Once-daily levodopa pill for Parkinson’s touted by developer – Clinical Daily News – McKnight’s Long Term Care News

§ September 17th, 2020 § Filed under Nanotechnology Journal Comments Off on Once-daily levodopa pill for Parkinson’s touted by developer – Clinical Daily News – McKnight’s Long Term Care News

Prof. Joachim Loo (left) and LiberaTx CEO Dr. Shashi Kesavapany holding engineered pill samples. Photo credit: NTU Singapore

Drug developers from Singapore are set to test a levodopa pill designed to be taken once daily, potentially resolving the problem of symptom flares between doses in patients with Parkinsons disease.

Levodopa commonly is prescribed to treat tremors, stiffness and slowness of movement in Parkinsons. Multiple oral doses may be needed each day and at set times to keep drug levels steady. The new pills microcapsule is designed to float in the stomach, slowly and continuously delivering levodopa into the upper intestine throughout the day for improved absorption, said Joachim Loo, Ph.D., from Nanyang Technological University.

This is key in maintaining the drugs concentration in the blood, so that dopamine levels in the brain are kept constant over prolonged periods rather than fluctuating, which is the case for current tablets, Loo explained.

The developers have created a start-up company, LiberaTx, to commercialize the microcapsule and are planning clinical trials in Singapore to test its efficacy.

We hope that by reducing dosage to just once a day would greatly improve patient compliance, lower the pill burden of these patients, while alleviating the off periods that these patients experience, Loo said.

An early study using multiple Parkinsons drugs was published in Small, a weekly peer-reviewed scientific journal covering nanotechnology.

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Once-daily levodopa pill for Parkinson's touted by developer - Clinical Daily News - McKnight's Long Term Care News

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