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Nanomedicine Market Projected to Be Resilient During 2017-2023 – Kentucky Journal 24

§ August 26th, 2020 § Filed under Nanotechnology Journal Comments Off on Nanomedicine Market Projected to Be Resilient During 2017-2023 – Kentucky Journal 24

Overview:

Nanomedicine is an offshoot of nanotechnology, and refers to highly-specific medical intervention at the molecular scale for curing diseases or repairing damaged tissues. Nanomedicine uses nano-sized tools for the diagnosis, prevention and treatment of disease, and to gain increased understanding of the complex underlying pathophysiology of the disease. It involves three nanotechnology areas of diagnosis, imaging agents, and drug delivery with nanoparticles in the 11,000 nm range, biochips, and polymer therapeutics.

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Majority of nanomedicines prescribedcurrently, allow oral drug delivery and its demand is increasing significantly. Although these nanovectors are designed to translocate across the gastrointestinal tract, lung, and bloodbrain barrier, the amount of drug transferred to the organ is lower than 1%; therefore improvements are challenging. Nanomedicines are designed to maximize the benefit/risk ratio, and their toxicity must be evaluated not only by sufficiently long term in vitro and in vivo studies, but also pass multiple clinical studies.

Market Analysis:

The Global Nanomedicine Market is estimated to witness a CAGR of 17.1% during the forecast period 20172023. The nanomedicine market is analyzed based on two segments therapeutic applications and regions.

The major drivers of the nanomedicine market include its application in various therapeutic areas, increasing R&D studies about nanorobots in this segment, and significant investments in clinical trials by the government as well as private sector. The Oncology segment is the major therapeutic area for nanomedicine application, which comprised more than 35% of the total market share in 2016. A major focus in this segment is expected to drive the growth of the nanomedicine market in the future.

Regional Analysis:

The regions covered in the report are the Americas, Europe, Asia Pacific, and Rest of the World (ROW). The Americas is set to be the leading region for the nanomedicine market growth followed by Europe. The Asia Pacific and ROW are set to be the emerging regions. Japan is set to be the most attractive destination and in Africa, the popularity and the usage of various nano-drugs are expected to increase in the coming years. The major countries covered in this report are the US, Germany, Japan, and Others.

Therapeutic Application Analysis:

Nanomedicines are used as fluorescent markers for diagnostic and screening purposes. Moreover, nanomedicines are introducing new therapeutic opportunities for a large number of agents that cannot be used effectively as conventional oral formulations due to poor bioavailability. The therapeutic areas for nanomedicine application are Oncology, Cardiovascular, Neurology, Anti-inflammatory, Anti-infectives, and various other areas. Globally, the industry players are focusing significantly on R&D to gain approval for various clinical trials for future nano-drugs to be commercially available in the market. The FDA should be relatively prepared for some of the earliest and most basic applications of nanomedicine in areas such as gene therapy and tissue engineering. The more advanced applications of nanomedicine will pose unique challenges in terms of classification and maintenance of scientific expertise.

Key Players:

Merck & Co. Inc., Hoffmann-La Roche Ltd., Gilead Sciences Inc., Novartis AG, Amgen Inc., Pfizer Inc., Eli Lilly and Company, Sanofi, Nanobiotix SA, UCB SA and other predominate & niche players.

Competitive Analysis:

At present, the nanomedicine market is at a nascent stage but, a lot of new players are entering the market as it holds huge business opportunities. Especially, big players along with the collaboration with other SMBs for clinical trials of nanoparticles and compounds are coming with new commercial targeted drugs in the market and they are expecting a double-digit growth in the upcoming years. Significant investments in R&D in this market are expected to increase and collaborations, merger & acquisition activities are expected to continue.

Benefits:

The report provides complete details about the usage and adoption rate of nanomedicines in various therapeutic verticals and regions. With that, key stakeholders can know about the major trends, drivers, investments, vertical players initiatives, government initiatives towards the nanomedicine adoption in the upcoming years along with the details of commercial drugs available in the market. Moreover, the report provides details about the major challenges that are going to impact on the market growth. Additionally, the report gives the complete details about the key business opportunities to key stakeholders to expand their business and capture the revenue in the specific verticals to analyze before investing or expanding the business in this market.

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Food Traceability Software Market Overview on Key Innovations 2026 – Kentucky Journal 24

§ August 22nd, 2020 § Filed under Nanotechnology Journal Comments Off on Food Traceability Software Market Overview on Key Innovations 2026 – Kentucky Journal 24

According to Stratistics MRC, the Global Food Traceability Software market is growing at a CAGR of 9.5% during the forecast period. Some of the key factors such as traces fault and assist product evoke, and rising user apprehension for food safety are driving the growth of the market. However, extra price on traceability systems is hampering the growth of the market.

Food traceability software allows user the capability to investigate, track, and store information concerning the form of food products. Numerous food traceability products offer tools for optimizing command expenses and budget, produce allergy warnings, and contacting seller. One of the most regular types is the capability to help users retain health and safety requirements.

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Based on Type, Enterprise Resource Planning system segment is likely to have a huge demand for the food and beverage manufacturing as it offers the essential visibility into food safety, quality control and traceability. Enterprise Resource Planning solution can also offer cost and efficiency profit in areas such as forecasting and scheduling or inventory, logistics, manufacture or waste organization.

By Geography, Asia Pacific region is likely to have a lucrative growth in forecast period owingthe rising R&D funding for expansion of microscopes, growing nanotechnology delve into, low material charge, and increasing capability and university quality in talented Asia Pacific countries such as China and India are the major factors driving the growth of this market.

Some of the key players profiled in the Food Traceability Software Market include IBM Corp., WaudWare Incorporated, Open Systems Inc., Minotaur Software Ltd., MarKov Computer Systems, LINKFRESH Software Limited., International Traceability Systems Limited, Famous Software LLC, Edible Software, and Carlisle Technology.

Product Types Covered: Web Based Cloud Based

Types Covered: Enterprise Resource Planning (ERP) Friction Stir Welding Laboratory Information Management Software (LIMS) Linear Friction Welding Quality Management Software Rotary Friction Welding Warehouse Software Other Types

Applications Covered: Small-to-Medium Enterprise (SMEs) Large Enterprises

End User: Warehouse Service Providers Food Retailers Food Manufacturers Other End Users

Regions Covered: North America o US o Canada o Mexico Europe o Germany o UK o Italy o France o Spain o Rest of Europe Asia Pacific o Japan o China o India o Australia o New Zealand o South Korea o Rest of Asia Pacific South America o Argentina o Brazil o Chile o Rest of South America Middle East & Africa o Saudi Arabia o UAE o Qatar o South Africa o Rest of Middle East & Africa

What our report offers: Market share assessments for the regional and country level segments Market share analysis of the top industry players Strategic recommendations for the new entrants Market forecasts for a minimum of 9 years of all the mentioned segments, sub-segments, and the regional markets Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations) Strategic recommendations in key business segments based on the market estimations Competitive landscaping mapping the key common trends Company profiling with detailed strategies, financials, and recent developments Supply chain trends mapping the latest technological advancements

Free Customization Offerings: All the customers of this report will be entitled to receive one of the following free customization options: Company Profiling o Comprehensive profiling of additional market players (up to 3) o SWOT Analysis of key players (up to 3) Regional Segmentation o Market estimations, Forecasts and CAGR of any prominent country as per the clients interest (Note: Depends of feasibility check) Competitive Benchmarking Benchmarking of key players based on product portfolio, geographical presence, and strategic alliances

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Coronavirus update: Kids may be the biggest spreaders, CDC to resume data-collection role – ConsumerAffairs

§ August 22nd, 2020 § Filed under Nanotechnology Journal Comments Off on Coronavirus update: Kids may be the biggest spreaders, CDC to resume data-collection role – ConsumerAffairs

Photo (c) FamVeld - Getty ImagesCoronavirus (COVID-19) tally as compiled by Johns Hopkins University. (Previous numbers in parentheses.)

Total U.S. confirmed cases: 5,584,154 (5,540,022)

Total U.S. deaths: 174,442 (173,415)

Total global cases: 22,734,522 (22,473,382)

Total global deaths: 794,721 (789,103)

Researchers at Massachusetts General Hospital have completed a study that concludes children and young adults -- more likely to be asymptomatic than older people -- may nonetheless be major spreaders of the coronavirus (COVID-19).

The study, published in the Journal of Pediatrics, featured nearly 200 children and young adults with suspected or confirmed coronavirus infections. Of the 49 who tested positive for the virus, only 25 had a fever.

But as they looked more closely, the researchers found the viral load in the infected children and young people was "significantly higher" than adults with severe COVID-19 cases. Its those viral loads that increase the risk of transmitting the virus to others, the researchers said.

The government is shifting gears and placing responsibility for collecting coronavirus case data back with the Centers for Disease Control and Prevention (CDC). A few weeks ago, the Department of Health and Human Services (HHS) took away that responsibility and put hospitals in charge.

Deborah Birx, the White Houses coronavirus coordinator, disclosed the change this week at a meeting in Arkansas. She said the current reporting system was never designed to be permanent.

CDC is working with us right now to build a revolutionary new data system so it can be moved back to the CDC, and they can have that regular accountability with hospitals relevant to treatment and PPE, Birx told hospital executives and government health officials.

Despite an increase in COVID-19 deaths in July, the monthly death toll has declined each month since April. Whether August breaks that trend is an open question, but a top official at the CDC expects daily deaths to begin falling off next week.

CDC Director Dr. Robert Redfield said more stringent mitigation policies put in place over the last two months have begun to lower cases, but he admitted that it takes some time before that success is reflected in the death rate.

"It is important to understand these interventions are going to have a lag, that lag is going to be three to four weeks," Redfield said in an interview with the Journal of the American Medical Association. "Hopefully this week and next week you're going to start seeing the death rate really start to drop."

A team of international researchers has developed a breathalyzer test to rapidly detect COVID-19, potentially solving the problem of prolonged delays in getting test results. The testing device is described as intelligent nanotechnology that can rapidly detect COVID-19 from specific volatile organic compounds (VOCs) in exhaled breath.

The effectiveness of the testing device, which is made up of a nanomaterial-based sensor array, was demonstrated in March by a preliminary case-control clinical study in Wuhan, China.

