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The Region’s Health Leaders on What’s New and What the Next Decade Will Bring – Business West

§ January 8th, 2020 § Filed under Nano Medicine Comments Off on The Region’s Health Leaders on What’s New and What the Next Decade Will Bring – Business West

Vision 2020

Few industries change as rapidly and as dramatically as the broad, multifaceted realm of healthcare. From oncologists use of cancer fingerprinting and gene therapy to facial transplants for accident victims; from cutting-edge protocols to save the lives of stroke and heart-surgery patients to a dizzying array of new treatments to improve vision the list is seemingly endless, making it impossible to paint a full picture of where healthcare has come in the past decade.

But we at BusinessWest wanted to try anyway and, at the same time, look ahead at what the next decade might bring. So, appropriately, here at the dawn of 2020, we invited a wide range of healthcare professionals to tell us what has been the most notable evolution in their field of practice in the past 10 years, and what they expect or hope will be the most significant development to come in the next decade.

The answers were candid, thoughtful, sometimes surprising, but mostly hopeful. Despite the many challenges healthcare faces in these times of advancing technology, growing cost concerns, and demographic shifts, the main thread is still innovation smart people working on solutions that help more people access better care. After all, healthcare is, at its core, about improving peoples lives, even when they seek it out during their direst moments.

Innovation and promise. Thats what we believe a new decade will bring to all corners of the healthcare world that is, if these leaders, and countless others like them, have anything to say about it.

Joanne Marqusee

President and CEO, Cooley Dickinson Health Care

Joanne Marqusee

The most significant recent development in healthcare administration has been a recognition of the role patients play in their own healthcare. Crossing the Quality Chasm: A New Health System for the 21st Century, published in 2001 by the Institute for Healthcare Improvement, called for a massive redesign of the American healthcare system. Specifically, it provided Six Aims for Improvement, five of which focused on safety, effectiveness, timeliness, efficiency, and equity. Not talked about as much, the sixth aim was to make healthcare patient-centered.

While we still have a ways to go to truly be patient-centered, we have witnessed a sea change in the past decade in this regard. Patients are increasingly active participants in their care, questioning their doctors and other providers to ensure that they understand their options, using electronic medical records to engage in their care, and speaking out about what they want from treatment or forgoing treatment at the end of life. The best healthcare providers both organizations and individuals embrace these changes, welcoming patients as more than recipients of care, but rather active partners in their own care and decision making.

My hope for the most significant development over the next decade has to do with providing universal healthcare coverage while controlling healthcare costs. While we almost have universal coverage in Massachusetts, too much of the nation does not. A hotly debated topic, universal healthcare has many benefits, including increasing access to preventive and routine medical care, improving health outcomes, and decreasing health inequalities.

Dr. Nicholas Jabbour

Chairman, Department of Surgery, Baystate Medical Center

Dr. Nicholas Jabbour

The most significant development in surgery over the past decade has been the move toward less invasive surgical approaches made possible through advanced technology. These approaches include robotic and minimally invasive surgery, including intraluminal surgery in areas such as gastroenterology, cardiology, and neurosurgery for exemple, the passage of an inflatable catheter along the channel inside of a blood vessel to enable the insertion of a heart valve instead of making a large opening in the chest. As a result, we have seen a big shift from inpatient to outpatient surgery with shorter hospital stays and improved post-op recovery.

In the next decade, we foresee these innovations in less invasive surgery will be enhanced by better computing and software integration. This interaction will include the merging of radiological and potentially pathological information which is currently available in a digital format with real-time visualization of anatomical structure during surgery. This will offer surgeons the opportunity to improve the accuracy and speed of a surgical procedure while minimizing the risks.

The next decade will also see major innovation in the area of transplantation with the development of tissues or whole organs through bio-engineering manipulation of animal or a patients own cells. The integration of this bio-engineering manipulation with currently available technology, such as 3D printing and 3D imaging, will provide patients with the needed tissue or organ including valves, bone grafts, hernia mesh, skin, livers, and kidneys in a timely manner. This development will revolutionize the field of transplantation and surgery in general.

Karin Jeffers

President & CEO, Clinical & Support Options Inc.

Karin Jeffers

Over the past 10 years, weve seen a growing adoption within the behavioral-health and medical fields of holistic treatment models. While the two disciplines were once treated as different animals, the entire health field is now moving to treat both the body and the mind together. The next 10 years are likely to bring these two fields even closer.

Today, youre seeing behavioral-health clinicians being hired into physical health practices. Likewise, physical health providers are cross-training to better understand behavioral issues. Whereas, a decade ago, a behavioral-health client might be assigned a therapist or a psychiatrist, they are now gaining access to more robust set of supports, including nursing, case management, recovery coaching, and peer support from those with lived experience. Government mandates and payment model changes are forcing outcomes-based integration, too. Pediatricians, for example, must now do behavioral-health screenings of all youth under 21. In the mental-health space, youre seeing clinicians ask about weight, exercise, and other physical factors.

Were seeing significant movement on both the state and federal levels to value outcomes over volume. Its reflected in the criteria set by the Excellence in Mental Health Act for certified community behavioral-health clinics, a designation CSO has earned, and in the work we have done with the Substance Abuse and Mental Health Services Administration. Our ability to tailor programs, like our grant-funded work at the Friends of the Homeless shelter in Springfield, has literally saved lives among those experiencing homelessness and co-occurring conditions, like substance-use disorders.

In the coming years, we hope to see integrated care models become even more mainstream. Things appear headed in the right direction, but government action establishing payment reform within the behavioral-health field needs to be taken and the integrated models need to be appropriately funded. Such changes would affirm overall health and wellness to include both physical and behavioral health.

Dr. Yannis Raftopoulos

Director, Holyoke Medical Center Weight Management Program

Dr. Yannis Raftopoulos

Weight management is a rapidly evolving field, and I am fortunate to be part of it. One of the most significant innovations this field has experienced in the last 10 years was the development of a new gastric balloon. Packaged in a small capsule and swallowed with water, the Elipse balloon provides satiety while requiring no procedure or anesthesia for its placement and removal. Together with its excellent safety profile, the Elipse balloon is the least invasive and yet effective weight-loss modality available today. Elipse is manufactured in Massachusetts by Allurion Technologies.

I had the opportunity to be an investigator in the European trial which led to the Elipse market approval in the European Union in 2016. Recently, Holyoke Medical Center was among 10 U.S. sites in which an FDA-regulated trial was conducted. The trial was completed successfully, and Allurion has submitted data requesting FDA approval to market Elipse in the U.S. The balloons use in Europe shows that patients can lose more than one-fifth of their initial weight.

A New England Journal of Medicine study reported that 107.7 million children and 603.7 million adults, among 195 countries, were obese in 2015. High body-mass index accounted for 4 million deaths and contributed to 120 million disability-adjusted life-years. Obesity is a chronic disease, and its management requires long-term guidance and close patient-physician communication. Successful collaborations between existing best practices with technology innovations that will allow delivery of effective weight-management care on a massive and global scale could be the most significant evolution in the field in the next 10 years.

Dr. Hong-Yiou Lin

Radiation Oncologist, Mercy Medical Center

Dr. Hong-Yiou Lin

The advent of new medical oncology drugs has improved control of microscopic and, to a lesser extent, macroscopic disease, allowing local treatments, such as surgery or radiotherapy, to increase survival. To cure cancer, we need to eliminate cancer cells where they started, as well as any microscopic cells traveling through the body. The idea of using immunotherapy to fight cancer has been around for decades, but bringing this idea to the clinic has been hampered by the cleverness of cancer cells knowing how to evade detection by our immune system. Recently FDA-approved immunotherapy either takes away that invisibility cloak or wakes up our dormant immune cells to start fighting cancer.

The biggest development in oncology in the next 10 years will be personalized precision medicine, which allows the oncology team to tailor treatment to each patients unique cancer biology and life circumstances. Meanwhile, improvements in cancer diagnosis will come from novel PET radiotracers and new MRI sequences that allow for more accurate staging and identification of the best site to biopsy. Pathologists will use novel tools such as genome sequencing to supplement traditional microscopy to subclassify the specific type of cancer within a certain diagnosis instead of grouping into broad categories.

Surgical, medical, and radiation oncologists can then use the above information to decide on the best sequencing between surgery, systemic therapy, and radiotherapy to minimize side effects and maximize cure. Medical oncologists will be able to offer more drugs that target new mutations, overcome drug resistance, increase specificity to a mutation, or better fine-tune immunotherapy, targeting only cancer cells by enlisting gene modification as well as natural killer cells. Radiation oncologists will have new radiomic and genomic tools to personalize the radiation dose and volume, and when to offer radiotherapy.

In short, over the next 10 years, cancer care will continue to move away from the traditional one-size-fits-all model toward a more personalized approach.

Dr. Jonathan Bayuk

Medical Director, Allergy & Immunology Associates of New England

Dr. Jonathan Bayuk

There have been incredible and exciting advances in allergy and immunology in the last two years. However, the unmet needs of allergic and autoimmune-disease-afflicted patients has grown dramatically in the last 20 years. In response to the increasing prevalence and acuity of allergic diseases and autoimmune diseases, the world has launched products to help address these very severe patients. These medications are indicated for many conditions and work very well. They are generally safe, but are very expensive. These medicines are different than traditional pharmaceutical drugs as they are not chemicals, but biologically derived medicines designed to augment or modify the immune response. As such, they are call biologic medications.

In the field of allergy and immunology, we can now dramatically treat and potentially cure many diseases that in the past were very challenging to manage. The biologic medicines that we have now treat asthma, eczema, allergic disease, and hives. The patient selection is based on severity of their condition, and these medicines are only for moderately to severely affected people. If, as a medical profession, we were to place as many people as possible on these therapies, the cost would be astronomical and not sustainable.

However, is it fair to deny any of these patients access to these treatments who truly need them? I would argue that choice is a very difficult one to make, and as physicians, our primary goal is healing at whatever cost. As a nation, we have a dilemma. Can we afford the medicines we have or not? It is unclear that any serious legislative body is willing to tackle that question. For now, the use of these medicines is changing lives dramatically, and it is an exciting time to be able to use these newer tools to help our patients live better lives.

