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Stem-cell transplant claims debunked

§ October 14th, 2012 § Filed under Nano Medicine Comments Off on Stem-cell transplant claims debunked

Hisashi Moriguchi presented his work at the New York Stem Cell Foundation meeting this week.

AP/Press Association

From the beginning, it seemed too good to be true. Days after Kyoto University biologist Shinya Yamanaka won a Nobel prize for his 2006 discovery of induced pluripotent stem (iPS) cells (see 'Cell rewind wins medicine Nobel'), Hisashi Moriguchi a visiting researcher at the University of Tokyo claimed to have modified that technology to treat a person with terminal heart failure. Eight months after surgical treatment in February, said a front-page splash in the Japanese newspaper Yomiuri Shimbun yesterday, the patient was healthy.

But after being alerted to the story by Nature, Harvard Medical School and Massachusetts General Hospital (MGH), where Moriguchi claimed to have done the work, denied that the procedure had taken place. No clinical trials related to Dr Moriguchi's work have been approved by institutional review boards at either Harvard University or MGH, wrote David Cameron, a spokesman for Harvard Medical School in Boston, Massachusetts. The work he is reporting was not done at MGH, says Ryan Donovan, a public-affairs official at MGH, also in Boston.

A video clip posted online by the Nippon News Network and subsequently removed showed Moriguchi presenting his research at the New York Stem Cell Foundation meeting this week.

If true, Moriguchis feat would have catapulted iPS cells into use in a wide range of clinical situations, years ahead of most specialists' predictions. I hope this therapy is realized in Japan as soon as possible, the head of a Tokyo-based organization devoted to helping children with heart problems told Yomiuri Shimbun.

But there were reasons to be suspicious. Moriguchi said he had invented a method to reprogram cells using just two chemicals: microRNA-145 inhibitor and TGF- ligand1. But Hiromitsu Nakauchi, a stem-cell researcher at the University of Tokyo, says that he has never heard of success with that method. He adds that he had also never heard of Moriguchi before this week.

Moriguchi also said that the cells could be differentiated into cardiac cells using a 'supercooling' method that he had invented. Thats another weird thing, says Nakauchi.

The article in which Moriguchi presented his two-chemical method, published in a book1 describing advances in stem-cell research, includes paragraphs copied almost verbatim from other papers. The section headed 2.3 Western blotting, for example, is identical to a passage from a 2007 paper by Yamanaka2. Section 2.1.1, in which Moriguchi describes human liver biopsies, matches the number of patients and timing of specimen extractions described in an earlier article3, although the name of the institution has been changed.

When contacted by Nature, Moriguchi stood by his publication. We are all doing similar things so it makes sense that wed use similar words, he says. He did admit to using other papers as reference.

Source:
http%3A//www.nature.com/doifinder/10.1038/nature.2012.11584

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10/11/2012 10:05 JAPAN Nobel Prize for Yamanaka, scientific research and ethics must go hand in hand

§ October 14th, 2012 § Filed under Nano Medicine Comments Off on 10/11/2012 10:05 JAPAN Nobel Prize for Yamanaka, scientific research and ethics must go hand in hand

10/11/2012 10:05 JAPAN Nobel Prize for Yamanaka, scientific research and ethics must go hand in hand by Pino Cazzaniga Research on iPS (induced pluripotent stem cells) can produce stem cells from adult cells, for use in regenerative medicine. Shinya Yamanakas discovery reveals that research on embryonic stem cells is unnecessary, saving the lives of many embryos. The Japanese researcher has searched for new ways driven by ethical question.

Tokyo (AsiaNews) - Shinya Yamanaka, fresh from the Nobel Prize for medicine, states that science and ethics must go hand in hand. Interviewed by the Mainichi Shimbun after the award, he said: "I would like to invite ethical experts as teachers at my laboratory and work to guide iPS [induced pluripotent stem] cell research from that direction as well. The work of a scientific researcher is just one part of the equation. "

Yamanaka, 50, found that adult cells can be transformed into cells in their infancy, stem cells (iPS), which are, so to speak, the raw material for the reconstruction of tissue irreparably damaged by disease. For regenerative medicine the implications of Yamanaka's discovery are obvious. Adult skin cells can for example be reprogrammed and transformed into any other cell that is desired: from the skin to the brain, from the skin to the heart, from the skin to elements that produce insulin.

"Their discovery - says the statement of the jury that awarded him the Nobel Prize on October 8 - has revolutionized our understanding of how cells and organisms develop. Through the programming of human cells, scientists have created new opportunities for the study of diseases and development of methods for the diagnosis and therapy ".

These "opportunities" are not only "scientific", but also "ethical". Much of the scientific research and global investment is in fact launched to design and produce stem cells from embryos, arriving at the point of manipulating and destroying them, facing scientists with enormous ethical problems.

" Ethics are really difficult - Yamanaka explainsto Mainichi - In the United States I began work on mouse experiments, and when I returned to Japan I learned that human embryonic stem cells had been created. I was happy that they would contribute to medical science, but I faced an ethical issue. I started iPS cell research as a way to do good things as a researcher, and I wanted to do what I could to expand the merits of embryonic stem cells. If we make sperm or eggs from iPS cells, however, it leads to the creation of new life, so the work I did on iPS cells led to an ethical problem. If we don't prepare debates for ethical problems in advance, technology will proceed ahead faster than we think.. "

The "ethical question" Yamanaka pushed to find a way to "not keep destroying embryos for our research."

Speaking with his co-workers at the University of Kyoto, immediately after receiving the award, Yamanaka showed dedication and modesty.

"Now - he said - I strongly feel a sense of gratitude and responsibility" gratitude for family and friends who have supported him in a demanding journey of discovery that lasted decades; responsibility for a discovery that gives hope to millions of patients. Now iPS cells can grow into any tissue of the human body allowing regeneration of parts so far irretrievably lost due to illness.

Source:
http%3A//www.asianews.it/news-en/Nobel-Prize-for-Yamanaka,-scientific-research-and-ethics-must-go-hand-in-hand-26054.html

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Read in

§ October 14th, 2012 § Filed under Nano Medicine Comments Off on Read in

TOKYO: Shinya Yamanaka, fresh from the Nobel Prize for medicine, states that science and ethics must go hand in hand. Interviewed by the Mainichi Shimbun after the award, he said: "I would like to invite ethical experts as teachers at my laboratory and work to guide iPS [induced pluripotent stem] cell research from that direction as well. The work of a scientific researcher is just one part of the equation. "

Yamanaka, 50, found that adult cells can be transformed into cells in their infancy, stem cells (iPS), which are, so to speak, the raw material for the reconstruction of tissue irreparably damaged by disease. For regenerative medicine the implications of Yamanaka's discovery are obvious. Adult skin cells can for example be reprogrammed and transformed into any other cell that is desired: from the skin to the brain, from the skin to the heart, from the skin to elements that produce insulin.

"Their discovery - says the statement of the jury that awarded him the Nobel Prize on October 8 - has revolutionized our understanding of how cells and organisms develop. Through the programming of human cells, scientists have created new opportunities for the study of diseases and development of methods for the diagnosis and therapy ".

These "opportunities" are not only "scientific", but also "ethical". Much of the scientific research and global investment is in fact launched to design and produce stem cells from embryos, arriving at the point of manipulating and destroying them, facing scientists with enormous ethical problems.