The technology will reportedly be developed for the market by the company Nanose Medical. The researchers have published their findings in the journal ACS Nano.

The coronavirus and its widespread impact havent been a drag on recent home sales. In fact, it may be serving as rocket fuel. The National Association of Realtors (NAR) reports that sales of existing homes rose a record 24.7 percent in July.

With the sizable shift in remote work, current homeowners are looking for larger homes and this will lead to a secondary level of demand even into 2021, said NARs chief economist, Lawrence Yun.

The only thing keeping sales from being even higher may be a lack of homes for sale. Total housing inventory at the end of July totaled 1.50 million units, down from both 2.6 percent from June and 21.1 percent from one year ago.

Illinois: Cases of the coronavirus are moving sharply higher in the state after they appeared to be under control a few weeks ago. State health officials report that the seven-day average of new cases is three times what it was at the pandemics low point.

Michigan: Children have returned to school in Michigan, but not without a worrisome uptick in coronavirus cases. State health officials are reporting 14 new outbreaks at schools around the state.

New York: Gov. Andrew Cuomo reports that the number of hospitalizations in the state has dropped to its lowest level since mid-March. Cuomo says the state has also seen 13 straight days of an infection rate below 1 percent.

Coronavirus update: Consumers caution affects the economy, jobless claims are growing again

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Coronavirus update: Kids may be the biggest spreaders, CDC to resume data-collection role

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Swallowing this colonoscopy-like bacteria grabber could reveal secrets about your health – Newsbug.info

§ August 16th, 2020 § Filed under Nanotechnology Journal Comments Off on Swallowing this colonoscopy-like bacteria grabber could reveal secrets about your health – Newsbug.info

WEST LAFAYETTE Your gut bacteria could say a lot about you, such as why youre diabetic or how you respond to certain drugs.

But scientists can see only so much of the gastrointestinal tract to study the role of gut bacteria in your health. What comes out of you is just a small sample of these bacteria, without indicating where they came from in the digestive system.

Purdue University researchers built a way to swallow a tool that acts like a colonoscopy, except that instead of looking at the colon with a camera, the technology takes samples of bacteria.

The technology could also move throughout the whole GI tract, not just the colon. This tract, in addition to the colon, includes the mouth, esophagus, stomach, pancreas, liver, gallbladder, small intestine and rectum.

Essentially, this tool would make it possible to conduct a gut-oscopy. A video showing how it would work is on YouTube

Once swallowed, this capsule is designed to collect bacteria throughout the gut. A scientist unscrews the cap to retrieve the sample after the capsule has left the digestive system. (Purdue University photo/Mark Simons)

Its all about being able to take samples of bacteria anywhere in the gut. That was impossible before, said Rahim Rahimi, a Purdue assistant professor of materials engineering.

The tool is a drug-like capsule that passively weasels through the gut without needing a battery. A pill version of a colonoscopy is already commercially available to view areas of the colon that a traditional colonoscopy cant see, but neither tool can sample bacteria.

If a colonoscopy or camera pill sees blood, it cant sample that area to investigate further. You could just sample bacteria from a persons fecal matter, but bacteria can vary a lot throughout the GI tract. Our approach could be complementary, Rahimi said.

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The bacteria-sampling capsule also would be a lot cheaper, each costing only about a dollar, he estimates.

Rahimis team is working on testing this capsule in pigs, which have a similar GI tract to humans. An initial demonstration of the prototype is published in RSC Advances, a journal by the Royal Society of Chemistry.

Rahim Rahimis lab develops innovative materials and biomedical devices to address health care challenges. (Purdue University photo/Mark Simons)

The researchers 3D-printed the capsule out of resin, the same material used in dental molds and implants. This material would need to be slightly modified for humans to ingest, but is otherwise nontoxic, Rahimi said.

When exposed to the pH of a certain gut location, the capsules biodegradable cap dissolves. Inside the capsule, a hydrogel similar to those used in diapers expands and collects intestinal fluid containing bacteria. Pressure closes shut the capsules aperture when the sampling is complete, kind of like a plunger.

The researchers have tested the prototype capsule in a culture solution designed to simulate the gut bacterial flora of a GI tract. They also tested the capsules ability to protect the sampled bacteria in different extreme environments. Their experiments so far show that the capsule could successfully sample bacteria common in the gut, such as E. coli, within an hour.

In a human, the capsule would continue to move throughout the GI tract with other fecal matter. A scientist could then recover the capsule from a study participants fecal matter, unscrew the capsule, and study the collected bacteria.

This approach is providing new opportunities to study what type of bacteria are present in the gut. It would help us figure out how to manipulate these bacteria to combat disease, Rahimi said.

A patent has been filed for this technology through the Purdue Research Foundation Office of Technology Commercialization. The work is funded by Eli Lilly and Company and Purdues School of Materials Engineering. Rahimis team is conducting this research at the Birck Nanotechnology Center in Purdue's Discovery Park.

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U of T researchers discover how to get more cancer-fighting nanoparticles to where they’re needed – News@UofT

§ August 12th, 2020 § Filed under Nanotechnology Journal Comments Off on U of T researchers discover how to get more cancer-fighting nanoparticles to where they’re needed – News@UofT

Researchers in the University of Toronto's Faculty of Applied Science & Engineering have discovered a dose threshold that greatly increases the delivery of cancer-fighting drugs into a tumour.

The findings,published recentlyin the journalNature Materials, provide a potentially universal method for gauging nanoparticle dosage and could help advance a new generation of cancer therapy, imaging and diagnostics.

Its a very simple solution adjusting the dosage but the results are very powerful, saysBen Ouyang, an MD/PhD candidate wholed the research under the supervision of ProfessorWarren Chanof U of T's Institute of Biomedical Engineering (BME).

The teams research provides a potential solutionto a drug-delivery problem previously raised by Chan and other researchers four years ago inNature Reviews Materials.

Nanotechnology carriers are used to deliver drugs to cancer sites, which, in turn, can help a patients response to treatment and reduce adverse side effects, including hair loss and vomiting. However, in practice, few injected particles reach the tumour site.

In theNature Reviews Materialspaper, the team surveyed literature from the past decade and found that a median ofonly0.7 per cent of the chemotherapeutic nanoparticlesmake it into a targeted tumour.

The promise of emerging therapeutics is dependent upon our ability to deliver them to the target site, says Chan. We have discovered a new principle of enhancing the delivery process. This could be important for nanotechnology, genome editors, immunotherapyand other technologies.

Chans team saw the liver, which filters the blood, as the biggest barrier to nanoparticle drug delivery. They hypothesized that the liver would have an uptake rate threshold in other words, once the organ became saturated with nanoparticles, it wouldnt be able to keep up with higher doses. Their solution was to manipulate the dose to overwhelm the organs filtering Kupffer cells, which line the liver channels.

The researchers discovered that injecting a baseline of one trillion nanoparticlesin vivowas enough to overwhelm the cells so that they couldnt take up particles quick enough to keep up with the increased doses. The result is a 12 per cent improvement in efficiency in delivering nanoparticles to the tumour.

Theres still lots of work to do to increase the 12 per cent but its a big step from 0.7 per cent, says Ouyang. The researchers also extensively tested whether overwhelming Kupffer cells led to any risk of toxicity in the liver, heart or blood.

We tested gold, silicaand liposomes, says Ouyang. In all of our studies, no matter how high we pushed the dosage, we never saw any signs of toxicity.

The team used thethreshold principle to improve the effectiveness of a clinically used and chemotherapy-loaded nanoparticle called Caelyx. The strategy shrank tumours 60 per cent more when compared to Caelyx on its own with a set dose of the chemotherapy drugdoxorubicin.

Because the researchers solution is a simple one, they hope to see the threshold have a positive impact in current nanoparticle-dosing conventions for human clinical trials. They calculate that the human threshold would be about 1.5 quadrillion nanoparticles.

Theres a simplicity to this method and it reveals that we dont have to redesign the nanoparticles to improve delivery, says Chan. This could overcome a major delivery problem.

The research received support from the Canadian Cancer Society, the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada, among others.

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2020 Market Study on the Future of Therapy: Technology Advances in Drug-device Combination Products – ResearchAndMarkets.com – Press Release – Digital…

§ August 10th, 2020 § Filed under Nanotechnology Journal Comments Off on 2020 Market Study on the Future of Therapy: Technology Advances in Drug-device Combination Products – ResearchAndMarkets.com – Press Release – Digital…

DUBLIN--(Business Wire)--The "Future of Therapy: Technology Advances in Drug-device Combination Products" report has been added to ResearchAndMarkets.com's offering.

Drug device combination products are aimed to provide targeted treatment, enable better drug delivery and improve the efficacy of the device and medicine.

This research service (RS) showcases some of these emerging drug-device combination products including drug eluting stents and drug loaded/coated orthopedic implants under implantable drug-device combination and drug-eluting lens and drug-eluting bandages under non-implantable drug device combinations. The research service discusses the impact of these innovations, patents, technology roadmap and growth opportunities.