Dr. David Momnie

Owner, Chicopee Eye Care

Dr. David Momnie

What are the most significant advancements in eye care in the last decade? It depends on whom you ask. Retinal ophthalmologists would probably say its the treatment of wet macular degeneration, a leading cause of blindness, with anti-VEGF injections. Cataract surgeons would most likely cite small-incision surgery and new lens implants that often leave patients with 20/20 vision. Glaucoma specialists might tell you its the development of MIGS, or minimally invasive glaucoma surgery. These operations to lower the pressure in the eye use miniature devices and significantly reduce the complication rate.

Primary-care optometrists and ophthalmologists would no doubt talk about the advances in optical coherence tomography, a remarkable instrument using light waves that gives cross-sectional pictures of the retina. The technique is painless and non-invasive and is becoming the gold standard in eye care because it has revolutionized the diagnosis and treatment of glaucoma and macular degeneration. For optometrists specializing in contact lenses, using newly designed scleral lenses to restore vision in people with a corneal disease called keratoconus has been a major development. There are many other specialists in eye care, including LASIK surgeons, that have seen remarkable changes in technology.

What will the next decade bring? Artificial intelligence (AI) is becoming more accurate for screening, diagnosing, and treating eye conditions. AI systems can increasingly distinguish normal from abnormal pictures of the retina. Where there is a shortage of ophthalmologists and optometrists, AI screenings combined with telemedicine, providing remote care using communications technology, may be able to find and treat more people who are falling between the cracks of our healthcare system. The term 20/20 is the most common designation in eye care, and the year 2020 will probably usher in another decade of remarkable developments in our field.

Teresa Grogan

Chief Information Officer, VertitechIT

Teresa Grogan

From the perspective of technology that enables healthcare, the biggest game changer of the last decade has been the iPhone and now, essentially any smartphone.

Steve Jobs introduced the first iPhone in 2007 (a little over a decade ago), and physicians embraced it quickly. It started as a simple tool for doctors (applications like the PDR, or Physicians Desk Reference) for looking up drug interactions. Today, its a portable EMR, a virtual visit facilitator, and a remote-monitoring device for many healthcare providers, as many patients have embraced and insisted on this technology to improve access to care. As the cost decreases and cellular bandwidth improves, the rapid growth of the IoMT (Internet of Medical Things) will place smartphones at the center of the next wave of healthcare technology breakthroughs.

Looking forward, Id like to see complete elimination of passwords to access electronic information. While there has been some movement toward this with tap and go badges and fingerprint readers, a single standard is needed that would work regardless of the software program used. I hope there are greater strides in the creation, deployment, and adoption of other biometric technologies, like iris, face, or voice recognition, so that a healthcare professional could walk into a patient room or into a hospital and the computer systems would know his or her identity in immediate and secure fashion. If access to the data needed by a healthcare provider were as easy as turning on a light switch, the improvements in quality of life and efficiency in work for that provider would translate to improved patient outcomes.

Dr. Aaron Kugelmass

Vice President and Medical Director, Heart and Vascular Program, Baystate Health

Dr. Aaron Kugelmass

We have seen many improvements in cardiovascular care over the last 10 years, but the development, approval for clinical use, and dissemination of transcutaneous aortic valve replacement (TAVR) stands out as the most dramatic. This new technique allows cardiologists and cardiac surgeons, working together, to replace the aortic valve without opening a patients chest or utilizing heart-lung bypass, which has been the standard for decades. This less invasive approach is typically performed under X-ray guidance and involves accessing a blood vessel in the leg and guiding a catheter to the heart.

The TAVR procedure was first approved for clinical use in November 2011. It was initially limited to very sick patients, who were not candidates for traditional surgery because of the risk it posed to them. TAVR allowed patients who otherwise could not receive life-saving valve surgery to have their valves replaced with improvement in longevity. With time and experience, the procedure was approved for lower-risk patients as well, and more recently has been approved for the majority of patients, including those with low operative risk. TAVR has been shown to be equivalent or safer than traditional aortic valve-replacement surgery, and is quickly becoming the procedure of choice for most patients who require an aortic valve replacement. Since the procedure typically does not require open-heart surgery, recovery time is much shorter, with some patients going home within a day or two.

In the next 10 years, we expect that similar less-invasive procedures with shorter recovery time will be developed for other heart-valve conditions in patients who otherwise could not receive therapy.

Beth Cardillo

Certified Dementia Practitioner and Executive Director, Armbrook Village

Beth Cardillo

During the last 10 years, neuroscientists have been researching the causes of Alzheimers disease. There has been much discussion about which comes first the amyloid plaque or the fibrillary tangles that develop in the brain, which are roadblocks to cognition, thus causing the difficulties with Alzheimers and other related dementia. That question has not been answered yet. Researchers were able to isolate the APOE gene, which is a mutant gene that is found in familial Alzheimers disease, helping us to better diagnose it. We have also better understood how diet, exercising both body and brain, and lifestyle contribute to the disease. Currently there are 101 types of dementia, with Alzheimers accounting for 75% of cases.

The next 10 years will result in more preventive actions. One major action will be to help people avoid developing type 2 diabetes, which may be labeled the next cause of Alzheimers (this type of Alzheimers is already being called type 3 diabetes). There has been a major link between sugar in the hippocampus and Alzheimers disease. Though there is no cure yet for Alzheimers, we are finding more information based on genetics, diet, and PET scans, which can show shrinkage in the brain.

Every year, researchers are more hopeful that a new drug will be developed to eradicate the disease. The last new drug from Biogen was looking hopeful in clinical trials, but that turned out to be not the case. Prevention continues to be at the forefront, as well as participating in clinical trials. More people who do not have dementia or mild cognitive impairment are desperately needed for clinical trials so comparisons of the brain can be made.

Ellen Furman

Director of Nursing, American International College

Ellen Furman

As in all healthcare, the one thing that can be ascertained is constant change. The same can be said in nursing education today. No longer is the instructor-led lecture method of teaching considered best practice in education, but rather the shift to using class time to apply learned concepts. One way this is done is through the flipped classroom. Using this educational modality, students study the concepts being taught preceding the class, followed by class time where students apply these concepts in an interactive activity, thereby developing students abilities to think critically, reason, and make healthcare judgements based upon the application of knowledge.

Another change in nursing education is an expanded focus away from pure inpatient (hospital-based) clinical education to outpatient (community-based) clinical education. While hospital-based education remains essential, the realization that most healthcare provided is in outpatient settings has broadened the clinical experiences required to prepare the graduate registered nurse for care provision.

Additionally, with healthcare as complex as it is, nursing students are being taught to be prepared for entry into practice. Education regarding the use of evidence-based practice, how to apply for the licensure examination, preparation to be successful on the National Certification Licensure Exam, nurse residency opportunities, interviewing techniques, transitioning from student nurse to registered nurse, etc. are all taught using a variety of educational modalities based upon the current best available evidence in nursing education.

As we forge ahead in healthcare, nurse educators will continue to evolve to meet healthcare needs through the education of nursing students so as to prepare them to provide care to meet the needs of those we serve well into the future.

James Haas

Co-owner, Orthotics & Prosthetics Labs Inc.

James Haas

Advances in prosthetic technology have clearly been the most significant development in my field over the past decade. From knees and feet that adapt to different walking speeds and terrains to hands that send sensations of touch to the brain, every aspect of patient care has changed and continues to change at a rapid pace.

Prosthetic feet, knees, and sockets have been greatly impacted. Once made from multi-durometer foams and wood, the prosthetic feet of today are made from carbon, fiberglass, and kevlar laminated with modified epoxy resins. They store energy and adjust to uneven terrain and hills. Microprocessor knees have on-board sensors that detect movement and timing and then adjust a fluid/air control cylinder accordingly. These knees not only make it safer for a person to walk, they also lower the amount of effort amputees must use, resulting in a more natural gait. Sockets once made from stiff materials are now incorporated with soothing gels and flexible adjustable systems that allow a patient to make their own adjustments to improve their comfort.

As for the next decade, I hope to see national insurance fairness. Devices typically last about three to five years. Some people make them last longer, but others, especially growing children, need replacements more often. Many private insurance plans have annual caps and lifetime limits on coverage for orthotics and prosthetics. The Amputee Coalition of America authored insurance-fairness legislation and has lobbied for its implementation for over a decade. This legislation has been ratified in 20 states, including Massachusetts. The Fairness Act requires all insurance policies within the state to provide coverage for prosthetics and orthotics equal to or better than the federal Medicare program and have no coverage caps and lifetime restrictions.

Dr. Lisa Emirzian

Co-owner, EMA Dental

Dr. Lisa Emirzian

The most significant development in the field of dentistry over the past decade has been the integration of digital technology into our daily practices. There are three components of digital dentistry: data acquisition, digital planning, and, finally, the manufacturing of the restoration to be created. Data acquisition today is accomplished with digital radiographs, paperless charting, intra-oral scanners, cone-beam 3D scanners, and video imaging. For the planning process, we now have the ability to merge the data with software that enables computer-aided design and digital smile design, allowing dentists to perform complex procedures, including guided surgical treatments and smile designs, with optimum results. Fabrication and execution of the final restorations can be done in the office or, more often, in laboratories with highly sophisticated digital milling machines, stereolithography, and 3D printing.

In the next decade, we will see data fusion to ultimately create the virtual patient. The next-generation digital workflow will merge intra-oral 3D data with 3D dynamic facial scans, allowing dentists to create 3D smile designs and engineer the dentofacial rehabilitation. The integration of scanners and software will expedite the delivery of teeth in a day. In addition, multi-functional intra-oral scanners will allow for early detection of carious lesions and determine risk levels for different patients.

Above and beyond this foreseeable future, artificial intelligence (AI) will be the next paradigm shift. Companies are already looking for big-data collection and deep machine learning to help the practitioner in their everyday chores of diagnosis and treatment. AI cloud-based design platforms will input data, and AI engines in the background will aid in all parts of dental treatment, including diagnosis, design, and fabrication of final restoration.

Let us not forget one thing: the future is all about us people utilizing technology to enhance the human connection between doctor and patient.