" Ethics are really difficult - Yamanaka explainsto Mainichi - In the United States I began work on mouse experiments, and when I returned to Japan I learned that human embryonic stem cells had been created. I was happy that they would contribute to medical science, but I faced an ethical issue. I started iPS cell research as a way to do good things as a researcher, and I wanted to do what I could to expand the merits of embryonic stem cells. If we make sperm or eggs from iPS cells, however, it leads to the creation of new life, so the work I did on iPS cells led to an ethical problem. If we don't prepare debates for ethical problems in advance, technology will proceed ahead faster than we think.. "

The "ethical question" Yamanaka pushed to find a way to "not keep destroying embryos for our research."

Speaking with his co-workers at the University of Kyoto, immediately after receiving the award, Yamanaka showed dedication and modesty.

"Now - he said - I strongly feel a sense of gratitude and responsibility" gratitude for family and friends who have supported him in a demanding journey of discovery that lasted decades; responsibility for a discovery that gives hope to millions of patients. Now iPS cells can grow into any tissue of the human body allowing regeneration of parts so far irretrievably lost due to illness.

His modesty also led him to warn against excessive hopes. To a journalist who asked him for a message to patients and young researchers awaiting the results of his research heresponded: "The iPS cells are also known as versatile cells, and the technology may be giving the false impression to patients that they could be cured any day now. It will still take five or 10 years of research before the technology is feasible. There are over 200 researchers at my laboratory, and I want patients to not give up hope"

"Dozens of times - he continued - I tried to get some results and I have often failed in the experiments .... Many times I was tempted to give up or cry. Without the support of my family, I could not have continued this search. From now on I will be facing the moment of truth. I would like to return to my laboratory as quickly as possible. "

Source:
http%3A//www.heraldmalaysia.com/news/Nobel-Prize-for-Yamanaka,-scientific-research-and-ethics-must-go-hand-in-hand-13372-10-1.html

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Analysis: Reprogrammed cells open new medical window

§ October 14th, 2012 § Filed under Nano Medicine Comments Off on Analysis: Reprogrammed cells open new medical window

LONDON (Reuters) - The Nobel Prize-winning discovery of how to reprogram ordinary cells to behave like embryonic stem cells offers a way to skirt around ethical problems with human embryos, but safety concerns make their future use in treating disease uncertain.

While researchers have already applied the scientific breakthroughs of Britain's John Gurdon and Japan's Shinya Yamanaka to study how diseases develop, making such cells into new treatments will involve a lot more checks.

Stem cells act as the body's master cells, providing the source material for all other cells. They could transform medicine by regenerating tissue for diseases ranging from blindness to Parkinson's disease.

Creating embryo-like stem cells without destroying embryos gets round a key controversy by avoiding the need to process embryos left over at fertility clinics - a system that has led to political objections in the United States and elsewhere.

Reprogrammed cells - known as induced pluripotent stem cells, or iPS cells - offer an ethically neutral alternative. They have been a source of intense research since Yamanaka discovered their potential in 2006, building on work that Gurdon did in frogs and tadpoles 40 years earlier.

SAFETY CONCERNS

Recently, however, different research groups have noticed problems with iPS cells, suggesting they may not be as good as embryonic ones. In one study, iPS cells died more quickly and another found multiple genetic mutations, raising concerns that they could cause tumors.

Despite this, Japanese researchers hope to test iPS cells in clinical trials for a form of blindness as early as next year - catching up with recent successful eye trials using embryonic stem cells.

Researchers in the West are generally more wary.

"There is a bit of a divergence between Japan and the rest of the world on this," Chris Mason, professor of regenerative medicine at University College London, told Reuters.

Source:
http://news.yahoo.com/analysis-reprogrammed-cells-open-medical-window-150024485.html;_ylt=A2KJ3CXn33pQs2gAze3_wgt.

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Johns Hopkins researchers at Society for Neuroscience Annual Meeting

§ October 14th, 2012 § Filed under Nano Medicine Comments Off on Johns Hopkins researchers at Society for Neuroscience Annual Meeting

Public release date: 13-Oct-2012 [ | E-mail | Share ]

Contact: Vanessa McMains vmcmain1@jhmi.edu 410-502-9410 Johns Hopkins Medicine

Oct. 13-17, 2012

Ernest N. Morial Convention Center 900 Convention Center Boulevard, New Orleans, La. 70130

IN ANIMALS, DRUG PREVENTS NERVE DAMAGE CAUSED BY CHEMOTHERAPY, HIV AND DIABETES

Poster#: 354.19/T6, Hall F-J, Monday, Oct. 15, 2012, 9-10 a.m. CST Authors: J. Zhu, W. Chen, C. Zhou, N. Reed, A. Hoke

AND

Poster#: 354.29/T16, Hall F-J, Monday, Oct. 15, 2012, 11 a.m.-12 p.m. CST Authors: M. Ray, N. Reed, J. Zhu, A. Hoke

Johns Hopkins researchers have identified a drug that seems to protect mice and rats from nerve degeneration caused by chemotherapy drugs, HIV and diabetes. Almost 20 million Americans suffer from nerve damage caused by chronic disease, infection or exposure to toxic chemicals, like the ones used to treat cancer. Nerve damage can cause numbness, tingling, pain and trouble walking. Although pain relievers can provide some relief, according to Ahmet Hoke, M.D., Ph.D., professor of neurology at the Johns Hopkins School of Medicine, there aren't any treatments on the market that prevent further nerve damage or repair injured nerves. To find neuroprotective drugs, Hoke's research team treated nerve cells grown in a dish with Taxol, a chemotherapy drug that causes nerve damage, also known as neuropathy, and one of 2,000 different compounds from a collection that was put together by a consortium funded by the National Institute of Neurological Disorders and Stroke to find treatments for neurodegenerative diseases. By looking in a microscope for healthy nerve cells ones without damaged, shriveled appendages in the presence of Taxol, they identified the protective drug ethoxyquin. Ethoxyquin effectively prevented 70 percent of the nerve damage in mice treated with Taxol, as well as protected the nerves in diabetic rats and in the mouse model of HIV. "Ethoxyquin or other drugs developed based on ethoxyquin's molecular structure will be important for developing neuroprotective therapies a hugely unmet clinical need," says Hoke. He cautions that safety studies still need to be carried out before clinical trials are considered. While investigating how ethoxyquin works, the researchers found the drug binds to a protein involved in the cell's stress response system. Further elucidation of ethoxyquin's method of action may help identify other targets for neuropathy treatment.

ENVIRONMENTAL CUES AND HORMONE LEVELS CONTROL BRAIN STRUCTURE IN CANARIES

Source:
http%3A//www.eurekalert.org/pub_releases/2012-10/jhm-jhr101212.php

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QualityStocks News – Power of the Dream Ventures Subsidiary Partners with German Cancer Research Center to Tackle HPV …

§ October 13th, 2012 § Filed under Nano Medicine Comments Off on QualityStocks News – Power of the Dream Ventures Subsidiary Partners with German Cancer Research Center to Tackle HPV …

Collaboration will initiate preclinical research aimed at developing a treatment for Human Papilloma Virus after infection has occurred

Scottsdale, Arizona (PRWEB) October 13, 2012

In the companys news yesterday,

Genetic Immunity, a wholly owned subsidiary of Power of the Dream Ventures, has inked an agreement with DKFZ (German Cancer Research Center, Heidelberg, Germany) to develop a DNA-based vaccine for the treatment of Human Papilloma Virus (HPV) infection that causes cervical and other cancers. The companies are addressing a gap in the market between vaccines such as Cervarix and Gardasil, which have no therapeutic effect on HPV-related diseases, and the need for a product to treat diseases or conditions caused by HPV.