Key Topics Covered:

1.0 Executive Summary

2.0 Industry Overview

2.1 Drug-device Combination Products Improving Delivery of Drugs or Therapeutics Efficacy of the Device

2.2 Segmentation of Drug-device Combination Based on Product Type

2.3 Segmentation of Drug-device Combination Based on Application Type

2.4 Growth Opportunity: Drug-device Combinations Improving Performance of Medical Devices

2.5 Growth Opportunity: Drug-device Combination Improves Patients' Acceptance of Medication

3.0 Drug-device Combination Product: Innovation Tracker

3.1 Innovations in Drug-eluting Stents

3.1.1 Drug-eluting Stent to Address the Challenge of in-stent Restenosis

3.1.2 Sirolimus-eluting Coronary Stent with Ultrathin Strut

3.1.3 Zotarolimus-eluting Coronary Stent System

3.1.4 Paclitaxel-eluting Vascular Stent System

3.1.5 Key Companies in Drug-eluting Stent Innovations

3.1.6 The US Leads Patent Activity for Drug-eluting Stents

3.1.7 Key Recent Patents in Drug-eluting Stents to Check

3.2 Innovations in Drug-eluting Contact Lens

3.2.1 Drug-eluting Lens Presenting Growth Opportunities to Replace Ocular Drug Delivery Systems

3.2.2 Drug-eluting Clear Corneal Bandage Lens

3.2.3 Antihistamine-releasing Contact Lens for Ocular Allergy

3.2.4 Digital Printed Drug Layers on Contact Lens for Glaucoma Therapy

3.2.5 Digital-eluting Lens for Treating Corneal Pathologies

3.2.6 Moderate to Low Patent Activity of Drug-eluting Contact Lens with Johnson & Johnson Vision Care Inc., Showing High Activity

3.2.7 Key Recent Drug-eluting Contact Lens Patents to Check

3.3 Innovations in Drug-eluting Bandages

3.3.1 Drug-eluting Wound Care Devices Provide Faster Healing and Eliminate Infections

3.3.2 Chitosan-based Wound Dressing for Hemostatic Effect

3.3.3 Kaolin-based Hemostatic Dressing for Emergency Medical Service

3.3.4 Antimicrobial Impregnated Wound Care Dressings to Avoid Wound Infections

3.3.5 Silver, Iodine, Copper Ions for Antimicrobial Activity in Wound Care Bandages

3.3.6 IP Activity of Drug Releasing Wound Care Bandages/Dressings

3.3.7 Key Recent Drug-eluting Kens Patents to Check

3.4 Drug-eluting Orthopedic Implant

3.4.1 Drug-eluting Orthopedic Implants Offering Better Osteointegration and Protection from Infection

3.4.2 Calcium Scaffold Carrying Antibiotic for Infection Management

3.4.3 Peptide-based Bone Graft for Faster Repair

3.4.4 Doxycycline-eluting Synthetic Bone Substitute

3.4.5 Key Research on Drug-coated Orthopedic Implants

3.4.6 Patent Activity of Drug-loaded Orthopedic Devices Dominated by the US Patents

3.4.7 Key Recent Drug Loaded Bone Scaffold Patents to Check

4.0 Emerging Technology Roadmap and Growth Opportunity

4.1 Emerging Technology Roadmap of Drug-eluting Stents (DES)

4.2 Future of Coronary Stents: Gene Eluting Stents to Overcome Restenosis and Late-stent Thrombosis Challenges

4.3 Drug-eluting Lens Envisions Sensor Technology Convergence into its Product

4.4 Smart Wound Dressing Including Sensor Technology Innovations

4.5 Nanotechnology to Improve the Regenerative Properties of Drug-eluting Bone Scaffold

4.6 Business Growth Opportunities - Patient Centric, Patient Specific, and Cost-effective Imaging Redefining Future of Therapy

4.7 Strategic Imperatives for the Future of the Drug-device Combination Products

5.0 Key Industry Contacts

For more information about this report visit https://www.researchandmarkets.com/r/o6msb5

View source version on businesswire.com: https://www.businesswire.com/news/home/20200810005426/en/

ResearchAndMarkets.com Laura Wood, Senior Press Manager press@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900

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Heat-related Injuries and How to Stay Cool – Newswise

§ August 10th, 2020 § Filed under Nanotechnology Journal Comments Off on Heat-related Injuries and How to Stay Cool – Newswise

Newswise Hot weather is here. That means it's the perfect time to go for a swim or relax in the shade. But before lathering on the sunscreen and heading outdoors, it's important to know the signs of heat-related injuries and how to stay cool when the temperatures soar.

Heat exhaustionincludes heavy sweating, breathlessness, a fast but weak pulse, headache, dizziness and nausea or vomiting. "Heat exhaustion can happen to anyone overexerting themselves in extreme heat," says BIDMC emergency medicine physicianLaura Burke, MD. "If symptoms are severe, call for medical help right away."

Individuals at an increased risk for heat exhaustion include:

Heat exhaustion can escalate to a life-threatening condition calledheat stroke. "During heat stroke, the body can no longer cool itself down through sweating, which can result in damage to major organs," Burke says.

Symptoms include hot and dry skin, a fever higher than 102F, headache, confusion and unconsciousness. "If you see someone suffering from heat stroke, try to cool the person down by getting to shade or into the air conditioning. Apply cool water with wet cloths and call for medical help immediately," Burke says.

Check out these important tips to help you stay cool and healthy in the heat.

Drink plenty of water.Avoid alcohol, which can impact your ability to sweat properly, and caffeine, which is a natural diuretic. "Two glasses of water per hour is the general rule in extreme heat," Burke says.

Dress in light-colored, loose-fitted clothing.Breathable clothing allows sweat to evaporate. In the hot sun, cover up with a hat andsunscreen.

Limit outdoor activity.If you plan to exercise outdoors, avoid peak hours when temperatures are highest. "Try to rest often in shady areas so that your body's thermostat will have a chance to recover," Burke says.

Take a cool shower.Another way to cool down quickly is to take a cool shower or bath, or to place a cool washcloth on your forehead.

Read moresummer health tipsfrom BIDMC experts.

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Nanotechnology and the Fight Against COVID-19 – AZoNano

§ August 10th, 2020 § Filed under Nanotechnology Journal Comments Off on Nanotechnology and the Fight Against COVID-19 – AZoNano

Image Credit:Lightspring/Shutterstock.com

As the quest for a COVID-19 vaccine continues, researchers working in other areas of science such as nanotechnology have joined the battle against thevirus.

In addition to being responsible for hundreds of thousands of deaths, the COVID-19 crisis has mobilized the scientific community in a way that no other situation has before. Multiple disciplines are currently researching the virus, whether this be developing diagnosis and treatment methods, or a modality to slow its spread.

Nanotechnology is being prepared for deployment in the fight against COVID-19 in a wide range of areas. A new paper published in the journal ACS Nano looks at the different ways in which nanotechnology will be used, with the authors describing the use of nanotech in fields as diverse as virology, biology, medicine, engineering, chemistry, materials science, and computational science.

The nanotechnology breakthroughs made in the coming months and years should not just bolster the resistance against COVID-19, but also help in the fight against other viruses, bacteria, and pathogens.

The authors of the study identified four key stages at which nanotechnology could be introduced to help the battle against COVID-19:

What follows is a rundown of the methods being developed that could be employed in future pandemics and epidemics, possibly preventing them from reaching global crisis status.

The ongoing COVID-19 crisis does not mark the first time that nanomaterials have been highlighted for their ability to limit the spread of viruses. Surfaces coated with polymers containing nanoparticles of metals such as copper can release metal ions, which are known for their antiviral activity and have already been suggested for use in certain areas. The widespread nature of the COVID-19 crisis calls for a corresponding widespread application of such measures.

Click here to find out more about nanoparticle size analyzers

Nanotechnology offers a safer alternative to the use of toxic chemicals such as disinfectants in medical settings. Such coatings are far more convenient than other non-toxic disinfectant measures such as irradiation with ultraviolet (UV) light. These nanomaterial coatings and alloys confer antiviral and antibacterial properties through the release of ions, which disrupt the operation of living cells.

One of the key difficulties in tackling COVID-19 is its hardiness and ability to survive on a variety of surfaces for prolonged periods often days on end. The beauty of a nanomaterial coating is that it could provide protection continuously after just one treatment. This is especially true if the material can be structured in such a way that the release of ions is gradual. Self-disinfecting surfaces would be of great use even after the COVID-19 crisis is over.

Silver, copper and zinc all show intrinsic antimicrobial properties and are already used in medical equipment and healthcare settings.

In unison with our growing understanding of bacteria and viruses, silver nanoparticles have found their way into commercial products such as silver zeolites in paints, and in food trays as a biocide, with the antiviral efficiency of silver nanoparticles demonstrated against a variety of viruses, including HIV-1.

Copper was shown to be effective against polio in the late 1970s and, more recently, was of great use in combating another coronavirus, HuCoV-229E. The virus, which typically lives for around six days on a surface, became inactive in approximately 60 minutes on surfaces coated with copper alloys. The similarity between HuCoV-229E and SARS-CoV-2 points to copper nanoparticles and alloy coatings being a key-player in slowing, if not stopping, the spread.

The authors suggest that copper alloys could also find themselves replacing more traditional stainless steel surfaces and appliances in medical settings as a result of this non-toxic antibacterial agency.

Nanomaterials are also employed in the production of vitally import personal protective equipment (PPE) to help reduce the spread of COVID-19 to frontline medical workers. In particular, nanomaterials could be used in facemasks and other PPE to capture and immobilize viral cells. This task would likely fall upon silver nanoparticles, which have been shown effective in this respect, severely limiting viral activity when loaded into filters.

Find out more about nanomaterials in several industries

However, even if the spread of COVID-19 can be slowed by such coatings and a switch to copper alloys, another vital step in combating COVID-19 is efficient testing and diagnosis. Fortunately, nanomaterials are on hand to aid in this regard too.

The SARS-CoV-2 virus cannot be eliminated from all surfaces, and not all surfaces can be coated with a nanomaterial layer. This means that even with such measures, the transmission is very likely to continue. Therefore, the next step in slowing the spread is the quick and effective diagnosis of those already infected.

The current testing methodology for COVID-19 involves the use of a swab applied to the throat and nasal passage of a potential patient. This swab is then analyzed using a reverse transcription-polymerase chain reaction (RT-PCR) testa procedure used in virology to test for the presence of specific RNA. The use of nanoparticles, however, could provide a more immediate on-site test result without the need to send samples away for lab analysis or the need for expensive equipment.

The principle behind the application is the binding of gold nanoparticles with antibodies and is in its very early planning stages. In the presence of further antibodies collected from the patient, the nanoparticles cluster, shifting the color of the test swab from blue to red. This provides an immediate indication of infection. A test of this nature could be of particular use in developing countries and regions of the world with little to no medical infrastructure.

Image Credit: BERMIX STUDIO/Shutterstock.com

Another alternative to the currently favored RT-PCR test is graphene-based field-effect transistors (FET), which are biosensing devices coupled to a specific antibody against SARS-CoV-2 spike protein. Again, this would be another method of on-site detection of COVID-19 that is cost-effective and delivers a rapid result.