John Hunt

CEO, Encompass Health Rehabilitation Hospital of Western Massachusetts

John Hunt

A significant rehabilitation development from the past includes one that may surprise you. Time. A luxury we once knew, time meant patients could recover in a hospital longer after a surgery, an accident, or an illness. Nurses had more time to assess patients to know exactly what they needed. Insurance companies approved longer patient stays through lengthy consideration. Ten years ago, a stroke survivor could recover for two weeks in a hospital and then join us for a rehabilitation stay that would last several weeks.

Today, a three- to five-day stay in the referring hospital, followed by a two-week stay in rehabilitation, is the norm. We are seeing significant decreases in the age of stroke survivors as well as an increase in the number patients who survive with cognitive and physical disabilities. Yet, we also see medical breakthroughs, including the discovery of tissue plasminogen activator (TPA) nothing short of a miracle. TPA actually reverses the effects of an evolving stroke in patients when used early on, making recoveries easier.

With new advanced technologies being introduced every year, rehabilitation continues to progress at a rapid speed. Looking into the future, evidence-based research will continue to grow to help us make knowledgeable decisions that ultimately impact patient outcomes. Increased clinical expertise will lead to higher functional gains in shorter amounts of time. As a result, acute inpatient rehabilitation will impact the lives of patients like weve never seen before.

Dr. Susan Bankoski Chunyk

Doctor of Audiology, Hampden Hearing Center

Dr. Susan Bankoski Chunyk

The most common treatment for hearing loss is hearing aids. Although digital processing has been available in hearing aids since 1996, the past 10 years have offered great leaps in technology for people with hearing loss. Each generation of computer chip provides faster and smarter processing of sound. Artificial intelligence allows the hearing-aid chip to adjust automatically as the listening environment changes, control acoustic feedback, and provide the best speech signal possible. People enjoy the convenience of current hearing aids Bluetooth streaming, smartphone apps, and rechargeable batteries.

These features are the icing on the cake, but the real cake is preservation of the speech signal, even in challenging listening situations. Since the primary complaint of people with hearing loss is understanding in noise, new hearing-aid technology works toward improving speech understanding while reducing listening effort in all environments. This significantly improves the individuals quality of life.

The negative effects of untreated hearing loss on quality of life are well-documented. Recent research has also confirmed a connection between many chronic health conditions including diabetes, cardiovascular disease, kidney disease, balance disorders, depression, and early-onset dementia and hearing loss. This research shows that hearing loss is not just an inevitable consequence of aging, but a health concern that should be treated as early as possible. My hope for the future is that all healthcare providers will recognize the value of optimal hearing in their patients overall health and well-being and, just as they monitor and treat other chronic health conditions, they will recommend early diagnosis and treatment of hearing loss.

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The Region's Health Leaders on What's New and What the Next Decade Will Bring - Business West

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Study focuses on key structure of C. difficle bacteria that could lead to future treatments – ETHealthworld.com

§ January 8th, 2020 § Filed under Nano Medicine Comments Off on Study focuses on key structure of C. difficle bacteria that could lead to future treatments – ETHealthworld.com

Washington D.C: Researchers have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics.

The finding of the study was published in the journal of Proceedings of the National Academy of Sciences. Researchers at the University of Maryland School of Medicine and their colleagues used cryo-electron microscopy, X-ray crystallography and other biophysical methods to identify the microscopic structures of the bacteria. The researchers mapped out the delivery and binding components of the toxin, which could pave the way for new drugs to neutralize it.

"We identified two structures that help explain the molecular underpinnings of C. difficile toxicity," said study co-author David Weber, Ph.D., a Professor of Biochemistry and Molecular Biology and Director of the Center for Biomolecular Therapeutics at UMSOM. "These structures will be important for targeting this human pathogen using structure-based therapeutic design methods."

Certain C. difficile infections are notoriously difficult to treat and often arise from antibiotic therapy given to fight other infections, which wipes out the beneficial bacteria that normally keep C. difficile bacteria in check. More than 500,000 cases occur annually in the United States, according to the Centers for Disease Control and Prevention, resulting in an estimated 15,000 deaths, usually from strains that are resistant to antibiotic treatment.

With the mapping of the structures of one of the binary toxins, called CDTb, the researchers' next aim to answer important new questions regarding the molecular mechanism of the C. difficile toxin, which can also benefit drug discovery. For example, they will investigate how the active binary toxin complex assembles and dissociates, how it binds to a healthy cell in a patient's gastrointestinal tract and how it enters the cell.

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Triple Negative Breast Cancer Treatment Market Is Expected To Expand US$ 720 Mn By 2026 – Instanews247

§ January 8th, 2020 § Filed under Nano Medicine Comments Off on Triple Negative Breast Cancer Treatment Market Is Expected To Expand US$ 720 Mn By 2026 – Instanews247

Ongoing advancements in cancer research continue to lead to the introduction of newer and better treatment options including drug therapies. The provision of newer drugs and treatments is expected to improve the diagnostic and treatment rate for triple-negative breast cancer. Some of the recent clinical efforts are being targeted at the molecular level characterization of triple-negative breast cancer across emerging therapeutic targets such as epigenetic proteins, PARP1, androgen receptors, receptor and non-receptor tyrosine kinases, and immune checkpoints.

These initiatives are anticipated to boost revenue growth of the triple-negative breast cancer treatment market. In a new research study, Persistence Market Research estimates the globaltriple-negative breast cancer treatment marketrevenue to crossUS$ 720 Mn by 2026from an estimated valuation of just underUS$ 505 Mn in 2018. This is indicative of aCAGR of 4.7%during the period2018 to 2026.

Development of generics is another key opportunity area in the triple-negative breast cancer treatment market. With the rapidly expanding number of cancer cases across the world, there is a need for effective cancer management, including the provision of better and more efficient drugs. Developing economies are faced with challenges on several fronts including paucity of funds and lack of proper treatment options, calling for more innovative approaches to affordable healthcare.

The availability of biosimilars and affordable generic anti-cancer drugs in developing regions is expected to significantly reduce the burden of cancer care. A projected cost reduction to the tune of more than 30% 40% and extended use of generic drugs is expected to reduce overall cancer treatment costs, thereby increasing the treatment rate for triple-negative breast cancer. This is further anticipated to create lucrative growth opportunities in the global triple-negative breast cancer treatment market.

Advances in Cancer Treatment and Introduction of Innovative Cancer Treatment Drugs to Boost Revenue Growth of the Triple-Negative Breast Cancer Treatment Market

Breast cancer is one of the most common types of cancer in women, and over the years, pharmaceutical and life sciences companies have been conducting advanced research and development activities to devise newer treatment options and drugs to treat breast cancer. Several new drug formulations are currently in the pipeline in different stages of clinical development and this is expected to bode well for the triple-negative breast cancer treatment market.

Innovation in oncology therapeutics has shifted focus towards an outcome based approach to cancer care, with an increasing emphasis on combination drugs and newer therapeutic modalities. This is further likely to put the global triple-negative breast cancer treatment market on a positive growth trajectory in the coming years.

Combination Therapy and Advancements in Nano Medicine Research Trending the Triple-Negative Breast Cancer Treatment Market

One of the biggest trends being observed in the global market for triple-negative breast cancer treatment is the shift towards combination therapy.

Companies in the global triple-negative breast cancer treatment market are conducting clinical trials for combination therapies by collaborating with other players in the market. Combination therapies are the latest innovation in the field of oncology and the combination of therapeutic drugs with chemotherapy is said to be an effective protocol for the treatment of triple-negative breast cancer.

Company Profiles

Another huge trend in the triple-negative breast cancer treatment market is the emergence of nanotechnology as an efficient tool in the clinical management of critical diseases such as triple-negative breast cancer. It has been observed that the combination of gold nanoparticles and folic acid results in higher cell entry rate in both in-vitro and in-vivo models, indicative of the fact that folate receptors are effective targeted therapies for the treatment of triple-negative breast cancer.

Nanoparticles facilitate systematic and efficient delivery of drugs and agents to the site of the tumor. Advanced R&D in nanotechnology and nano medicine is one of the top trends likely to impact the global triple-negative breast cancer treatment market in the years to come.

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What are the Upcoming Trends of Nanotechnology in Medicine? – Medical Tech Outlook

§ January 7th, 2020 § Filed under Nano Medicine Comments Off on What are the Upcoming Trends of Nanotechnology in Medicine? – Medical Tech Outlook

Nanotechnology is a rapidly expanding area of research with massive potential in many sectors ranging from healthcare to construction, and electronics.

FREMONT, CA: In the field of medicine, nanotechnology has revolutionized drug delivery, gene therapy, diagnostics, and various other areas of research, development and clinical application. Nanotechnology is a leading technology in medicine, bettering the potential of nanotechnology to target specific cells or tissues is a popular area of interest for the companies producing nanomedicines. Numerous registered clinical trials are in progress and involve nanotechnology; many of these studies are related to oncology and other therapy areas such as autoimmune diseases, anti-fungal agents and rare diseases. Playing a significant role in the transformation of medicine, identifying the trends in nanotechnology industry is essential.

Target Specification

The area of medicinal research involves attaching nanoparticles into drugs or liposomes to enhance specific localization. Different cell types have remarkable properties, and nanotechnology can be used to recognize cells of interest. This method enables associated drugs and therapeutics to reach diseased tissue while bypassing healthy cells.

Controlled Drug Release

The capability to control the discharge of a drug or therapeutic compound from its associated nanotechnology is benefitting a lot of interest from the industry. This triggered release can be gained from inside the body or from outside the body. The internal system consists of changes in the ecosystem of tumours in comparison with the surrounding tissues, while external stimuli comprise temperature change, ultrasound, or light. At present, the research efforts are dedicated to trying to understand how to release diagnostic molecules and drugs from liposomes with heat, and microbubbles using ultrasound.

Understanding Varied Patient Populations

Generally, there is a need for a better understanding of what makes patients distinctive from each other in terms of lack of ubiquitous drug efficacy. This raises a question, why nanotechnologies are not always able to improve the therapeutic output of drugs for an individual patient. Understanding the behaviour of nanomedicines when encountering different physiological characteristics of the patients and their disease states is significant.

Production of Nanomedicine

When compared to standard drug compounds, synthesizing and producing nanomedicine is primarily believed to be more complicated. In a few cases, this can limit the potential of drug manufacturers or pharmaceutical companies to deliver large quantities of nanomedicines. Not addressing the issues related to production may make the companies less interested in investing resources in this industry.