There is a huge unmet medical need for such cancer vaccine, because vaccines we have developed earlier do not provide protection against cancer when used for treatment of existing conditions caused by HPV. Our goal is to provide protection against cancer for patients after the onset of sexual activity, after they might be exposed to HPV, Dr. Julianna Lisziewicz, CEO of Genetic Immunity stated in the press release.

The Division of Genome Modifications and Carcinogenesis will commence a preclinical research program to evaluate the therapeutic efficacy of the DKFZs HPV-specific plasmid DNA using Genetic Immunitys nanomedicine formulation and Langerhans cell-targeting administration technologies.

The newly formed collaboration will use Genetic Immunitys clinically proven technology, as demonstrated in clinical trials of DermaVir as an immunotherapy for the cure of HIV, in its research. The collaboration will test whether HPV-specific memory T cells induced by Genetic Immunitys nanomedicine products could protect against cancer after infection has already occurred.

We found that Genetic Immunity technology is unique to target the vaccine DNA into the nucleus of the Langerhans cells. We believe that it will provide a breakthrough in cancer immunotherapy. We pioneered HPV prophylactic vaccines with new innovations and we would like to expand this tradition to therapeutic setting, said DKFZs Dr. Prof. Gissmann, who will initiate the preclinical research program.

About QualityStocks

QualityStocks, based in Scottsdale, Arizona, is a free service that collects data from hundreds of Small-Cap and Micro-Cap online Investment Newsletters into one Daily Newsletter Report. QualityStocks is dedicated to assisting emerging public companies with their investor communication efforts and connecting subscribers with companies that have huge potential to succeed in the short and long-term future.

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DKFZ and Genetic Immunity Sign Collaboration Agreement to Develop HPV Therapeutic Vaccine

§ October 12th, 2012 § Filed under Nano Medicine Comments Off on DKFZ and Genetic Immunity Sign Collaboration Agreement to Develop HPV Therapeutic Vaccine

HEIDELBERG, GERMANY and BUDAPEST, HUNGARY--(Marketwire - Oct 12, 2012) - Genetic Immunity ( OTCBB : PWRV ), a leader in immunotherapy technology product development, and DKFZ (German Cancer Research Center, Heidelberg, Germany) signed a collaborative agreement to develop a DNA-based vaccine for the treatment of Human Papilloma Virus (HPV) infection that causes cervical cancer and other cancers of the anus, penis, vulva, vagina, and oropharynx. Present HPV vaccines (Cervarix, Gardasil) have no therapeutic effect on HPV-related diseases, so they will not treat existing diseases or conditions caused by HPV.

The Division of Genome Modifications and Carcinogenesis led by Prof. Dr. Lutz Gissmann will initiate a preclinical research program to evaluate the therapeutic efficacy of the DKFZ's HPV-specific plasmid DNA using Genetic Immunity's nanomedicine formulation and Langerhans cell-targeting administration technologies. DKFZ is a world leading research center in tumor virology. Harald zur Hausen was awarded the Nobel Medicine Prize for his work on HPV-caused cancer of the cervix. Zur Hausen, former Scientific Director of the German Cancer Research Center, is recognized for finding that cervical cancer is caused by viral infections. His research made it possible to develop a vaccine against one of the most frequent cancers in women. Zur Hausen shared the Nobel Prize for Medicine with Franoise Barr-Sinoussi and Luc Montagnier for discovering HIV, the virus that causes AIDS.

"There is a huge unmet medical need for such cancer vaccine, because vaccines we have developed earlier do not provide protection against cancer when used for treatment of existing conditions caused by HPV. Our goal is to provide protection against cancer for patients after the onset of sexual activity, after they might be exposed to HPV," said Dr. Julianna Lisziewicz, CEO of Genetic Immunity.

Genetic Immunity has successfully tested in clinical trials DermaVir, a candidate immunotherapy for the cure of HIV. This new collaboration is using the clinically proven technology expanding the pipeline to another deadly viral disease that causes cancer. The partners will test whether HPV-specific memory T cells induced by Genetic Immunity's nanomedicine products could protect against cancer after infection has occurred.

"We found that Genetic Immunity technology is unique to target the vaccine DNA into the nucleus of the Langerhans cells. We believe that it will provide a breakthrough in cancer immunotherapy. We pioneered HPV prophylactic vaccines with new innovations and we would like to expand this tradition to therapeutic setting," said Dr. Prof. Gissmann of DKFZ.

Genetic Immunity is a wholly owned subsidiary of Power of the Dream Ventures, Inc. ( OTCBB : PWRV ).

About Genetic Immunity

Genetic Immunity, part of Power of the Dream Ventures, Inc. (PWRV), is a clinical stage technology company committed to discovering, developing, manufacturing and commercializing a new class of immunotherapeutic biologic drugs for the treatment of viral infections, cancer and allergies. Our Langerhans cell-targeting nanomedicines are exceptional in both safety and immune modulating activity boosting specific Th1-type central memory T cells. These are essential to eliminate infected cells or cancerous cells, and balance the immune reactivity in response to allergens.

In 1988 Drs. Lisziewicz and Lori founded Genetic Immunity in the US after they described the 1st patient whose immune system was boosted to control HIV after treatment interruption (Lisziewicz et al. New England Journal of Medicine 1999) that lead to the invention of DermaVir. The Company's innovative technology team directed by Dr. Lisziewicz, a champion of immune boosting therapies, is now headquartered in Budapest, Hungary. She has been invited into the Scientific Advisory Board of the HIV Cure Initiative led by Francoise Barre-Sinoussi Nobel Prize Laureate for her HIV research in 2009. For more information please visit http://www.geneticimmunity.com

About DKFZ

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SENAI/SESI of Sao Paulo Selects NanoProfessor as Foundation for "Nanomundo" Nanotechnology Education Initiative

§ October 8th, 2012 § Filed under Nano Medicine Comments Off on SENAI/SESI of Sao Paulo Selects NanoProfessor as Foundation for "Nanomundo" Nanotechnology Education Initiative

SKOKIE, IL--(Marketwire - Oct 8, 2012) - NanoProfessor, the global leader in hands-on undergraduate nanotechnology education, announced today that SENAI (Servio Nacional de Aprendizagem Industrial) and SESI (Servio Social da Indstria) of So Paulo, Brazil recently incorporated the NanoProfessor Nanoscience Education Program into five mobile nanotechnology classrooms in launching its Nanomundo Nanotechnology Educational Program.

SENAI is Brazil's largest organization of professional and technological education in Latin America, while SESI is Brazil's leader in promoting improved quality of life for workers and their dependents including providing high quality basic education for students from first through twelfth grade.

The mobile Nanomundo nanotechnology classrooms can accommodate up to 30 students at a time and will travel between the SENAI/SESI network of schools within So Paulo.Each Nanomundo classroom comes equipped with nano-focused instrumentation provided by the NanoProfessor Program including NanoInk's NLP 2000 Desktop NanoFabrication System, a student-friendly atomic force microscope, and a best-of-class fluorescence microscope.The Nanomundo classrooms will also use the NanoProfessor textbook, "Introduction to Nanoscale Science and Technology," and the cutting-edge lab experiments provided by the NanoProfessor Program.Both the NanoProfessor textbook and lab guide have been translated into Portuguese to further support the Nanomundo Program.The SENAI/SESI teachers will undergo an intensive two-week training program in So Paulo conducted by NanoProfessor's Scientific Education Team.