Gold nanoparticles can also be used in nano biosensors, which combine the excellent electrical and optical properties of nanomaterials with biological or synthetic molecules used as receptors to detect specific whole viral cells selectively. This cell-sensing device is based on the reaction of cell surface proteins with specific antibodies conjugated to gold nanoparticles taking advantage of the known antigens and available antibodies.

It should be noted that this is a field in its relative infancy, but any developments spearheaded in response to the COVID-19 crisis could be carried forward to future epidemics and pandemics.

The rapid spread of COVID-19 and the relative failure to tackle it has exposed a weakness in medicine: the lack of a broad-spectrum antiviral drug. That means that when a new virus emerges, there is little in the way of medical intervention that can be done to mitigate the spread. Therefore, drugs that could tackle both COVID-19 and future viruses are of the utmost importance.

Though other organs can be affected, the main target of COVID-19 once inside the body of a sufferer is the respiratory system. In particular, the virus targets the upper respiratory tract and the lungs, with the latter being the most critically affected area. Therefore, the review paper focuses on methods that seek to inactivate the virus in the deep-lung.

Airborne nanomaterials can penetrate the deep-lung, delivering medicine directly to the cells that SARS-CoV-2 uses to spread further into a patients system. Nanomedicine is currently being heavily researched in terms of providing drugs and using beneficial proteins via aerosol nano-devices.

A general antiviral nanomaterial intervention could work by preventing viruses from interacting with and binding to cell membranes. Previous work has shown that this could possibly be achieved by a wealth of nanomaterials such as polymers, liposomes, and small molecules.

However, the implementation of these methods via aerosol has been hampered by the necessary dilution of these nanomaterials, which negatively impacts their effectiveness. This loss of efficiency allows virus cells to begin replication again.

This setback can be combated by nanoparticles that, after introduction to a patients lungs or other organs, attack the virion the infective form of a virus outside a host cellpermanently damaging it and stopping replication.

A specific COVID-19 drug administered in a similar way to the general antiviral treatment discussed above could be created by engineering it to block the S spike protein from interacting with the ACE2 receptor.

Part of the key to saving the lives of COVID-19 patients may not just hinge on attacking the virus, but limiting the bodys response to it.

As a result of the COVID-19 crisis, many more people are familiar with the phrase Cytokine Storm. Cytokine storms are associated with a wide variety of infectious and noninfectious diseases, in particular the H1N1 influenza strain. The term itself summons images of a terrible and violent reaction within the patients body, arising from their excessive immune response.

Although a well-regulated cytokine response that is rapidly triggered by the hosts innate immunity can serve to prevent and counteract infection, an excessive, unbalanced and prolonged immune response can seriously harm the body.

In many COVID-19 cases, this inflammatory storm is responsible for acute respiratory distress syndrome (ARDS), which is often associated with multiple organ failure and a leading cause of death in critical patients.

Nanomaterials have been used to adjust the immune response, bringing it to an optimal level, and could be used to limit the cytokine storm. This can be done in a number of ways.

Firstly, nanotechnology can deliver immunosuppressants to target immune cells and organs, leading to reductions in drug dose, drug distribution to non-target tissues and organs, and, in-turn, unwanted side effects.

Secondly, nanotools can be explicitly designed to evade the immune system and finely tune the patients system to receive a high drug load that could otherwise trigger a harmful immune response.

With regards to COVID-19 specifically, the authors of the review point to the use of nanodiamonds to reduce macrophage infiltrationa process linked to inflammation.

How Could Polymer Nanoparticles Slow the Spread of COVID-19?

COVID-19 has presented the scientific community with the kind of challenge it has perhaps never had to face before, but it has also created the awareness that this situation could arise again.

The nanotech advancements described, while being engineered in response to this current crisis, are designed by scientists with an eye to the future and the next potential pandemic.

The authors of the review paper have a message to the general public, policy-makers, politicians, and the scientific community: we must stop thinking of human health as an isolated phenomenon. Instead, we have to embrace the concept of one health with understanding that our well-being is intrinsically and irreversibly linked with the ecosystems we inhabit.

The field of nanotechnology points towards the benefits of adopting a holistic and inclusive attitude, spreading across so many aspects of science and bringing together scientists from diverse backgrounds, all converging on a multifaceted solution to a crisis that threatens our very way of life.

The study of nanotechnology could emerge such big ideas with the capability of changing the world.

Using Nanotechnology to Identify those Most at Risk from COVID-19

Weiss, C., Carriere, M., Fusco, L., et al. (2020) Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic. ACS Nano.https://doi.org/10.1021/acsnano.0c03697.

Lea, R. (2020) The Development of a New Anti-COVID-19 Nanocoating. [Online] AZO Nano. Available at: https://www.azonano.com/news.aspx?newsID=37294.

Lea. R. (2020) Graphene-Based Masks Launched to Combat COVID-19. [Online] AZO Nano. Available at: https://www.azonano.com/news.aspx?newsID=37431.

Disclaimer: The views expressed here are those of the author expressed in their private capacity and do not necessarily represent the views of AZoM.com Limited T/A AZoNetwork the owner and operator of this website. This disclaimer forms part of the Terms and conditions of use of this website.

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Masks matter: How we know face coverings slow the spread of COVID-19 – Las Vegas Sun

§ July 9th, 2020 § Filed under Nanotechnology Journal Comments Off on Masks matter: How we know face coverings slow the spread of COVID-19 – Las Vegas Sun

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By Emma Cauthorn

Thursday, July 9, 2020 | 2 a.m.

A simple cloth face mask can help prevent the spread of COVID-19, and in doing so, contribute to the safe reopening of our city and state while potentially saving lives

On June 24, Gov. Steve Sisolak issued a mandatory face-covering policy in public spaces for all Nevadans and visitorsin line with current Centers for Disease Control and Prevention and World Health Organization guidelinesbut the directive has been met with some resistance. Heres what you need to know about the importance of wearing masks.

Why masks work

In the early months of the pandemic and before much was known about the novel coronavirus, public health officials stated that it wasnt necessary for the general population to wear cloth masks. The thought at the time was that medical-grade N95 respirators were the only effective face covering against the virusbut the PPE shortage meant those masks were not easily accessible and should be strictly reserved for health care professionals. The WHO suggested that cloth masks were only necessary for those who had symptoms of COVID-19 and their caregivers. By April, however, the CDC began recommending cloth masks for everyone, and in June, the WHO followed suit

What changed? We know more about how the disease is spread today than we did six months ago.

According to the CDC, recent studies indicate that a large portion of people with COVID-19 are asymptomaticresearchers at Stanford Medicine report that this might be true for up to 40% of those infected. This is an important thing to understand when considering mask usage, because a large portion of the population can spread COVID-19 and never show symptoms themselves.

While a cloth face covering might not protect the wearer like an N95 mask will, it may keep the wearer from spreading the virus to others. So if everyone is wearing masks, well be able to limit transmission rates.

Wearing a face mask helps to intercept particles and keep them out of the air, explains Dr. G. Rodney Buzzas, chief medical officer at Dignity Health-St. Rose Dominican, Siena and Rose de Lima Campuses. These particles are created and spread not only by coughing or sneezing, but also by talking, laughing and even breathing. The COVID virus is known to travel and be passed through these particles.

Because so many people might be infected with COVID-19 and never feel sickor may be pre-symptomaticseemingly innocuous and casual social interactions can spread the disease rapidly.

How we know masks work

Theres a growing body of evidence that demonstrates the efficacy of cloth face masks. A recent study published in peer-reviewed healthcare journal Health Affairs compared the growth rate of COVID-19 before and after mask mandates in 15 states and the District of Columbia. They found the disease growth rate slowed daily. During the first five days, the daily growth rate slowed 0.9 percentage points, and at three weeks, it had slowed a full 2 percentage points.

The CDC advises that N95 respirators and surgical masks are critical supplies that should be reserved for health care workers and first responders.

Researchers at Virginia Commonwealth University evaluated COVID-19 deaths across 198 different countries and found that those with cultural norms or government policies about wearing masks had lower death rates.

One study published in peer-reviewed medical journal Nature Medicine analyzed people who had the flu or the common cold and found that wearing a surgical mask significantly reduced the amount of respiratory viruses emitted in droplets.

An experiment published by the New England Journal of Medicine used a high-speed video camera to determine that hundreds of droplets, ranging from 20 to 500 micrometers, are generated when someone says a simple phrase, and nearly all of them were blocked when the mouth was covered with a damp washcloth.

And the University of California San Francisco analyzed a wide variety of different studies to conclude wearing masks was effective at protecting the general population.

As we continue to venture into the phases of reopening, its more important than ever to wear a mask in public spaces. Wearing a mask protects others from the person wearing the mask, says Dr. Clarence M. Dunagan, chairman of emergency services and facility medical director at MountainView Hospital. During this pandemic, making everyone wear masksespecially when inside or close togetherwill hopefully drastically decrease the spread of the virus. Id much rather be required to wear a mask in public for the protection of others instead of another stay-at-home quarantine order being issued, which no one wants.

Who shouldnt be wearing masks?

The CDC states that cloth face coverings should not be worn by children under the age of 2 or anyone who has trouble breathing, is unconscious, incapacitated or otherwise unable to remove the mask without assistance.

Tips for effective cloth masks

Researchers at Stanford Medicine, who conducted the study that helped shape WHO guidelines about mask wearing, recently published an article in peer-reviewed journal Nanotechnology Letters assessing the filtering and breathability of different fabrics often used to make masks. Here are some of their recommendations:

Masks are considered most effective at stopping the spread when combined with other healthy practices, such as frequent hand washing and social distancing.

Cloth masks should feature at least three layers of different materials.

The outer layer should be made of a fabric thats at least somewhat water resistant. (It can be a combination of cotton and polyester, nylon or rayon.)

The middle layer should either be polypropylene or three-ply disposable facial tissues.

The inner layer should be a wicking material, like 100% soft cotton, to draw moisture away from the face.

A mask should not fit so tightly that its too uncomfortable to wear, but it should sit against the skin all the way around from the middle of your nose to under your chin and almost to your ears. It should not gape when you move your head or speak.

Masks should be treated with care. Dont share them with others, and keep them in sealed plastic bags when not in use. Wash them regularly, and when you remove them, do so in a way that doesnt spread germs from the front of the mask to your face. Wash hands after touching the mask.