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Global Nanomedicines Market 2019 Trends, Segmentation, Swot Analysis, Opportunities And Forecast To 2025 – Food & Beverage Herald

§ January 7th, 2020 § Filed under Nano Medicine Comments Off on Global Nanomedicines Market 2019 Trends, Segmentation, Swot Analysis, Opportunities And Forecast To 2025 – Food & Beverage Herald

The Nanomedicines Market research added by Dataintelo.com, offers a comprehensive analysis of growth trends prevailing in the global business domain. This report also provides definitive data concerning market, size, commercialization aspects and revenue forecast of the industry. In addition, the study explicitly highlights the competitive status of key players within the projection timeline while focusing on their portfolio and regional expansion endeavors.

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This report on Nanomedicines Market delivers an in-depth analysis that also comprises an elaborate assessment of this business. Also, segments of the Nanomedicines Market have been evidently elucidated in this study, in addition to a basic overview pertaining to the markets current status as well as size, with respect to the profit and volume parameters.

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Major Players included in this report are as follows AbbottGE HealthcareJohnson & JohnsonMerckPfizerCombiMatrixCelgeneMallinckrodtSigma-Tau PharmaceuticalsTeva PharmaceuticalNanosphereUCB SA

Nanomedicines Market can be segmented into Product Types as NanoparticlesNanoshellsNanotubesNanodevicesOthers

Nanomedicines Market can be segmented into Applications as HospitalsClinicsResearch Institute

Nanomedicines Market: Regional analysis includes:Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)Europe (Turkey, Germany, Russia UK, Italy, France, etc.)North America (United States, Mexico, and Canada.)South America (Brazil etc.)The Middle East and Africa (GCC Countries and Egypt.)

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Nanomedicines Market scope A basic summary of the competitive landscape A detailed breakdown of the regional expanse A short overview of the segmentation

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Some of the Major Highlights of TOC covers:Nanomedicines Regional Market Analysis Nanomedicines Production by Regions Global Nanomedicines Production by Regions Global Nanomedicines Revenue by Regions Nanomedicines Consumption by Regions

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Nanomedicines Segment Market Analysis (by Application) Global Nanomedicines Consumption by Application Global Nanomedicines Consumption Market Share by Application (2014-2019)

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This post was originally published on Food and Beverage Herald

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A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Thera | IJN – Dove Medical Press

§ January 7th, 2020 § Filed under Nano Medicine Comments Off on A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Thera | IJN – Dove Medical Press

Yaser H Gholami, 1 4 Lee Josephson, 3 Eman A Akam, 5 Peter Caravan, 5 Moses Q Wilks, 3 Xiang-Zuo Pan, 3, 6 Richard Maschmeyer, 1 Aleksandra Kolnick, 3, 7 Georges El Fakhri, 3 Marc D Normandin, 3 Zdenka Kuncic, 1, 4, 8Hushan Yuan 3

1The University of Sydney, Faculty of Science, School of Physics, Sydney, NSW, Australia; 2Bill Walsh Translational Cancer Research Laboratory, The Kolling Institute, Northern Sydney Local Health District, Sydney, Australia; 3Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; 4Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia; 5The Institute for Innovation in Imaging and the A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; 6Bouve College of Health Sciences, CaNCURE Program, Northeastern University, Boston, MA, USA; 7Internal Medicine Residency Program, Lahey Hospital and Medical Center, Burlington, MA, USA; 8The University of Sydney Nano Institute, Sydney, NSW, Australia

Correspondence: Hushan YuanGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 149 13 th Street, Charlestown, MA 02129, USATel +1 617-643-1963Email hyuan@mgh.harvard.edu

Purpose: Using our chelate-free, heat-induced radiolabeling (HIR) method, we show that a wide range of metals, including those with radioactive isotopologues used for diagnostic imaging and radionuclide therapy, bind to the Feraheme (FH) nanoparticle (NP), a drug approved for the treatment of iron anemia.Material and methods: FH NPs were heated (120C) with nonradioactive metals, the resulting metal-FH NPs were characterized by inductively coupled plasma mass spectrometry (ICP-MS), dynamic light scattering (DLS), and r 1 and r 2 relaxivities obtained by nuclear magnetic relaxation spectrometry (NMRS). In addition, the HIR method was performed with [ 90Y]Y 3+, [ 177Lu]Lu 3+, and [ 64Cu]Cu 2+, the latter with an HIR technique optimized for this isotope. Optimization included modifying reaction time, temperature, and vortex technique. Radiochemical yield (RCY) and purity (RCP) were measured using size exclusion chromatography (SEC) and thin-layer chromatography (TLC).Results: With ICP-MS, metals incorporated into FH at high efficiency were bismuth, indium, yttrium, lutetium, samarium, terbium and europium (> 75% @ 120 oC). Incorporation occurred with a small (less than 20%) but statistically significant increases in size and the r 2 relaxivity. An improved HIR technique (faster heating rate and improved vortexing) was developed specifically for copper and used with the HIR technique and [ 64Cu]Cu 2+. Using SEC and TLC analyses with [ 90Y]Y 3+, [ 177Lu]Lu 3+ and [ 64Cu]Cu 2+, RCYs were greater than 85% and RCPs were greater than 95% in all cases.Conclusion: The chelate-free HIR technique for binding metals to FH NPs has been extended to a range of metals with radioisotopes used in therapeutic and diagnostic applications. Cations with f-orbital electrons, more empty d-orbitals, larger radii, and higher positive charges achieved higher values of RCY and RCP in the HIR reaction. The ability to use a simple heating step to bind a wide range of metals to the FH NP, a widely available approved drug, may allow this NP to become a platform for obtaining radiolabeled nanoparticles in many settings.

Keywords: nanomedicine, radiolabeling, radionuclide therapy, HIR, Feraheme

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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PV may regenerate excitable cells in the heart and brain – BPhrm Dv

§ January 7th, 2020 § Filed under Nano Medicine Comments Off on PV may regenerate excitable cells in the heart and brain – BPhrm Dv

Research led by Aarhus University in Denmark has led to a microscopic organic PV technology that could be used by its developers to create light-controlled, neural stimulating scaffolds in the body.

According to the researchers, the technology consists of water-based nanofibers coated with a photovoltaic biological material that can be quickly injected into the body. Although the organic photovoltaic nanomaterial semiconductors found in the nanofibers are not in direct contact with light, they can obtain a minimal amount of light that can penetrate tissue.

We want to develop a wireless, non-invasive, safe and very accurate method of therapy that can regenerate heart and brain cells through an external light source, said the technology creators.

The hope is that electrical stimulation will regenerate excitable cells in the heart and brain.

Research has shown that electrical stimulation can regenerate neurons, the research team said. Menglin Chen, one of the authors of a paper explaining the results, added: If we succeed, this will have a major impact on the future implementation of new methods of treatment for different brain and heart conditions.

In the report, Visible-Light Neural Stimulation on Graphitic-Carbon Nitride / Graphene Photocatalytic Fibers, published in Applied Material & Interfaces, the research project, funded by the Danish government with DKK4.2 million ($627,000), is identified.

Separate research released last year from the United States showed how to use PV technology to kill cancer cells. This breakthrough included light-activated fluorescent colours based on PV technology that could be used for disease detection, imaging-guided surgery and customized site-specific therapy.

Cardiovascular diseases are very common between humans especially after growing in age. These diseases occur due to weakening of the hearts muscles or other problems in blood vessels. The final complication of such disorders is a heart attack which can

Organ transplant has been considered a breakthrough in the medicine field for a very long time. This is due to the fact that it helps save a lot of humans worldwide. It has definitely changed the course of medicine especially

Cardiovascular diseases are very common between humans at old age. In our modern day, it is becoming even more common due to the unhealthy lifestyle and diets being used. Accordingly, it is important to treat these diseases carefully to prevent

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PV may regenerate excitable cells in the heart and brain - BPhrm Dv

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Has The Beauty Industry’s Obsession With Blood Gone Too Far? – Glamour UK

§ January 6th, 2020 § Filed under Nano Medicine Comments Off on Has The Beauty Industry’s Obsession With Blood Gone Too Far? – Glamour UK

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Tweeting the Talmud – The Atlantic

§ January 3rd, 2020 § Filed under Nano Medicine Comments Off on Tweeting the Talmud – The Atlantic

By the age of 46, however, I wanted to see the Talmuds breadth. I began Daf Yomi (literally a page a day), a cycle of learning one folio page (two sides, a and b) of the Talmud a day. Its a seven-and-a-half-year project, undertaken simultaneously across the globe: the same page each day, no matter where you are. (One afternoon, on Amtraks Northeast Corridor, a stranger walked by me in the caf car, saw my open Talmud, said 32b, and kept walking). The pace of the project is staggering. A friend described Daf Yomi as forgetting one page of the Talmud a day.

Every once in a while, Id encounter a text that had a jarring run-in with modernity. When I encountered, for example, a quip about what women should studyWomens wisdom is solely in the spindleI laughed. I can barely sew a button on a shirt.

But my 21st-century spindle is Twitter. It can spin anything. And it has.

Read: eTalmud: the iPad future of the ancient text

As part of my Daf Yomi project, every morning I tweet an insight from the daily Talmud page and then a corresponding relevant quote Ive found online, amusing myself with the juxtaposition of old and new. On Nidda, page 9a, I tweeted this from Rabbi Judah, Who is an elderly woman? Any woman about whom her friends say she is an elderly woman, next to Arthur Baers keen observation about women at a party: The ladies looked one another over with microscopic carelessness. On Keritot 12a, I tweeted A person is deemed more credible about himself than 100 people beside Ann Landerss astute advice: Know yourself. Dont accept your dogs admiration as conclusive evidence that you are wonderful.

Talmudic scholarly insults are also great to tweet, such as this one from Bekhorot 58a, starring my champion: Ben Azzai says, All the sages of Israel appear to me as garlic peel, except this bald one. Arrogance and humility live side by side in the Talmud, so when a scholar issued a retraction or caught his own errors, I almost always tweeted it. It was, however, more fun when scholars caught one anothers mistakes or mishaps, such as when Rav Sheshet said of a colleague, He must have been falling asleep when he said this.