"Nanotechnology is a rapidly emerging industry that is responsible for life-changing breakthroughs in fields such as medicine, manufacturing, alternative energy, and electronics," said Professor Walter Vicioni, Diretor Regional and Superintendente Operacional of SENAI/SESI So Paulo."By using the NanoProfessor Program as the foundation of the Nanomundo Program and the five mobile nanotechnology classrooms, we are ensuring that students throughout our vast network of schools in So Paulo will have access to state-of-the-art nanotechnology education and be prepared for exciting jobs in the nanotechnology industry."

"We salute SENAI/SESI So Paulo for their ingenuity, visionary thinking, and strong commitment to nanotechnology education," said Dean Hart, Chief Commercial Officer of NanoProfessor."By integrating the NanoProfessor Nanoscience Education Program into its five Nanomundo mobile nanotechnology classrooms, SENAI/SESI is not only providing their students with the skills and education needed to succeed in nanotechnology-related careers, but also building a nano-savvy workforce to help support the strong economic growth within So Paulo and Brazil as a whole."

In just over 24 months, the NanoProfessor Nanoscience Education Program has been chosen to serve as the foundation for undergraduate hands-on nanotechnology education by over 20 institutions in five countries.The NanoProfessor Program alternates between classroom lectures and exciting, hands-on nanoscale lab work.The NanoProfessor curriculum includes a textbook authored by leading nanotechnology experts, covering the topics of Nanotechnology Instrumentation, Imaging and Nanofabrication techniques, Nanophysics, Nanochemistry, Nanobiology, and perspectives on Environmental, Health, and Safety within nanotechnology.In conducting the hands-on lab experiments, students work with state-of-the-art nano-centric instrumentation including NanoInk's NLP 2000 Desktop NanoFabrication System, the first desktop nanofabrication system allowing students to quickly and easily build custom-engineered nanoscale structures with a wide variety of materials from biomolecules to metal nanoparticles using NanoInk's proprietary Dip Pen Nanolithography (DPN).

Nanotechnology is the understanding and control of matter at dimensions between approximately one and 100 nanometers (nm), where unique phenomena enable novel applications which are not feasible when working with bulk materials.A nanometer is one-billionth of a meter.Encompassing nanoscale science, engineering, and technology, nanotechnology involves imaging, measuring, modeling, and manipulating matter at the nanoscale.A study funded by the National Science Foundation projects that 6 million nanotechnology workers will be needed worldwide by 2020, with 2 million of those jobs in the United States.However, as of 2008, there were only 400,000 estimated workers worldwide in the field of nanotechnology, with an estimated 150,000 of those in the United States.

About the NanoProfessor Nanoscience Education Program The NanoProfessor Nanoscience Education Program aims to advance undergraduate nanotechnology education and address the growing need for a skilled, nano-savvy workforce. The NanoProfessor Program, including state-of-the-art, nano-centric instruments, an expert-driven curriculum, and student/teacher support materials, is available for high schools, community colleges, technical institutes, and universities worldwide.More information is available at http://www.NanoProfessor.net or (847)679-NANO (6266).You can also like NanoProfessor on Facebook at http://www.facebook.com/NanoProfessor1 and follow on Twitter at http://www.twitter.com/nanoprofessor1.

NanoInk, NanoProfessor, Dip Pen Nanolithography, DPN, and the NanoProfessor logo are trademarks or registered trademarks of NanoInk, Inc.

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Genetic Immunity Receives GMP Certification for In-House Manufacturing Facility

§ October 8th, 2012 § Filed under Nano Medicine Comments Off on Genetic Immunity Receives GMP Certification for In-House Manufacturing Facility

BUDAPEST, HUNGARY--(Marketwire - Oct 8, 2012) - Genetic Immunity ( OTCBB : PWRV ) is pleased to announce the GMP approval of its manufacturing facility. The development of the GMP manufacturing process and the facility was financed from a $4 million grant received from the Hungarian Office for Innovation and Technology.

"To establish a GMP manufacturing facility is a major milestone for Genetic Immunity. Initially, it will serve our need to produce high quality ingredients to our nanomedicine products tested in clinical trials. We developed our GMP manufacturing technology and processes to be suitable to upgrade them to a commercial scale. This approval demonstrates the capability of our team to advance our DermaVir HIV-specific immunotherapy to the market, and our new candidate products from the bench to the bedside,"said Dr. Julianna Lisziewicz, CEO of Genetic Immunity.

The GMP status is provided for the manufacturing and the validated quality control processes of the Active Pharmaceutical Ingredient of our immunotherapeutic nanomedicine products.Genetic Immunity has a state of the art R&D laboratory that includes a dedicated GMP facility. Due to the platform feature of our plasmid DNA based nanomedicine technology, only the nucleotide sequence of the DNA is specific for the target disease. Consequently, the manufacturing and the quality control process of the lead and all pipeline products is the same. This means that the GMP facility can be used for the manufacturing all products of Genetic Immunity regardless of clinical stage. The common GMP manufacturing technology simplifies the regulatory process, saves costs and time in clinical development, and reduces time to market approval of medicinal products.

"With this GMP facility we have successfully closed the manufacturing gap between clinical trial scale and the commercial production. With continuous development of the manufacturing processes we are able to control the costs and achieve a competitive price for each market segments at an attractive ROI ratio for every product. We are strongly focused on the market and are well prepared for large scale manufacturing for our planned Expanded Access program of DermaVir," said Mr. Viktor Rozsnyay, CEO of Power of the Dream Ventures.

Genetic Immunity is a wholly owned subsidiary of Power of the Dream Ventures, Inc. ( OTCBB : PWRV ).

About Genetic Immunity Genetic Immunity is part of Power of the Dream Ventures, Inc. (PWRV) committed to bring innovative Hungarian products and services to public. GeneticImmunity is a clinical stage technology company committed to discovering, developing, manufacturing and commercializing a new class of immunotherapeutic biologic drugs for the treatment of viral infections, cancer and allergy. The Company's two distinguished technology platforms will revolutionize the treatment of these chronic diseases. Our Langerhans cell targeting nanomedicines are exceptional in both safety and immune modulating activity boosting specific Th1-type central memory T cells. Such immune responses differ from antibodies induced by vaccines. These are essential to eliminate infected cells or cancerous cells, and balance the immune reactivity in response to allergens. Our IT team generated a complex algorithm to match the mechanism of action of our drugs with clinical efficacy. In the future, we will predict the clinical and immunological benefits of our drugs based on the patient's disease and genomic background. The unique mixture of our technologies represents the next generation of personalized but not individualized medicines ensuring a longer and higher economic return. Genetic Immunity's primary focus is the development of DermaVir that acts to boost the immune system of HIV-infected people to eliminate the infected cells that remained in the reservoirs after successful antiretroviral treatment. Three clinical trials conducted in EU and US showed that DermaVir immunizations were as safe as placebo and only four sequential patch treatments were required to reduce the HIV infected cells in the blood within 24 weeks.

