillators Global Nano Therapy Market, By Application

Cardiovascular Disease Cancer Therapy Diabetes Treatment Rheumatoid Arthritis Global Nano Therapy Market, By Regions

North America Europe Asia-Pacific South America Middle East and Africa (MEA) Key Players operating the Global Nano Therapy Market

Selecta Biosciences Inc. Cristal Therapeutics Sirnaomics Inc. Nanobiotix Luna CytImmune Science Inc. NanoBio Corporation Nanospectra Biosciences Inc. Nanoprobes Inc. NanoBioMagnetics.n.nu Smith and Nephew NanoMedia Solutions Inc. Nanosphere Inc. DIM Parvus Therapeutics Tarveda Therapeutics

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Cend Therapeutics Announces Acquisition of Impilo Therapeutics – GlobeNewswire

§ September 26th, 2020 § Filed under Nano Medicine Comments Off on Cend Therapeutics Announces Acquisition of Impilo Therapeutics – GlobeNewswire

September 21, 2020 07:00 ET | Source: Cend Therapeutics Inc.

SAN DIEGO, Sept. 21, 2020 (GLOBE NEWSWIRE) -- Cend Therapeutics, Inc., a clinical-stage biotech company, announced today that it has acquired Impilo Therapeutics, Inc. The combination expands Cends drug delivery capabilities to create a unique platform for targeted tissue penetrating delivery of nucleic acid-based medicines to solid tumor cancers.

While antisense and siRNA medicines have reached market for a range of metabolic, neurological and neuro-muscular conditions, none have reached market for anticancer applications. By combining Impilo with Cend our objective is to address delivery issues that have limited the ability of nucleic acid-based medicines to benefit cancer patients, commented David Slack, CEO of Cend.

Cends lead asset, CEND-1, has generated encouraging clinical data showing the ability to enhance delivery of standard-of-care chemotherapy for pancreatic cancer patients, and the Company has generated similarly encouraging preclinical results for a variety of therapeutic modalities, commented Sangeeta Bhatia, MD, PhD, scientific co-founder of Impilo and Director of MITs Center for Cancer Nanomedicine.

With the combination of Cend and Impilo technologies, we have demonstrated unique abilities to deliver antisense, siRNA, microRNA, and immunostimulatory oligonucleotides selectively to solid tumor cancers and certain immune cells, commented Frank Slack, PhD, scientific co-founder of Impilo and Director of Harvards Initiative for RNA Medicine.

The scientific founders of Cend and Impilo have collaborated for many years and generated significant publications, commented Cend Executive Chairman, Erkki Ruoslahti. Cend will continue to work closely with Impilos founders as part of our extended team.

Via acquisition of Impilos assets, the CendR Platform combines Cends clinical-stage targeted tumor penetrating peptide, CEND-1, with additional targeting capabilities. It also brings nanoparticle technologies, including fusogenic nanoparticles that can deliver high payloads of nucleic acid-based drugs directly into the cytosol compartment of cells.

Financial details of the transaction have not been disclosed. Accompanying the acquisition, Sangeeta Bhatia and Frank Slack will join Erkki Ruoslahti, MD, PhD; Tambet Teesalu, PhD; and Kazuki Sugahara, MD on Cends Scientific Advisory Board. Impilo scientific co-founder and Distinguished Professor at UC San Diego, Michael Sailor, PhD will join Cends Board of Directors.

About Cend Therapeutics

Cend is a clinical-stage biotech company focused on a novel approach to enhance and more selectively deliver treatments for solid tumor cancers. Poor penetration of drugs into tumors is a major issue in cancer therapy as it limits access and therefore efficacy of current therapies. The CendR Platform provides a targeted tissue penetration capability to specifically enhance drug delivery to tumors.

For additional information, please visit http://www.cendrx.com or contact us via info@cendrx.com.

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https://www.drugcendr.com/

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