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Five Local High School Students Awarded 2020 HOPE for Youth Foundation Scholarships – River Journal Staff

§ July 2nd, 2020 § Filed under Nanotechnology Journal Comments Off on Five Local High School Students Awarded 2020 HOPE for Youth Foundation Scholarships – River Journal Staff

Lakeland, Peekskill, Putnam Valley, and Walter Panas High School Students Receive Awards

The HOPE for Youth Foundation awarded five local high school students with scholarships this year at their recent scholarship awards ceremony held via ZOOM for the first time ever. The scholarships are usually presented in person at an annual luncheon, but because of social distancing guidelines, the annual event could not take place.

Instead, HOPE for Youth arranged for the ZOOM call and for pizzas to be delivered to each recipients home at the end of the online presentationone delivery had to be made to North Carolina. More than 50 board members, parents, scholarship recipients and former scholarship winners participated.

I am so proud of this years scholarship recipients because they all have had their senior year cut short because of the Coronavirus, but they still exude optimism, resiliency and hope for the future. Every single one of these bright and community-minded students reminds me that no matter how bad things seem, there is always a bright side, said Jim Witt, HOPE for Youth.

Honored for their academic and civic accomplishments were:

Walter Panas High School Senior Amaavi Miriyagalla and Lakeland High School Senior Taylor Allen were awarded HOPE For Youth Scholarships; Putnam Valley High School Senior Sydney Goldberg was presented with the Thomas J. Witt Memorial Scholarship; Peekskill High School Senior Dejuan White was presented with the LaMarr Barnes Scholarship; and Lakeland High School Senior Maria Davino was presented with the Bill Sherry Memorial Scholarship.

HOPE for Youth established the scholarship program in 1998 for graduating seniors who demonstrated outstanding service to school and community. The scholarships are funded from the sales of Witts Long Range Weather Calendar and other fundraising efforts conducted by the foundation and its board of directors. To date, the foundation has distributed $4.3 million to childrens charities, including these scholarships.

Some of the 2019 scholarship winners also attended the call, including former Walter Panas High School student Hannah Sophia Soloway, former Lakeland High School student Michael Gajdosik, and former Putnam Valley High School student Gavon Mitchell.

Amaavi Miriyagalla

Walter Panas High School Senior Amaavi Miriyagalla is the Valedictorian of her class, and excels in athletics and music. She is a three season athlete, plays the saxophone and has done research in DNA nanotechnology. Notwithstanding all of these remarkable attributes, the Hope For Youth Scholarship is focused on service. She has been volunteering since the 8th grade at the Yorktown Rehabilitation and Nursing Center where she helps the seniors wash their laundry, fix their smartphones, and takes them outdoors all in an effort to provide companionship and encouragement for them to recall their fondest memories. Miriyagallas service extends to tutoring adults in English as a Second language and building close relationships with the Hispanic immigrant community. Miriyagalla plans to attend Vassar College. She was awarded the Hope For Youth Scholarship.

Taylor Allen

Lakeland High School Senior Taylor Allen maintains a rigorous academic program including Calculus, AP Biology, AP MacroEconomics, AP English, and Psychology. She is a member of the National Honor Society and the Spanish Honor Society. Her GPA is 95.36. In addition to managing a rigorous schedule, Allen is President of the UNICEF Club. Allen is also a volunteer at NY Presbyterian/Hudson Valley Hospital and at the YMCA camp in Putnam Valley during summers. Taylors volunteer work at the hospital and with the children at camp has prepared her well for her goal of becoming a pediatric nurse practitioner. Allens grandfather who passed away last year was her role model and she notes his legacy has helped her grow and become independent. Taylor will be attending The University of Buffalo in the honors college in the nursing program. She was awarded the Hope For Youth Scholarship.

Sydney Goldberg

Putnam Valley High School Senior Sydney Goldberg participates in numerous clubs such as SADD, Make-a-Difference and MAGMAH, a group of high school students who volunteer to work with special education students on Sundays to create fun and enjoyable experiences for them. Goldberg spreads joy in whatever she does. Her peers were sad to miss out on the end of the year activities, so Sydney made up senior posters for every senior in her class highlighting their post high school plans, and anything the student wanted to add. At a young age, Goldberg was diagnosed with Crohns disease. The flares ups, hospitalizations, intravenous medications, created physical, emotional and social challenges, but Goldberg didnt let her Crohns Disease to define her. Instead she uses her experience with Crohns to deal with any kind of setback. Her GPA is 95.95 and she is planning to attend the University of Buffalo majoring in Chemistry with the goal of a career in dentistry.

Dejaun White

Despite facing hardships and adversity as a young African American male, White will be attending Monroe College to study business management and will play football for the D1 school in the fall. He was active on the Peekskill varsity football team for four consecutive years. He was a member of My Brothers Keeper a college prep program for young men. He also was involved with the Interact Club in which he participated in events such as the Special Olympics, blood drives, and helping seniors at a local nursing home. White will pursue his bachelors degree and plans to become involved in the auto body industry. He excelled at the BOCES program learning auto body/mechanics. White was presented with the LaMarr Barnes scholarship, created in honor of LaMarr Barnes, a longtime Peekskill resident who tragically died at age 27 in a car accident on Bear Mountain Parkway in 2011. Barnes legacy and memory live on through this memorial scholarship created and supported by Nick and Jenet Ferris of Ferris Carpentry.

Maria Davino

Lakeland High School Senior Davino has devoted her school years to working with kids, all the while maintaining a commitment to her academics. She plans on continuing in her studies at Mt. Saint Mary College where she will pursue a bachelors degree in English followed by a masters degree in Special Education. In addition to being an active member of the Lakeland Pioneers, a sports team that teaches students with special needs sports skills, Davino has been involved with the Yorktown Leos, a division of the Lions Club. For the past five years she helped run various activities, including a board game night with students with special needs and a Guiding Eyes for the Blind pizza party. Davino has been treasurer, secretary, vice-president, and now serves as its president. Davino was presented with he Bill Sherry Memorial Scholarship, named after Bill Sherry who was a 7th Grade English teacher at Copper Beech Middle School for 32 years.

HOPE for Youth Foundation was founded in 1986 by WHUD Weatherman and former educator Jim Witt, who is noted for his annual long-range weather forecast calendars featuring photographs of the Hudson Valley. Witt has formulated a complex system that relies on historic weather patterns in order to predict what the weather will be like years, even decades, ahead. The precision of his forecasts over the past 40 years has made him a successful, charismatic and eerily accurate weather prophet. Witt is also a former high school science teacher.

Learn more about Hope For Youth Foundation at http://www.hfyf.org.

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This Scientist Says He’s Built a Jet Engine That Turns Electricity Directly Into Thrust – Futurism

§ July 2nd, 2020 § Filed under Nanotechnology Journal Comments Off on This Scientist Says He’s Built a Jet Engine That Turns Electricity Directly Into Thrust – Futurism

This past autumn, a professor at Wuhan University named Jau Tang was hard at work piecing together a thruster prototype that, at first, sounds too good to be true.

The basic idea, he said in an interview, is that his device turns electricity directly into thrust no fossil fuels required by using microwaves to energize compressed air into a plasma state and shooting it out like a jet. Tang suggested, without a hint of self-aggrandizement, that it could likely be scaled up enough to fly large commercial passenger planes. Eventually, he says, it might even power spaceships.

Needless to say, these are grandiose claims. A thruster that doesnt require tanks of fuel sounds suspiciously like science fiction like the jets on Iron Mans suit in the Marvel movies, for instance, or the thrusters that allow Doc Browns DeLorean to fly in Back to the Future.

But in Tangs telling, his invention lets just call it a Tang Jet, which he worked on with Wuhan University collaborators Dan Ye and Jun Li could have civilization-shifting potential here in the non-fictional world.

Essentially, the goal of this technology is to try and use electricity and air to replace gasoline, he said. Global warming is a major threat to human civilization. Fossil fuel-free technology using microwave air plasma could be a solution.

He anticipates this happening fast. In two years, he says, he thinks Tang Jets could power drones. In a decade, hed like to see them fly a whole airplane.

That would all be awesome, obviously. But its difficult to evaluate whether Tangs invention could ever scale up enough to become practical. And even if it did, there would be substantial energy requirements that could doom aerospace applications.

One things for sure: If the tech works the way he hopes, the world will never be the same.

Tangs curriculum vitae flits between a dazzling array of strikingly disparate academic topics, from 4D electron microscopy to quantum dot lasers, nanotechnology, artificial photosynthesis, and, of course, phase transitions and plasmonics.

Hes held several professorships, done research at Caltech and Bell Laboratories, published scores of widely-cited papers, edited several scientific journals, and won a variety of awards. He holds a U.S. patent for a device he calls a synchrotron shutter, designed to capture electrons traveling near the speed of light.

Tang says he first stumbled onto the idea for the plasma thruster when he was trying to create synthetic diamonds. As he tried to grow them using microwaves, he recalls, he started to wonder whether the same technology could be used to produce thrust.

Other huge stories, like the coronavirus pandemic and the baffling saga of Elon Musk naming his baby X A-12, were sucking a lot of oxygen out of the news cycle in early May, when Tang announced his invention to the world. A few outlets picked up Tangs story, including New Atlas, Popular Mechanics, and Ars Technica, but no journalist appears to have actually talked to him.

Because of that, there was little fanfare surrounding the sheer scope of his ambition for the technology and it went overlooked that Tang sometimes sounds as though hes invented a hammer and is now seeing a lot of things as nails.

After describing his plans to conquer aerospace with his new thruster, for instance, he starts to describe plans to take on the automotive industry as well with jet-powered electric cars.

I think the jet engine is more efficient than the electric motor, you can drive a car at much faster speeds, he mused. Thats what I have in mind: to combine the plasma jet engine with a turbine to drive a car.

But you wouldnt want to drive behind it, he warned, because you could be scorched by its fiery jet stream.

Over the course of our interview, Tang also brought up the possibilities of using the technology to build projectile weapons, launch spaceships, power boats, and even create a new type of stove for cooking. On that last point, Tang said that hes already built a prototype kitchen stove powered by a microwave air plasma torch but its so deafeningly loud that it sounds like a constant lightning strike.

