Hundreds Of Scientists Say Coronavirus Is Airborne And The WHO Is Dragging Its Feet Conceding – IFLScience

§ July 6th, 2020 § Filed under Nano Medicine Comments Off on Hundreds Of Scientists Say Coronavirus Is Airborne And The WHO Is Dragging Its Feet Conceding – IFLScience

Over 230 experts are urging the World Health Organization (WHO) to revisittheir information on whether Covid-19 can be spread through airborne transmission that can lurk in indoor spaces, suggesting their hesitancy to do so is putting people in danger.

The 239 signatories from 32 countries argue the UNs health authority needs to seriously explore the possibility that the disease can also be spread via microscopic particles pumped out by breathing and talking that can linger in indoor spaces, according to a statementby theQueensland University of Technology ahead of publication in the journal Clinical Infectious Diseases.

The WHOcurrently advises Covid-19 spreads primarily through droplets of saliva or discharge from the nose when an infected person coughs or sneezes. However, the international group of scientists says this downplays the risk, and the WHO is dragging its feet when it comes to revising its information.

WHOs credibility is being undermined through a steady drip-drip of confusing messages, including asymptomatic spread, the use of masks, and now airborne transmission, Lawrence Gostin, a professor of global health law at Georgetown University who provides technical assistance to the WHO, told the Washington Post.

Critically, the debate about airborne transmission underpins many of the worlds public health strategies. For example, if the novel coronavirus truly is viable in its aerosolized airborne form, it would mean thatpoorly ventilated spaces including workplace environments, schools, restaurants, buses, trains, etc could still be potentiallydangerous, even if peoplestick to a 2-metersocial distancing rule.

Studies by the signatories and other scientists have demonstrated beyond any reasonable doubt that viruses are exhaled in microdroplets small enough to remain aloft in the air and pose a risk of exposure beyond 1 to 2 meters by an infected person, Professor Lidia Morawska, director of the International Air Quality and Health Laboratory, said in a statement.

Naturally, the WHOs information on the ongoing pandemic has been subject to change when new insights have come to light about the Covid-19.The nature of airborne transmission, however, has remained the subject of long, hot debate between scientists. Some argue Covid-19 is mainly spread by larger droplets of mucus flung out by coughs, spitting, and spluttering. Since these droplets are heavy, they can only remain airborne for a short period before heading towards the ground and theres a relatively low risk of the virus lingering in the air. On the other side of the debate, some argue that there is strong evidence the virus can spread through smaller aerosolized particles. Aerosols, or droplets smaller than 5 microns, can float in the air for notably longer and increases the risk of airborne transmission, especially in a stuffy room.

While the SARS-CoV-2 viruscan live in the air under lab conditions for several hours, some scientists have remained doubtful ofwhether it can remainviable and infectious in this form. However, a number of case studies have shown the contrary. One report suggested though it did not definitively prove that air conditioning may have helped to infect at least nine people with Covid-19 at a restaurant in the Chinese city of Guangzhou.

Nevertheless, the debate is ongoing and, in spite of some evidence, the WHO is sticking to its guns for the meantime.

Especially in the last couple of months, we have been stating several times that we consider airborne transmission as possible but certainly not supported by solid or even clear evidence, Dr Benedetta Allegranzi, the WHOs technical lead of infection prevention and control, was quoted by the New York Times.

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Hundreds Of Scientists Say Coronavirus Is Airborne And The WHO Is Dragging Its Feet Conceding - IFLScience

Factfile: The Endocannabinoid System Control Panel of the Human Body – VolteFace Magazine

§ July 6th, 2020 § Filed under Nano Medicine Comments Off on Factfile: The Endocannabinoid System Control Panel of the Human Body – VolteFace Magazine

Is there really an endocannabinoid system? Yes. Although not currently included in textbooks and science curriculums, the endocannabinoid system (ECS) does exist. Cannabis is a plant that happens to interact with the ECS to cause a range of effects. Since cannabis re-emergence into mainstream health and media, it has been under heavy political pressure from all sides; involving scheduling, classification, patient access, medicinal effects, and safety. Therefore, the following article aims to shed light on the intricate, yet mysterious system that is responsible for orchestrating the effects of cannabis, while also providing useful insight for society.

The bodily systems that receive all the attention in textbooks are the circulatory, digestive, endocrine, integumentary, immune, lymphatic, muscular, nervous, renal, reproductive, respiratory, and skeletal systems. The endocannabinoid (endo-can-na-bin-oid) system is a biological system much like the other twelve systems in the human body. Compared to the discovery of the other systems, the ECS is relatively new, with its discovery only taking place in the 1990s. Scientists were late to the party, as phylogenetic studies (the study of evolutionary relationships) showed that the ECS had evolved over 600 million years prior to its discover and currently exists in all mammals. In fact, the ECS enables the constant balance of physiological processes; which includes pain, inflammation, sleep, learning, memory, energy, metabolism, digestion, reproduction, exercise, stress, thermoregulation, and appetite. In other words, balance is the core function of the ECS, biologically known as homeostasis. How does it manage to do all of this? To answer that, we will first need to introduce the components of the system. Until then, one can imagine the way in which the ECS operates to be synonymous to a complex audio control panel. By being able to finely tune a wide variety of outputs in response to changes in the environment.

The ECS is comprised of three different components that help take care of the aforementioned processes. Whether you have ever taken cannabis or not, these three components are working around the clock to keep physiological processes in check. They include the endocannabinoids, their metabolising enzymes, as well as the cannabinoid receptors. First off, endocannabinoids are the molecules that are naturally synthesised within your body and help control many of the key functions stated earlier. The two endocannabinoids produced in our body are Anandamide and 2-AG. Secondly, the metabolising enzymes help with the degradation of these endocannabinoids after they have fulfilled their purpose. These enzymes are called MAG-L and FAAH. Finally, the cannabinoid receptors are the structures that endocannabinoids and other molecules can bind to and broadly speaking, result in downstream effects. The two cannabinoid receptors in the body are the cannabinoid type-1 (CB1) and cannabinoid type-2 (CB2) receptors. The CB1 receptor is found in large concentrations in the brain and less so throughout the body, whereas the CB2 receptor is found in greater quantities throughout the body and less so in the brain. Collectively, their extensive coverage allows for the diversity of functions the ECS plays a role in. To illustrate this point, below is a microscopic image taken during my studies into the RNA expression of the cnr1 gene in mouse models. Depicted is a mouse brain slice that has been prepared and stained for the cnr1 gene (red), which is responsible for producing the CB1 receptor. The red dots serve as a marker, demonstrating the abundance of CB1 receptors in various areas of the brain.