When I first started, distilling a complex, ancient Babylonian legal debate into 140 characters seemed ridiculous. But then Twitter became a vehicle for determining foreign policy and waging political and culture wars. The Talmud looks almost simple in comparison. And while I was tweeting, others were learning and producing daily haikus, limericks, and artwork on the daily page. One woman wrote a stunning personal memoir of studying Daf Yomi. Others wrote thematic literary essays or blogged about science and medicine on the Talmuds pages. These timeworn and sometimes tedious texts were being reinterpreted and explained in fresh, creative ways by unexpected students.

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Culling the World: The Catastrophic Conquests of the Black Death – Ancient Origins

§ January 2nd, 2020 § Filed under Nano Medicine Comments Off on Culling the World: The Catastrophic Conquests of the Black Death – Ancient Origins

Medieval history is seldom kind. The decades and centuries slumbered onwards, each one bringing its own share of wars, crime, poverty...and disease. Happiness and prosperity were rare and almost unknown for the lowest classes, and the common mans future looked about as bright as a bottom of a barrel. And to make things worse, the 14th century brought a devastating disease, a vermin-borne plague that swept from the windswept steppes and trade routes of the East, a microscopic death that rode triumphantly on the backs of rats.

This striking plague, known as the Pestilence, the bubonic plague, or the Black Death, ravaged Europe from roughly 1347 to 1351, harvesting around 200 million lives in one fell swoop. From 30-60% of the entire European population was dead, taken away by the invisible hand of an unknown and merciless illness. How did Europe recover?

How did medieval society deal with this uncompromising illness, in a time when medicine was crude, superstitious, and not even in its infancy? Today we are painting a truly macabre and unsettling picture, as we recount the grim tale of the Black Death.

The Black Death is widely regarded as one of the most debilitating, disastrous, and catastrophic pandemics of recent human history. The sheer magnitude of this pestilence, and the inability of the populations of Eurasia to resist its merciless onslaught, meant that millions upon millions perished powerlessly.

The disease took both the rich and the poor alike, the nobles and the beggars all dying in the same, violent manner. For death does not differentiate between creed and wealth and power. The scythe mows down all.

It is believed that the Black Death on the whole was a bubonic plague, one of the three types of highly infectious diseases known simply as a plague . It is caused by the bacteria called Yersinia pestis . The bubonic plague was and is mostly spread by fleas.

The bacteria blocks the fleas digestive tract and when they try to feed on a host (i.e. a rat) they are forced to regurgitate, spreading the disease further. These tiny infected insects thus infect small animals and rodents, mostly rats, who can further spread the disease through human populations, either via their bite or simply by contaminating food stores and the like. The plague can also be acquired simply from the exposure to the bodily fluid that comes from decomposition of plague afflicted creatures, so even death is sufficient to spread the illness.

Oriental rat fleainfected with theYersinia pestis bacteriumwhich appears as a dark mass in the gut. (7mike5000 / Public Domain )

Once in the bloodstream, this malignant bacteria travels through the lymphatic vessels and goes to certain lymph nodes, causing them to swell. This swelling is the first and most characteristic symptom of the plague. These are known as buboes and give this pestilence its name - bubonic plague.

Seven days after being affected, a person develops severe flu-like symptoms. Swelling occurs at the groin, the armpits, and neck. High fever follows, as well as chills and ill feelings.

Seizures occur and gangrene sets in on the fingers, toes, lips, and nose. As the illness matures, the person is victim to continual blood vomiting, decomposition of the skin, necrotic swollen bulbs on the body, and eventual gruesome death.

But this plague that decimated Europe originated somewhere much further - Asia. Modern scholars mostly agree that the Black Plague originated somewhere in the area of China and Mongolia. During that period, the Mongols waged war on China, causing widespread economic decline and poverty. This in turn started a widespread famine, from which a plague was born.

It is believed that the Yersinia pestis and the fleas that carried it, via the rats, was transported from that region through the major trading route of the Silk Road , infecting all nations along the way.It eventually reached Crimea, where the rats traveled to mainland Europe via trading ships.

Most notably, a ship of Genoese traders that fled the Crimean port of Kaffa in 1347, sailed for Sicily and by the time they reached their destination, they were fully afflicted by the plague.The ship was denied entrance and expelled, but it was too late. The plague spread through Italy, from Genoa and Venice, all the way to Pisa.

In the meantime, the ships that were denied docking due to the plague sought other destinations and arrived at Marseille. From there, the rats and with them the plague, successfully spread out through Europe, reaching Spain and Portugal, and soon after, England. From there it spread all over northern Europe.

In 1349 a single ship arrived in a Norwegian port, introducing death. From there it spread through Scandinavia and Germany, and eventually it reached northwest Russia. It also entered Egypt through the Nile. Its population was nearly halved.

Spread of the Black Death in Europe and the Near East from 1346 to 1353. (Flappiefh / CC BY-SA 4.0 )

The plague spread like wildfire. The then-primitive medieval medicine knew nothing of such magnitude and could in no way pinpoint the source. The royalty and the clergy were quick to blame the heavens, and they all wanted to quarantine the sick people.

They simply overlooked the true source of the disease, which were rats they spread freely from port to port, from fishing village to fishing village, and from there further and further inland. Entire villages were depopulated and Europes major towns were almost halved in their population. In fact, the death tolls were so high and so rapid that the dead were often left lying where they perished, without sufficient workforce to bury them.

In Italy, major towns such as Florence had between 45-75% loss of population. Venice, Pisa, and Rome were also struck with huge losses. In France, mainly in Provence and Normandy, around 60% decrease in populations were recorded. Hamburg and Bremen in Germany suffered as much as 70% of losses.

And England suffered incredibly, as its total population fell from 7 million before the plague, to just 2 million some 50 years after. Death tolls were high in Asia as well, especially in ground zero China. Its losses were numbered in the millions, and the total Chinese population fell from 125 million in 1200 to just 65 million in late 1300s.

The poor classes suffered the most. Life in the urban centers in the 1300s was far from idyllic. The society was mostly divided in three major classes, the highest being the nobility, the craftsmen and tradesmen below them, and the serfs at the lowest rung.

Life in a city was unhygienic - to put it mildly. Towns were notorious for their open sewage and rampant diseases. Feces were dropped from windows and flowed freely down the streets. Pigs, dogs, and rats roamed freely and died freely often remaining on the street.

The open sewage contaminated the water and caused further health hazards. In England, laws were made to curb these unsanitary conditions, but were mostly in vain. A law was passed in 14th century London, that proclaimed that all those who were dumping their feces onto the street below were required to shout: Look out below! three times before tossing the waste.

Furthermore, medicine was in its most primitive state and was thoroughly unprepared for a disease on the scale of the Black Plague. All these conditions combined caused the rampant spread of the Black Death and a high number of deaths. It is interesting that isolated rural communities that lived in high mountains were almost not affected or suffered only minor losses.

Some of the iconic figures that connect us to the infamous pestilence, were the so-called plague doctors. Known for their unique appearance, these doctors were far from successful. In fact, they werent successful at all, as they rarely or never cured anyone who was struck with the bubonic plague.

Many of them werent doctors at all, but rather jumped on the wagon in order to exploit the diseased. These plague doctors were hired by city officials in hopes of treating the sick both the poor and the rich alike. But their usual methods of treatment were not too suited for treating a plague.

Their usual routine involved bloodletting and the placing of leeches and frogs on to the buboes the inflamed lymph nodes. It was thought that this would rebalance the humors in a persons body. Unsurprisingly, the method was not a success.

Abuboon the upper thigh of a person infected with the Black Death. (CDC / Public Domain )

But even funnier than their medicinal methods were their outfits. Later on, these plague doctors developed an outfit that was designed to protect them from the plague. At the time, it was believed that diseases were brought by bad air and their suits were designed with that in mind.

Doctors wore long overcoats, made from thick material, that reached the floor. Long leather gloves and boots were a must, as well as a wide brimmed hat. They carried long canes, which were used to keep people at bay and to point out certain details on a body without the need to get close.

But the most iconic part of the outfit was the leather mask. This was also the chief protective measure. It fully enclosed the face and had two eye holes protected with glass.

In the front it had a large and long beak, which gave them the look of a vulture. This beak was stuffed with aromatic herbs, such as lavender, roses, mint, laudanum, cloves, myrrh, and camphor. Sometimes it held a sponge soaked in vinegar. Either way it served as a primitive respirator.

Aplague doctorin his typicalapparel. ( channarongsds / Adobe Stock)

The Black Plague of the 14th century eventually faded significantly by the 1350s, but it wasnt entirely gone. The main reason for its end is the fact that such diseases have a certain lifespan.

This is mostly due to the severity of the disease. The pathogen that needs victims to reproduce eventually runs out of victims, as it is simply too deadly. It eventually evolved into a less deadly virus.

But the plague epidemics were not over. From that period onwards, bouts of plague were a constant occurrence in Europe, albeit on a much smaller scale. Roughly every 20 years it returned, all the way up to the 19th century.

London was one of the towns that was severely afflicted by these recurring bouts of plague, which is generally known as the Second Pandemic. Between 1360 and 1363, roughly 10 years after the Black Death, London again suffered a plague, which killed 20% of its inhabitants. Just six years later, in 1369, 15% of Londons population died.

The next major suffering was in 1665 and 1666, with the arrival of the Great Plague of London, which killed over 100,000 people 25% of the London population of that time. It was also an indirect precursor to the Great Fire of London of 1666 , which completely ravaged the city and prolonged the suffering of the plague survivors.

Collecting the dead for burial during the Great Plague of London.The last major outbreak of the Black Death in England. (7mike5000 / Public Domain )

From 1596 to 1602, a major outbreak of plague returned to Spain, once again entering through the ports. It ravaged Madrid and Castile and claimed roughly 700,000 lives in Spain. The plague returned to Spain not too long after this, from 1646 to 1652, this time called the Great Plague of Seville.

It swept through Valencia, Malaga, Seville, Aragon, and Catalonia, claiming 500,000 lives. It returned roughly 25 years later, sweeping through Spain for nine years from 1676 to 1685, claiming 250,000 lives.