Technically, the Tang Jet is an attempt to build a plasma thruster, a concept thats periodically gained attention in scientific circles. Michael Heil, a retired aerospace and propulsion engineer with a long career of Air Force and NASA research, told Futurism that Tangs research reminds him of several other attempts to build air propulsion tech that hes encountered over the years.

Plasma thrusters like those that would power a Tang Jet have been around for a while. NASA first launched a satellite equipped with plasma thrusters back in 2006, but its capabilities are a far cry from what Tang is proposing with his research.

Engineers have long dreamed of a plasma jet-powered plane, but every attempt has been smacked down by the technological limitations of the day. For example, New Scientist reported in 2017 that a team from the Technical University of Berlin attempted to build a similar thruster but like every attempt over the previous decade, their work never became useful outside of the lab.

The problems with these attempts arent so much faults with the theory the concept of generating thrust with a plasma torch is fairly sound. Rather, issues begin to pop up when working out the logistics of building a vehicle that actually works.

Tang has little interest in commercializing the jet himself. Instead, he wants to demonstrate its merits in hopes that well-funded government leaders or titans of industry will be inspired to take the ideas and run with them.

The steps toward realization of a full plasma jet engine would cost lots of money, time and energy, he said. Such investment is beyond our present resources. Such tasks should be taken by aerospace industries or governmental agencies.

Thats a common mindset for scientists, said Christopher Combs, an aerodynamics researcher at the University of Texas at San Antonio.

Thats what us academics do, we figure out the physics and say Well I dont want to make a product,' he told Futurism. Its kind of a common refrain to see people in academia who have had something that gets a lot of attention.

Though hes intrigued by the underlying principles of the Tang Jet, Combs says its unlikely that it will scale up to the size needed to lift a plane in other words, the same challenges that proved insurmountable to previous plasma thrusters will rear their heads once again. The current prototype, for perspective, only produces about 10 Newtons of thrust about the same as a medium-sized model rocket.

Youre talking about scaling something by five orders of magnitude more than 100,000 times! Combs said. Which almost never works linearly. Lots of engineering happens in the middle.

And even if it were to scale perfectly, theres the issue of power. Iron Mans suit was powered by an Arc Reactor, and the flying DeLorean was powered by a Mr. Fusion unit that turned household trash into more than a gigawatt of power both of which, unfortunately, are fictional.

Fossil fuels store vastly more energy by weight than batteries, and thats unlikely to change any time soon. And thats too bad, because the Tang Jet needs a whole lot of power.

According to a paper Tang and his collaborators publishedabout the thruster prototype in the journal AIP Advances in May, the technology produces about 28 Newtons of thrust per kilowatt of power. The engines on the Airbus A320, a common commercial jet, produce about 220,000 Newtons of thrust combined, meaning that a comparably-sized jet plane powered by Tang Jets would require more than 7,800 kilowatts.

For perspective, that would mean loading an aircraft up with more than 570 Tesla Powerwall 2 units for a single hour of flight an impractical load, especially because the A320s payload could only carry about 130 of the giant battery units. Long story short, no existing battery tech could provide enough juice.

Does this thing just become a flying Tesla battery? Combs said. With the weight of these batteries, you dont have room for anything else.

The battery weight issue doesnt doom the Tang Jet, but it pushes options for its power source into the fringe. Tang is banking on improvements to battery technology over the next years and decades; those Technical University of Berlin researchers speculated about nuclear fusion. Unfortunately, any possible answers could be decades away or impossible.

It is worth noting that there exist compact nuclear fission reactors, like Russias KLT-40S, that produce enough power and weigh little enough that they could fit in a passenger plane or rocket.

But the safety and environmental implications of nuclear-powered aircraft are grim, and Heil was quick to point out that generating enough power isnt the only problem facing a Tang Jet. Actually getting the electricity from the power source to the thrusters would pose its own difficulties, perhaps requiring superconducting materials that dont exist yet.

You need power to generate thrust. And how do you move that power around on the aircraft? Heil said. Moving and controlling megawatts from the reactor to the jet is a huge challenge. You have to use big thick copper wires, that adds a lot of weight.

Overall, both Combs and Heil questioned the feasibility of a practical Tang Jet based on the technology we have today. Without a quick fix to the energy problem, its certainly a tall order.

But both said they were fascinated by the research and hoped to see future progress. They also pointed out that a plasma thruster could be useful for pushing satellites or spacecraft that are already in orbit though at that point it would need to bring propellant with it rather than using atmospheric air, since thered be none in the vacuum of space.

The bottom line, Heil and Combs agreed, is that we wont have a firmer grasp of the future of the tech until Tangs colleagues have evaluated and experimented with it.

Im rooting for this, and Id love to see it pan out, Combs said. But the scientist in me has some questions and some concerns.

More on Tangs plasma jets: Scientists Create Jet Engine Powered by Only Electricity

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Global Nanotechnology in Medical Equipment Market 2020 Industry Insights, Top Trends, Drivers, Growth & Forecast to 2025 – Bandera County Courier

§ June 30th, 2020 § Filed under Nanotechnology Journal Comments Off on Global Nanotechnology in Medical Equipment Market 2020 Industry Insights, Top Trends, Drivers, Growth & Forecast to 2025 – Bandera County Courier

RecentlyMarketsandResearch.bizhas published a new report entitledGlobal Nanotechnology in Medical Equipment Market Growth (Status and Outlook) 2020-2025goes into the past for analyzing the market scenario, at the same time, it provides a complete insight into the market. Starting from the number of sales made, the price structure of each segment, revenue generated and expected to be made, the margin of the profit, past performance, and all other aspects that can influence the market are covered in this report. The report has segmented and sub-segmented with respect to regions, players, dynamics, and strategies to simplify the actual conditions of the industry. It development trends, competitive landscape analysis, and key regions development status on the types, applications, and major players of the global Nanotechnology in Medical Equipment market are studied in detail.

NOTE:Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.

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The Nanotechnology in Medical Equipment market has been segmented into key segments such as product types, end-users, leading regions, and noteworthy players. The market report also includes statistics about sales, consumption rate, volume, value, gross margin, and more. The report also inspects the financial standing of the leading companies, which covers gross profit, revenue generation, sales volume, sales revenue, manufacturing cost, individual growth rate, and other financial ratios. The segmentation included in the report is beneficial for companies to reach desired business goals. Business events, including corporate deals, mergers and acquisitions, joint ventures, partnerships, product launches, and brand promotions are some of the business events made by key players.

Leading manufacturers/companies operating at both regional and global levels:Stryker Corporation, AAP Implantate AG, 3M, Thermo Fisher Scientific, PerkinElmer, Inc., Abbott, Dentsply International, Starkey Hearing Technologies, Mitsui Chemicals, Inc., Smith + Nephew,

With the product, the market could be divided into: Active Implantable Medical Equipments, Biochip, Portable Material,

With users/application, the market can be split into: Treatment Using, Diagnostic Using, Research Using,

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Analysts have created this report by gathering information through primary through surveys and interviews and secondary included industry body databases, reputable paid sources, and trade journal methods of data collection. The report includes exhaustive qualitative and quantitative evaluation. Analysts have taken meticulous efforts to take a look at the right and valuable statistics and serve this intelligence document.

This includes key regional areas such as Americas (United States, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia), Middle East & Africa (Egypt, South Africa, Israel, Turkey, GCC Countries)

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Microplastics found in fruit and veg – Fruitnet

§ June 29th, 2020 § Filed under Nanotechnology Journal Comments Off on Microplastics found in fruit and veg – Fruitnet

Calls for an end to the ubiquitous use of plastic grew louder this week following the release of two peer-reviewed studies on the presence of microplastics in plants.

Since last year's publication of research estimating that the average person consumes at least 50,000 particles of microplastics a year, and breathes in a similar quantity, all eyes have been on these microscopic pollutants.

But that research, published in Environmental Science & Technology, relied on data from studies measuring only the amounts of microplastic particles found in fish, shellfish, sugar, salt, beer and water, as well as in the air in cities.

The two studies published this week, however, show that microplastics are also contaminating fruit and vegetables.

According to the first study, by University of Catania scientistMargherita Ferrante, apples are the most contaminated fruit while carrots are the most affected vegetable.

Published this week in the journalEnvironmental Research, the report calls for an urgent review of the impact of microplastics on human health.

The second study, set for publication in the journal Nature Sustainability, reportedly demonstrates how plastic is sucked up with water through the root systems of food crops.

The study, performed jointly by Dr Lianzhen Li of the Yanthai Institute of Coastal Zone Research in China and Professor Willie Peijnenburg from Leiden University in the Netherlands, found that microplastics penetrate the roots of lettuce and wheat plants, before being passed to the edible plant parts above ground.

As such, root vegetables, such as carrots, radishes and turnips, as well as leafy vegetables like lettuce, were found to be most at risk of contamination.

Another study published this week in the journal Nature Nanotechnology discovered that plants' absorption of microplastics through their roots slowed their growth, creating smaller plants with shorter roots, possibly impacting incomes for farmers.

Maria Westerbos, the founder of Dutch NGO the Plastic Soup Foundation, commented: For years we have known about plastic in crustaceans and fish, but this is the first time we have known about plastic getting into vegetables. If it is getting into vegetables, it is getting into everything that eats vegetables as well, which means it is in our meat and dairy."

Sian Sutherland, co-founder of environmental campaign group A Plastic Planet, called for an urgent investigation into the impact of micro plastics on human health. "Now more than ever we must listen to the scientists," she warned, "not the plastic lobbyists.

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IIT Guwahati, Shri Sankaradeva Nethralaya Develop Device For Detection Of Diabetic Retinopathy – NDTV

§ June 29th, 2020 § Filed under Nanotechnology Journal Comments Off on IIT Guwahati, Shri Sankaradeva Nethralaya Develop Device For Detection Of Diabetic Retinopathy – NDTV

IIT Guwahati Team Develops Device To Detect Diabetic Retinopathy Without The Need For Invasive Testing

The Indian Institute of Technology Guwahati (IIT Guwahati) and Shri Sankaradeva Nethralaya Guwahati, have jointly developed a testing device to detect diabetic retinopathy at an early stage without the need of invasive testing. The device comprises a small plate containing microchannels for guidance of fluids. The team has also filed an Indian patent for this idea and device. Diabetic retinopathy is a serious non-communicable disease in India. It is caused by abnormal growth in the retinal blood vessels in people with diabetes and is usually worsened when the person is on insulin for diabetic treatment.