Besides the endocannabinoids, anandamide and 2-AG, there are other types of cannabinoid molecules. Cannabinoids are classified depending on their source. Ultimately, cannabinoids are either endo-cannabinoids, meaning they are produced within the body or exogenous cannabinoids meaning they are produced outside of the body. Besides the endocannabinoids discussed above, exogenous cannabinoids are further classified as either phytocannabinoids or synthetic cannabinoids. Phytocannabinoid are plant-derived, like those found in cannabis. In fact, a total of 144 unique phytocannabinoids have been isolated from the cannabis plant alone, including the widely known THC and CBD phytocannabinoids. On the other hand, synthetic cannabinoids are those that are produced in a laboratory. Regardless of their source, cannabinoids, in some form or another interact with our cannabinoid receptors.

Each of us has an ECS but the capacity in which that system operates may be different. This is referred to as endocannabinoid tone. This tone can be described as the level of ECS activity. This activity is based on factors such as the extent of endocannabinoid synthesis, enzymatic activity, density of cannabinoid receptors. It also includes environmental factors such as but not limited to stress, exercise, and mood. Therefore, even though ones endocannabinoid tone may vary from year to year or even day to day, this tone is generally unique to each of us. The variability in endocannabinoid tone helps explain the inconsistencies in response people may have to taking cannabinoids, such as those found in cannabis.

So, what exactly do our endocannabinoids do? The endocannabinoids represent brakes to the system. Essentially, they dampen the probability of neurotransmitters getting released and thus taking effect. As you may know, different neurotransmitters such as dopamine, glutamate, noradrenaline, serotonin, GABA, and glutamate all have differing effects. Therefore, based on the type of neurotransmitter whose response was dampened, the resulting effect is also changed. Generally speaking, these can be categorised into either the blocking of an excitatory signal (inhibitory effect) or blocking of an inhibitory signal (excitatory effect). Furthermore, the spatial considerations of where in the brain these neurotransmitters are or are not being released plays further into the variances in effect.

Despite the large efforts of research and development (R&D), as well as clinical trials, regulatory approval of cannabinoid-based treatments are few and far between. Currently, there are four cannabinoid-based medicines approved by the US Food and Drug Administration (FDA). Three of these medications are synthetic cannabinoids indicated for either adult AIDS patients suffering from anorexia related weight loss or adult patients suffering from chemotherapy induced nausea and vomiting. These drugs are synthetic forms of THC; they include Dronabinol (Marinol, Syndros) and Nabilone (Cesamet).

The fourth medicine, demonstrates that cannabinoid-based treatments may not solely be synthetic. As of June 25th, 2018, Epidiolex (Epidyolex) became the first plant-derived cannabinoid drug to be approved by the FDA. Epidiolex is an oral solution of highly purified, plant-derived CBD approved for the treatment of two rare and highly debilitating forms of epilepsy, known as Lennox-Gastaut syndrome (LGS) and Dravet syndrome. After Epidiolex was approved by the FDA, it was classified as a Schedule I drug. This was because cannabis and anything derived from the cannabis plant was considered to be Schedule I. This included CBD, and thus implicated Epidiolex (CBD) into the same classification. Upon examination, Cannabis Schedule I classification was justified based on the high abuse potential and lack of medical value confirmed by standardised, double-blind, randomised control trials. What about Epidiolex? It has demonstrated the medical efficacy to warrant an FDA approval. Therefore, nonclinical and clinical studies were conducted to further investigate its abuse potential. After a few months, the Drug Enforcement Administration (DEA) reclassified Epidiolex as Schedule V, the lowest level due to its established medical use and low abuse potential.

So far, this article has examined some of the science behind the ECS and regulatory approaches to the approval and scheduling of cannabinoid-based medicines. It is time to consider the patients because what value can a treatment truly have without patient access. There is an underlying pattern behind currently approved cannabinoid-based medications. They are last choice treatments, only considered after all other conventional therapies have failed. This has made patient access difficult, even in areas of the world that have legalised medical cannabis. For example, the United Kingdom (UK) maintained the Schedule I classification for Epidiolex, which significantly hindered patient access. Additional factors such as the stigma behind cannabis-derived medicines and lack of understanding behind the mechanisms of CBD have led health care professionals and consultants to feel uneasy when it comes to prescribing these treatments, especially given their scheduling. Fortunately, on June 24th, 2020, the British National Health Service (NHS) also down-scheduled Epidiolex to the lowest level (Schedule V) of controlled substances. This would resolve many of the aforementioned difficulties patients encountered when trying to access this medication. Although this may seem like a simple decision that should have been made long ago, regulatory bodies like the NHS and FDA have legitimate cause for concern.