Collectively, the plagues of the entire 17th century were crippling for Spain, whose population didnt increase for roughly a century. In central Europe, it was Vienna that suffered, being hit with the Great Plague of 1679, which claimed roughly 76,000 of its citizens. In the 1700s, The Great Plague of Marseille swept through this region of France and claimed 100,000 lives.

Contemporary engraving ofMarseilleduring theGreat Plaguein 1720. (Rvalette / CC BY-SA 4.0 )

The Black Death was considered as the Wrath of God by those that suffered it. But it was far from it it was the Wrath of Nature. A deadly bacteria that spread rapidly and could thrive in the unsanitary conditions of the Middle Ages .

It was a wakeup call, a great culling that reminded the victims that hygiene does matter. The sheer deadliness and the threat it posed caused the people of Europe and the rest of the world to seek better hygiene, better medicine, and better understanding of the world around them. But the Pestilence was never forgotten it rocked the foundations of Europe and claimed victims in numbers that are hard to imagine.

Top image: The Black Death was spread across Europe by rats. Source: rawinfoto / Adobe Stock.

By Aleksa Vukovi

Byrne, J. 2012. Encyclopedia of the Black Death . ABC-Clio.

Cantor, N. 2001. In the Wake of the Plague: The Black Death and the World It Made . The Free Press.

Gottfried, R. 1983. The Black Death: Natural and Human Disaster Medieval Europe . The Free Press.

Salzberg, S. 2011. The Black Death is dead (thanks to evolution) . Forbes. [Online] Available at: https://www.forbes.com/sites/stevensalzberg/2011/09/02/the-black-death-is-dead-thanks-to-evolution/#1df9f97f33d2

Zahler, D. 2009. The Black Death (Pivotal Moments in History). Twenty-First Century Books.

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High-resolution Melting Analysis Market Scope, Segmented By Company, Application and Region, Forecast To 2025 – Filmi Baba

§ January 2nd, 2020 § Filed under Nano Medicine Comments Off on High-resolution Melting Analysis Market Scope, Segmented By Company, Application and Region, Forecast To 2025 – Filmi Baba

High-resolution Melting Analysis Market: Snapshot

The global market for high-resolution melting analysis is gaining momentum on account of the advancements in molecular biology. High-resolution melting analysis involves the microscopic study of double-stranded DNA samples to successively detect polymorphisms, epigenetics, and mutations. The study involves the amplification of the region where the mutational analysis needs to be carried out and generation of multiple copies of that region in the sample tube. The applications of high-resolution melting analysis in molecular biology are expansive, which is expected to play to the advantage of the market. TMR Research throws light on several market forces that are expected to contribute to the growth of the market over the coming. Moreover, a multifaceted approach to understand the knit and grit of the market was followed during research and analysis.

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One of the most important applications of point high-resolution melting (HRM) analysis is the detection of point mutation. The conventional method of SNP typing is expensive and time-consuming which shifts the focus on HRM analysis. Testing of zygotes has also emerged as an important application of HRM analysis, which is propelling demand within the global market. Apart from the above-mentioned applications, intercalating dyes used for the transition of double-standard DNAs to single-stranded ones are another key area that is projected to contribute to the growth of the market.

Genetic testing centers have been specifically very successful in North America which has given an impetus to the market. On the other hand, prominence of academic Institutes and research centers in Europe has also contributed to the growth of the regional market.

Global High-resolution Melting Analysis Market: Overview

High resolution melting analysis is a powerful and strong methodology in molecular biology for the purpose of detecting epigenetic differences, polymorphisms, and mutations in double-stranded DNA samples. It was first discovered and developed by the Idaho Technology and University of Utah. High resolution melting analysis has several advantages over genotyping technologies such as cost effectiveness, it is powerful and fast as compared to genotyping technologies, and it is comparatively simple. Based on products and services, the global high-resolution melting analysis market can be segmented into software and services, consumables and reagents, and instruments. In terms of application, it can be segmented into epigenetics, pathogen identification, species identification, mutation scanning, and SNP genotyping.

The global market for high-resolution melting analysis is likely to have a fruitful future owing to ongoing research and developments in this field sponsored by several leading companies operating in this particular field. For instance, FDA in the U.S. approves many treatments which are made for addressing a specific genomic profile or genetic makeup of the tumor of the patient.

Global High-resolution Melting Analysis Market: Drivers and Restraints

The prime factors that are boosting the growth of the market comprise the growing prevalence of cardiovascular diseases, COPD, chronic diseases such as cancer, and other different infectious diseases. The prime benefits associated with high-resolution melting analysis are optimization of therapies, patient compliance, drug safety, cost savings on several treatments, and disease diagnosis. In return, these are also expected to propel the demand for DNA testing services. Moreover, rising awareness pertaining to the applications of high resolution melting analysis technologies for HLA typing, mutation discovery, and DNA mapping are additional aspects that are anticipated to propel the growth of the high-resolution melting analysis market during the forecast period. High resolution melting analysis is a technology employed for assessing melting curve plots of amplified gene. This particular technology is basically used for gene mutation scanning, microbial species identification, methylation profiling, and other different diagnostics based on PCR. Thus, mutation scanning and other applications are likely to gain prominence over time owing to rising prevalence of advancements in technology of molecular biology, genetic disorders, and growing awareness pertaining to SNP typing.

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Global High-resolution Melting Analysis Market: Market Potential

Growing government budget provision for research and development in the field of pharmaceuticals, biotechnology, and applied life sciences is a crucial factor heightening the demand for numerous diagnostic techniques and tools. For instance, in 2015, the Obama led administration announced the introduction of the Precision Medicine Initiative with a huge investment of US$216 mn in the Presidents budget of 2016. This initiative is further expected to have positive impact on the growth of the high resolution melting analysis market.

Global High-resolution Melting Analysis Market: Regional Overview

Region-wise, the market can be segmented into North America, Asia Pacific, Europe, and the Rest of the World. North America is expected to perform extremely owing to factors such as robust adoption of advanced technology in healthcare, numerous genetic testing centers, strong biotech and pharmaceutical industry, prevalence many academic universities, and high prevalence of diseases. Asia Pacific has also been identified as one of the potential regions where the market can grow steadily owing to dynamics such as rising prevalence of chronic diseases such as HIV, COPD, and cancer, growing cases of genetic disorders, and rising private and public expenditure on genetic testing and molecular diagnostic.

Global High-resolution Melting Analysis Market: Competitive Landscape

The top drawer companies operating in the market are Thermo Fisher Scientific, Kapa Biosystems, Idaho Technology Corporation, and Roche Molecular Systems.

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Global Healthcare Nanotechnology (Nanomedicine) Trends and Forecast to 2025 – Industry Analysis by Geographical Regions – TechAnnouncer

§ January 1st, 2020 § Filed under Nano Medicine Comments Off on Global Healthcare Nanotechnology (Nanomedicine) Trends and Forecast to 2025 – Industry Analysis by Geographical Regions – TechAnnouncer

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Los Angeles, United State,December 2019 :

The latest report up for sale by QY Research demonstrates that the global Healthcare Nanotechnology (Nanomedicine) market is likely to garner a great pace in the coming years. Analysts have scrutinized the market drivers, confinements, risks, and openings present in the overall market. The report shows course the market is expected to take in the coming years along with its estimations. The careful examination is aimed at understanding of the course of the market.

Global Healthcare Nanotechnology (Nanomedicine) Market: Segmentation

The global market for Healthcare Nanotechnology (Nanomedicine) is segmented on the basis of product, type, services, and technology. All of these segments have been studied individually. The detailed investigation allows assessment of the factors influencing the market. Experts have analyzed the nature of development, investments in research and development, changing consumption patterns, and growing number of applications. In addition, analysts have also evaluated the changing economics around the market that are likely affect its course.

Get PDF template of Healthcare Nanotechnology (Nanomedicine) market report@ https://www.qyresearch.com/sample-form/form/1121493/global-Healthcare-Nanotechnology-Nanomedicine-market

This report focuses on the global top players, coveredAmgenTeva PharmaceuticalsAbbottUCBRocheCelgeneSanofiMerck & CoBiogenStrykerGilead SciencesPfizer3M CompanyJohnson & JohnsonSmith&NephewLeadiant BiosciencesKyowa Hakko KirinShireIpsenEndo International

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Market segment by Type, the product can be split intoNanomedicineNano Medical DevicesNano DiagnosisOther

Market segment by Application, the market can be split intoAnticancerCNS ProductAnti-infectiveOther

What will the report include?

Market Dynamics: The report shares important information on influence factors, market drivers, challenges, opportunities, and market trends as part of market dynamics.

Global Market Forecast: Readers are provided with production and revenue forecasts for the global Healthcare Nanotechnology (Nanomedicine) market, production and consumption forecasts for regional markets, production, revenue, and price forecasts for the global Healthcare Nanotechnology (Nanomedicine) market by type, and consumption forecast for the global Healthcare Nanotechnology (Nanomedicine) market by application.

Regional Market Analysis: It could be divided into two different sections: one for regional production analysis and the other for regional consumption analysis. Here, the analysts share gross margin, price, revenue, production, CAGR, and other factors that indicate the growth of all regional markets studied in the report.

Market Competition: In this section, the report provides information on competitive situation and trends including merger and acquisition and expansion, market shares of top three or five players, and market concentration rate. Readers could also be provided with production, revenue, and average price shares by manufacturers.

Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Healthcare Nanotechnology (Nanomedicine) market

Chapter 2: Evaluating the leading manufacturers of the global Healthcare Nanotechnology (Nanomedicine) market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Healthcare Nanotechnology (Nanomedicine) market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

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Contact US:QY Research, INC.17890 Castleton, Suite 218,Los Angeles, CA 91748USA: +1 626 295 2442China: +86 1082 945 717Japan: +81 9048 009 273India: +91 9766 478 224Emails enquiry@qyresearch.com

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Global Healthcare Nanotechnology (Nanomedicine) Trends and Forecast to 2025 - Industry Analysis by Geographical Regions - TechAnnouncer

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Nanomedicine Market to witness Huge Growth with Projected up to 2026 – Market Reports Observer

§ January 1st, 2020 § Filed under Nano Medicine Comments Off on Nanomedicine Market to witness Huge Growth with Projected up to 2026 – Market Reports Observer

Latest release from SMI with title Nanomedicine Market Research Report 2019-2026 (by Product Type, End-User / Application and Regions / Countries) provides an in-depth assessment of the Nanomedicine including key market trends, upcoming technologies, industry drivers, challenges, regulatory policies, key players company profiles and strategies. Global Nanomedicine Market study with 100+ market data Tables, Pie Chat, Graphs & Figures is now released BY SMI. The report presents a complete assessment of the Market covering future trends, current growth factors, attentive opinions, facts, and industry-validated market data forecast until 2026.