The research funded by the Ministry of Human Resource and Development, Indian Council of Medical Research and Ministry of Electronics and Information Technology was led by Dr. Dipankar Bandyopadhyay, Professor, Department of Chemical Engineering and Head of Center for Nanotechnology, IIT Guwahati.

Descriptions and results of the testing device have been published in the ACS journal -- ACS Sustainable Chemistry And Engineering. The paper has been authored by Dr Bandyopadhyay, his students of IIT Guwahati, Mr Surjendu Maity, Mr Subhradip Ghosh and Ms Tamanna Bhuyan and collaborator Dr. Dipankar Das, Head of the Department of Ocular Pathology and Uvea in Shri Sankaradeva Nethralaya, Guwahati.

Dr Bandyopadhyay in a statement said: Currently, the first step in the test for diabetic retinopathy is an invasive eye exam, in which the eyes are dilated and the ophthalmologist inspects the eye.

As people who have had eye examinations know, this is inconvenient, with blurry vision for a long time after examination, the professor added.

The team of IIT Guwahati, as per a statement, wondered if there was a simple test such as a blood or urine test, to detect retinopathy even before symptoms are seen in the eye. This induced the researchers to look for appropriate biomarkers of retinopathy chemicals that are found in body fluids, that can indicate impending or ongoing retinopathy.

The statement issued by IIT Guwahati said: Researchers found that -2-microglobulin (B2M), a protein found in tears and urine, is a reliable indicator for retinopathy. Armed with this knowledge, they set out to develop a device that can detect this protein in these body fluids.

We designed a microfluidic system, in which, the body fluid tear or urine was drawn into very thin tubes or capillaries, where they came in contact with the gold-antibody nanoparticles, and the change in colour was assessed to detect B2M, explained Dr Bandyopadhyay.

Numerous microfluidic devices have already been developed for the biomarker detection in cancer and other diseases, but there are hitherto, none for detection of diabetic retinopathy. The IIT Guwahati teams work is among the first in this area and has tremendous practical implications, especially in India, the diabetic capital of the world, the statement added.

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Beware of These Common Food Additive in Desserts or be Ready For Long-Term Health Damage – India.com

§ June 28th, 2020 § Filed under Nanotechnology Journal Comments Off on Beware of These Common Food Additive in Desserts or be Ready For Long-Term Health Damage – India.com

Next time when you hop on desserts, candy, beverages or gum, read on. Researchers have found that a common food additive significantly alters gut microbiota in mice, causing inflammation in the colon and changes in protein expression in the liver. Also Read - E-cigarette additives may impair lung function: Study

The study confirmed a strong linkage between foodborne titanium dioxide nanoparticles (TiO2 NPs) and adverse health effects, said researchers from University of Massachusetts Amherst. Also Read - Flavouring And Additive Ingredients Used in E-Cigarettes More Likely to Impair Lung Function: Study

Human exposure to food-borne TiO2 NPs commonly used as a food additive known as E171, recently banned in France but allowed in the US and some other countries, which is made up of different-size particles of TiO2, including one-third or more that are nanoscale.

E171 makes products look whiter and more opaque. Its exposure is two to four times higher in US. children than in adults.

I think our results have a lot of implications in the food industry and on human health and nutrition, said lead author Hang Xiao, professor and Clydesdale Scholar of Food Science.

Gut microbiota, which refers to the diverse and complex community of microorganisms in the gut, plays a vital role in human health.

An imbalance of gut microbiota has been associated with a range of health issues, including inflammatory bowel disease, obesity and cardiovascular disease.

Smaller than 100 nanometers, foodborne nanoscale particles may have unique physiological properties that cause concern.

The bigger particles wont be absorbed easily, but the smaller ones could get into the tissues and accumulate somewhere, Xiao said in Small, a weekly, peer-reviewed journal that covers nanotechnology.

In their study, Xiao and his team fed either E171 or TiO2 NPs to two populations of mice as part of their daily diet.

The mice fed a high-fat diet eventually became obese, while the mice on the low-fat diet did not.

In both the non-obese mice and obese mice, the gut microbiota was disturbed by both E171 and TiO2 NPs, Xiao said.

The nanosized particles caused more negative changes in both groups of mice.

Moreover, the obese mice were more susceptible to the adverse effects of TiO2 NPs, causing more damage in obese mice than in non-obese ones.

The researchers found TiO2 NPs decreased cecal levels of short-chain fatty acids, which are essential for colon health, and increased pro-inflammatory immune cells and cytokines in the colon, indicating an inflammatory state.

The study also measured levels of TiO2 in human stool samples, finding a wide range.

Xiao said further research is needed to determine the health effects of long-term such as life-long and multigenerational exposure to TiO2 NPs.

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Sixth Wave Innovations Inc. to Webcast Live at Life Sciences Investor Forum June 25th – Press Release – Digital Journal

§ June 23rd, 2020 § Filed under Nanotechnology Journal Comments Off on Sixth Wave Innovations Inc. to Webcast Live at Life Sciences Investor Forum June 25th – Press Release – Digital Journal

HALIFAX, Nova Scotia, June 23, 2020 (GLOBE NEWSWIRE) -- Sixth Wave Innovations Inc. (CSE:SIXW | OTCQB:ATURF | FSE:AHUH), focused on Cannabinoid Purification, today announcedthat Dr. Jonathan Gluckman, President/CEO, will present live at LifeSciencesInvestorForum.com on June 25th.

DATE: Thursday, June 25th TIME: 1 PM EST LINK: https://tinyurl.com/062520LSIFPR

This will be a live, interactive online event where investors are invited to ask the company questions in real-time. If attendees are not able to join the event live on the day of the conference, an archived webcast will also be made available after the event.

It is recommended that investors pre-register and run the online system check to expedite participation and receive event updates.

Learn more about the event at http://www.lifesciencesinvestorforum.com.

Recent Company Highlights

About Sixth Wave Innovations Inc.

Sixth Wave is a development stage nanotechnology company with patented technologies that focus on extraction and detection of target substances at the molecular level using highly specialized Molecularly Imprinted Polymers (MIPs). The Company is in the process of commercializing its AffinityTM cannabinoid purification system, as well as, IXOS, a line of extraction polymers for the gold mining industry.

Sixth Wave can design, develop and commercialize MIP solutions across a broad spectrum of industries. The company is focused on nanotechnology architectures that are highly relevant for detection and separation of viruses, biogenic amines and other pathogens, for which the Company has products at various stages of development.

For more information about Sixth Wave, please visit our web site at: https://sixthwave.com

About Life Sciences Investor Forum

Life Sciences Investor Forum is the leading proprietary investor conference series that provides an interactive forum for Life Sciences companies to meet with and present directly to investors.

A real-time solution for investor engagement, Life Sciences Investor Forum is powered by Intrado Digital Media and specifically designed for more efficient investor access. Replicating the look and feel of on-site investor conferences, Life Sciences Investor Forum combines leading-edge conferencing and investor communications capabilities with a comprehensive global investor audience network.

CONTACTS:

Dr. Jonathan Gluckman President/CEO 801-582-0559 info@sixthwave.com

Life Sciences Investor Forum John M. Viglotti SVP Corporate Services, Investor Access (212) 220-2221 johnv@lifesciencesinvestorforum.com

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To Build Tiny Supercomputers, Scientists Are Modeling Circuits on the Human Brain – Yahoo News

§ June 12th, 2020 § Filed under Nanotechnology Journal Comments Off on To Build Tiny Supercomputers, Scientists Are Modeling Circuits on the Human Brain – Yahoo News

Photo credit: Sanford/Agliolo - Getty Images

From Popular Mechanics

Researchers at the Massachusetts Institute of Technology have developed a "brain-on-a-chip" that includes tens of thousands of artificial brain synapses.

Called memristors, the artificial synapses are made of silver and copper alloys, rendering them more efficient than their earlier non-alloyed counterparts.

They published their work on Monday in the journal Nature Nanotechnology.

In the future, you just might be able to carry around a tiny machine in your pocket that works like the human brain. It could do anything that the most advanced artificial neural network couldbut with no internet, and no software download required. That is, if new brain-on-a-chip research published Monday in the journal Nature Nanotechnology is any indication of where miniature computers are headed.

At the Massachusetts Institute of Technology, scientists have been developing that tech, squeezing tens of thousands of artificial brain synapses, called memristors (short for memory transistors), onto a confetti-sized slab of silicon and metal alloys. The goal is to produce tiny devices that can pack the punch of artificial intelligence, locally, without having to connect to the cloud, or rely on a supercomputer.

"Imagine connecting a neuromorphic device to a camera on your car, and having it recognize lights and objects and make a decision immediately, without having to connect to the internet," Jeehwan Kim, associate professor of mechanical engineering at MIT who led the work, said in a prepared statement. "We hope to use energy-efficient memristors to do those tasks on-site, in real-time.

Brain-on-a-chip research is a step toward neuromorphic devices, or electronics that contain a new kind of circuitry meant to mimic the brain's neural architecture. These devices are meant to be energy efficient and fluent in cognitive tasks like object recognition, association, adaption, and learning. One day, researchers hope to make them as capable as today's supercomputersand MIT is a step toward that reality.

Story continues

To fabricate the memristors, the team used silver and copper alloys, along with silicon. The resulting chip is only about one millimeter square, and can "remember" stored images and reproduce them over and over again. Those replications were more exact than in past efforts, which relied on unalloyed metals in the chip.

In one test, researchers recreated a grayscale image of the Captain America shield. Each pixel corresponded to one memristor in the chip. So, the team altered the conductivity of each memristor such that it was relative in strength to the color in the pixel it would illustrate. They were able to reproduce the image many times over.

Then, in an image processing task, the team programmed the memristors to change the appearance of an image depicting MIT's Killian Court, a manicured lawn before a classical domed building on campus. They found that they could better sharpen and blur the original image with these memristors than the prior state-of-the-art circuits.