This can be highlighted through the history of one such drug. As covered earlier, the ECS plays a role in behaviours like feeding and appetite. It is through this same process that cannabinoids like THC bind to the CB1 receptor and cause cravings, commonly known as the munchies. Therefore, researchers theorised that blocking this pathway of the ECS would suppress appetite and lead to weight loss. This led to the innovation of a potential weight loss wonder-drug for obese patients. Clinical trials and research proceeded, demonstrating considerable effects in reducing both appetite and weight in animal and human models. In 2006, Europe approved Rimonabant while the FDA remained concerned about its safety profile. Two years later, it was removed from market. It was found that the antagonistic effects on the CB1 receptor not only reduced appetite but also modified other processes and functions. This led to the incidence of negative psychoactive side effects, such as depression and suicidal ideation being associated with the use of Rimonabant. With regards to the ECS-control panel example, while attempting to block or reduce the effects of one switch in the system, many other switches were also affected which throws the endocannabinoid system out of balance. Due to the complexity of the ECS, it is incredibly difficult to achieve desired outcomes without a more fine-tuned approach. This combined with the lack of knowledge regarding the mechanisms of cannabinoid action and long-term safety studies, warrants a careful and comprehensive approach to policy and regulation. Going back to the topic of Epidiolex, at the high doses indicated in such patients, CBD can cause nausea, sedation, and liver toxicity. Therefore, when it comes down to such decisions, it inevitably becomes an evaluation of whether the potential benefits outweigh the potential risks. The evaluation of potential benefits and risks can be extremely difficult, which is why research and clinical trials must continue to deepen our understanding of the endocannabinoid system and how novel molecules can maximise therapeutic benefit.

With that being said, the number of approved cannabinoid-based medicines and products will only continue to rise. Particularly because research and development around the cannabinoid space has been overly active with companies pushing their lead compounds through various stages of the developmental pipeline. In addition, the market is quickly expanding as companies are working to deliver cannabinoids via novel formulations that are more precise and deliberate in their actions. As is usually the case when it comes to dealing with uncertainty, only time will tell.

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Health Matters: Mystery of the diseased toenail | News, Sports, Jobs – Marquette Mining Journal

§ July 6th, 2020 § Filed under Nano Medicine Comments Off on Health Matters: Mystery of the diseased toenail | News, Sports, Jobs – Marquette Mining Journal

Tuesday: Health

Jun 30, 2020

It was a Thursday, another workday at the office. The first patient of the day was new to my practice, but presenting with a common complaint, that of thick, ugly fungal toenails. Do you suffer from such an affliction? Many do. Medically, there was nothing remarkable about this individual. Likewise, her foot health history: unremarkable, just the diseased toenails.

It sounds so simple. Over the last year, this individual had developed two diseased big toenails. They were uncomfortable at times, but never distinctly painful. Initially she had attempted treatment with an over-the-counter fungus medicine but saw little change. Her family doctor had prescribed a course of terbinafine, the most common oral agent prescribed for onychomycosis, but this also had produced no difference in the appearance of the nail.

She had subsequently sought the care of a dermatologist. This physician had prescribed, despite the inordinate expense, one of the new topical agents for nail fungus. The patient managed to obtain the medicine and used it faithfully as prescribed. Much to her dismay, its effectiveness did not match the medications cost and no real transformation was forthcoming. Understandably, my patients frustration was mounting, which brought her in to see me.

Experts in fungal disease recognize the difficulties in treating the resistant, disfiguring nail changes associated with this type of infection. One of the most challenging aspects of these is the diagnosis: people assume they know the cause. Obviously, her physicians had made assumptions regarding the diagnosis. Yet studies reveal only about half the time is the discoloration, the thickening, and the changes in shape, due to a fungal infection. To accurately ascertain the cause of your nail transformations, a specimen for biopsy must be obtained, which is sent to a specialized lab. This sometimes requires the use of a local anesthetic, but is the best way to get a definitive diagnosis.

As you may not have guessed, the individual in question was not diagnosed with onychomycosis (fungal nails) but psoriatic nails. Psoriasis is a chronic disease causing inflammation of various tissues, especially skin, resulting in the rapid overgrowth of skin cells. It is not due to an allergy or a bad diet. For this reason, it is not treatable with dietary changes. Although there is a strong genetic component, environmental factors are of critical importance. About 1 to 2% of the global population has some form of psoriasis, with considerable differences among regions and people of varying skin types. Neither gender nor race predilection appears to exist. Approximately half of those with psoriasis will exhibit nail alterations at some point.

Nail psoriasis causes changes to your fingernails and/or toenails. These changes are mistaken for a fungal infection far too often. Inappropriate, since they are treated very differently. One is an infection (and can spread), while the other is an autoimmune condition. The occurrence of psoriatic nail changes is indicative of a poorer prognosis overall. Nail psoriasis also portends a higher risk of developing psoriatic arthritis. Some common signs of nail psoriasis include the appearance of tiny dents in the nail (pitting), discoloration (white, yellow or brown), and nail separation, the lifting of the nail off the digit. My patient had all these changes, the classic three characteristics of the psoriatic nail.

A wonderful diagnostic tool I used in this patients case was a dermatoscope. Basically, it is a small, hand-held, very portable microscope. It allows the physician to easily observe microscopic changes of the skin, even into the skin. The benefits are innumerable and especially beneficial in podiatric medicine. My latest iteration is digital and plugs into the laptop, magnifying minute changes for all to see. (It can be quite a show.) Still, the gold standard in dermatologic medicine is histologic testing. The science of analyzing pathologic tissues has come so far, allowing us to learn so much from so little material.

Like skin psoriasis, nail psoriasis is chronic but may improve or worsen for no discernible reason. Trauma has a critical role in exacerbations and remissions of nail psoriasis. For example, because artificial nails increase mechanical stress to the nail plate, they will reliably worsen nail psoriasis. Those engaged in professions demanding significant use of the fingers will often experience an increase in the severity and frequency of psoriatic attacks. The same applies to any more physical means of employment, such as a job requiring the frequent pulling or pushing of heavy objects.

In most cases, nail psoriasis follows the skin changes of psoriasis and is therefore easy to diagnose. But in approximately five percent of cases, nail psoriasis occurs without the skin lesions and can pose a real diagnostic challenge, as in the case of our protagonist. This is especially true when alterations in the nail are atypical such as a single nail being affected. The analysis of a specimen by a pathologist, termed histopathology, is usually all that is necessary to make the diagnosis, provided the biopsy specimen is appropriately obtained.