In 1988 Drs. Lisziewicz and Lori founded the Genetic Immunity in the US after they described the 1st patient whose immune system was boosted to control HIV after treatment interruption (Lisziewicz et al. New England Journal of Medicine 1999) that lead to the invention of DermaVir. The Company's innovative technology team directed by Dr. Lisziewicz, a champion of immune busting therapies, is now headquartered in Budapest (Hungary). For more information please visit http://www.geneticimmunity.com

Forward-looking statements Statements in this press release that are not strictly historical in nature constitute forward-looking statements qualified in their entirety by this cautionary statement. Forward-looking statements include, without limitation, statements regarding business combination and similar transactions, prospective performance and opportunities and the outlook for the companies' businesses, including, without limitation, the ability of PWRV to advance Genetic Immunity's product pipeline or develop a curative immunotherapy for HIV, performance and opportunities and regulatory approvals, the anticipated timing of data from clinical data; the possibility of unfavorable results of the company's clinical trials; filings and approvals relating to the transaction; the expected timing of the completion of the transaction; the ability to complete the transaction considering the various closing conditions; and any assumptions underlying any of the foregoing. Investors are cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties and are cautioned not to place undue reliance on these forward-looking statements. Actual results may differ materially from those currently anticipated due to a number of risks and uncertainties. All forward-looking statements are based on information currently available to the companies, and the companies assume no obligation to update any such forward-looking statements.

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Nanodevice delivers drugs in hard-to-reach places

§ October 5th, 2012 § Filed under Nano Medicine Comments Off on Nanodevice delivers drugs in hard-to-reach places

A new type of controlled-release drug-delivery vehicle made from nanostructured polymer membranes has been unveiled by researchers at the University of California at San Francisco in the US. The device, which releases its therapeutic payload slowly and continuously over a period of several months, could come in useful for a wide variety of drug-delivery applications in the body including in difficult-to-access areas like the back of the eye and limb joints.

One of the most important applications of nanomedicine is drug delivery using tiny drug-carrying vehicles. Such vehicles are normally made of hollow nanoparticles in which therapeutic molecules can easily be transported. However, nanostructured membranes in which the drug is loaded between a nanofilm and a backing layer also show promise. The advantage of the membrane option is that drug molecules around the same size as the membrane pores (which can range from tens of nanometres to hundreds of nanometres across) can be released slowly thanks to the fact that they travel through the pores in a single file.

Until now, most such nanostructured membranes have been made from inorganic materials, such as silicon, alumina or titania because they are relatively easy to fabricate. However, the problem is that these materials are generally rigid and often not biodegradable. Polymeric nanostructured membranes could come into their own here, say Tejal Desai and colleagues, who have been studying biodegradable polymers like poly(caprolactone) (PCL) as the active element in drug-delivery systems capable of controlled release.

By templating the PCL off a zinc oxide mould, the researchers succeeded in fabricating nanostructured PCL membranes containing nanosized pores that were able to release the model therapeutic protein immunoglobuline G (IgG) over the course of several months.

Desais team create the nanostructured features of their membranes by spin casting a thin film of PCL and poly(ethylene glycol) (PEG) onto a ZnO template that penetrates the thickness of the polymer film. Under appropriate conditions the PEG forms an interconnected network that spans the supporting PCL film layer. When the PEG is removed, a porous PCL film is generated and the ZnO template can subsequently be etched with acid to generate individual nanostructured PCL pores. The technique is described in Nano Letters.

We showed that functional proteins, like IgG, can be released steadily and at a constant rate over a period of four months, Desai told nanotechweb.org. Such sustained and controlled release has never been achieved before with other such biodegradable film devices and will be important for maintaining therapeutic concentrations of a drug in the body for long periods of time.

The amount of drug released can also be controlled by changing the membrane surface area smaller membranes release smaller amounts of drug, for example.

These devices might be used to deliver drugs in various parts of the body, and particularly into confined and hard-to-reach spaces where long-term delivery might be needed such as the back of the eye or in spaces between joints, said Desai.

The team is currently looking at using its device to deliver drugs to the retina in an effort to control and treat age-related macular degeneration.

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Nanomed2020 intends to bring more nanomedicine products to European patients

§ October 4th, 2012 § Filed under Nano Medicine Comments Off on Nanomed2020 intends to bring more nanomedicine products to European patients

PARIS--(BUSINESS WIRE)--

Nanobiotix announced today a collaboration with key European nanomedicine players which is funded by the European Commission. This strong partnership of relevant stakeholders aims to identify key areas of nanomedicine with novel concepts for translation of nanomedical innovations into clinical practice. The project called Nanomed2020 started on 1stSeptember 2012 and has a duration of 18 months.

Making Europe a center for nanomedicine research, development and translation is the goal of this project. To achieve this goal, the proposed project unites partners already representing the largest network of active stakeholders in the nanomedicine area as of today in Europe, embracing roughly 200 Universities, Research Institutes, Hospitals and Public Health Institutions, Small and Medium-sized Enterprises (SMEs) and small and large industry organizations.

What are the needs and the problems? Excellent academic research groups may need to better understand the market and the medical needs. There are a large number of pharmaceutical and medtech companies that have a comprehensive and direct access to market but these companies struggle to handle radical innovation. At the same time, there is a small number of SMEs trying to add new innovation onto the market, but these few companies are too small to exploit the large potential of nanomedicine. A consolidated pan-European approach to structure this field is therefore highly needed to bring nanomedicine products more efficiently to patients.

We are proud that we were able to receive funding for this project from the European Commission, said Dr. Sebastian Lange, the coordinator of this project at VDI/VDE-IT. Seven renowned nanomedicine players from six European countries hope to build a pertinent European nanomedicine community involving all key players. We aim to define the resources, gaps and needs for development and implementation of nanomedicine research into marketable innovations to be used by doctors for the benefit of patients.

The Nanomed2020 project is an opportunity for all stakeholders from industry, academia, clinic and public authorities to provide the European Commission with input for a future nanomedicine topic within Horizon 2020. This will make nanomedicine an important contributor to the future European healthcare system with a beneficial impact on improved treatment for patients and on social challenges such as aging population.

Being a leader in the nanomedicine field with therapeutic products in clinical development, we are interested to grow and mature the European environment and infrastructure for nanomedicine, commented Laurent Levy, CEO of Nanobiotix. We will therefore contribute with our 15 years of experience in this field, our network and commercial knowledge to this project to show that nanomedicine can overcome societal challenges and has a huge economic potential through an improved and cost-effective health care.

ABOUT Nanomed2020

The Nanomed2020 Support Action project, funded with a contribution of 500000 by the European Commission under the Work Programme FP7-HEALTH-2012 (Area 2012.4.1-5: Preparing the future for health research and innovation) was launched on 1st September 2012 and is planned to have a duration of 18 months.

Partners of the Nanomed2020 project:

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Nanomed2020 intends to bring more nanomedicine products to European patients

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Blind Mice Get Experimental Stem Cell Treatment For Blindness

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on Blind Mice Get Experimental Stem Cell Treatment For Blindness

April Flowers for redOrbit.com Your Universe Online

Columbia University ophthalmologists and stem cell researchers have developed an experimental treatment for blindness using the patients skin cells, which has improved the vision of blind mice in testing.

The findings of this research, published online in the journal Molecular Medicine, suggest that induced pluripotent stem cells (iPS) could soon be used to improve vision in people with macular degeneration and other eye retina diseases. iPS cells are derived from adult human skin cells but have embryonic qualities.