Global Nanomedicine Market Segmentations

The segmentation chapter allows readers to understand aspects of the Global Nanomedicine Market such as products/services, available technologies, and applications. These chapters are written in a way that describes years of development and the process that will take place in the next few years. The research report also provides insightful information on new trends that are likely to define the progress of these segments over the next few years.

Download Free Sample Report with Latest Industry Trends 2019 @ https://www.stratagemmarketinsights.com/sample/9943(**Note: Free Sample with TOC, Graph, Charts)

Global Nanomedicine Market and Competitive Analysis

Know your current market situation! Not only an important element for new products but also for current products given the ever-changing market dynamics. The study allows marketers to stay in touch with current consumer trends and segments where they can face a rapid market share drop. Discover who you really compete against in the marketplace, with Market Share Analysis know market position, % market Share and Segmented Revenue of Nanomedicine Market

Segmentation and Targeting

Essential demographic, geographic, psychographic and behavioral information about business segments in the Nanomedicine market is targeted to aid in determining the features company should encompass in order to fit into the business requirements. For the Consumer-based market the study is also classified with Market Maker information in order to better understand who the clients are, their buying behavior and patterns.

*** For the global version, a list of below countries by region can be added as part of customization at minimum cost.North America (United States, Canada & Mexico)Asia-Pacific (Japan, China, India, Australia, etc)Europe (Germany, UK, France, etc)Central & South America (Brazil, Argentina, etc)Middle East & Africa (United Arab Emirates, Saudi Arabia, South Africa, etc)

Nanomedicine Product/Service Development

Knowing how the product/services fit the needs of clients and what changes would require to make the product more attractive is the need of an hour. Useful approaches to focus group by utilizing User Testing and User Experience Research. Demand-side analysis always helps to correlate consumer preferences with innovation.

Marketing Communication and Sales Channel

Understanding marketing effectiveness on a continual basis help determine the potential of advertising and marketing communications and allow us to use best practices to utilize an untapped audience. In order to make marketers make effective strategies and identify why the target market is not giving attention, we ensure the Study is Segmented with appropriate marketing & sales channels to identify potential market size by Revenue and Volume* (if Applicable).

Pricing and Forecast

Pricing/subscription always plays an important role in buying decisions; so we have analyzed pricing to determine how customers or businesses evaluate it not just in relation to other product offerings by competitors but also with immediate substitute products. In addition to future sales Separate Chapters on Cost Analysis, Labor*, production* and Capacity are Covered.

How geography and sales fit together

This study is helpful to all operators who want to identify the exact size of their target audience at a specific geographic location. Nanomedicine Market allows entrepreneurs to determine local markets for business expansion. This study answers the questions below:

1. Where do the requirements come from?2. Where do non-potential customers reside?3. What is the buying behavior of customers in a specific region?4. What is the spending power of the customers in a particular region?

** Enquire for customization in Report @ https://www.stratagemmarketinsights.com/quiry/9943

Having our reviews and subscribing our report will help you solve the subsequent issues:

*Uncertainty about the future: Our research and insights help our customers predict the upcoming revenue pockets and growth areas. This will guide customers to invest their resources.

*Understanding market sentiments: It is very important to have a fair understanding of market sentiment for your strategy. Our insights will help you see every single eye on market sentiment. We maintain this analysis by working with key opinion leaders on the value chain of each industry we track.

*Understanding the most reliable investment center: Our research evaluates investment centers in the market, taking into account future demand, profits, and returns. Clients can focus on the most prestigious investment centers through market research.

*Evaluating potential business partners: Our research and insights help our clients in identifying compatible business partners.

Furthermore, the years considered for the study are as follows:

Historical year 2013-2018Base year 2018Forecast period** 2019 to 2026 [** unless otherwise stated]

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Nanomedicine Market to witness Huge Growth with Projected up to 2026 - Market Reports Observer

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What is the Role of Nanomedicine in Treating Melanoma? – Medical Tech Outlook

§ December 31st, 2019 § Filed under Nano Medicine Comments Off on What is the Role of Nanomedicine in Treating Melanoma? – Medical Tech Outlook

Nanomedicine involves smaller particles, yet their capabilities are tremendous, playing a more significant part in the diagnosis and treatment of cancer.

Fremont, CA: Nanomedicine uses particles and technology that is one-billionth of a meter in medicine for diagnosis and treatment of disease. Irrespective of their smaller size, these nanoparticles play a significant role in the medical field. According to cancer.net, nearly 96,480 cases of invasive melanoma of the skin will be diagnosed in 2019 in the US. Even though it is not the most common type of skin cancer, an estimation of 7,230 deaths will occur this year. In recent research, nanomedicine has been employed to help with improving detection, prevention and treatment of a severe form of skin cancer, melanoma.

The disease begins in the melanocytes, which are the cells responsible for the synthesis of a dark pigment called melanin. And when the skin is exposed to the sun for a long time, melanocytes start producing more pigment as a protective response causing the skin to darken more. When these cells grow out of control, it can result in melanoma.

Tel Aviv researchers have developed a nano-vaccine for melanoma. The vaccine was tested in mice, and it turned out to be useful as it prevents the development of melanoma. It also treats both primary tumors and disease that has spread throughout the body. It was observed by administering with immunotherapy that activates the immune system to fight against the foreign cells. Meanwhile, these cells learn to identify the melanoma cells and will start attacking cells of this specific cancer.

The researchers also examined the vaccine in different conditions. They injected the vaccine into healthy mice and then placed the melanoma cells in the mice where the vaccine halted the development of the disease. In another scenario, the vaccine and immunotherapy together were used to treat the mice already infected by melanoma. Here a significant delay in the progression of the disease was observed. Also, peptides which are the short amino acid chains used in the vaccine were present in the samples of melanoma tissue from different sites in the mice's body other than the one where melanoma had been injected initially. This proves that the vaccine is also suitable for patients affected severely for whom melanoma has spread beyond the primary site.

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What is the Role of Nanomedicine in Treating Melanoma? - Medical Tech Outlook

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Infrared dye under the skin could be used as a vaccine record – Infosurhoy

§ December 27th, 2019 § Filed under Nano Medicine Comments Off on Infrared dye under the skin could be used as a vaccine record – Infosurhoy

Doctors could one day create medical records under peoples skin to show which vaccinations theyve had.

A small patch which injects dye under the skin at the same time as someone is having their jab could save lives by highlighting who needs which vaccines.

Lack of vaccination kills 1.5million people worldwide every year and many countries dont have vaccination cards or reliable medical records.

But putting tiny drops of invisible dye beneath the skin when patients are vaccinated could give medics a quick and easy record to use in future.

The patch, which uses 1.5mm microneedles to deliver the dye, was invented by researchers at the Massachusetts Institute of Technology (MIT).

In areas where paper vaccination cards are often lost or do not exist at all, and electronic databases are unheard of, this technology could enable the rapid and anonymous detection of patient vaccination history to ensure that every child is vaccinated, said Professor Kevin McHugh, who helped develop the patch.

The dye contains microscopic dye crystals just four nanometres across around 25,000 times thinner than a human hair and producing light similar to infrared.

It could then be seen by a smartphone camera or other camera without an infrared filter, but not by the naked eye.

Most smartphones can pick up infrared on their normal cameras but have software to filter it out because people dont see it normally.

It would be simple for scientists to adapt a phone by switching off the filter, enabling it to see the light given off by the crystals, the MIT researchers said.

They tested the dye on dead human flesh and on mice and found it could still be seen after five years.

This was important because many vaccines, including the measles, mumps and rubella (MMR) jab, require regular doses spread over a number of years.

Without getting all the doses someone may not be fully protected and, without quality medical records, children must rely on their parents to remember which ones they had and when.

In some areas in the developing world, it can be very challenging to do this, said Dr Ana Jaklenec.

There is a lack of data about who has been vaccinated and whether they need additional shots or not.

Tests on mice proved that the dye worked and did not interfere with a polio vaccine, and tests on dead human skin showed it could still be detected much later.

Different vaccines could correspond to different patterns of dots, effectively allowing health workers to create an accurate patient record beneath the skin.

They might even be able to communicate the date the vaccine was given and a serial number for the exact medicine, the team said.

Their research was published in the journal Science Translational Medicine.

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Nanomedicine Market A comprehensive study with Key Players| GE Healthcare, Mallinckrodt plc, Nanosphere Inc., Pfizer Inc., and More – Galus Australis

§ December 26th, 2019 § Filed under Nano Medicine Comments Off on Nanomedicine Market A comprehensive study with Key Players| GE Healthcare, Mallinckrodt plc, Nanosphere Inc., Pfizer Inc., and More – Galus Australis

The global Nanomedicinemarketis comprehensively and Insightful information in the report, taking into consideration various factors such as competition, regional growth, segmentation, and NanomedicineMarket size by value and volume. This is an excellent research study specially compiled to provide the latest insights into critical aspects of the Nanomedicinemarket. The report includes different market forecasts related to market size, production, revenue, consumption, CAGR, gross margin, price, and other key factors.It is prepared with the use of industry-best primary and secondary research methodologies and tools.

TheMajorPlayers Covered in this Report:GE Healthcare, Mallinckrodt plc, Nanosphere Inc., Pfizer Inc., Merck & Co Inc., Celgene Corporation, CombiMatrix Corporation, Abbott Laboratories& More.

In 2018, the global Nanomedicine market size was million US$ and it is expected to reach a million US$ by the end of 2024, with a CAGR between 2019 and 2024.

Get a Sample PDF Report:https://www.reportsmonitor.com/request_sample/610414

This report studies the Nanomedicine market size by players, regions, product types and end industries, history data 2014-2018 and forecast data 2019-2024; This report also studies the global market competition landscape, market drivers and trends, opportunities and challenges, risks and entry barriers, sales channels, distributors and Porters Five Forces Analysis.