Genes are the most important factor in an individuals psoriatic manifestations. Many different genes contribute to psoriasis and how it develops in each sufferer, which partially explains the enormous variability in the response to treatment. Trauma is the most obvious causative agent other than genetic. Some of the identified risk factors for developing psoriasis include smoking, obesity, and alcohol use. Trauma to the nail unit will inevitably exacerbate the condition or induce recurrences.

The many treatments available give evidence that none is the ideal therapy. Nail psoriasis treatments require a long time, as the nail is a slow-growing skin structure. The effect of any nail treatment cant be accurately evaluated before a year has elapsed, at a minimum. This is how long, on average, it takes for a big toenail to grow out and this length of time must pass prior to determining maximal improvement of any therapy. Additionally, excluding the presence of a fungal infection is a necessity when starting nail psoriasis therapy (as our patient discovered).

Nail psoriasis is highly resistant to almost all topical treatments, and thus this approach is less commonly used. The problem with all topical drugs is their limited penetration to the diseased tissue. As with fungal nails, reducing the barrier in some fashion increases the benefits of a topical. This can be achieved through nail removal, thinning of the nail, or drilling of small holes in the nail to provide better access of the medicine. As is often the case in these matters, topicals are nearly always safer. Those systemic therapies used to produce clearing of the skin are usually effective also in nail psoriasis. These can also be injected around the nail root, which largely avoids the systemic side effects.

Nail psoriasis can have a tremendous impact on many aspects of life for those afflicted. Need I say, the changes are negative ones, as a rule. With such a common problem (one out of every fifty people), one might hope there would be some semblance of a cure, but there is not. Surprisingly, nail psoriasis is only briefly mentioned in most guidelines on the diagnosis and treatment of psoriasis.

Truly, modern medicine has come so far, yet there is much we simply do not know. Still, there are treatments for controlling the signs and symptoms of this disease. Early and accurate identification is the key to proper treatment. Any therapy works better when its used on the appropriate condition. Get your nail changes looked at (REALLY closely) by a specialist. And get a biopsy. It only makes sense!

Editors note: Dr. Conway McLean is a physician practicing foot and ankle medicine in the Upper Peninsula, with a move of his Marquette office to the downtown area. McLean has lectured internationally on wound care and surgery, being double board certified in surgery, and also in wound care. He has a sub-specialty in foot-ankle orthotics. Dr. McLean welcomes questions or comments atdrcmclean@outlook.com.

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28 cool health things that started with a Canadian – Regina Leader-Post

§ July 5th, 2020 § Filed under Nano Medicine Comments Off on 28 cool health things that started with a Canadian – Regina Leader-Post

Alzheimers in mice

Dr. Peter St George-Hyslopof the Weston Brain Institute identified a number of genes responsible for Alzheimers disease and nerve cell degeneration using mouse models. He has published nearly 400 papers on Alzheimers research.

In the early 2000s, he essentially cured Alzheimers in mice through the discovery that certain types of sugars would block the development of amyloid proteins, one of the hallmarks of Alzheimers.

Genomics

University of Torontos Brenda Andrews pioneered the field of functional genomics and systems biology to discover how genes and their protein products regulate cell function in health and disease. She is also an elected member of the National Academy of Sciences and a specialist in the application of artificial intelligence to personalized medicine.

Kathleen Dickson is a former chief technician from the Montreal Neurological Institute.

John Bergeron is the Emeritus Robert Reford Professor and a Professor of Medicine at McGill University.

Dont miss the latest on COVID-19, reopening and life. Subscribe to Healthings daily newsletterComing Out of COVID.

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28 cool health things that started with a Canadian - Regina Leader-Post

The permafrost pandemic: could the melting Arctic release a deadly disease? – Unearthed

§ July 5th, 2020 § Filed under Nano Medicine Comments Off on The permafrost pandemic: could the melting Arctic release a deadly disease? – Unearthed

Dr Brigitta Evengrd, who led in putting together the historic Hannover event, was far less ready to dismiss the threat of frozen bacteria she sees the emerging antibiotic resistance crisis as a threat multiplier.

After returning from a brief hiatus practicing medicine as Swedens doctors were called in to support Covid-19 efforts, she told Unearthed: My worst case scenario? Whats happening already every now and then, there was an outbreak in Madagascar just a few years back. And thats antibiotic resistant Pasteurella pestis plague.

Though she admitted the risk of antibiotic-resistant diseases emerging is thin, it is not impossible.

The antibiotic resistance pandemic will kill annually more than the coronavirus pandemic.

As for possible pandemics from the Arctic? The two that we know could come out of the permafrost are anthrax and thats pox viruses, other than that its pandoras box.

Finding a host

Once unfrozen, these permafrost microbes must find a host in order to survive. But they have a problem: there arent many people who live in the area, and those that do often indigenous villages are not in frequent contact with outsiders, meaning the spread of infection would likely be limited.

The real danger is not the thawing of permafrost per se, Dr Claverie said, its that humans the Russians mainly are now starting to exploit the Arctic regions, and are making big holes by which to excavate layers permafrost that are up to a million years old.

This is the recipe for disaster because you have humans here and you have the virus when it is fresh. When viruses are released from the permafrost in nature, what happens? They fall into the river. They are exposed to oxygen, which is bad for viruses. They are exposed to light, which is also bad for viruses. And so they will not be revived for very long if they dont find a host very quickly.

So its like the permafrost is the ocean, and the microbes the sharks. Dont go surfing when there are sharks in the water and things should be alright.

Dr Abergel said: If [the viruses] come into contact with a proper host then they will reactivate. So if you put a human in a place with frozen viruses associated with pandemic then those humans could be infected and replicate the virus and start a new pandemic.

But as Dr Evengrd pointed out, humans are not the only potential hosts out there.

With climate change, we have movement of animals. People, we tend to stay in our homes if we are well enough. If you are near the coastline of Bangladesh, lets say, you may already be moving inland. The biggest migration of climate refugees is still inside their home countries. But animals, they move.