With eye diseases, I think were getting close to a scenario where a patients own skin cells are used to replace retina cells destroyed by disease or degeneration, says Stephen Tsang, MD, PhD, associate professor of ophthalmology and pathology & cell biology. Its often said that iPS transplantation will be important in the practice of medicine in some distant future, but our paper suggests the future is almost here.

Scientists were very excited by the advent of human iPS cells when they were discovered in 2007, as they provide a way to avoid the ethical complications of embryonic stem cells. Another advantage is that the iPS cells are created from the patients own skin, eliminating the need for anti-rejection medications. Like the ethically challenged embryonic cells, iPS cells can develop into any type of cell. To-date, no iPS cells have been implanted into people, but many ophthalmologists say that the eye would prove to be ideal testing ground for iPS therapies.

The eye is a transparent and accessible part of the central nervous system, and thats a big advantage. We can put cells into the eye and monitor them every day with routine non-invasive clinical exams, Tsang said. And in the event of serious complications, removing the eye is not a life-threatening event.

Professor Tsang is running a new preclinical iPS study using human iPS cells derived from the skin cells of a 53-year-old donor. The cells were first transformed with a cocktail of growth factors into cells in the retina that lie underneath the eyes light-sensing cells.

Retina cells nourish the light-sensing cells and protect the fragile cells from excess light, heat and cellular debris. In macular degeneration and retinitis pigmentosa, retina cells die, which allows the photoreceptor cells to degenerate causing the patient to lose their vision. It is estimated that 30 percent of people will have some form of macular degeneration by the time they are 75 years old, as it is the leading cause of vision loss in the elderly. Currently, it affects 7 million Americans and that is expected to double by 2020.

The Columbia research team injected the iPS-derived retina cells into the right eyes of 34 mice that had a genetic mutation that caused their retina cells to degenerate. In many of the mice, the iPS cells assimilated into the retina without disruption and functioned as normal retina cells well into the animals old age. Mice in the control group, who received injections of saline or inactive cells, showed no improvement in retina tests.

Our findings provide the first evidence of life-long neuronal recovery in a preclinical model of retinal degeneration, using stem cell transplant, with vision improvement persisting through the lifespan, Tsang says. And importantly, we saw no tumors in any of the mice, which should allay one of the biggest fears people have about stem cell transplants: that they will generate tumors.

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Stem cells improve visual function in blind mice

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on Stem cells improve visual function in blind mice

ScienceDaily (Oct. 1, 2012) An experimental treatment for blindness, developed from a patient's skin cells, improved the vision of blind mice in a study conducted by Columbia ophthalmologists and stem cell researchers.

The findings suggest that induced pluripotent stem (iPS) cells -- which are derived from adult human skin cells but have embryonic properties -- could soon be used to restore vision in people with macular degeneration and other diseases that affect the eye's retina.

"With eye diseases, I think we're getting close to a scenario where a patient's own skin cells are used to replace retina cells destroyed by disease or degeneration," says the study's principal investigator, Stephen Tsang, MD, PhD, associate professor of ophthalmology and pathology & cell biology. "It's often said that iPS transplantation will be important in the practice of medicine in some distant future, but our paper suggests the future is almost here."

The advent of human iPS cells in 2007 was greeted with excitement from scientists who hailed the development as a way to avoid the ethical complications of embryonic stem cells and create patient-specific stem cells. Like embryonic stem cells, iPS cells can develop into any type of cell. Thousands of different iPS cell lines from patients and healthy donors have been created in the last few years, but they are almost always used in research or drug screening.

No iPS cells have been transplanted into people, but many ophthalmologists say the eye is the ideal testing ground for iPS therapies.

"The eye is a transparent and accessible part of the central nervous system, and that's a big advantage. We can put cells into the eye and monitor them every day with routine non-invasive clinical exams," Tsang says. "And in the event of serious complications, removing the eye is not a life-threatening event."

In Tsang's new preclinical iPS study, human iPS cells -- derived from the skin cells of a 53-year-old donor -- were first transformed with a cocktail of growth factors into cells in the retina that lie underneath the eye's light-sensing cells.

The primary job of the retina cells is to nourish the light-sensing cells and protect the fragile cells from excess light, heat, and cellular debris. If the retina cells die -- which happens in macular degeneration and retinitis pigmentosa -- the photoreceptor cells degenerate and the patient loses vision. Macular degeneration is a leading cause of vision loss in the elderly, and it is estimated that 30 percent of people will have some form of macular degeneration by age 75. Macular degeneration currently affects 7 million Americans and its incidence is expected to double by 2020.

In their study, the researchers injected the iPS-derived retina cells into the right eyes of 34 mice that had a genetic mutation that caused their retina cells to degenerate.

In many animals, the human cells assimilated into mouse retina without disruption and functioned as normal retina cells well into the animals' old age. Control mice that got injections of saline or inactive cells showed no improvement in retina tests.

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International Stem Cell Corp Granted Key Patent for Liver Disease Program

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on International Stem Cell Corp Granted Key Patent for Liver Disease Program

CARLSBAD, CA--(Marketwire - Sep 25, 2012) - International Stem Cell Corporation ( OTCQB : ISCO ) (www.internationalstemcell.com) ("ISCO" or "the Company") a California-based biotechnology company, today announced that the United States Patent and Trademark Office (USPTO) has granted the Company a patent for a method of creating pure populations of definitive endoderm, precursor cells to liver and pancreas cells, from human pluripotent stem cells.This patent is a key element of ISCO's metabolic liver disease program and allows the Company to produce the necessary quantities of precursor cells in a more efficient and cost effective manner.

The patent, 8,268,621, adds to the Company's growing portfolio of proprietary technologies relating to the development of potential treatments for incurable diseases using human parthenogenetic Stem Cells (hpSC).Human parthenogenetic stem cells are unique pluripotent stem cells that offer the possibility to reduce the cost of health care while avoiding the ethical issues that surround the use of fertilized human embryos.Aside from the Company's current liver disease program, this new patented method can be used as a route to create pancreatic and endocrine cells that could be used in future studies of diabetes and other metabolic disorders.

ISCO currently has the largest collection of hpSC including cell lines which immune match the donor, as is the case with induced pluripotent stem cells (iPS), and cell lines which immune-match millions of individuals and potentially reduce tissue rejection issues.The Company is focusing its therapeutic development efforts on three clinical applications where cell and tissue therapy is already proven but where there currently is an insufficient supply of safe and efficacious cells: Parkinson's disease, inherited/metabolic liver diseases and corneal blindness.

About International Stem Cell Corporation

International Stem Cell Corporation is focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell-based research and cosmetic products.ISCO's core technology, parthenogenesis, results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs) hence avoiding ethical issues associated with the use or destruction of viable human embryos.ISCO scientists have created the first parthenogenetic, homozygous stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages and racial background with minimal immune rejection after transplantation. hpSCs offer the potential to create the first true stem cell bank, UniStemCell. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology (www.lifelinecelltech.com), and stem cell-based skin care products through its subsidiary Lifeline Skin Care (www.lifelineskincare.com). More information is available at http://www.internationalstemcell.com.