Product Type SegmentationNeurologyCardiovascularAnti-inflammatoryAnti-infectiveOncology

Industry SegmentationHospitalOthers

Each section of the report reveals critical information about the global Nanomedicine market that could be used to ensure strong growth in the coming years. Our unique blend of primary and secondary research techniques helped us to recognize hidden business opportunities available in the global Nanomedicinemarket, besides collecting significant insights of market participants and obtaining precise market data.It includes several research studies such as manufacturing cost analysis, absolute dollar opportunity, pricing analysis, company profiling, production and consumption analysis, and market dynamics.

Regional Analysis For Nanomedicine Market:

North America(United States, Canada, and Mexico)Europe(Germany, France, UK, Russia, and Italy)Asia-Pacific(China, Japan, Korea, India, and Southeast Asia)South America(Brazil, Argentina, Colombia, etc.)Middle East and Africa(Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

In this study, the years considered to estimate the market size of the Nanomedicine are as follows:

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The study objectives of this report are:

For More Details On this Report:https://www.reportsmonitor.com/report/610414/Nanomedicine-Market

To conclude, the Nanomedicine Industry report mentions the key geographies, market landscapes alongside the product price, revenue, volume, production, supply, demand, market growth rate, and forecast, etc. This report also provides SWOT analysis, investment feasibility analysis, and investment return analysis.

Contact UsJay MatthewsDirect: +1 513 549-5911 (U.S.)+44 203 318 2846 (U.K.)Email: sales@reportsmonitor.com

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Nanomedicine Market A comprehensive study with Key Players| GE Healthcare, Mallinckrodt plc, Nanosphere Inc., Pfizer Inc., and More - Galus Australis

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Go easy on the antibiotics, warn Thai medical experts – The Thaiger

§ December 25th, 2019 § Filed under Nano Medicine Comments Off on Go easy on the antibiotics, warn Thai medical experts – The Thaiger

The lowest rainfall ever recorded in Thailand was in 1979. Now, Thailands Meteorological Department is forecasting an even worse drought and dry season saying it will last until May 2020. Forty-three provinces in the north, northeast, and central regions will be the most affected. Some are already in the grip of critical water shortages with farmers being asked to swap their crops or delay plantings for the season.

Kornrawee Sitthichivapak, the TMDs deputy director-general for operations, says the worst period will be January and February, as water reserves fall and the situations worsens.

There is unlikely to be any rain until the beginning of the rainy season in May, and high temperatures brought on by the climate condition known as El Nino will prevail.

Even in the tourist island of Phuket, where 84% of the economy relies on tourism, the three main catchments are either a lot lower than in the past or, in the case of Manik Dam in Srisoontorn, completely empty.

The TMD predicts 2020 is likely to be worse than 1995 and 2015/2016, when water needed to be drawn up from aquifers. Residents in Bangkok and surrounding areas were affected and competed for meagre water resources. Roads cracked, riverbanks collapsed and saltwater seeped into the groundwater in Pathum Thani province, affecting the local tap water supply.

Thailand commonly suffers from both drought and flood. But as demands on agriculture grow, along with population, tourism and development, the effects of these extremes become more evident and critical. Critics say the outlook of scarce rains for 2020 exposes the poor management of the Kingdoms water resources with the government perpetually locked into historic and ineffective practices that havent kept pace with modern agriculture.

The long dry season is expected to produce lower farm outputs and push up prices, even as overall farm income declines due to the drought. This will affect the purchasing power of farm households, which account for one third of Thais. The fallout is also likely to fuel further political unrest with the strong northern and north-eastern opposition sentiment being mainly agricultural communities.

SOURCE: The Nation

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Go easy on the antibiotics, warn Thai medical experts - The Thaiger

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Where are Thai airbnb customers staying over the holiday period? – The Thaiger

§ December 25th, 2019 § Filed under Nano Medicine Comments Off on Where are Thai airbnb customers staying over the holiday period? – The Thaiger

Where are the people booking share accomodation staying for the Christmas and New Year period?

Tokyo, Osaka and Hokkaido are among the top five trending destinations where Thai travellers usher in another year

Seoul is the most-booked overseas destination for Thai travellers on New Years Eve

Chiang Mai is the most popular domestic destination for Thai travellers on New Years Eve with bookings up 90% year-on-year

(Stats from airbnb.com)

For more than a decade, millions of hosts and guests have been coming together through travel on Airbnb. This New Years Eve a record number of travellers will be using the Airbnb platform to book their accommodation. Airbnb have shared their stats for accommodation favourites this Christmas and New Year.Most popular overseas destinations for Thai travellers

With increased flight connectivity and a growing middle class, more and more Thais are travelling overseas to explore new destinations and new cultures. This year their spending power is getting them more value than ever with he strong Thai baht. On New Years Eve, the most booked international destination by Thai travellers, based on growth in guest arrivals from last year, is Seoul, South Korea.

While Seoul is the most popular, growth of travel to Japan is rising with Tokyo, Osaka and Hokkaido all making the top five trending international destinations for Thai travellers this New Years Eve*, based on guest arrival growth.

Most popular domestic destinations for Thai travellers

For those opting to stay home and explore Thailand, the cool mountains of northern Thailand are the most popular this New Years Eve with Chiang Mai being the most popular domestic destination for Thai travellers. Chiang Mai has also experienced the highest growth rate, with bookings up 90% year-over-year. The top three trending domestic destinations for Thai travellers are:

Most popular destinations in Thailand

Combining both domestic and international Airbnb booking data, its clear that the allure of the city and its large-scale end-of-year celebrations has helped to make Bangkok the most booked Thai destination on Airbnb this New Years Eve.

The top five most-booked Thai destinations this New Years Eve* are:

Trending New Years Eve Experiences in Thailand

During the peak New Years Eve** travel season, the top trending Airbnb Experiences booked in Thailand are:

*Based on Airbnb internal data of year-over-year growth in guest arrivals for New Years Eve weekend 2019 compared to New Years Eve weekend 2018.

**Based on Airbnb internal data of year-over-year growth in Airbnb Experiences booking from 30 December to 5 January.

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Where are Thai airbnb customers staying over the holiday period? - The Thaiger

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Indian visitors bolster Thailands 2019 tourist arrival record – The Thaiger

§ December 25th, 2019 § Filed under Nano Medicine Comments Off on Indian visitors bolster Thailands 2019 tourist arrival record – The Thaiger

She is visiting Thailand for the first time and plans to enjoy the beaches in Pattaya, Thai food and shopping.

With just ten days to go in 2019, Thailand has stepped over last years record arrivals of 38,260,000. The 38,260,000th visitor arrived yesterday (Friday), a tourist from India, Devanshi Deepak Kesaria (sure she wondered what all the fuss was about!)

Thailand has exceeded last years record for foreign tourist arrivals. This final result for tourist arrivals into the Kingdom in 2019 will end up around 4% up on last years audited numbers.

Ms Kesaria also broke the record of 1.9 million arrivals from India into Thailand in one year.

Ms Kesaria, who flew from Mumbai with friends, will get two free round-trip tickets and accommodation for her next trip to Thailand. She is visiting Thailand for the first time and plans to enjoy the beaches in Pattaya, Thai food and shopping, according to Chattan Kunjara Na Ayudhya, deputy governor of marketing for Asia and South Pacific at the TAT.

The Indian market has grown significantly, projected at 22% growth in arrivals this year to 1.9 million, with 85 billion baht in tourism revenue, a 27% uptick.

The Thai tourism authority says that marketing promotions with airlines will be offered throughout next year to induce Indian tourism, especially from secondary provinces such as Jaipur, Srinagar and Pune.

This years arrivals will finish about 4% up from last year. Next years arrivals projection is being set at 40.8 million, which would be up 2.5% on this years audited numbers.

TAT governor Yuthasak Supasorn said the waiver of visa-on-arrival fees and tourism stimulus plans, including more spots for tourists to claim value-added tax refunds, are measures to draw tourists next year. The extension in operating hours at border checkpoints such as 24-hour operation at the Sadao-Bukit Kayu Hitam checkpoint between Thailand and Malaysia until June 16, 2020 will also facilitate tourists from Malaysia.

Yuthasak has raised concerns over negative conditions that could obstruct growth next year, including the strong baht, the ongoing trade spat between the US and China, as well as the current South Korea and Japan trade negotiations) and Japans consumption tax rise and the fallout from Brexit.

The TAT governor says next years world events hosted by Japan and Dubai will attract tourists from around the globe and could reduce visits to Thailand. Additionally, visa facilitation offered by Taiwan, Vietnam and Georgia will induce more travel.

SOURCE: Bangkok Post

PHOTO: Thailands 38,260,000th visitor arrived yesterday, Devanshi Deepak Kesaria, a tourist from India Bangkok Post

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Nanomedicine | AIS | Virginia Tech

§ December 24th, 2019 § Filed under Nano Medicine Comments Off on Nanomedicine | AIS | Virginia Tech

Nanomedicineseeks to develop therapeutics to maintain and improve human health by destroying infective agents and malignant cells while enhancing the ability to detect and identify diseases at a much earlier stage than is currently possible. Today, research in nanomedicine has also led the development of implantablenanodevices forin situmonitoring of medical conditions post-surgery and for the alleviation of pain.Nanomedine is no longer a promise - it is a reality and it is here to stay.

The global nanomedicine market was estimated at $139 billion in 2016, a number that reflects the impact of nanotechnological advances in medicine and that is expected to grow with the advent of its use in prevention and intervention of chronic and acute disorders. This is particularly relevant to areas of cancer where targeted delivery by means of nanoparticles and nanoscale systems are among the most promising developments and the area of cardiology where rapid progress arises from the use of nanovectors, nanostructure-based stents, and nanotube scaffolds for tissue regeneration.

Virginia Tech has the only undergraduate Nanomedicine major in the United States. Students in our major will be part of an interdisciplinary programrooted in hands-on laboratory research experience in a collaborative and creative setting with access to state-of-the-art facilitiesand research and educational resources.Nanomedicinestudents will be well-prepared for professional and graduate school as well as exciting careers in health professions, pharmaceuticals, diagnostics and imaging, medical devices and products, and many related areas.

We recommend students in Nanomedicine consider applying to the Integrated Science Curriculum.

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