She stressed that climate change has sent the global ecosystem into flux, and its nigh impossible to say where things will end up.

Moose and hares, for instance, are migrating north as vegetation crops up, and then of course theres birds and fish and their sometimes globe-spanning migratory patterns.

These animals can bring microorganisms into virgin areas, Dr Evengrd said, and things will happen that we simply cant predict. You can say the Arctic is spacious and not so populated but there are people coming and going yes, miners and there are microorganisms coming in there with animals and even coming up from the earth. The dynamic that is ongoing is new.

The Coronavirus experience, she said, has just reinforced my belief that what Im doing is absolutely important.

Im not surprised, its not a question of if this was going to happen it was when. The only enemy we really have is our own ignorance that were not preparing for this. We have all this knowledge, its really not that new. This dynamic process that were getting into with the climate change era. We should be better prepared, instead were sitting here paralysed by fear.

This is a warning from nature and its going to happen again and again and again, Im sure.

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The permafrost pandemic: could the melting Arctic release a deadly disease? - Unearthed

Leveraging The Power Of Full Spectrum Hemp Oil (Synchronicity) – Anti Aging News

§ July 5th, 2020 § Filed under Nano Medicine Comments Off on Leveraging The Power Of Full Spectrum Hemp Oil (Synchronicity) – Anti Aging News

1004 0 Posted on Jul 01, 2020, 6 p.m.

Article courtesy of: Dr. Joel Kahn, MD, who is a Clinical Professor of Medicine at Wayne State University School of Medicine, one of the world's top cardiologists, best selling author, lecturer, and a leading expert in plant-based nutrition and holistic care.

Did you attend biology classes in school? If so, you may remember your first introduction to the cardiovascular system, how the rhythmic beating of the heart circulates oxygen and nutrients throughout the body. Most likely, that first lesson was relatively simple to understand.

Eventually, the lessons got more complicated. You soon learned that dietary choices, physical habits, and sleep quality all play a significant role in cardiovascular health. Once you understood that heart health is also affected by inflammation, free radical damage, and hormone levels, you recognized the importance of maintaining a balance between essential bodily processes.

A relatively short time ago, researchers identified a regulatory system that influences nearly every essential function in the body, including processes directly impacting cardiovascular health. They also discovered that this universal regulatory system responds to the phytocannabinoids, terpenes, and flavonoids in hemp. Of the more than 100 cannabinoids in Full-Spectrum Hemp Oil, its the therapeutic potential of CBD(cannabidiol) that has people talking. CBD is a phytocannabinoid with anxiolytic, analgesic, anti-inflammatory, and anti-spasmodic properties (1).

If youre intrigued by the therapeutic potential of Hemp Oil, its important to understand that the composition of the oil you select will have a considerable impact on your health. For the best experience, youll need to know how your body will react to hemp. Youll also need to know the differences between CBD oil and Whole-Plant Full-Spectrum Hemp Oil.

Investigating the Health and Wellness Potential of Phytocannabinoids

If youve been investigating the therapeutic potential of phytocannabinoids, you may already have a basic understanding of how these plant elements relay urgent messages to the receptors of the endocannabinoid system (ECS)(2), the largest regulatory system in the body. What you may not realize is how essential this communication is to your overall health and wellbeing.

Modern researchers believe the main purpose of ECS signaling is to regulate the processes involved in homeostasis (the internal balance all living organisms must maintain to survive). When internal or external forces threaten that balance, homeostatic processes restore equilibrium (3).

That equilibrium affects nearly every essential function in your body. The ECS messengers (endocannabinoids) are produced by your body as needed and then broken down by metabolic enzymes once their messages are delivered to cannabinoid receptors. The response initiated by the receptors depends on the chemical composition of the message received. Just a few of the numerous processes regulated by ECS signaling (4) include:

Ideally, your body would make all the ECS messengers needed to ensure that all internal processes run efficiently. But, this is an ideal scenario. Under the influences of stress, illness, or injury, the demand for endocannabinoids can exceed the available supply.

When demand exceeds supply, essential communication between endocannabinoids and cannabinoid receptors becomes less efficient. Important messages may not be received. Since phytocannabinoids mimic the effects of the endocannabinoids produced in your body, supporting ECS function with Hemp Oil can potentially restore essential balance.

How Supporting ECS Function Can Protect Cardiovascular Health

Today, many cannabinoid researchers believe endocannabinoid deficiencies cause disease. Current research appears to support the connection between the lack of ECS messengers and fibromyalgia, IBS, migraine, several neurodegenerative disorders, and other treatment-resistant syndromes (5).

The evidence supporting the therapeutic potential of phytocannabinoids for a number of health concerns is based on animal studies, laboratory tests, clinical trials, and user reviews. In particular, the studies investigating the cardiovascular benefits of CBD and other phytocannabinoids are particularly intriguing.

Preliminary research suggests the phytocannabinoids in Hemp Oil may be beneficial in reducing the risk of heart disease for people with diabetes (6). The research also shows that cannabidiol may protect the heart from ischemic damage. In animal studies, the CBD in Hemp Oil shows potential for stabilizing cardiac arrhythmia, a condition that causes the heart to beat too fast or in an irregular pattern (7)

Of course, far more testing needs to be done before reaching a universal consensus on hemp. Thats why Its important to note that CBD and other phytocannabinoids in Hemp Oil are not intended to be used as a preventative, treatment, or cure for any known health conditions. However, animal studies, lab results, and user testimonials suggest Hemp Oil products may be beneficial for heart health. To help determine how Hemp Oil can help you, consider the value of the following observations.

Phytocannabinoids May Help You Get the Rest You Need

While occasional sleeplessness is unlikely to cause irreparable damage, chronic sleep deprivation can take a considerable toll on your overall health. Current research shows that adults who sleep less than seven hours each night have an increased risk of Type 2 diabetes, weight gain, high blood pressure, and other chronic health conditions that can contribute to a higher risk of heart disease (8) Numerous Hemp Oil users claim nightly use improves sleep quality. Thats not entirely surprising. Sleep and sleep cycles are regulated by the endocannabinoid system. The CBD in Hemp Oil is shown to stabilize sleep cycles and improve REM sleep. Plus, the anxiolytic and analgesic properties of cannabidiol have the potential to provide mood and nervous system support (9).

