Scientists Create Human ‘Body-On-A-Chip’ Featuring Tiny Replica Organs In The Lab – IFLScience

§ March 9th, 2020 § Filed under Nano Medicine Comments Off on Scientists Create Human ‘Body-On-A-Chip’ Featuring Tiny Replica Organs In The Lab – IFLScience

Researchers have created what they say is the world's most sophisticated lab model of the human body: a system of mini-organs made fromreal human cells and stem cells.

While it may sound like attempts to make a miniature Frankensteins monster in a petri dish, the researchers are actually hoping to create an entire lab model of miniaturized human organs that could become invaluable for drug testing and biomedical research.

Reporting in the journal Biofabrication, scientists from Wake Forest Institute for Regenerative Medicine (WFIRM) in North Carolina created a human organ tissue system that features a miniature heart-like organ that beats about 60 times a minute, a lung that breathes the air from the surrounding environment, and a liver that breaks down toxic compounds, as well as testicles and a colon.

Although just one-millionth the size of a full-sized adult human organ, these body-on-a-chip" systems are remarkably detailed, complete with their own blood vessel cells, immune system cells, and connective tissue cells. It also contains a microfluidic circuit thats able to circulate a drug throughout the system between organs, just like how a cardiovascular system pumps molecules through the human body in the blood.

Creating microscopic human organs for drug testing was a logical extension of the work we have accomplished in building human-scale organs, said study co-author Thomas Shupe of WFIRM in astatement. Many of the same technologies we have developed at the human-scale level, like including a very natural environment for the cells to live in, also produced excellent results when brought down to the microscopic level.

Don't worry, this isn't scientists creating a tiny "artificial human" the system is barely more thana load of blobs in a petri dish, not a conscious organism.

Organoids are invaluable tools for scientists looking to understand the human body. In one of the most incredible breakthroughs, researchers recently observed brain organoids that began to show signs of brain waves similar to those of preterm infants. Its hoped this kind of research could be used to understand how brain cells develop into the intensely complex organ currently sitting in your head.

They are also extremely useful for testing new pharmaceutical drugs because they react, in theory, just as a real human organ would. Plus, they are safe and relatively low-cost. The newly developed miniature organ model has already been used for a number of tests to assessthetoxicity of some drugs. In some instances, the organ model managed to show adrug might be dangerous or have some undesired effect, thereby potentially preventing harm to humans.

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Scientists Create Human 'Body-On-A-Chip' Featuring Tiny Replica Organs In The Lab - IFLScience

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