All of this adds up to a move away from large-scale computing. Because researchers could complete these tasks on the tiny memristors, rather than through software on a computer, it's a step toward small devices that can use artificial intelligence without reliance on a massive data center. That could mean better onboard cameras in smartphones, or more intelligent computers in our cars.

"We would like to develop this technology further to have larger-scale arrays to do image recognition tasks" Kim said. "And some day, you might be able to carry around artificial brains to do these kinds of tasks, without connecting to supercomputers, the internet, or the cloud."

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Need A New Pair Of Work Shoes? Then Zappos Has You Covered – Men’s Journal

§ June 12th, 2020 § Filed under Nanotechnology Journal Comments Off on Need A New Pair Of Work Shoes? Then Zappos Has You Covered – Men’s Journal

Mens Journal aims to feature only the best products and services. We update when possible, but deals expire and prices can change. If you buy something via one of our links, we may earn a commission. Questions? Reach us at [emailprotected].

As the world slowly starts to open back up in America, that means a lot of guys are heading back to work. So now might be a good time to get some new work clothes. And if you work a physical job, then you might want to pick up the Timberland PRO Reaxion Composite Safety Toe Work Shoes.

Thats right. Timberland doesnt just make legendary boots. With these Timberland PRO Reaxion Composite Safety Toe Work Shoes, you get the comfort and flexibility of shoes with the sturdiness and protection of a pair of boots.

Work boots may be good for some jobs, but others need a little more flexibility than a pair of boots can offer. Thats where the Timberland PRO Reaxion Composite Safety Toe Work Shoes come in. Right off the bat, the most obvious benefit for the working man is the safety toe feature.

The safety toe feature on these shoes has no metal in it. It is made with a CarbonShield Nanotechnology so your feet (and especially your toes) are safe from any falling objects. And since theres no metal in there, the shoe has a little more flexibility to it for your working needs.

Another added benefit that the Timberland PRO Reaxion Composite Safety Toe Work Shoes has is that they help to fight odor. You shouldnt have to worry about these shoes getting all stunk up thanks to the antimicrobial mesh lining.

Of course, the Timberland PRO Reaxion Composite Safety Toe Work Shoes wouldnt be all that great if they werent comfortable. And they really are. The soles absorb shock to relieve stress from your feet, sending energy back to your foot so it never gets fatigued while youre working

Your feet will be comfortable all day thanks to the soles adding a ton of support and stability to the proceedings. You wont have to worry about rips or abrasions thanks to the material used on the midsole. And the sole is slip, oil, and heat resistant up to 248 degrees Fahrenheit. All jobs should be easy with these shoes on.

If you want to go back to work with some new shoes, the Timberland PRO Reaxion Composite Safety Toe Work Shoes are for you. Comforting your feet while protecting them in such a stylish looking package. And at this sales price, who can say no?

Get It: Pick up the Timberland PRO Reaxion Composite Safety Toe Work Shoes ($115; was $130) at Zappos

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Curadigm Announces Publication of Results Using Proprietary Nanoprimer to Improve RNA Therapeutics in Collaboration With the Langer Lab – Press…

§ June 12th, 2020 § Filed under Nanotechnology Journal Comments Off on Curadigm Announces Publication of Results Using Proprietary Nanoprimer to Improve RNA Therapeutics in Collaboration With the Langer Lab – Press…

PARIS & CAMBRIDGE, Mass.--(Business Wire)--Curadigm today announced the publication, with Prof. Robert Langers lab at MIT, of pre-clinical in vivo results showing that its Nanoprimer can improve the efficacy of RNA-based therapeutics. This collaboration utilized next-generation RNA technology developed at the Langer Lab, in combination with Curadigms proprietary Nanoprimer technology. The Nanoprimer is designed to precisely, but transiently, occupy the hepatic pathways responsible for therapeutic clearance. In pre-clinical studies, the combination resulted in significantly increased bioavailability and efficacy of siRNA and mRNA in vivo.

Published in Nano Lettersone of the premier nanotechnology journalsthe results are the culmination of a 2-year research collaboration evaluating the utility of the Curadigms Nanoprimer in increasing the efficacy of nucleic-acid based therapeutics. Combined with mRNA and siRNA-based therapeutics, the Nanoprimer increased efficacy by 32% and 49% respectively in the study. This was correlated with decreased liver trapping and increased blood bioavailability of 8 and 16- fold, respectively, without any additional associated toxicity.

Nucleic acid-based therapeutics (RNA and DNA) represent a rapidly growing segment of the biotech and pharma market, showing nearly exponential growth in programs over the last decade. While RNA-based therapeutics hold great potential to treat diverse and challenging diseases, their clinical utility has been limited by the difficulty achieving efficient accumulation in target tissues. This is largely due to the rapid liver clearance of RNA and DNA-based therapeutics. This promising new data, highlights the potential for the Nanoprimer technology to enable greater efficacy for nucleic acid-based therapeutics, facilitate their advancement toward the clinic and strengthen their ability to efficiently target a diverse range of tissues, including non-liver.

This collaboration provides validation of Curadigms approach to increasing therapeutic bioavailability and efficacy. The Nanoprimer technology is broadly applicable across multiple drug classes including nanomedicines, nucleic acid therapeutics, and gene editing technologies. The system does not modify the therapeutic at all, rather it is a precisely designed nanoparticle that is administered just prior to a therapeutic and works on a universal liver clearance mechanism for intravenous (IV) therapeutics.

About Curadigm:

Curadigm, a Nanobiotix Corp S. A. subsidiary, is an early-stage nanotechnology company dedicated to improving outcomes for patients by shifting the therapeutic delivery paradigm. Curadigms Nanoprimer platform is designed to increases drug bioavailability while decreasing unintended off-target effects, specifically liver toxicity. The platform can be used with most intravenous (IV) therapeutics across multiple drug classes. Curadigm is dedicated to advancing therapeutic development based on our deep understanding of how drugs interact with the body, to impact both known and novel drugs across multiple clinical indications.

For more information about Curadigm visit http://www.curadigm.com

View source version on businesswire.com: https://www.businesswire.com/news/home/20200609005710/en/

CURADIGM

Kate ROCHLIN (US) +1 (617)-583-0990

kate.rochlin@curadigm.com

Matthieu GERMAIN (FR) +33 (0)6 63 16 13 86

contact@curadigm.com

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Holders of negative opinions towards GM food likely to be against other novel food tech – Science Codex

§ June 10th, 2020 § Filed under Nanotechnology Journal Comments Off on Holders of negative opinions towards GM food likely to be against other novel food tech – Science Codex

Scientists at Nanyang Technological University, Singapore (NTU Singapore) and the Harvard T. H. Chan School of Public Health (HSPH) have found that people who hold negative opinions of genetically-modified (GM) food are likely to feel the same about nano-enabled food - food with nano-additives to enhance flavour, nutrition or prolong shelf life.

In a survey of 1,000 respondents led by NTU comprising adult Singaporeans and permanent residents, close to a third found GM food unappealing, and their negative feelings influenced how they viewed nano-enabled food. Over a third felt neutral about GM food, while the remaining respondents welcomed it.

While the study focused specifically on reactions towards nano-enabled foods, lead investigator and NTU Associate Professor Shirley Ho said that the "spillover effect" they observed from GM food to nano-enabled food could possibly extend to other novel food technologies as well, given that mental associations that people make between similar technologies have shown to influence their behaviour towards a newer technology. This represents a cause for concern for policy makers as Singapore invests in food science and technology as one of its strategies to bolster food security.

With the COVID-19 outbreak extending into the second quarter of the year, the Food and Agriculture Organisation of the United Nations has warned of global disruption in food supply brought about by movement restrictions and border controls in a protracted crisis.

The global pandemic has thrust the issue of food security and the necessity to explore cutting edge research in novel food technologies into the spotlight, said Assoc Prof Ho of NTU's Wee Kim Wee School of Communication and Information.

"The COVID-19 pandemic has highlighted the importance of food security for a small country like Singapore, which imports more than 90 per cent of its food consumed in the country. We don't have the problem of disrupted food supply yet, but we have to anticipate the possibility," said Assoc Prof Ho.

"Our study is a timely examination of the public's reactions towards novel food technologies. We may soon be able to make food last longer with the help of science, or dine on lab-cultured meat, but all these would be futile if a sizeable group of people reject these new food innovations."

"This study highlights the challenge in communicating safety of new food technologies as innovations advance to meet global food needs for a growing world population," added Dr K. Viswanath, Lee Kum Kee Professor of Health Communication at Harvard T.H. Chan School of Public Health and a co-author on the paper.

The study was published in the Journal of Communication on 5 June.

Tech-enabled food doesn't go down well with some Singaporeans

To study public opinion on engineered food, the NTU-Harvard team first surveyed 1,000 Singapore citizens and permanent residents on their thoughts on GM food - for example, asking whether they consider it to be delightful, nutritious, fresh and appealing.

Close to a third, or 305 respondents, showed unfavourable attitudes towards GM food.

The team then investigated how the respondents' pre-existing attitudes towards GM food affected their feelings about nano-enabled food, and found that those who had unfavourable attitudes towards GM food were also unfavourable about nano-enabled food - what the scientists called a spillover effect.

The scientists also found that participants who were unfavourable towards technology-enabled food may not be swayed to do the same after watching others eat this food.

Assoc Prof Ho, who is also NTU's Research Director for Arts, Humanities, Education and Social Sciences, explained: "This spillover effect could potentially be due to a general rejection of technology-enabled food and other notions associated with it. The mental associations that people make between similar technologies may influence their behaviours toward a newer technology. This is especially so in cases where the technology from which people draw cues is socially contestable."

The findings also highlight the key role communication plays in bridging the gap between science and the public, she added.

The study was funded by the NTU-HSPH Initiative for Sustainable Nanotechnology, and done in collaboration with Prof K. Vish Viswanath and Dr Mesfin Awoke Bekalu at the Harvard T. H. Chan School of Public Health. Other NTU authors include PhD student Tong Jee Goh, research fellow Dr Agnes Chuah, and research associate Yan Wah Leung.

A similar survey is being conducted by the team in the US. The findings will provide a comparative study of attitudes towards tech-enabled food across different regions and populations.

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