Hemp Oil May Help Your Body Manage the Impact of Stress

Stress initiates a cascade of events that can compromise your health. In response to physical or emotional stress, your body increases the production of adrenaline and the stress hormone cortisol. The longer the duration of the stress-inducing experience, the longer it takes for your body to restore balance. Prolonged stress can result in chronic inflammation, high blood pressure, stroke, and heart attack. For women, the risk increases after menopause due to estrogen loss (10).

Unresolved stresses can also trigger insomnia and anxiety. Researchers have found that CBD and other minor cannabinoids in Hemp Oil interact with receptors directly involved in stress responses. These receptors include endocannabinoid, GABA, dopamine, and serotonin receptors (11). That interaction explains the anxiolytic properties of CBD and other plant-based cannabinoids. Essentially, plant cannabinoids may be critical in providing nervous system, balanced mood, and neuroprotective support.

Phytocannabinoids May Reduce Your Risk of Developing High Blood Pressure

When doctors measure blood pressure, they are evaluating the amount of force exerted on arterial walls as blood flows through them. When this force remains unnaturally high for long periods of time, it can cause considerable damage to blood vessels. This can result in a long list of potential complications, including atherosclerosis, chronic kidney disease, angina, and heart attack. Most people with high blood pressure never experience symptoms until problems develop (12).

Pre-clinical studies suggest that the CBD in Hemp Oil helps reduce blood pressure by initiating blood vessel dilation. Once blood vessels expand, there is less stress exerted on the arterial walls. A 2017 randomized study revealed that a single dose of CBD reduced the resting blood pressure and the stress-induced blood pressure increases of nine healthy volunteers (13). While the results of initial investigations are intriguing, further study is needed.

Hemp Oil Has the Potential to Calm Systemic Inflammation

Inflammation is a defense mechanism, a healing response initiated by your immune system. The reaction is a sign that an army of white blood cells is responding to an injury or fighting an infection. However, the same immune system response that protects your body from harm can also cause significant damage. Modern researchers believe chronic inflammation contributes to diabetes, arthritis, various cancers, and heart disease (14).

While several medications can alleviate inflammation caused by medical disorders, there are currently no pharmacological treatments for the low-level inflammatory responses triggered by sugar, trans fats, stress, and free radical damage. Research shows that CBD and several lesser-known phytocannabinoids have the potential to neutralize inflammation by inhibiting COX enzymes(15), delaying the breakdown of anandamide (16), and activating vanilloid receptors. The latter, vanilloid receptors, influence pain perception and temperature regulation.

Phytocannabinoids May Enhance Post-Workout Recovery

Regular exercise helps modify the risk factors for developing heart disease. As strength and endurance build, decreased strain on the heart is promoted by reduced blood pressure, improved fat to muscle ratios, and reduced inflammation. But, while exercise benefits your heart, it can take a significant toll on the rest of your body. The resultant sore muscles, joint stiffness, and temporary loss of muscle strength can derail even the strongest wills. Most post-workout pain is caused by microscopic tears to over-worked muscles (17).

The analgesic, anti-inflammatory, and anti-spasmodic properties of the many phytocannabinoids in Hemp Oil show considerable therapeutic potential for enhancing post-workout recovery. Using Hemp Oil before or after a strenuous workout may help your body recover faster, so the pain and discomfort of increasing the intensity of your workouts wont keep you on the sidelines.

The Significant Differences Between the Three Main Types of CBD Oil

CBD (cannabidiol) is the most abundant of the many phytocannabinoids found in Hemp Oil. When a manufacturer puts CBD Oil on a product label, that description tells you far less than you may realize. Not all CBD products contain the full spectrum of phytocannabinoids, terpenes, and other plant-based nutrients found naturally in the original plant source.

Up to 99% of the time, over-the-counter CBD Oil is made with a single cannabinoid blended with a carrier oil or is derived from plant oils that have been compromised by harsh extraction methods. Thats why its important to have a clear understanding of your options and realistic expectations about commercial CBD Oil preparations. To ensure you are selecting the best Hemp Oil for your needs, consider what you may achieve using the following products.

Understanding the Limitations of CBD Isolate

Isolating CBD from the numerous plant elements found in industrial hemp can greatly reduce its supportive potential. To produce CBD isolate, the cannabinoid-rich oil must first be separated from the plant matter. Most often, the production process begins with soaking the stalks, stems, and flowers of the plant in ethyl alcohol, a commonly used food additive. Hemp seeds dont contain CBD or other phytocannabinoids. The concern with this extraction method is the presence of potentially harmful residues after the alcohol evaporates from the Hemp Oil.

After the extraction process is complete, the oil is heated for a certain amount of time. Any extreme temperatures can compromise product potency. Next, a third step called winterization is used to remove the plants fatty acids, terpenes, additional cannabinoids, and other plant components. All thats left behind is a white, crystalline CBD powder lacking many of the nutrients found in the original plant source (18).

Navigating the Specifications of Broad-Spectrum CBD Oil

Hemp-derived products are labeled as broad-spectrum when they contain many of the phytocannabinoids, terpenes, and phytonutrients of the original plant. Although a considerable number of the minor cannabinoids are left intact, the trace amounts of THC (tetrahydrocannabinol) are removed through a process called chromatography (19). While hemp plants dont synthesize enough of this somewhat controversial cannabinoid to cause intoxication, CBD users who would rather avoid THC typically select Hemp Oil products made with CBD isolate or Broad-Spectrum Hemp Oil.

Broad-spectrum Hemp Oil contains CBD and a wide array of phytonutrients but doesnt contain the entire spectrum of nutrients from the original plant source. In some cases, individual cannabinoids are isolated and then recombined in different ratios.