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Safe harbor statement

Statements pertaining to anticipated developments, the potential use of technologies to develop therapeutic products and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects" or "estimates") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

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Global Human Embryonic Stem Cell (hESC) Research Industry

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on Global Human Embryonic Stem Cell (hESC) Research Industry

NEW YORK, Sept. 3, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Human Embryonic Stem Cell (hESC) Research Industry

http://www.reportlinker.com/p0960425/Global-Human-Embryonic-Stem-Cell-hESC-Research-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy

This report analyzes the worldwide markets for Human Embryonic Stem Cell (hESC) Research in US$ Million. The report provides separate comprehensive analytics for the US, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2018. The report profiles 26 companies including many key and niche players such as Advanced Cell Technology, Inc., BD Biosciences, BioTime, Inc., Cell Cure Neurosciences Ltd., Cellartis AB, GE Healthcare, Millipore Corporation, Molecular Transfer, Inc., PerkinElmer, Inc., Pfizer, Inc., Research & Diagnostics Systems, Inc., Reliance Life Sciences Ltd., Stem Cell Network, Stemina Biomarker Discovery, Inc., UK Stem Cell Bank, and ViaCyte, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1

Disclaimers I-2

Data Interpretation & Reporting Level I-2

Quantitative Techniques & Analytics I-3

Product Definitions and Scope of Study I-3

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Bestellen Sie den kostenlosen Newsletter von 4investors:

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on Bestellen Sie den kostenlosen Newsletter von 4investors:

PRESS RELEASE: MagForce to radically enforce market set up strategy with new management team

MagForce AG / MagForce to radically enforce market set up strategy with new management team . Processed and transmitted by Thomson Reuters ONE. The issuer is solely responsible for the content of this announcement.

* Focus on most important value drivers in the short-term

* Experienced senior executives added to the management board

* Core functions will be centralized in Munich

* Million Euro cost savings expected from resturcturing measures

Berlin, Germany, October 1, 2012 - MagForce AG (Frankfurt, XETRA: MF6), a leading medical device company in the field of nanomedicine with a focus on oncology, today announced additions to the management board and further measures to enforce commercialization of NanoTherm therapy. Thus, focussing on establishing the NanoTherm therapy in the oncology market as well as on its commercialization for near-term value generation.

In the short to mid term, MagForce will dedicate its financial resources to the post marketing trial in glioblastoma, which is expected to start in early 2013 and is supposed to make a significant contribution to its strategic set up. Simultaneously, the Company will also focus on the commercialization of its NanoTherm therapy with its distribution partners including DELRUS and TekGrup, development partners such as the Mayo Clinic for gastro-intestinal cancer and the Department of Urology at Duesseldorf University for prostate cancer, as well as the production of nanoparticles.

In line with this strategy, the Company's core functions, including clinical and business development, medical affairs plus legal & IP will be concentrated at the MagForce site in Munich where these teams are already located. Production of nanoparticles, NanoActivators((TM)), software engineering as well as the finance department will remain at the Company's registered office in Berlin. All early research activities will be reduced to a minimum and will be outsourced as deemed neccessary.

In this respect experienced senior executives are added to the management board. Prof Dr Hoda Tawfik, currently VP Clinical Development and Medical Affairs, will be appointed COO. Christian von Volkmann, currently acting CFO, will assume the position of CFO, both effective immediately. They will jointly lead the Company as co-CEOs going forward. The founder and long-term Board member Dr Andreas Jordan will step down from the management board of MagForce to pursue new projects, but will continue to serve the Company as an advisor.

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PRESS RELEASE: MagForce publishes half-year report

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on PRESS RELEASE: MagForce publishes half-year report

MagForce AG / MagForce publishes half-year report . Processed and transmitted by Thomson Reuters ONE. The issuer is solely responsible for the content of this announcement.

* Comprehensive restructuring introduced

* Integration of medical opinion leaders into post-marketing trial to increase acceptance of NanoTherm therapy

* Strategic and distribution partnerships established

* Cost savings expected to amount to million Euros due to a package of measures

* Loss for the period reduced by 22% to EUR3.6 million

Berlin, Germany, October 1, 2012 - MagForce AG (Frankfurt, Xetra: MF6), a leading medical device company in the field of nanomedicine with a focus on oncology, today announced the financial results for the first half of the 2012 fiscal year, ending June 30, 2012. Simultaneously, the company released details of a package of measures (see today's press release "MagForce to radically enforce market setup strategy with new management team"). With this restructuring, MagForce is completing a period of important strategic refocus.

"In the first half of the year, we laid out the basic requirements for the acceptance and future commercialization of our NanoTherm therapy, and for the future development of our company. Today we are concluding this phase of strategic focus with the introduction of vital measures and additions to the management team. Over the short term, we are concentrating all our efforts and financial resources on establishing NanoTherm therapy in the area of oncology and consequentially on the post-marketing clinical trial in glioblastoma. Together with strategic and distribution partners, we want to reinforce the commercialization of NanoTherm therapy, ensuring sufficient funding." commented Christian von Volkmann, CFO.

In the first half of the year, MagForce was able to successfully finalize distribution partnerships with DELRUS (Russia) and Tek Grup (Turkey), as well as a development partnership with the Mayo Clinic (USA).

During the reporting period, the company recorded a loss of EUR3.6 million (prior year period: EUR4.6 million). The decline is essentially a result of the restructuring measures introduced at the end of 2011 and the accompanying strategic change. Personnel expenses decreased due to the reduction in staff, particularly in the second management level, as well as in commercial functions.

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MagForce publishes half-year report

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on MagForce publishes half-year report

Comprehensive restructuring introduced

Integration of medical opinion leaders into post-marketing trial to increase acceptance of NanoTherm therapy

Strategic and distribution partnerships established

Cost savings expected to amount to million Euros due to a package of measures

Loss for the period reduced by 22% to 3.6 million

Berlin, Germany, October 1, 2012 - MagForce AG (Frankfurt, Xetra: MF6), a leading medical device company in the field of nanomedicine with a focus on oncology, today announced the financial results for the first half of the 2012 fiscal year, ending June 30, 2012. Simultaneously, the company released details of a package of measures (see today`s press release "MagForce to radically enforce market setup strategy with new management team"). With this restructuring, MagForce is completing a period of important strategic refocus.

"In the first half of the year, we laid out the basic requirements for the acceptance and future commercialization of our NanoTherm therapy, and for the future development of our company. Today we are concluding this phase of strategic focus with the introduction of vital measures and additions to the management team. Over the short term, we are concentrating all our efforts and financial resources on establishing NanoTherm therapy in the area of oncology and consequentially on the post-marketing clinical trial in glioblastoma. Together with strategic and distribution partners, we want to reinforce the commercialization of NanoTherm therapy, ensuring sufficient funding." commented Christian von Volkmann, CFO.

In the first half of the year, MagForce was able to successfully finalize distribution partnerships with DELRUS (Russia) and Tek Grup (Turkey), as well as a development partnership with the Mayo Clinic (USA).

During the reporting period, the company recorded a loss of 3.6 million (prior year period: 4.6million). The decline is essentially a result of the restructuring measures introduced at the end of 2011 and the accompanying strategic change. Personnel expenses decreased due to the reduction in staff, particularly in the second management level, as well as in commercial functions.

In the first half of the year, the company successfully raised 4.5 million by issuing new shares. After the reporting period end, two further capital increases took place with gross proceeds amounting to 665,000. The capital measures serve to safeguard liquidity and maintain business operations, as well as financing further business growth.