Recognizing the Benefit Maximizing Effects of Full-Spectrum Hemp Oil Full-Spectrum Hemp Oil products are most often preferred by CBD enthusiasts looking to get the most benefit from their investment. Less processed than Broad-Spectrum Hemp Oil, Full-Spectrum Hemp Oil contains CBD plus the entire range of potentially beneficial phytocannabinoids, terpenes, flavonoids, and other plant components found in nature. Youll likely find that a significant number of companies favor CO2 extraction over other methods because the resulting product is cleaner than oils derived from soaking plant matter in alcohol.

Full-Spectrum Hemp Oil is believed to be the more potent of the three options because of a little-known phenomenon known as the Entourage Effect that maximizes the oils therapeutic potential. This theory is used to explain how the combined effects of the many cannabinoids, plant terpenes, and other plant elements work together synergistically, with each plant component enhancing the impact of the others. The combined effects of each phytonutrient are far greater than those accorded by individual plant elements (20).

How a LipidTrans Infusion Process Delivers a True Entourage Effect

Although many Hemp Oil companies claim their full-spectrum products contain all the phytocannabinoids, terpenes, and plant nutrients in the same ratios found in natural hemp plants, those claims may not be entirely accurate. To experience the full potential of a True Entourage Effect, your body needs access to the full range of polyphenols, essential fats, and phytocannabinoids commonly altered or removed during conventional production methods. Thus, in order to gain the most benefit from your investment, its important to select Hemp Oil products crafted without high pressure, extreme heat, or chemical solvents.

Functional Remedies Synchronicity Full-Spectrum, Whole-Plant Hemp Oil relies on the power of nature to deliver the highest quality Hemp Oil possible, LipidTrans Infusion. The lipid infusion process transfers all the plant nutrients, phytocannabinoids, and other beneficial compounds to a heart-healthy oil (MCT oil). This gentle process preserves the integrity of Hemp Oil, protecting the delicate balance found in nature. While Synchronicity Full-Spectrum Whole Plant Hemp Oil shows considerable potential for protecting heart health, the only way to know if its right for you is to try it. Ask Your Body. To ensure purity and potency, all Synchronicity Full-Spectrum, Whole-Plant Hemp Oil tinctures, capsules, and topical products are third-party tested and produced in a cGMP certified facility. cGMP certification guarantees all production processes meet or exceed FDA enforced manufacturing standards.

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Magnesium Derivatives size and Key Trends in terms of volume and value 2019-2022 – Apsters News

§ July 5th, 2020 § Filed under Nano Medicine Comments Off on Magnesium Derivatives size and Key Trends in terms of volume and value 2019-2022 – Apsters News

The Magnesium Derivatives Market research report added by Market Study Report, LLC, provides a succinct analysis on the recent market trends. In addition, the report offers a thorough abstract on the statistics, market estimates and revenue forecasts, which further highlights its position in the industry, in tandem with the growth strategies adopted by leading industry players.

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The competitive expanse of this business has been flawlessly categorized into companies such as

Market Segment Analysis The research report includes specific segments by Type and by Application. Each type provides information about the production during the forecast period of 2015 to 2026. Application segment also provides consumption during the forecast period of 2015 to 2026. Understanding the segments helps in identifying the importance of different factors that aid the market growth. Segment by Type Magnesia Magnesium Sulfate Magnesium Hydroxide Other

Segment by Application Water Treatment Medicine Cosmetics Animal Feed Other

Global Magnesium Derivatives Market: Regional Analysis The report offers in-depth assessment of the growth and other aspects of the Magnesium Derivatives market in important regions, including the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, Taiwan, Southeast Asia, Mexico, and Brazil, etc. Key regions covered in the report are North America, Europe, Asia-Pacific and Latin America. The report has been curated after observing and studying various factors that determine regional growth such as economic, environmental, social, technological, and political status of the particular region. Analysts have studied the data of revenue, production, and manufacturers of each region. This section analyses region-wise revenue and volume for the forecast period of 2015 to 2026. These analyses will help the reader to understand the potential worth of investment in a particular region. Global Magnesium Derivatives Market: Competitive Landscape This section of the report identifies various key manufacturers of the market. It helps the reader understand the strategies and collaborations that players are focusing on combat competition in the market. The comprehensive report provides a significant microscopic look at the market. The reader can identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and production by manufacturers during the forecast period of 2015 to 2019. The major players in the market include Causmag International, GRECIAN MAGNESITE, IBAR Nordeste, Martin Marietta Magnesia Specialties, Sinwon Chemical, Baymag, YINGKOU MAGNESITE CHEMICAL IND GROUP, Oksihim, Tateho, Gongyi Qianghong Magnesium Technology, Compass Minerals, Karnalyte Resources, Intrepid Potash, OLE Chemical, K+S Group, NIKOMAG, RHI Magnesita, etc.

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The Magnesium Derivatives market research study conscientiously mentions a separate section that enumerates details with regards to major parameters like the price fads of key raw material and industrial chain analysis, not to mention, details about the suppliers of the raw material. That said, it is pivotal to mention that the Magnesium Derivatives market report also expounds an analysis of the industry distribution chain, further advancing on aspects such as important distributors and the customer pool.

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Gov. Walz is urged to require Minnesotans to wear masks in COVID-19 fight – msnNOW

§ July 5th, 2020 § Filed under Nano Medicine Comments Off on Gov. Walz is urged to require Minnesotans to wear masks in COVID-19 fight – msnNOW

Star Tribune/Star Tribune/Alex Kormann/Star Tribune/TNS Duluth Human Rights Officer Carl Crawford greeted Minnesota Gov. Tim Walz with an elbow bump last month.

Minnesota Gov. Tim Walz is being urged to require residents of the state to wear masks when out in public, as COVID-19 cases hit record highs nationally and health officials worry infections may regain dangerous momentum here.

Governors in states with rising COVID-19 numbers, including California, Kansas and Pennsylvania, have mandated mask use statewide in recent weeks, saying its a simple and effective step to slow the spread of a virus that has killed more than 127,000 Americans, including 1,445 in Minnesota. Even President Donald Trump, who has resisted wearing a mask in public, said Wednesday hes all for wearing masks, adding that people should wear them if they feel good about it.

Walzs potential step comes amid growing evidence for how masks can work in concert with other safety protocols health officials are pleading with people to adopt if masks are worn properly and made with the right materials. Physician groups in Minnesota and the state Health Department are now fully backing a mandate.

Thats been a vigorous conversation within the executive branch, and with the governor directly. And I think he is listening, Minnesota Health Commissioner Jan Malcolm said Wednesday.

It is our advice from the health departments perspective that this is so important and so effective and the evidence has gotten more and more clear on this point. We do recommend that it become a requirement at the statewide level.

When properly worn, cloth masks, like those made at home or bought from retail stores, are intended to capture the microscopic droplets of moisture on the wearers breath that are a main source for spreading the virus. Since people can be contagious without having symptoms of COVID-19, many health officials say its important they be worn all the time while in public. The mask must cover the nose and mouth to work to be most effective.

To date, more than a dozen states are requiring people to wear masks while in public.

Walz said Wednesday that hes considering factors, such as the continued spread of COVID-19 in Minnesota, as part of a daily evaluation of whether to issue an order requiring public mask-wearing statewide.

Does our thinking change as we start to see these numbers in other states? Yes, absolutely, Walz said Wednesday. But were still looking at our own.

The number of new lab-confirmed cases of COVID-19 nationally hit a new daily record of 48,365 on Tuesday, just ahead of the Independence Day holiday weekend.

Minnesota reported 426 newly confirmed cases of COVID-19 on Wednesday, bringing the statewide total of lab-confirmed cases to 36,716. Minnesotas rate of new positive cases declined during the first half of June on a seven-day average basis, but started climbing again June 16. The seven-day average surpassed 400 on June 26.

Yet the number of new deaths and hospitalizations from COVID-19 remain on downward trajectories in Minnesota. The state added four deaths of elderly, group-home residents to its tally of 1,445 COVID-19 fatalities on Wednesday.

Pressure for mandate

Walz, at the urging of physician groups and public health officials, is facing mounting pressure to declare a statewide mask order. Even some members of the states business community are watching closely.

Business leaders, who have been urging Walz to safely lift pandemic restrictions first declared in March, see both risks and benefits in such an order. The key is its scope, and whether it provides enough flexibility for businesses, said Doug Loon, president of the Minnesota Chamber of Commerce.

Safety and engaging workers and customers is the biggest priority for businesses right now because without safety and without reassuring customers, we will not have our economy back, Loon said. Theres plenty of evidence to show that face masks work.

In April, the federal Centers for Disease Control and Prevention (CDC) recommended that people wear cloth face coverings in places like grocery stores and pharmacies where its difficult to stay at least 6 feet apart. The National Academies of Science, Engineering and Medicine issued a report that month that found the available evidence is inconclusive about the degree to which homemade fabric masks may suppress spread of COVID-19 from the wearer to others.

But many public health experts have become convinced of the benefits of wearing homemade masks after seeing what has happened in hospitals, where workers who dont directly work with patients have had to resort to cloth masks, said Dr. Priya Sampathkumar, a critical care and infectious disease specialist at the Mayo Clinic.

When we instituted that, we did see a significant decrease in person-to-person transmission between these workers, she said. So, it definitely works.

Internal hospital data at Duke University suggest universal masking requirements significantly reduces the spread among health care workers, Dr. Sallie Permar, a pediatric infectious disease specialist at Duke. She also cited the emergence of case studies, such as one published in Missouri about a hair salon, where masks were credited with helping 140 clients and six co-workers avoid illness even though two stylists were infected.

Dr. Roger Shapiro, associate professor of immunology and infectious diseases at Harvard T.H. Chan School of Public Health in Boston, said Asian nations including Japan, South Korea and Singapore have proved that social distancing and mask use are effective in controlling the viral outbreak.

If everyone wears masks, this epidemic will go down. Its very simple, Shaprio said in a June 20 call with reporters. Association is not causation, but these [results] are hard to ignore. We really need to be looking to Asia for how to control this.

Dr. Keith Stelter, a family medicine physician in Mankato and president of the Minnesota Medical Association, said some research shows mask-wearing adds an additional 20% protection when used with other pandemic precautions, like social distancing and hand-washing.

Statistically speaking, its a no-brainer, said Dr. Jon Pryor, president of Essentia Healths east market. Masks make a difference. They have been proven to protect us. By wearing a mask you are not making a political statement, you are making a statement that says I care about others.?

False sense of security

Still, some remain skeptical that the quality of evidence for cloth masks is strong.

Dr. Michael Osterholm, director of the University of Minnesotas Center for Infectious Disease Research and Policy, said he is concerned that advocates have oversold the scientific data on cloth masks, giving users a false sense of security.

Distance, distance and distance its the most important risk reduction activity you can do, he said, referring to social distancing of 6 feet or more.

Yet even Osterholm supports using cloth masks. He says there is no harm in wearing one, even if it helps only a little bit, as long as it is worn properly.

After studying news footage showing crowds of people gathered in public in recent weeks, Osterholms research group at the U estimated 26% of people fail to cover their noses when wearing a mask.

Thats like fixing three of the five screen doors on your submarine, he said.

Staff writers Brooks Johnson and Torey Van Oot contributed to this report.

Joe.Carlson@startribune.com 612-673-4779

Chris.Snowbeck@startribune.com 612-673-4744

2020 the Star Tribune (Minneapolis)

Visit the Star Tribune (Minneapolis) at http://www.startribune.com

Distributed by Tribune Content Agency, LLC.

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Gov. Walz is urged to require Minnesotans to wear masks in COVID-19 fight - msnNOW