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MagForce to radically enforce market set up strategy with new management team

§ October 2nd, 2012 § Filed under Nano Medicine Comments Off on MagForce to radically enforce market set up strategy with new management team

Focus on most important value drivers in the short-term

Experienced senior executives added to the management board

Core functions will be centralized in Munich

Million Euro cost savings expected from resturcturing measures

Berlin, Germany, October 1, 2012 - MagForce AG (Frankfurt, XETRA: MF6), a leading medical device company in the field of nanomedicine with a focus on oncology, today announced additions to the management board and further measures to enforce commercialization of NanoTherm therapy. Thus, focussing on establishing the NanoTherm therapy in the oncology market as well as on its commercialization for near-term value generation.

In the short to mid term, MagForce will dedicate its financial resources to the post marketing trial in glioblastoma, which is expected to start in early 2013 and is supposed to make a significant contribution to its strategic set up. Simultaneously, the Company will also focus on the commercialization of its NanoTherm therapy with its distribution partners including DELRUS and TekGrup, development partners such as the Mayo Clinic for gastro-intestinal cancer and the Department of Urology at Duesseldorf University for prostate cancer, as well as the production of nanoparticles.

In line with this strategy, the Company`s core functions, including clinical and business development, medical affairs plus legal & IP will be concentrated at the MagForce site in Munich where these teams are already located. Production of nanoparticles, NanoActivators(TM), software engineering as well as the finance department will remain at the Company`s registered office in Berlin. All early research activities will be reduced to a minimum and will be outsourced as deemed neccessary.

In this respect experienced senior executives are added to the management board. Prof Dr Hoda Tawfik, currently VP Clinical Development and Medical Affairs, will be appointed COO. Christian von Volkmann, currently acting CFO, will assume the position of CFO, both effective immediately. They will jointly lead the Company as co-CEOs going forward. The founder and long-term Board member DrAndreas Jordan will step down from the management board of MagForce to pursue new projects, but will continue to serve the Company as an advisor.

Along with these measures the headcount of MagForce will be reduced from 27 to 12. These measures are meant to annually save the Company a seven digit Euro amount.

"With this restructuring MagForce is completing a period of important strategic refocus. In the short-term, we have to concentrate all our efforts and financial resources on the development of strategic partnerships as well as on establishing NanoTherm therapy in the area of oncology. Thus, concentrating on the post-marketing clinical study planned at different sites in Germany, which is critical to achieving acceptance of our NanoTherm therapy in the German medical community. We are encouraged about the progress we are making and need to ensure that we translate this momentum into commercial success," commented Prof Dr Hoda Tawfik, COO of MagForce AG.

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Power of the Dream Ventures Acquires Genetic Immunity

§ October 1st, 2012 § Filed under Nano Medicine Comments Off on Power of the Dream Ventures Acquires Genetic Immunity

BUDAPEST, HUNGARY--(Marketwire - Sep 28, 2012) - Power of the Dream Ventures, Inc. ( OTCBB : PWRV ) is pleased to announce the acquisition of Genetic Immunity, Inc., a Phase III clinical stage biotechnology company with experimental nanomedicines that will lead to the next generation of immunotherapies, in a market that is projected to reach $11.00 billion by 2018.

Genetic Immunity's lead product candidate is an immune boosting drug for HIV, which is now only treated by antiretroviral drugs that decrease the ability of the immune system to fight with the virus. DermaVir HIV-specific Immunotherapy is the first of a new line of curative nanomedicine products developed for the treatment and eradication of HIV. In addition, Genetic Immunity has implemented a Predictive Genomic Biomarker as companion diagnostics to accurately predict potential responder patients to DermaVir treatment. Such innovations towards personalized medicine increase the treatment effect and reduce the cost of pivotal trials in full compliance with the FDA's initiatives to improve products for patients (Driving Biomedical Innovation, 2011). In addition, following a successful DermaVir trial on HIV-infected adults, the US government is sponsoring a Phase II pediatric clinical trial.

DermaVir is the first therapeutic vaccine that consistently boosts broadly directed central memory T-cells in human subjects. This immune response has been correlated with containment of viremia in Elite Controllers. The Phase II randomized, multicenter, placebo controlled trial conducted in Germany established the optimal DermaVir dose and provided data that demonstrates the killing of HIV-infected cells. Therefore, the eradication of HIV or the conversion of progressors to Elite Controllers via DermaVir immunization became a testable hypothesis.

"This acquisition milestone is the result of our collaboration for a common goal to sell stock in Genetic Immunity to the public. The acquisition of a private company by a public one corresponds to a novel IPO, and offers tremendous upside potential for all the shareholders of Genetic Immunity and PWRV. Starting today, financial market participants will have an opportunity to determine the price of our business. We are eager, because comparable technology companies trade at over half a billion dollar valuation. On a more personal note, I believe that Genetic Immunity's platform technology is a once in a lifetime opportunity. For the first time we are truly in reach of eradicating a highly infectious disease. We are proud to be a part of the process whereby the innovations presented by Genetic Immunity can become publicly available," commented Viktor Rozsnyay, CEO of Power of the Dream Ventures.

"Through this highly innovative financial transaction, Genetic Immunity achieves its corporate objective to become a publicly traded company and to retain the control over the business. The financial and technological synergy between the two Companies provides for substantial growth opportunity and high return on investment to our shareholders," said Dr. Julianna Lisziewicz, CEO of Genetic Immunity.

With the acquisition Genetic Immunity becomes a 100% wholly owned subsidiary of Power of the Dream Ventures, Inc.

About PDV Power of the Dream Ventures, Inc. is a leading technology holding company. We identify and harness the unique technological prowess of Hungary's high-tech industry, turning promising ideas and ready to market products/technologies into global industry leaders. We focus on developing, acquiring, or co-developing technologies that originate exclusively in Hungary. For more information, please visit http://www.powerofthedream.com

About Genetic Immunity Genetic Immunity is a clinical stage technology company committed to discovering, developing, manufacturing and commercializing a new class of immunotherapeutic biologic drugs for the treatment of viral infections, cancer and allergies. The Company's two distinguished technology platforms will revolutionize the treatment of these chronic diseases. Our Langerhans' cell targeting nanomedicines are exceptional in both safety and immune modulating activity boosting specific Th1-type central memory T cells. Such immune responses differ from antibodies induced by vaccines. These are essential to eliminate infected cells or cancerous cells, and balance the immune reactivity in response to allergens. Our IT team generated a complex algorithm to match the mechanism of action of our drugs with clinical efficacy. In the future, we will predict the clinical and immunological benefits of our drugs based on the patient's disease and genomic background. The unique mixture of our technologies represents the next generation of personalized but not individualized medicines ensuring a longer and higher economic return.

Genetic Immunity's primary focus is the development of DermaVir that acts to boost the immune system of HIV-infected people to eliminate infected cells that remain in the reservoirs after successful antiretroviral treatment. Three clinical trials conducted in the EU and US showed that DermaVir immunizations were as safe as placebo and only four sequential patch treatments required to reduce the HIV infected cells in the blood within 24 weeks.

In 1988 Drs. Lisziewicz and Lori founded Genetic Immunity in the US after they described the 1st patient whose immune system was boosted to control HIV after treatment interruption (Lisziewicz et al. New England Journal of Medicine 1999) that lead to the invention of DermaVir. The Company's innovative technology team directed by Dr. Lisziewicz, a champion of immune busting therapies, is now headquartered in Budapest, Hungary. For more information please visit http://www.geneticimmunity.com

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